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Volumn 39, Issue 3, 2017, Pages 1-11

Obesity-associated digestive cancers: A review of mechanisms and interventions

Author keywords

Digestive cancers; Inflammation; Mechanisms of cancers; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; BETA CATENIN; COLLAGENASE 3; CYCLOOXYGENASE 2; INSULIN; INTERLEUKIN 6; K RAS PROTEIN; LEPTIN; SOMATOMEDIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STAT3 PROTEIN;

EID: 85016923695     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1177/1010428317695020     Document Type: Review
Times cited : (25)

References (147)
  • 1
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008; 371: 569–578.
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3
  • 3
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348: 1625–1638.
    • (2003) N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3
  • 4
    • 85027951435 scopus 로고    scopus 로고
    • Body-mass index and risk of 22 specific cancers: A population-based cohort study of 5.24 million UK adults
    • Bhaskaran K, Douglas I, Forbes H, et al. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5.24 million UK adults. Lancet 2014; 384: 755–765.
    • (2014) Lancet , vol.384 , pp. 755-765
    • Bhaskaran, K.1    Douglas, I.2    Forbes, H.3
  • 5
    • 84881479689 scopus 로고    scopus 로고
    • Chemotherapy dosing in overweight and obese patients with cancer
    • Lyman GH and Sparreboom A. Chemotherapy dosing in overweight and obese patients with cancer. Nat Rev Clin Oncol 2013; 10: 451–459.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 451-459
    • Lyman, G.H.1    Sparreboom, A.2
  • 6
    • 84862986506 scopus 로고    scopus 로고
    • Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline
    • Griggs JJ, Mangu PB, Anderson H, et al. Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2012; 30: 1553–1561.
    • (2012) J Clin Oncol , vol.30 , pp. 1553-1561
    • Griggs, J.J.1    Mangu, P.B.2    Anderson, H.3
  • 7
    • 42949129053 scopus 로고    scopus 로고
    • Associations between obesity and changes in adult BMI over time and colon cancer risk
    • Nock NL, Thompson CL, Tucker TC, et al. Associations between obesity and changes in adult BMI over time and colon cancer risk. Obesity 2008; 16: 1099–1104.
    • (2008) Obesity , vol.16 , pp. 1099-1104
    • Nock, N.L.1    Thompson, C.L.2    Tucker, T.C.3
  • 8
    • 58349113391 scopus 로고    scopus 로고
    • Survival with retinoblastoma in the USA: 1975–2004
    • Broaddus E, Topham A and Singh AD. Survival with retinoblastoma in the USA: 1975–2004. Br J Ophthalmol 2009; 93: 24–27.
    • (2009) Br J Ophthalmol , vol.93 , pp. 24-27
    • Broaddus, E.1    Topham, A.2    Singh, A.D.3
  • 9
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005; 11: 191–198.
    • (2005) Nat Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 10
    • 71449120059 scopus 로고    scopus 로고
    • Insulin resistance and hyperinsulinaemia in the development and progression of cancer
    • Godsland IF. Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clin Sci 2010; 118: 315–332.
    • (2010) Clin Sci , vol.118 , pp. 315-332
    • Godsland, I.F.1
  • 11
    • 84883654040 scopus 로고    scopus 로고
    • Diabetes, antihyperglycemic medications and cancer risk: Smoke or fire?
    • Gallagher EJ and LeRoith D. Diabetes, antihyperglycemic medications and cancer risk: smoke or fire? Curr Opin Endocrinol Diabetes Obes 2013; 20: 485–494.
    • (2013) Curr Opin Endocrinol Diabetes Obes , vol.20 , pp. 485-494
    • Gallagher, E.J.1    Leroith, D.2
  • 12
    • 84891763374 scopus 로고    scopus 로고
    • Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer
    • Gallagher EJ and LeRoith D. Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer. Diabetes Care 2013; 36(Suppl. 2): S233–S239.
    • (2013) Diabetes Care , vol.36 , pp. S233-S239
    • Gallagher, E.J.1    Leroith, D.2
  • 13
    • 47349117519 scopus 로고    scopus 로고
    • Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies
    • Pisani P. Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies. Arch Physiol Biochem 2008; 114: 63–70.
    • (2008) Arch Physiol Biochem , vol.114 , pp. 63-70
    • Pisani, P.1
  • 14
    • 47349129465 scopus 로고    scopus 로고
    • Cancer: Pathophysiological and biological mechanisms
    • Renehan AG, Roberts DL, Dive C, et al. Cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 2008; 114: 71–83.
    • (2008) Arch Physiol Biochem , vol.114 , pp. 71-83
    • Renehan, A.G.1    Roberts, D.L.2    Dive, C.3
  • 15
    • 84856764349 scopus 로고    scopus 로고
    • IGF-1 and its receptor in esophageal cancer: Association with adenocarcinoma and visceral obesity
    • Doyle SL, Donohoe CL, Finn SP, et al. IGF-1 and its receptor in esophageal cancer: association with adenocarcinoma and visceral obesity. Am J Gastroenterol 2012; 107: 196–204.
    • (2012) Am J Gastroenterol , vol.107 , pp. 196-204
    • Doyle, S.L.1    Donohoe, C.L.2    Finn, S.P.3
  • 16
    • 77951630296 scopus 로고    scopus 로고
    • Primary prevention of colorectal cancer
    • Chan AT and Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology 2010; 138: 2029–2043.e10.
    • (2010) Gastroenterology , vol.138 , pp. 2029-2043
    • Chan, A.T.1    Giovannucci, E.L.2
  • 17
    • 0026504138 scopus 로고
    • Characterization of insulin like growth factor I receptors in human colon cancer
    • Guo YS, Narayan S, Yallampalli C, et al. Characterization of insulin like growth factor I receptors in human colon cancer. Gastroenterology 1992; 102: 1101–1108.
    • (1992) Gastroenterology , vol.102 , pp. 1101-1108
    • Guo, Y.S.1    Narayan, S.2    Yallampalli, C.3
  • 18
    • 38349146520 scopus 로고    scopus 로고
    • The association of gastric leptin with oesophageal inflammation and metaplasia
    • Francois F, Roper J, Goodman AJ, et al. The association of gastric leptin with oesophageal inflammation and metaplasia. Gut 2008; 57: 16–24.
    • (2008) Gut , vol.57 , pp. 16-24
    • Francois, F.1    Roper, J.2    Goodman, A.J.3
  • 19
    • 17744367852 scopus 로고    scopus 로고
    • Regulation of t cell-mediated hepatic inflammation by adiponectin and leptin
    • Sennello JA, Fayad R, Morris AM, et al. Regulation of t cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology 2005; 146: 2157–2164.
    • (2005) Endocrinology , vol.146 , pp. 2157-2164
    • Sennello, J.A.1    Fayad, R.2    Morris, A.M.3
  • 20
    • 0035957040 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class a scavenger receptor expression in human monocytederived macrophages
    • Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class a scavenger receptor expression in human monocytederived macrophages. Circulation 2001; 103: 1057–1063.
    • (2001) Circulation , vol.103 , pp. 1057-1063
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 21
    • 80054970809 scopus 로고    scopus 로고
    • Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer
    • Gialamas SP, Petridou ET, Tseleni-Balafouta S, et al. Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer. Metabolism 2011; 60: 1530–1538.
    • (2011) Metabolism , vol.60 , pp. 1530-1538
    • Gialamas, S.P.1    Petridou, E.T.2    Tseleni-Balafouta, S.3
  • 22
    • 17444419414 scopus 로고    scopus 로고
    • Involvement of proinflammatory cytokines IL-1beta and IL-6 in progression of human gastric carcinoma
    • Kai H, Kitadai Y, Kodama M, et al. Involvement of proinflammatory cytokines IL-1beta and IL-6 in progression of human gastric carcinoma. Anticancer Res 2005; 25: 709–713.
    • (2005) Anticancer Res , vol.25 , pp. 709-713
    • Kai, H.1    Kitadai, Y.2    Kodama, M.3
  • 23
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197–208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3
  • 24
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D and Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 2009; 9: 798–809.
    • (2009) Nat Rev Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 25
    • 77955992756 scopus 로고    scopus 로고
    • STAT3 activation of MIR-21 and MIR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
    • Iliopoulos D, Jaeger SA, Hirsch HA, et al. STAT3 activation of MIR-21 and MIR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 2010; 39: 493–506.
    • (2010) Mol Cell , vol.39 , pp. 493-506
    • Iliopoulos, D.1    Jaeger, S.A.2    Hirsch, H.A.3
  • 26
    • 42549164807 scopus 로고    scopus 로고
    • WNT signalling and its impact on development and cancer
    • Klaus A and Birchmeier W. WNT signalling and its impact on development and cancer. Nat Rev Cancer 2008; 8: 387–398.
    • (2008) Nat Rev Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 27
    • 84874927068 scopus 로고    scopus 로고
    • Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with beta-catenin (CTNNB1) status
    • Morikawa T, Kuchiba A, Lochhead P, et al. Prospective analysis of body mass index, physical activity, and colorectal cancer risk associated with beta-catenin (CTNNB1) status. Cancer Res 2013; 73: 1600–1610.
    • (2013) Cancer Res , vol.73 , pp. 1600-1610
    • Morikawa, T.1    Kuchiba, A.2    Lochhead, P.3
  • 28
    • 84888267890 scopus 로고    scopus 로고
    • A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice
    • Philip B, Roland CL, Daniluk J, et al. A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology 2013; 145: 1449–1458.
    • (2013) Gastroenterology , vol.145 , pp. 1449-1458
    • Philip, B.1    Roland, C.L.2    Daniluk, J.3
  • 29
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adenocarcinoma
    • Hezel AF, Kimmelman AC, Stanger BZ, et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 2006; 20: 1218–1249.
    • (2006) Genes Dev , vol.20 , pp. 1218-1249
    • Hezel, A.F.1    Kimmelman, A.C.2    Stanger, B.Z.3
  • 30
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase- 2 in human neoplasia: Rationale and promise
    • Dannenberg AJ and Subbaramaiah K. Targeting cyclooxygenase- 2 in human neoplasia: rationale and promise. Cancer Cell 2003; 4: 431–436.
    • (2003) Cancer Cell , vol.4 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 31
    • 84937850360 scopus 로고    scopus 로고
    • Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production
    • Fan Y, Gan Y, Shen Y, et al. Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production. Oncotarget 2015; 6: 16120–16134.
    • (2015) Oncotarget , vol.6 , pp. 16120-16134
    • Fan, Y.1    Gan, Y.2    Shen, Y.3
  • 32
    • 0036293591 scopus 로고    scopus 로고
    • Leptin signaling, adiposity, and energy balance
    • Jéquier E. Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci 2002; 967: 379–388.
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 379-388
    • Jéquier, E.1
  • 33
    • 77953307285 scopus 로고    scopus 로고
    • Esophageal adenocarcinoma incidence: are we reaching the peak?
    • Pohl H, Sirovich B and Welch HG. Esophageal adenocarcinoma incidence: are we reaching the peak? Cancer Epidemiol Biomarkers Prev 2010; 19: 1468–1470.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 1468-1470
    • Pohl, H.1    Sirovich, B.2    Welch, H.G.3
  • 34
    • 84877689938 scopus 로고    scopus 로고
    • A global assessment of the oesophageal adenocarcinoma epidemic
    • Edgren G, Adami HO, Weiderpass E, et al. A global assessment of the oesophageal adenocarcinoma epidemic. Gut 2013; 62: 1406–1414.
    • (2013) Gut , vol.62 , pp. 1406-1414
    • Edgren, G.1    Adami, H.O.2    Weiderpass, E.3
  • 36
    • 33744732468 scopus 로고    scopus 로고
    • Body mass index and adenocarcinomas of the esophagus or gastric cardia: A systematic review and meta-analysis
    • Kubo A and Corley DA. Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2006; 15: 872–878.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 872-878
    • Kubo, A.1    Corley, D.A.2
  • 37
    • 23044493202 scopus 로고    scopus 로고
    • Meta-analysis: Obesity and the risk for gastroesophageal reflux disease and its complications
    • Hampel H, Abraham NS and El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005; 143: 199–211.
    • (2005) Ann Intern Med , vol.143 , pp. 199-211
    • Hampel, H.1    Abraham, N.S.2    El-Serag, H.B.3
  • 38
    • 34547518829 scopus 로고    scopus 로고
    • Central adiposity and risk of Barrett’s esophagus
    • Edelstein ZR, Farrow DC, Bronner MP, et al. Central adiposity and risk of Barrett’s esophagus. Gastroenterology 2007; 133: 403–411.
    • (2007) Gastroenterology , vol.133 , pp. 403-411
    • Edelstein, Z.R.1    Farrow, D.C.2    Bronner, M.P.3
  • 39
    • 33644872549 scopus 로고    scopus 로고
    • Obesity: A challenge to esophagogastric junction integrity
    • Pandolfino JE, El-Serag HB, Zhang Q, et al. Obesity: a challenge to esophagogastric junction integrity. Gastroenterology 2006; 130: 639–649.
    • (2006) Gastroenterology , vol.130 , pp. 639-649
    • Pandolfino, J.E.1    El-Serag, H.B.2    Zhang, Q.3
  • 40
    • 33947322204 scopus 로고    scopus 로고
    • Obesity is associated with increased transient lower esophageal sphincter relaxation
    • Wu JC, Mui LM, Cheung CM, et al. Obesity is associated with increased transient lower esophageal sphincter relaxation. Gastroenterology 2007; 132: 883–889.
    • (2007) Gastroenterology , vol.132 , pp. 883-889
    • Wu, J.C.1    Mui, L.M.2    Cheung, C.M.3
  • 41
    • 0033490457 scopus 로고    scopus 로고
    • The role of hiatus hernia in GERD
    • Kahrilas PJ. The role of hiatus hernia in GERD. Yale J Biol Med 1999; 72: 101–111.
    • (1999) Yale J Biol Med , vol.72 , pp. 101-111
    • Kahrilas, P.J.1
  • 42
    • 0036304191 scopus 로고    scopus 로고
    • Symptomatic improvement in gastroesophageal reflux disease (GERD) following laparoscopic Roux-en-Y gastric bypass
    • Frezza EE, Ikramuddin S, Gourash W, et al. Symptomatic improvement in gastroesophageal reflux disease (GERD) following laparoscopic Roux-en-Y gastric bypass. Surg Endosc 2002; 16: 1027–1031.
    • (2002) Surg Endosc , vol.16 , pp. 1027-1031
    • Frezza, E.E.1    Ikramuddin, S.2    Gourash, W.3
  • 43
    • 0027249544 scopus 로고
    • Barrett’s esophagus: Pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical management
    • Stein HJ and Siewert JR. Barrett’s esophagus: pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical management. Dysphagia 1993; 8: 276–288.
    • (1993) Dysphagia , vol.8 , pp. 276-288
    • Stein, H.J.1    Siewert, J.R.2
  • 44
    • 0027302720 scopus 로고
    • Barrett’s esophagus: Cell cycle abnormalities in advancing stages of neoplastic progression
    • Reid BJ, Sanchez CA, Blount PL, et al. Barrett’s esophagus: cell cycle abnormalities in advancing stages of neoplastic progression. Gastroenterology 1993; 105: 119–129.
    • (1993) Gastroenterology , vol.105 , pp. 119-129
    • Reid, B.J.1    Sanchez, C.A.2    Blount, P.L.3
  • 45
    • 84888320412 scopus 로고    scopus 로고
    • A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett’s esophagus
    • Levine DM, Ek WE, Zhang R, et al. A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett’s esophagus. Nat Genet 2013; 45: 1487–1493.
    • (2013) Nat Genet , vol.45 , pp. 1487-1493
    • Levine, D.M.1    Ek, W.E.2    Zhang, R.3
  • 46
    • 70350757799 scopus 로고    scopus 로고
    • Systematic review: The effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease
    • De Groot NL, Burgerhart JS, Van De Meeberg PC, et al. Systematic review: The effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2009; 30: 1091–1102.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 1091-1102
    • De Groot, N.L.1    Burgerhart, J.S.2    Van De Meeberg, P.C.3
  • 47
    • 84929949038 scopus 로고    scopus 로고
    • Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma
    • Alexandre L, Long E and Beales IL. Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma. World J Gastrointest Pathophysiol 2014; 5: 534–549.
    • (2014) World J Gastrointest Pathophysiol , vol.5 , pp. 534-549
    • Alexandre, L.1    Long, E.2    Beales, I.L.3
  • 48
    • 78649688674 scopus 로고    scopus 로고
    • Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and women
    • Nam SY, Choi IJ, Ryu KH, et al. Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and women. Gastroenterology 2010; 139: 1902–1911.
    • (2010) Gastroenterology , vol.139 , pp. 1902-1911
    • Nam, S.Y.1    Choi, I.J.2    Ryu, K.H.3
  • 49
    • 84880614274 scopus 로고    scopus 로고
    • Association between markers of obesity and progression from Barrett’s esophagus to esophageal adenocarcinoma
    • Duggan C, Onstad L, Hardikar S, et al. Association between markers of obesity and progression from Barrett’s esophagus to esophageal adenocarcinoma. Clin Gastroenterol Hepatol 2013; 11: 934–943.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 934-943
    • Duggan, C.1    Onstad, L.2    Hardikar, S.3
  • 50
    • 15444377785 scopus 로고    scopus 로고
    • Abdominal adipose tissue cytokine gene expression: Relationship to obesity and metabolic risk factors
    • You T, Yang R, Lyles MF, et al. Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. Am J Physiol Endocrinol Metab 2005; 288: E741–E747.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E741-E747
    • You, T.1    Yang, R.2    Lyles, M.F.3
  • 51
    • 77956114717 scopus 로고    scopus 로고
    • Anti-inflammatory effects of excessive weight loss: Potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression
    • Moschen AR, Molnar C, Geiger S, et al. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut 2010; 59: 1259–1264.
    • (2010) Gut , vol.59 , pp. 1259-1264
    • Moschen, A.R.1    Molnar, C.2    Geiger, S.3
  • 52
    • 84859494180 scopus 로고    scopus 로고
    • Body mass index, abdominal fatness and pancreatic cancer risk: A systematic review and non-linear dose-response meta-analysis of prospective studies
    • Aune D, Greenwood DC, Chan DS, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol 2012; 23: 843–852.
    • (2012) Ann Oncol , vol.23 , pp. 843-852
    • Aune, D.1    Greenwood, D.C.2    Chan, D.S.3
  • 53
    • 84930609028 scopus 로고    scopus 로고
    • Sarcopenic obesity: A probable risk factor for dose limiting toxicity during neo-adjuvant chemotherapy in oesophageal cancer patients
    • Anandavadivelan P, Brismar TB, Nilsson M, et al. Sarcopenic obesity: a probable risk factor for dose limiting toxicity during neo-adjuvant chemotherapy in oesophageal cancer patients. Clin Nutr 2016; 35: 724–730.
    • (2016) Clin Nutr , vol.35 , pp. 724-730
    • Anandavadivelan, P.1    Brismar, T.B.2    Nilsson, M.3
  • 54
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F, Dores GM and Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006; 24: 2137–2150.
    • (2006) J Clin Oncol , vol.24 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 55
    • 70350010461 scopus 로고    scopus 로고
    • Overweight, obesity and gastric cancer risk: Results from a meta-analysis of cohort studies
    • Yang P, Zhou Y, Chen B, et al. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer 2009; 45: 2867–2873.
    • (2009) Eur J Cancer , vol.45 , pp. 2867-2873
    • Yang, P.1    Zhou, Y.2    Chen, B.3
  • 56
    • 0010002834 scopus 로고    scopus 로고
    • Trends in incidence rates of adenocarcinoma of the oesophagus and gastric cardia in New Zealand, 1978–1992
    • Armstrong RW and Borman B. Trends in incidence rates of adenocarcinoma of the oesophagus and gastric cardia in New Zealand, 1978–1992. Int J Epidemiol 1996; 25: 941–947.
    • (1996) Int J Epidemiol , vol.25 , pp. 941-947
    • Armstrong, R.W.1    Borman, B.2
  • 59
    • 0033004093 scopus 로고    scopus 로고
    • Association between body mass and adenocarcinoma of the esophagus and gastric cardia
    • Lagergren J, Bergstrom R and Nyren O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann Intern Med 1999; 130: 883–890.
    • (1999) Ann Intern Med , vol.130 , pp. 883-890
    • Lagergren, J.1    Bergstrom, R.2    Nyren, O.3
  • 60
    • 17944386992 scopus 로고    scopus 로고
    • Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia
    • Chow WH, Blot WJ, Vaughan TL, et al. Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst 1998; 90: 150–155.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 150-155
    • Chow, W.H.1    Blot, W.J.2    Vaughan, T.L.3
  • 61
    • 0034878894 scopus 로고    scopus 로고
    • Gastric cancer and Helicobacter pylori: A combined analysis of 12 case control studies nested within prospective cohorts
    • Helicobacter Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001; 49: 347–353.
    • (2001) Gut , vol.49 , pp. 347-353
  • 62
    • 0033552961 scopus 로고    scopus 로고
    • Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
    • Alm RA, Ling LS, Moir DT, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 1999; 397: 176–180.
    • (1999) Nature , vol.397 , pp. 176-180
    • Alm, R.A.1    Ling, L.S.2    Moir, D.T.3
  • 63
    • 8644223271 scopus 로고    scopus 로고
    • Obesity and risk of cancer in Japan
    • Kuriyama S, Tsubono Y, Hozawa A, et al. Obesity and risk of cancer in Japan. Int J Cancer 2005; 113: 148–157.
    • (2005) Int J Cancer , vol.113 , pp. 148-157
    • Kuriyama, S.1    Tsubono, Y.2    Hozawa, A.3
  • 64
    • 84893762040 scopus 로고    scopus 로고
    • Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response
    • Ericksen RE, Rose S, Westphalen CB, et al. Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response. Gut 2014; 63: 385–394.
    • (2014) Gut , vol.63 , pp. 385-394
    • Ericksen, R.E.1    Rose, S.2    Westphalen, C.B.3
  • 65
    • 35348979761 scopus 로고    scopus 로고
    • Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression
    • Jackson CB, Judd LM, Menheniott TR, et al. Augmented gp130-mediated cytokine signalling accompanies human gastric cancer progression. J Pathol 2007; 213: 140–151.
    • (2007) J Pathol , vol.213 , pp. 140-151
    • Jackson, C.B.1    Judd, L.M.2    Menheniott, T.R.3
  • 66
    • 84891740143 scopus 로고    scopus 로고
    • Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice
    • Inagaki-Ohara K, Mayuzumi H, Kato S, et al. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. Oncogene 2014; 33: 74–84.
    • (2014) Oncogene , vol.33 , pp. 74-84
    • Inagaki-Ohara, K.1    Mayuzumi, H.2    Kato, S.3
  • 68
    • 27744604016 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment
    • Kuroda T, Kitadai Y, Tanaka S, et al. Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment. Clin Cancer Res 2005; 11: 7629–7636.
    • (2005) Clin Cancer Res , vol.11 , pp. 7629-7636
    • Kuroda, T.1    Kitadai, Y.2    Tanaka, S.3
  • 69
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004; 101: 15718–15723.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15718-15723
    • Backhed, F.1    Ding, H.2    Wang, T.3
  • 70
    • 84960377344 scopus 로고    scopus 로고
    • The microbiome and its potential as a cancer preventive intervention
    • Bultman SJ. The microbiome and its potential as a cancer preventive intervention. Semin Oncol 2016; 43: 97–106.
    • (2016) Semin Oncol , vol.43 , pp. 97-106
    • Bultman, S.J.1
  • 71
    • 84878256698 scopus 로고    scopus 로고
    • Obesity-associated oxidative stress: Strategies finalized to improve redox state
    • Savini I, Catani MV, Evangelista D, et al. Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci 2013; 14: 10497–10538.
    • (2013) Int J Mol Sci , vol.14 , pp. 10497-10538
    • Savini, I.1    Catani, M.V.2    Evangelista, D.3
  • 72
    • 0036019943 scopus 로고    scopus 로고
    • Oxidants and tyrosine phosphorylation: Role of acute and chronic oxidative stress in Tand B-lymphocyte signaling
    • Verweij CL and Gringhuis SI. Oxidants and tyrosine phosphorylation: role of acute and chronic oxidative stress in Tand B-lymphocyte signaling. Antioxid Redox Signal 2002; 4: 543–551.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 543-551
    • Verweij, C.L.1    Gringhuis, S.I.2
  • 73
    • 0036714218 scopus 로고    scopus 로고
    • Overweight, obesity, and cancer risk
    • Bianchini F, Kaaks R and Vainio H. Overweight, obesity, and cancer risk. Lancet Oncol 2002; 3: 565–574.
    • (2002) Lancet Oncol , vol.3 , pp. 565-574
    • Bianchini, F.1    Kaaks, R.2    Vainio, H.3
  • 74
    • 0028941608 scopus 로고
    • Physical activity, obesity, and risk for colon cancer and adenoma in men
    • Giovannucci E, Ascherio A, Rimm EB, et al. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Int Med 1995; 122: 327–334.
    • (1995) Ann Int Med , vol.122 , pp. 327-334
    • Giovannucci, E.1    Ascherio, A.2    Rimm, E.B.3
  • 75
    • 1842371455 scopus 로고    scopus 로고
    • Leisuretime physical activity, body size, and colon cancer in women. Nurses’ Health Study Research Group
    • Martinez ME, Giovannucci E, Spiegelman D, et al. Leisuretime physical activity, body size, and colon cancer in women. Nurses’ Health Study Research Group. J National Cancer Inst 1997; 89: 948–955.
    • (1997) J National Cancer Inst , vol.89 , pp. 948-955
    • Martinez, M.E.1    Giovannucci, E.2    Spiegelman, D.3
  • 76
    • 28944439010 scopus 로고    scopus 로고
    • Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies
    • Park Y, Hunter DJ, Spiegelman D, et al. Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies. JAMA 2005; 294: 2849–2857.
    • (2005) JAMA , vol.294 , pp. 2849-2857
    • Park, Y.1    Hunter, D.J.2    Spiegelman, D.3
  • 77
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • Fontana L, Eagon JC, Trujillo ME, et al. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007; 56: 1010–1013.
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3
  • 78
    • 79961047053 scopus 로고    scopus 로고
    • Intestinal inflammation and colorectal cancer: A double-edged sword?
    • Rizzo A, Pallone F, Monteleone G, et al. Intestinal inflammation and colorectal cancer: a double-edged sword? World J Gastroenterol 2011; 17: 3092–3100.
    • (2011) World J Gastroenterol , vol.17 , pp. 3092-3100
    • Rizzo, A.1    Pallone, F.2    Monteleone, G.3
  • 79
  • 80
    • 0035160628 scopus 로고    scopus 로고
    • Insulin insulin-like growth factors and colon cancer: A review of the evidence
    • Giovannucci E. Insulin insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 2001; 131: 3109S–3120S.
    • (2001) J Nutr , vol.131 , pp. 3109S-3120S
    • Giovannucci, E.1
  • 81
    • 0033747214 scopus 로고    scopus 로고
    • Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways
    • Attoub S, Noe V, Pirola L, et al. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J 2000; 14: 2329–2338.
    • (2000) FASEB J , vol.14 , pp. 2329-2338
    • Attoub, S.1    Noe, V.2    Pirola, L.3
  • 82
    • 34547760898 scopus 로고    scopus 로고
    • Overexpression of the obesity hormone leptin in human colorectal cancer
    • Koda M, Sulkowska M, Kanczuga-Koda L, et al. Overexpression of the obesity hormone leptin in human colorectal cancer. J Clin Pathol 2007; 60: 902–906.
    • (2007) J Clin Pathol , vol.60 , pp. 902-906
    • Koda, M.1    Sulkowska, M.2    Kanczuga-Koda, L.3
  • 83
    • 33947157137 scopus 로고    scopus 로고
    • Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus
    • Mojiminiyi OA and Abdella NA. Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus. Scand J Clin Lab Invest 2007; 67: 215–225.
    • (2007) Scand J Clin Lab Invest , vol.67 , pp. 215-225
    • Mojiminiyi, O.A.1    Abdella, N.A.2
  • 84
    • 81755185430 scopus 로고    scopus 로고
    • Neuroendocrine and metabolic activities of ghrelin gene products
    • Baragli A, Lanfranco F, Allasia S, et al. Neuroendocrine and metabolic activities of ghrelin gene products. Peptides 2011; 32: 2323–2332.
    • (2011) Peptides , vol.32 , pp. 2323-2332
    • Baragli, A.1    Lanfranco, F.2    Allasia, S.3
  • 85
    • 0037380842 scopus 로고    scopus 로고
    • The potential autocrine/paracrine roles of ghrelin and its receptor in hormone- dependent cancer
    • Jeffery PL, Herington AC and Chopin LK. The potential autocrine/paracrine roles of ghrelin and its receptor in hormone- dependent cancer. Cytokine Growth Factor Rev 2003; 14: 113–122.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 113-122
    • Jeffery, P.L.1    Herington, A.C.2    Chopin, L.K.3
  • 86
    • 84894245324 scopus 로고    scopus 로고
    • The relationship of oxidative stress, adiposity and metabolic risk factors in healthy Black and White American youth
    • Warolin J, Coenen KR, Kantor JL, et al. The relationship of oxidative stress, adiposity and metabolic risk factors in healthy Black and White American youth. Pediatr Obes 2014; 9: 43–52.
    • (2014) Pediatr Obes , vol.9 , pp. 43-52
    • Warolin, J.1    Coenen, K.R.2    Kantor, J.L.3
  • 87
    • 84999188222 scopus 로고    scopus 로고
    • Oxidative stress and carbonyl lesions in ulcerative colitis and associated colorectal cancer
    • Wang Z, Li S, Cao Y, et al. Oxidative stress and carbonyl lesions in ulcerative colitis and associated colorectal cancer. Oxid Med Cell Longev 2016; 2016: 9875298.
    • (2016) Oxid Med Cell Longev , vol.2016
    • Wang, Z.1    Li, S.2    Cao, Y.3
  • 88
    • 33749986298 scopus 로고    scopus 로고
    • Free radicals and antioxidants in normal physiological functions and human disease
    • Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Bio 2007; 39: 44–84.
    • (2007) Int J Biochem Cell Bio , vol.39 , pp. 44-84
    • Valko, M.1    Leibfritz, D.2    Moncol, J.3
  • 89
    • 84900394642 scopus 로고    scopus 로고
    • Colorectal cancer: Role of adipokines in tumor initiation and progression
    • Riondino S, Roselli M, Palmirotta R, et al. colorectal cancer: role of adipokines in tumor initiation and progression. World J Gastroenterol 2014; 20: 5177–5190.
    • (2014) World J Gastroenterol , vol.20 , pp. 5177-5190
    • Riondino, S.1    Roselli, M.2    Palmirotta, R.3
  • 90
    • 7044229778 scopus 로고    scopus 로고
    • Primary liver cancer: Worldwide incidence and trends
    • Bosch FX, Ribes J, Diaz M, et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004; 127: S5–S16.
    • (2004) Gastroenterology , vol.127 , pp. SS5-S16
    • Bosch, F.X.1    Ribes, J.2    Diaz, M.3
  • 91
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet JM, Burroughs A and Bruix J. Hepatocellular carcinoma. Lancet 2003; 362: 1907–1917.
    • (2003) Lancet , vol.362 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 93
    • 84866480533 scopus 로고    scopus 로고
    • Excess body mass index and risk of liver cancer: A nonlinear dose-response meta-analysis of prospective studies
    • Rui R, Lou J, Zou L, et al. Excess body mass index and risk of liver cancer: a nonlinear dose-response meta-analysis of prospective studies. PLoS ONE 2012; 7: e44522.
    • (2012) Plos ONE , vol.7
    • Rui, R.1    Lou, J.2    Zou, L.3
  • 94
    • 33750296975 scopus 로고    scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma
    • McKillop IH, Moran DM, Jin X, et al. Molecular pathogenesis of hepatocellular carcinoma. J Surg Res 2006; 136: 125–135.
    • (2006) J Surg Res , vol.136 , pp. 125-135
    • McKillop, I.H.1    Moran, D.M.2    Jin, X.3
  • 95
    • 84954417122 scopus 로고    scopus 로고
    • Targeting Wnt/β- catenin pathway in hepatocellular carcinoma treatment
    • Vilchez V, Turcios L, Marti F, et al. Targeting Wnt/β- catenin pathway in hepatocellular carcinoma treatment. World J Gastroenterol 2016; 22: 823–832.
    • (2016) World J Gastroenterol , vol.22 , pp. 823-832
    • Vilchez, V.1    Turcios, L.2    Marti, F.3
  • 96
    • 84905168783 scopus 로고    scopus 로고
    • Usefulness of the molecular profile in the diagnosis, prognosis and treatment of hepatocellular carcinoma
    • Bruix J. Usefulness of the molecular profile in the diagnosis, prognosis and treatment of hepatocellular carcinoma. Gastroentero Hepatol 2014; 37(Suppl. 2): 81–89.
    • (2014) Gastroentero Hepatol , vol.37 , pp. 81-89
    • Bruix, J.1
  • 97
    • 76649119814 scopus 로고    scopus 로고
    • Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks
    • Barash H, R Gross E, Edrei Y, et al. Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks. Proc Natl Acad Sci U S A 2010; 107: 2207–2212.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2207-2212
    • Barash, H.1    R Gross, E.2    Edrei, Y.3
  • 98
    • 78149386734 scopus 로고    scopus 로고
    • Tumor initiation and progression in hepatocellular carcinoma: Risk factors, classification, and therapeutic targets
    • Severi T, van Malenstein H, Verslype C, et al. Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. Acta Pharmacol Sin 2010; 31: 1409–1420.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1409-1420
    • Severi, T.1    Van Malenstein, H.2    Verslype, C.3
  • 99
    • 77957200500 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: Mechanisms and implications
    • Stickel F and Hellerbrand C. Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications. Gut 2010; 59: 1303–1307.
    • (2010) Gut , vol.59 , pp. 1303-1307
    • Stickel, F.1    Hellerbrand, C.2
  • 100
    • 33645274921 scopus 로고    scopus 로고
    • Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: Report of two cases
    • Hai S, Kubo S, Shuto T, et al. Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases. Surg Today 2006; 36: 390–394.
    • (2006) Surg Today , vol.36 , pp. 390-394
    • Hai, S.1    Kubo, S.2    Shuto, T.3
  • 101
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle EE and Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4: 579–591.
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 102
    • 79959538616 scopus 로고    scopus 로고
    • Hyde: A paradoxical oncogenic and tumor suppressive role of signal transducer and activator of transcription 3 in liver cancer
    • Calvisi DF., Dr. Jekyll and Mr. Hyde: a paradoxical oncogenic and tumor suppressive role of signal transducer and activator of transcription 3 in liver cancer. Hepatology 2011; 54: 9–12.
    • (2011) Hepatology , vol.54 , pp. 9-12
    • Calvisi, Dr. Jekyll, D.F.1
  • 103
    • 0036854891 scopus 로고    scopus 로고
    • Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: Regulation by SOCS
    • Hong F, Jaruga B, Kim WH, et al. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 2002; 110: 1503–1513.
    • (2002) J Clin Invest , vol.110 , pp. 1503-1513
    • Hong, F.1    Jaruga, B.2    Kim, W.H.3
  • 104
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol 2011; 12: 492–499.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 105
    • 84055199890 scopus 로고    scopus 로고
    • Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
    • Malato Y, Naqvi S, Schurmann N, et al. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest 2011; 121: 4850–4860.
    • (2011) J Clin Invest , vol.121 , pp. 4850-4860
    • Malato, Y.1    Naqvi, S.2    Schurmann, N.3
  • 106
    • 0035392939 scopus 로고    scopus 로고
    • Hepatic hyperplasia in noncirrhotic fatty livers: Is obesity-related hepatic steatosis a premalignant condition?
    • Yang S, Lin HZ, Hwang J, et al. Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? Cancer Res 2001; 61: 5016–5023.
    • (2001) Cancer Res , vol.61 , pp. 5016-5023
    • Yang, S.1    Lin, H.Z.2    Hwang, J.3
  • 107
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893–2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 108
    • 84936990220 scopus 로고    scopus 로고
    • Current status and progress of pancreatic cancer in china
    • Lin QJ, Yang F, Jin C, et al. Current status and progress of pancreatic cancer in china. World J Gastroenterol 2015; 21: 7988–8003.
    • (2015) World J Gastroenterol , vol.21 , pp. 7988-8003
    • Lin, Q.J.1    Yang, F.2    Jin, C.3
  • 109
    • 33644877995 scopus 로고    scopus 로고
    • Anthropometric factors and pancreatic cancer in a population-based casecontrol study in the San Francisco bay area
    • Eberle CA, Bracci PM and Holly EA. Anthropometric factors and pancreatic cancer in a population-based casecontrol study in the San Francisco bay area. Cancer Causes Control 2005; 16: 1235–1244.
    • (2005) Cancer Causes Control , vol.16 , pp. 1235-1244
    • Eberle, C.A.1    Bracci, P.M.2    Holly, E.A.3
  • 110
    • 27944478668 scopus 로고    scopus 로고
    • Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population- based cohorts
    • Larsson SC, Permert J, Hakansson N, et al. Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population- based cohorts. Br J Cancer 2005; 93: 1310–1315.
    • (2005) Br J Cancer , vol.93 , pp. 1310-1315
    • Larsson, S.C.1    Permert, J.2    Hakansson, N.3
  • 111
    • 77952177097 scopus 로고    scopus 로고
    • Anthropometric measures, body mass index, and pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
    • Arslan AA, Helzlsouer KJ, Kooperberg C, et al. Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med 2010; 170: 791–802.
    • (2010) Arch Intern Med , vol.170 , pp. 791-802
    • Arslan, A.A.1    Helzlsouer, K.J.2    Kooperberg, C.3
  • 112
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • McCarthy MI. Genomics, type 2 diabetes, and obesity. New Engl J Med 2010; 363: 2339–2350.
    • (2010) New Engl J Med , vol.363 , pp. 2339-2350
    • McCarthy, M.I.1
  • 113
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889–894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 114
    • 79955752416 scopus 로고    scopus 로고
    • Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer
    • Tang H, Dong X, Hassan M, et al. Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2011; 20: 779–792.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 779-792
    • Tang, H.1    Dong, X.2    Hassan, M.3
  • 115
    • 77649188501 scopus 로고    scopus 로고
    • A genomewide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
    • Petersen GM, Amundadottir L, Fuchs CS, et al. A genomewide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 2010; 42: 224–228.
    • (2010) Nat Genet , vol.42 , pp. 224-228
    • Petersen, G.M.1    Amundadottir, L.2    Fuchs, C.S.3
  • 116
    • 35748970488 scopus 로고    scopus 로고
    • Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project
    • Fox CS, Heard-Costa N, Cupples LA, et al. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. BMC Med Genet 2007; 8(Suppl. 1): S18.
    • (2007) BMC Med Genet , vol.8
    • Fox, C.S.1    Heard-Costa, N.2    Cupples, L.A.3
  • 117
    • 84865505738 scopus 로고    scopus 로고
    • Metzner J, et al. 5-lipoxygenase: Underappreciated role of a pro-inflammatory enzyme in tumorigenesis
    • Steinhilber D, Fischer AS, Metzner J, et al. 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. Front Pharmacol 2010; 1: 143.
    • (2010) Front Pharmacol , vol.1 , pp. 143
    • Steinhilber, D.1    Fischer, A.S.2
  • 118
    • 78650788269 scopus 로고    scopus 로고
    • Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats
    • Chakrabarti SK, Wen Y, Dobrian AD, et al. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Am J Physiol Endocrinol Metab 2011; 300: E175–E187.
    • (2011) Am J Physiol Endocrinol Metab , vol.300 , pp. E175-E187
    • Chakrabarti, S.K.1    Wen, Y.2    Dobrian, A.D.3
  • 119
    • 48149112746 scopus 로고    scopus 로고
    • Leptin beyond body weight regulation—current concepts concerning its role in immune function and inflammation
    • Lago R, Gomez R, Lago F, et al. Leptin beyond body weight regulation—current concepts concerning its role in immune function and inflammation. Cell Immunol 2008; 252: 139–145.
    • (2008) Cell Immunol , vol.252 , pp. 139-145
    • Lago, R.1    Gomez, R.2    Lago, F.3
  • 120
    • 77952349493 scopus 로고    scopus 로고
    • Insulin-like growth factor-I regulation of immune function: A potential therapeutic target in autoimmune diseases?
    • Smith TJ. Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases? Pharmacol Rev 2010; 62: 199–236.
    • (2010) Pharmacol Rev , vol.62 , pp. 199-236
    • Smith, T.J.1
  • 121
    • 33947615887 scopus 로고    scopus 로고
    • Peroxisome Proliferator-Activated Receptor γ (PPARγ) and immunoregulation: Enhancement of regulatory T cells through PPARγ- dependent and -independent mechanisms
    • Wohlfert EA, Nichols FC, Nevius E, et al. Peroxisome Proliferator-Activated Receptor γ (PPARγ) and immunoregulation: enhancement of regulatory T cells through PPARγ- dependent and -independent mechanisms. J Immunol 2007; 178: 4129–4135.
    • (2007) J Immunol , vol.178 , pp. 4129-4135
    • Wohlfert, E.A.1    Nichols, F.C.2    Nevius, E.3
  • 122
    • 0036854487 scopus 로고    scopus 로고
    • Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1
    • Raso GM, Pacilio M, Esposito E, et al. Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1. Br J Pharmacol 2002; 137: 799–804.
    • (2002) Br J Pharmacol , vol.137 , pp. 799-804
    • Raso, G.M.1    Pacilio, M.2    Esposito, E.3
  • 123
    • 0035109175 scopus 로고    scopus 로고
    • Leptin: A potential regulator of polymorphonuclear neutrophil bactericidal action?
    • Caldefie-Chezet F, Poulin A, Tridon A, et al. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J Leukocyte Biol 2001; 69: 414–418.
    • (2001) J Leukocyte Biol , vol.69 , pp. 414-418
    • Caldefie-Chezet, F.1    Poulin, A.2    Tridon, A.3
  • 124
    • 0036431034 scopus 로고    scopus 로고
    • Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation
    • Tian Z, Sun R, Wei H, et al. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun 2002; 298: 297–302.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 297-302
    • Tian, Z.1    Sun, R.2    Wei, H.3
  • 125
    • 77956538747 scopus 로고    scopus 로고
    • Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    • Douglas JB, Silverman DT, Pollak MN, et al. Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 2010; 19: 2298–2306.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2298-2306
    • Douglas, J.B.1    Silverman, D.T.2    Pollak, M.N.3
  • 126
    • 75949102926 scopus 로고    scopus 로고
    • Biological mechanisms linking obesity and cancer risk: New perspectives
    • Roberts DL, Dive C and Renehan AG. Biological mechanisms linking obesity and cancer risk: new perspectives. Ann Rev Med 2010; 61: 301–316.
    • (2010) Ann Rev Med , vol.61 , pp. 301-316
    • Roberts, D.L.1    Dive, C.2    Renehan, A.G.3
  • 127
    • 84880538920 scopus 로고    scopus 로고
    • Hyperglycemia, insulin resistance, impaired pancreatic beta-cell function, and risk of pancreatic cancer
    • Wolpin BM, Bao Y, Qian ZR, et al. Hyperglycemia, insulin resistance, impaired pancreatic beta-cell function, and risk of pancreatic cancer. J Natl Cancer Inst 2013; 105: 1027–1035.
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1027-1035
    • Wolpin, B.M.1    Bao, Y.2    Qian, Z.R.3
  • 128
    • 84865045103 scopus 로고    scopus 로고
    • VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells
    • Doi Y, Yashiro M, Yamada N, et al. VEGF-A/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. Ann Surg Oncol 2012; 19: 2733–2743.
    • (2012) Ann Surg Oncol , vol.19 , pp. 2733-2743
    • Doi, Y.1    Yashiro, M.2    Yamada, N.3
  • 129
    • 83455198203 scopus 로고    scopus 로고
    • Obesity and pancreatic cancer: Overview of epidemiologic evidence and biologic mechanisms
    • Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinogen 2012; 51: 53–63.
    • (2012) Mol Carcinogen , vol.51 , pp. 53-63
    • Bracci, P.M.1
  • 130
    • 84892476014 scopus 로고    scopus 로고
    • Cancer: Two diseases with obesity as a common risk factor
    • Garg SK, Maurer H, Reed K, et al. Cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab 2014; 16: 97–110.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 97-110
    • Garg, S.K.1    Maurer, H.2    Reed, K.3
  • 131
  • 132
    • 65949124036 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009; 32: 193–203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 133
    • 84864371674 scopus 로고    scopus 로고
    • Metformin and cancer: New applications for an old drug
    • Kourelis TV and Siegel RD. Metformin and cancer: new applications for an old drug. Med Oncol 2012; 29: 1314–1327.
    • (2012) Med Oncol , vol.29 , pp. 1314-1327
    • Kourelis, T.V.1    Siegel, R.D.2
  • 134
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans JM, Donnelly LA, Emslie-Smith AM, et al. Metformin and reduced risk of cancer in diabetic patients. BMJ 2005; 330: 1304–1305.
    • (2005) BMJ , vol.330 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3
  • 135
    • 67650945180 scopus 로고    scopus 로고
    • Antidiabetic therapies affect risk of pancreatic cancer
    • Li D, Yeung SC, Hassan MM, et al. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 2009; 137: 482–488.
    • (2009) Gastroenterology , vol.137 , pp. 482-488
    • Li, D.1    Yeung, S.C.2    Hassan, M.M.3
  • 136
    • 84887100519 scopus 로고    scopus 로고
    • Cancer, physical activity, and exercise
    • Brown JC, Winters-Stone K, Lee A, et al. Cancer, physical activity, and exercise. Compr Physiol 2012; 2: 2775–2809.
    • (2012) Compr Physiol , vol.2 , pp. 2775-2809
    • Brown, J.C.1    Winters-Stone, K.2    Lee, A.3
  • 137
    • 38449098674 scopus 로고    scopus 로고
    • Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    • Andreasen CH, Stender-Petersen KL, Mogensen MS, et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008; 57: 95–101.
    • (2008) Diabetes , vol.57 , pp. 95-101
    • Andreasen, C.H.1    Stender-Petersen, K.L.2    Mogensen, M.S.3
  • 138
    • 70350686380 scopus 로고    scopus 로고
    • Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
    • Sonestedt E, Roos C, Gullberg B, et al. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr 2009; 90: 1418–1425.
    • (2009) Am J Clin Nutr , vol.90 , pp. 1418-1425
    • Sonestedt, E.1    Roos, C.2    Gullberg, B.3
  • 139
    • 84908138845 scopus 로고    scopus 로고
    • Obesity and cancer: The role of vitamin D
    • Shanmugalingam T, Crawley D, Bosco C, et al. Obesity and cancer: the role of vitamin D. BMC Cancer 2014; 14: 712.
    • (2014) BMC Cancer , vol.14 , pp. 712
    • Shanmugalingam, T.1    Crawley, D.2    Bosco, C.3
  • 140
    • 17844366564 scopus 로고    scopus 로고
    • Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects
    • O’Brien KD, Brehm BJ, Seeley RJ, et al. Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects. J Clin Endocrinol Metab 2005; 90: 2244–2249.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2244-2249
    • O’Brien, K.D.1    Brehm, B.J.2    Seeley, R.J.3
  • 141
    • 84895529793 scopus 로고    scopus 로고
    • Calorie restriction and cancer prevention: A mechanistic perspective
    • Hursting SD, Dunlap SM, Ford NA, et al. Calorie restriction and cancer prevention: a mechanistic perspective. Cancer Metab 2013; 1: 10.
    • (2013) Cancer Metab , vol.1 , pp. 10
    • Hursting, S.D.1    Dunlap, S.M.2    Ford, N.A.3
  • 142
    • 84870218548 scopus 로고    scopus 로고
    • Obesity, energy balance, and cancer: New opportunities for prevention
    • Hursting SD, Digiovanni J, Dannenberg AJ, et al. Obesity, energy balance, and cancer: new opportunities for prevention. Cancer Prev Res 2012; 5: 1260–1272.
    • (2012) Cancer Prev Res , vol.5 , pp. 1260-1272
    • Hursting, S.D.1    Digiovanni, J.2    Dannenberg, A.J.3
  • 143
    • 84894227008 scopus 로고    scopus 로고
    • Genetics of oxidative stress in obesity
    • Ruperez AI, Gil A and Aguilera CM. Genetics of oxidative stress in obesity. Int J Mol Sci 2014; 15: 3118–3144.
    • (2014) Int J Mol Sci , vol.15 , pp. 3118-3144
    • Ruperez, A.I.1    Gil, A.2    Aguilera, C.M.3
  • 144
    • 84906791978 scopus 로고    scopus 로고
    • Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasis
    • Zhao X, Rezonzew G, Wang D, et al. Diet modulation is an effective complementary agent in preventing and treating breast cancer lung metastasis. Clin Exp Meta 2014; 31: 625–638.
    • (2014) Clin Exp Meta , vol.31 , pp. 625-638
    • Zhao, X.1    Rezonzew, G.2    Wang, D.3
  • 145
    • 84857061051 scopus 로고    scopus 로고
    • The role of adiponectin in human vascular physiology
    • Vaiopoulos AG, Marinou K, Christodoulides C, et al. The role of adiponectin in human vascular physiology. Int J Cardiol 2012; 155: 188–193.
    • (2012) Int J Cardiol , vol.155 , pp. 188-193
    • Vaiopoulos, A.G.1    Marinou, K.2    Christodoulides, C.3
  • 146
    • 84879989100 scopus 로고    scopus 로고
    • Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects
    • De Rosa A, Monaco ML, Capasso M, et al. Adiponectin oligomers as potential indicators of adipose tissue improvement in obese subjects. Eur J Endocrinol 2013; 169: 37–43.
    • (2013) Eur J Endocrinol , vol.169 , pp. 37-43
    • De Rosa, A.1    Monaco, M.L.2    Capasso, M.3
  • 147
    • 78449267024 scopus 로고    scopus 로고
    • Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus
    • Wen JP, Liu CE, Hu YT, et al. Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus. Mol Cell Biochem 2010; 344: 109–115.
    • (2010) Mol Cell Biochem , vol.344 , pp. 109-115
    • Wen, J.P.1    Liu, C.E.2    Hu, Y.T.3


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