Hepatic hyperplasia in noncirrhotic fatty livers: Is obesity-related hepatic steatosis a premalignant condition?

Cancer Research

Volumn 61, Issue 13, 2001, Pages 5016-5023

  Yang, ShiQi ^a   Lin, Hui Zhi ^a   Hwang, Jiawen ^a   Diehl, Anna Mae ^a   Chacko, Vadappuram P ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN D1; PROTEIN C JUN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER RISK; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVATION; FATTY LIVER; GENE EXPRESSION; LIPID ANALYSIS; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER HYPERPLASIA; MOUSE; NONHUMAN; OBESITY; PRECANCER; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL DIVISION; ENZYME ACTIVATION; ENZYME PRECURSORS; FATTY LIVER; GENE EXPRESSION; GENES, CDC; HEPATOMEGALY; HYPERPLASIA; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PRECANCEROUS CONDITIONS;

EID: 0035392939     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (76)

1. Energy balance and cancers
2. Increased blood glucose, insulin, body size and incident colorectal cancer
3. Adiposity as a risk determinant for postmenopausal breast cancer
4. Evidence for an association between the aetiology of cirrhosis and pattern of hepatocellular carcinoma development
5. Hepatocellular carcinoma in Germany: A retrospective epidemiological study from a low-endemic area
6. Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
7. Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease
8. A case-control study of diabetes mellitus and cancer risk
9. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark
10. Implications of the hyperinsulinaemiadiabetes-cancer link for preventive efforts
11. Induction of apoptosis by tumor suppressor genes and oncogenes
12. The effect of non-genotoxic carcinogens, phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis
13. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice
14. Fatty infiltration of the liver: Analysis of prevalence, radiological and clinical features and influence on patient management
15. A natural history of nonalcoholic fatty liver: A follow-up study
16. Molecular mapping of the mouse ob mutation
17. Weight-reducing effects of the protein encoded by the obese gene
18. The OB protein (leptin) pathway - A link between adipose tissue mass and central neural networks
19. Abnormal splicing of the leptin receptor in diabetic mice
20. Leptin receptor missense mutation in the fatty Zucker rat
21. Genetic obesity and neoplasia
22. Effects of the obese gene product on body weight regulation in ob/ob mice
23. Obesity increases sensitivity to endotoxin liver injury: Implications for pathogenesis of steatohepatitis
24. Leptin is required for the development of hepatic fibrosis
25. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
26. Effects of alcohol on cytokine-inducible transcription factors
27. Tumor necrosis factor alpha increases mitochondrial oxidant production and induces expression of uncoupling protein-2 expression in the regenerating mouse liver
28. Single step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction
29. Altered hepatic lymphocyte subpopulations in obesity-related fatty livers
30. A general method for isolation of high molecular weight DNA from eukaryotes
31. Apoptosis in liver disease
32. Processing activation of CPP32-like proteases is involved in transforming growth factor β-1-induced apoptosis in rat hepatocytes
33. Liver regeneration
34. Rel/NF-κB transcription factors and the control of apoptosis
35. The proto-oncogene Bcl-2 and its role in regulating apoptosis
36. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1
37. Multiple nuclear factors interact with the immunoglobulin enhancer sequences
38. Mitochondrial adaptations to obesity-related oxidant stress
39. Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters
40. Occurrence of cell death (apoptosis) during the involution of liver hyperplasia
41. Failure of regeneration of the steatotic rat liver: Disruption at two different levels in the regeneration pathway
42. Tumor necrosis factor α induces c-jun during the regenerative response to liver injury
43. Activation of Jun kinase is an early event in hepatic regeneration
44. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
45. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
46. Method for analysis of cellular DNA content of paraffin embedded pathological material using flow cytometry
47. Nonalcoholic fatty liver disease: A spectrum of clinical pathological severity
48. Activation of caspase 3 (CPP32)-like proteases is essential for TNF α-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxic shock model
49. Endotoxin induced cellular communication in the liver: Murine models for clarification of the role of LPS-responsive macrophages in the pathogenesis of liver diseases
50. NF κB prevents apoptosis and liver dysfunction during liver regeneration
51. The role of intracellular oxidants in apoptosis
52. Superoxide in apoptosis: Mitochondrial generation triggered by cytochrome c loss
53. Regulation of the NF-κβ/rel transcription factor and I κβ inhibitor system
54. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
55. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux
56. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis
57. Interaction of c-myc with transforming growth factor α and hepatocyte growth factor in hepatocarcinogenesis
58. Acceleration of c-myc-induced hepatocarcinogenesis by co-expression of transforming growth factor (TGF)-α in transgenic mice is associated with TGF β-1 signaling disruption
59. Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF α transgenic mice
60. Biochemical, pathological, and genetic aspects of a spontaneous mouse hepatoma
61. Susceptible and resistant subgroups in genetically identical populations: Response of mouse liver neoplasia and body weight to phenobarbital
62. Liver in obesity
63. Liver pathology and the metabolic syndrome X in severe obesity
64. Association of nonalcoholic fatty liver disease with insulin resistance
65. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
66. Liver fibrosis in overweight patients
67. Role of IκB kinase complex in oncogenic ras- and raf-mediated transformation of rat liver epithelial cells
68. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NF-κB activation in primary hippocampal neurons
69. Regulation of NF-κB activation by MAP kinase cascades
70. Insulin activates nuclear factor κB in mammalian cells through a raf-1-mediated pathway
71. A role for nuclear factor κB in the antiapoptotic function of insulin
72. Disruption of redox homeostasis in the transforming growth factor α/c-myc transgenic mouse model of accelerated hepatocarcinogenesis
73. Leptin regulates proinflammatory immune responses
74. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice
75. Obesity
76. The natural history of nonalcoholic steatohepatitis: A follow-up study of 42 patients followed for up to 21 years