The microbiome and its potential as a cancer preventive intervention

Seminars in Oncology

Volumn 43, Issue 1, 2016, Pages 97-106

  Bultman, Scott J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Butyrate; Gut microbiome; HDAC inhibitor

Indexed keywords

BUTYRIC ACID; HISTONE DEACETYLASE INHIBITOR; NUTRACEUTICAL; PREBIOTIC AGENT; PROBIOTIC AGENT; SHORT CHAIN FATTY ACID; BUTYRIC ACID DERIVATIVE;

CANCER PREVENTION; CANCER RISK; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; COMMENSAL; DIET; DIETARY FIBER; ENVIRONMENTAL FACTOR; FERMENTATION; FUNCTIONAL FOOD; GASTROINTESTINAL TRACT; HUMAN; INTESTINE FLORA; MICROBIAL COMMUNITY; MICROBIOME; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW; ADMINISTRATION AND DOSAGE; ANIMAL; COLORECTAL NEOPLASMS; METABOLISM; ORGANISMAL INTERACTION; PHYSIOLOGY;

ANIMALS; BUTYRATES; COLORECTAL NEOPLASMS; DIETARY FIBER; GASTROINTESTINAL MICROBIOME; HUMANS; MICROBIAL INTERACTIONS; PREBIOTICS; PROBIOTICS;

EID: 84960377344     PISSN: 00937754     EISSN: 15328708     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2015.09.001     Document Type: Review

References (83)

1. A.B. Mariotto, K.R. Yabroff, Y. Shao, E.J. Feuer, and M.L. Brown Projections of the cost of cancer care in the United States: 2010-2020 J Natl Cancer Inst 103 2011 117 128
2. P. Anand, A.B. Kunnumakkara, C. Sundaram, and et al. Cancer is a preventable disease that requires major lifestyle changes Pharmaceut Res 25 2008 2097 2116
3. W.C. Willett Diet and cancer Oncologist 5 2000 393 404
4. D.C. Savage Microbial ecology of the gastrointestinal tract Ann Rev Micribiol 31 1977 107 133
5. Anonymous A framework for human microbiome research Nature 486 2012 215 221
6. J.K. Goodrich, S.C. Di Rienzi, A.C. Poole, and et al. Conducting a microbiome study Cell 158 2014 250 262
7. G.M. Weinstock Genomic approaches to studying the human microbiota Nature 489 2012 250 256
8. Anonymous Structure, function and diversity of the healthy human microbiome Nature 486 2012 207 214
9. E.K. Costello, C.L. Lauber, M. Hamady, and et al. Bacterial community variation in human body habitats across space and time Science 326 2009 1694 1697
10. P.J. Turnbaugh, V.K. Ridaura, J.J. Faith, and et al. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice Sci Translat Med 1 2009 6ra14
11. L.A. David, C.F. Maurice, R.N. Carmody, and et al. Diet rapidly and reproducibly alters the human gut microbiome Nature 505 2014 559 563
12. L.A. David, A.C. Materna, J. Friedman, and et al. Host lifestyle affects human microbiota on daily timescales Genome Biol 15 2014 R89
13. S.R. Gill, M. Pop, R.T. Deboy, and et al. Metagenomic analysis of the human distal gut microbiome Science 312 2006 1355 1359
14. R.E. Ley, P.J. Turnbaugh, S. Klein, and J.I. Gordon Microbial ecology: human gut microbes associated with obesity Nature 444 2006 1022 1023
15. L. Dethlefsen, M. McFall-Ngai, and D.A. Relman An ecological and evolutionary perspective on human-microbe mutualism and disease Nature 449 2007 811 818
16. R.E. Ley, M. Hamady, C. Lozupone, and et al. Evolution of mammals and their gut microbes Science 320 2008 1647 1651
17. B.S. Wostmann The germfree animal in nutritional studies Ann Rev Nutr 1 1981 257 279
18. S.J. Bultman Emerging roles of the microbiome in cancer Carcinogenesis 35 2014 249 255
19. R.F. Schwabe, and C. Jobin The microbiome and cancer Nat Rev 13 2013 800 812
20. M. Castellarin, R.L. Warren, J.D. Freeman, and et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma Genome Res 22 2012 299 306
21. A.D. Kostic, D. Gevers, C.S. Pedamallu, and et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma Genome Res 22 2012 292 298
22. A.N. McCoy, F. Araujo-Perez, A. Azcarate-Peril, and et al. Fusobacterium is associated with colorectal adenomas PloS One 8 2013 e53653
23. W.S. Garrett Cancer and the microbiota Science 348 6230 2015 80 86
24. C. Gur, and et al. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack Immunity 42 2015 344 355
25. M.M. Huycke, and H.R. Gaskins Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models Exp Biol Med 229 2004 586 597
26. M.G. Rooks, and W.S. Garrett Bacteria, food, and cancer F1000 Biol Rep 3 2011 12
27. F.M. Nagengast, M.J. Grubben, and I.P. van Munster Role of bile acids in colorectal carcinogenesis Eur J Cancer 31A 1995 1067 1070
28. S. Yoshimoto, T.M. Loo, K. Atarashi, and et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome Nature 499 2013 97 101
29. J.C. Arthur, E. Perez-Chanona, M. Muhlbauer, and et al. Intestinal inflammation targets cancer-inducing activity of the microbiota Science 338 2012 120 123
30. E. Buc, D. Dubois, P. Sauvanet, and et al. High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer PloS One 8 2013 e56964
31. G. Cuevas-Ramos, C.R. Petit, I. Marcq, and et al. Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells Proc Natl Acad Sci U S A 107 2012 11537 11542
32. A.C. Goodwin, C.E. Destefano Shields, S. Wu, and et al. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis Proc Natl Acad Sci U S A 108 2011 15354 15359
33. C.L. Sears Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes Clin Microbiol Rev 22 2009 349 369
34. S.A. Shiryaev, A.E. Aleshin, N. Muranaka, and et al. Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island FEBS J 281 2014 2487 2502
35. A. Boleij, E.M. Hechenbleikner, A.C. Goodwin, and et al. The bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients Clin Infect Dis 60 2014 208 215
36. C.L. Sears, A.L. Geis, and F. Housseau Bacteroides fragilis subverts mucosal biology: from symbiont to colon carcinogenesis J Clin Invest 124 2014 4166 4172
37. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
38. J. Terzic, S. Grivennikov, E. Karin, and M. Karin Inflammation and colon cancer Gastroenterology 138 2010 2101 2114
39. J.K. Nicholson, E. Holmes, J. Kinross, and et al. Host-gut microbiota metabolic interactions Science 336 2012 1262 1267
40. C.C. Lim, L.R. Ferguson, and G.W. Tannock Dietary fibres as "prebiotics": implications for colorectal cancer Mol Nutr Food Res 49 2005 609 619
41. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2013 Cancer J Clin 63 2013 11 30
42. M.M. Center, A. Jemal, and E. Ward International trends in colorectal cancer incidence rates Cancer Epidemiol Biomarkers Prev 18 2009 1688 1694
43. D.P. Burkitt, A.R. Walker, and N.S. Painter Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease Lancet 2 1972 1408 1412
44. J.A. Baron Dietary fiber and colorectal cancer: an ongoing saga JAMA 294 2005 2904 2906
45. S.A. Bingham, N.E. Day, R. Luben, and et al. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study Lancet 361 2003 1496 1501
46. L.R. Ferguson, and P.J. Harris The dietary fibre debate: more food for thought Lancet 361 2003 1487 1488
47. C.S. Fuchs, E.L. Giovannucci, G.A. Colditz, and et al. Dietary fiber and the risk of colorectal cancer and adenoma in women N Engl J Med 340 1999 169 176
48. Y. Park, D.J. Hunter, D. Spiegelman, and et al. Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies JAMA 294 2005 2849 2857
49. R.A. Goodlad Dietary fibre and the risk of colorectal cancer Gut 48 2001 587 589
50. S.J. Bultman Molecular pathways: gene-environment interactions regulating dietary fiber induction of proliferation and apoptosis via butyrate for cancer prevention Clin Cancer Res 20 2014 799 803
51. D.R. Donohoe, D. Holley, L.B. Collins, and et al. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner Cancer Disc 4 2014 1387 1397
52. C. Sebastian, and R. Mostoslavsky Untangling the fiber yarn: butyrate feeds Warburg to suppress colorectal cancer Cancer Disc 4 2014 1368 1370
53. D.R. Donohoe, N. Garge, X. Zhang, and et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon Cell Metab 13 2011 517 526
54. W.E. Roediger Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man Gut 21 1980 793 798
55. W.E. Roediger Utilization of nutrients by isolated epithelial cells of the rat colon Gastroenterology 83 1982 424 429
56. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
57. D.R. Donohoe, D.R. Collins, A. Wali, and et al. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation Mol Cell 48 2012 612 626
58. J.R. Davie Inhibition of histone deacetylase activity by butyrate J Nutr 133 7 Suppl 2003 2485S 2493SS
59. H.M. Hamer, D. Jonkers, K. Venema, and et al. Review article: the role of butyrate on colonic function Aliment Pharmacol Therapeut 27 2008 104 119
60. P. Goncalves, and F. Martel Butyrate and colorectal cancer: the role of butyrate transport Curr Drug Metab 14 2013 994 1008
61. M. Thangaraju, G.A. Cresci, K. Liu, and et al. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon Cancer Res 69 2009 2826 2832
62. S.H. Itzkowitz, and N. Harpaz Diagnosis and management of dysplasia in patients with inflammatory bowel diseases Gastroenterology 126 2004 1634 1648
63. N. Arpaia, C. Campbell, X. Fan, and et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nature 504 2013 451 455
64. Y. Furusawa, Y. Obata, S. Fukuda, and et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Nature 504 2013 446 450
65. N. Singh, A. Gurav, S. Sivaprakasam, and et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis Immunity 40 2014 128 139
66. P.M. Smith, M.R. Howitt, N. Panikov, and et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis Science 341 2013 569 573
67. P.V. Chang, L. Hao, S. Offermanns, and R. Medzhitov The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition Proc Natl Acad Sci U S A 111 2014 2247 2252
68. K.Y. Fung, L. Cosgrove, T. Lockett, R. Head, and D.L. Topping A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate Br J Nutr 108 2012 820 831
69. L.M. Bode, D. Bunzel, M. Huch, and et al. In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota Am J Clin Nutr 97 2013 295 309
70. M. Larrosa, A. Gonzalez-Sarrias, M.T. Garcia-Conesa, F.A. Tomas-Barberan, and J.C. Espin Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities J Ag Food Chem 54 2006 1611 1620
71. A. Gonzalez-Sarrias, M. Larrosa, F.A. Tomas-Barberan, P. Dolara, and J.C. Espin NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts Br J Nutr 104 2010 503 512
72. C. Atkinson, C.L. Frankenfeld, and J.W. Lampe Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health Exp Biol Med 230 2005 155 170
73. C.D. Davis, and J.A. Milner Gastrointestinal microflora, food components and colon cancer prevention J Nutr Biochem 20 2009 743 752
74. M.A. Hullar, A.N. Burnett-Hartman, and J.W. Lampe Gut microbes, diet, and cancer Cancer Treat Res 159 2014 377 399
75. S. Bolca, S. Possemiers, A. Herregat, and et al. Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women J Nutr 137 2007 2242 2246
76. J.W. Lampe Emerging research on equol and cancer J Nutr 140 2010 1369S 1372SS
77. F. Guarner, and J.R. Malagelada Gut flora in health and disease Lancet 361 2003 512 519
78. M.L. Mayer, C.M. Phillips, R.A. Townsend, S.A. Halperin, and S.F. Lee Differential activation of dendritic cells by Toll-like receptor agonists isolated from the Gram-positive vaccine vector Streptococcus gordonii Scand J Immunol 69 2009 351 356
79. M.L. Mayer, C.M. Phillips, A.W. Stadnyk, S.A. Halperin, and S.F. Lee Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor Mol Immunol 46 2009 1883 1891
80. K. Khazaie, M. Zadeh, M.W. Khan, and et al. Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid Proc Natl Acad Sci U S A 109 2012 10462 10467
81. J.P. Motta, L.G. Bermudez-Humaran, C. Deraison, and et al. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis Sci Translat Med 4 2012 158ra144
82. I.M. Carroll, J.M. Andrus, J.M. Bruno-Barcena, and et al. Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis Am J Physiol Gastrointest Liver Physiol 293 2007 G729 G738
83. M. Blaser Antibiotic overuse: stop the killing of beneficial bacteria Nature 476 2011 393 394