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Volumn 54, Issue , 2017, Pages 133-143

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Immunohistochemistry; Microglia; Mild cognitive impairment; Tau; TREM2; Western blot

Indexed keywords

AMYLOID PROTEIN; IBA1 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; TREM2 PROTEIN, HUMAN;

EID: 85016513627     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2017.02.012     Document Type: Article
Times cited : (39)

References (59)
  • 3
    • 1542268242 scopus 로고    scopus 로고
    • Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
    • Bennett, D.A., Schneider, J.A., Wilson, R.S., Bienias, J.L., Arnold, S.E., Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch. Neurol. 61 (2004), 378–384.
    • (2004) Arch. Neurol. , vol.61 , pp. 378-384
    • Bennett, D.A.1    Schneider, J.A.2    Wilson, R.S.3    Bienias, J.L.4    Arnold, S.E.5
  • 4
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: back to the future
    • Bertram, L., Lill, C.M., Tanzi, R.E., The genetics of Alzheimer disease: back to the future. Neuron 68 (2010), 270–281.
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 6
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak, H., Braak, E., Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82 (1991), 239–259.
    • (1991) Acta Neuropathol. , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 0037805700 scopus 로고    scopus 로고
    • TREMs in the immune system and beyond
    • Colonna, M., TREMs in the immune system and beyond. Nat. Rev. Immunol. 3 (2003), 445–453.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 445-453
    • Colonna, M.1
  • 10
    • 51349085578 scopus 로고    scopus 로고
    • TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
    • Frank, S., Burbach, G.J., Bonin, M., Walter, M., Streit, W., Bechmann, I., Deller, T., TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia 56 (2008), 1438–1447.
    • (2008) Glia , vol.56 , pp. 1438-1447
    • Frank, S.1    Burbach, G.J.2    Bonin, M.3    Walter, M.4    Streit, W.5    Bechmann, I.6    Deller, T.7
  • 11
    • 78650803250 scopus 로고    scopus 로고
    • Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease
    • Ginsberg, S.D., Mufson, E.J., Counts, S.E., Wuu, J., Alldred, M.J., Nixon, R.A., Che, S., Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease. J. Alzheimers Dis. 22 (2010), 631–639.
    • (2010) J. Alzheimers Dis. , vol.22 , pp. 631-639
    • Ginsberg, S.D.1    Mufson, E.J.2    Counts, S.E.3    Wuu, J.4    Alldred, M.J.5    Nixon, R.A.6    Che, S.7
  • 15
    • 0015443132 scopus 로고
    • Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia
    • Hakola, H.P., Neuropsychiatric and genetic aspects of a new hereditary disease characterized by progressive dementia and lipomembranous polycystic osteodysplasia. Acta Psychiatr. Scand. Suppl. 232 (1972), 1–173.
    • (1972) Acta Psychiatr. Scand. Suppl. , vol.232 , pp. 1-173
    • Hakola, H.P.1
  • 18
    • 85027946081 scopus 로고    scopus 로고
    • Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease
    • Jiang, T., Tan, L., Zhu, X.C., Zhang, Q.Q., Cao, L., Tan, M.S., Wang, H.F., Chen, Q., Zhang, Y.D., Yu, J.T., Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology 39 (2014), 2949–2962.
    • (2014) Neuropsychopharmacology , vol.39 , pp. 2949-2962
    • Jiang, T.1    Tan, L.2    Zhu, X.C.3    Zhang, Q.Q.4    Cao, L.5    Tan, M.S.6    Wang, H.F.7    Chen, Q.8    Zhang, Y.D.9    Yu, J.T.10
  • 19
    • 84897401882 scopus 로고    scopus 로고
    • Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2)
    • Jones, B.M., Bhattacharjee, S., Dua, P., Hill, J.M., Zhao, Y., Lukiw, W.J., Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2). Front Cell Neurosci., 8, 2014, 94.
    • (2014) Front Cell Neurosci. , vol.8 , pp. 94
    • Jones, B.M.1    Bhattacharjee, S.2    Dua, P.3    Hill, J.M.4    Zhao, Y.5    Lukiw, W.J.6
  • 22
    • 33846316333 scopus 로고    scopus 로고
    • The TREM receptor family and signal integration
    • Klesney-Tait, J., Turnbull, I.R., Colonna, M., The TREM receptor family and signal integration. Nat. Immunol. 7 (2006), 1266–1273.
    • (2006) Nat. Immunol. , vol.7 , pp. 1266-1273
    • Klesney-Tait, J.1    Turnbull, I.R.2    Colonna, M.3
  • 24
    • 84931401474 scopus 로고    scopus 로고
    • TREM2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in post-mortem temporal cortices
    • Lue, L.F., Schmitz, C.T., Serrano, G., Sue, L.I., Beach, T.G., Walker, D.G., TREM2 protein expression changes correlate with Alzheimer's disease neurodegenerative pathologies in post-mortem temporal cortices. Brain Pathol. 25 (2015), 469–480.
    • (2015) Brain Pathol. , vol.25 , pp. 469-480
    • Lue, L.F.1    Schmitz, C.T.2    Serrano, G.3    Sue, L.I.4    Beach, T.G.5    Walker, D.G.6
  • 27
    • 77956238665 scopus 로고    scopus 로고
    • Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
    • Melchior, B., Garcia, A.E., Hsiung, B.K., Lo, K.M., Doose, J.M., Thrash, J.C., Stalder, A.K., Staufenbie, L.M., Neumann, H., Carson, M.J., Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN Neuro., 2, 2010, e00037.
    • (2010) ASN Neuro. , vol.2 , pp. e00037
    • Melchior, B.1    Garcia, A.E.2    Hsiung, B.K.3    Lo, K.M.4    Doose, J.M.5    Thrash, J.C.6    Stalder, A.K.7    Staufenbie, L.M.8    Neumann, H.9    Carson, M.J.10
  • 28
    • 0030700593 scopus 로고    scopus 로고
    • The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary
    • Mirra, S.S., The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: a commentary. Neurobiol. Aging 18 (1997), S91–S94.
    • (1997) Neurobiol. Aging , vol.18 , pp. S91-S94
    • Mirra, S.S.1
  • 35
    • 0015736566 scopus 로고
    • A lipid metabolic disease-“membranous lipodystrophy”—an autopsy case demonstrating numerous peculiar membrane-structures composed of compound lipid in bone and bone marrow and various adipose tissues
    • Nasu, T., Tsukahara, Y., Terayama, K., A lipid metabolic disease-“membranous lipodystrophy”—an autopsy case demonstrating numerous peculiar membrane-structures composed of compound lipid in bone and bone marrow and various adipose tissues. Acta Pathol. Jpn. 23 (1973), 539–558.
    • (1973) Acta Pathol. Jpn. , vol.23 , pp. 539-558
    • Nasu, T.1    Tsukahara, Y.2    Terayama, K.3
  • 36
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: an essential link between degeneration and regeneration
    • Neumann, H., Kotter, M.R., Franklin, R.J.M., Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132 (2009), 288–295.
    • (2009) Brain , vol.132 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.M.3
  • 37
    • 0032749171 scopus 로고    scopus 로고
    • Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease
    • Newell, K.L., Hyman, B.T., Growdon, J.H., Hedley-Whyte, E.T., Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. J. Neuropathol. Exp. Neurol. 58 (1999), 1147–1155.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 1147-1155
    • Newell, K.L.1    Hyman, B.T.2    Growdon, J.H.3    Hedley-Whyte, E.T.4
  • 40
    • 84929657659 scopus 로고    scopus 로고
    • Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease
    • Perez, S.E., He, B., Nadeem, M., Wuu, J., Scheff, S.W., Abrahamson, E.E., Ikonomovic, M.D., Mufson, E.J., Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease. Biol. Psychiatry 77 (2015), 693–703.
    • (2015) Biol. Psychiatry , vol.77 , pp. 693-703
    • Perez, S.E.1    He, B.2    Nadeem, M.3    Wuu, J.4    Scheff, S.W.5    Abrahamson, E.E.6    Ikonomovic, M.D.7    Mufson, E.J.8
  • 41
    • 84878486664 scopus 로고    scopus 로고
    • Genetics of familial and sporadic Alzheimer's disease
    • Piaceri, I., Nacmias, B., Sorbi, S., Genetics of familial and sporadic Alzheimer's disease. Front Biosci. 5 (2013), 167–177.
    • (2013) Front Biosci. , vol.5 , pp. 167-177
    • Piaceri, I.1    Nacmias, B.2    Sorbi, S.3
  • 46
    • 84904540712 scopus 로고    scopus 로고
    • Late-onset Alzheimer's disease genes and the potentially implicated pathways
    • Rosenthal, S.L., Kamboh, M.I., Late-onset Alzheimer's disease genes and the potentially implicated pathways. Curr. Genet. Med. Rep. 2 (2014), 85–101.
    • (2014) Curr. Genet. Med. Rep. , vol.2 , pp. 85-101
    • Rosenthal, S.L.1    Kamboh, M.I.2
  • 48
    • 9644307970 scopus 로고    scopus 로고
    • Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
    • Sessa, G., Podini, P., Mariani, M., Meroni, A., Spreafico, R., Sinigaglia, F., Colonna, M., Panina, P., Meldolesi, J., Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur. J. Neurosci. 20 (2004), 2617–2628.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 2617-2628
    • Sessa, G.1    Podini, P.2    Mariani, M.3    Meroni, A.4    Spreafico, R.5    Sinigaglia, F.6    Colonna, M.7    Panina, P.8    Meldolesi, J.9
  • 50
    • 84937468720 scopus 로고    scopus 로고
    • Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARγ
    • Strobel, S., Grünblatt, E., Riederer, P., Heinsen, H., Arzberger, T., Al-Sarraj, S., Troakes, C., Ferrer, I., Monoranu, C.M., Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARγ. J. Neural. Transm. 122 (2015), 1069–1076.
    • (2015) J. Neural. Transm. , vol.122 , pp. 1069-1076
    • Strobel, S.1    Grünblatt, E.2    Riederer, P.3    Heinsen, H.4    Arzberger, T.5    Al-Sarraj, S.6    Troakes, C.7    Ferrer, I.8    Monoranu, C.M.9
  • 52
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • Takahashi, K., Rochford, C.D., Neumann, H., Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201 (2005), 647–657.
    • (2005) J. Exp. Med. , vol.201 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.2    Neumann, H.3
  • 54
    • 0030882883 scopus 로고    scopus 로고
    • Nasu-Hakola syndrome: polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy and presenile dementia
    • Verloes, A., Maquet, P., Sadzot, B., Vivario, M., Thiry, A., Franck, G., Nasu-Hakola syndrome: polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy and presenile dementia. J. Med. Genet. 34 (1997), 753–757.
    • (1997) J. Med. Genet. , vol.34 , pp. 753-757
    • Verloes, A.1    Maquet, P.2    Sadzot, B.3    Vivario, M.4    Thiry, A.5    Franck, G.6
  • 57
    • 84992028918 scopus 로고    scopus 로고
    • TREM2 Binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia
    • Yeh, F.L., Wang, Y., Tom, I., Gonzalez, L.C., Sheng, M., TREM2 Binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia. Neuron 91 (2016), 328–340.
    • (2016) Neuron , vol.91 , pp. 328-340
    • Yeh, F.L.1    Wang, Y.2    Tom, I.3    Gonzalez, L.C.4    Sheng, M.5
  • 58
    • 84968764145 scopus 로고    scopus 로고
    • TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy
    • Yuan, P., Condello, C., Keene, C.D., Wang, Y., Bird, T.D., Paul, S.M., Luo, W., Colonna, M., Baddeley, D., Grutzendler, J., TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron 90 (2016), 724–739.
    • (2016) Neuron , vol.90 , pp. 724-739
    • Yuan, P.1    Condello, C.2    Keene, C.D.3    Wang, Y.4    Bird, T.D.5    Paul, S.M.6    Luo, W.7    Colonna, M.8    Baddeley, D.9    Grutzendler, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.