R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

Alzheimer's and Dementia

Volumn 10, Issue 6, 2014, Pages 602-608.e4

  Slattery, Catherine F ^a   Beck, Jonathan A ^a   Harper, Lorna ^a   Adamson, Gary ^a   Abdi, Zeinab ^a   Uphill, James ^a   Campbell, Tracy ^a   Druyeh, Ron ^a   Mahoney, Colin J ^a   Rohrer, Jonathan D ^a   Kenny, Janna ^a   Lowe, Jessica ^a   Leung, Kelvin K ^a   Barnes, Josephine ^a   Clegg, Shona L ^a   Blair, Melanie ^a   Nicholas, Jennifer M ^b   Guerreiro, Rita J ^a   Rowe, James B ^c   Ponto, Claudia ^d   Zerr, Inga ^d   Kretzschmar, Hans ^e   Gambetti, Pierluigi ^f   Crutch, Sebastian J ^a   Warren, Jason D ^a   Rossor, Martin N ^a   Fox, Nick C ^a   Collinge, John ^a   Schott, Jonathan M ^a   Mead, Simon ^a   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Alzheimer's; Frontotemporal dementia; Phenotype; Prion; TREM2

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; BRAIN SIZE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE DURATION; EXON; FEMALE; FRONTOTEMPORAL DEMENTIA; GENE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROFIBRILLARY TANGLE; NEUROIMAGING; NEUROPIL THREAD; NEXT GENERATION SEQUENCING; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; SENILE PLAQUE; SPORADIC CREUTZFELDT JAKOB DISEASE; TREM2 GENE; VARIANT CREUTZFELDT JAKOB DISEASE; WHITE MATTER LESION; BRAIN; COHORT ANALYSIS; CREUTZFELDT JAKOB DISEASE; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MIDDLE AGED; PATHOLOGY; RISK FACTOR; VERY ELDERLY;

ARGININE; HISTIDINE; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ARGININE; BRAIN; COHORT STUDIES; CREUTZFELDT-JAKOB SYNDROME; EXONS; FEMALE; FRONTOTEMPORAL DEMENTIA; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HISTIDINE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PHENOTYPE; RECEPTORS, IMMUNOLOGIC; RISK FACTORS;

EID: 84927137044     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.05.1751     Document Type: Article

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