Cryo-EM structure of a human spliceosome activated for step 2 of splicing

Nature

Volumn 542, Issue 7641, 2017, Pages 318-323

  Bertram, Karl ^a   Agafonov, Dmitry E ^a   Liu, Wen Ti ^a   Dybkov, Olexandr ^a   Will, Cindy L ^a   Hartmuth, Klaus ^a   Urlaub, Henning ^a,b   Kastner, Berthold ^a   Stark, Holger ^a   Lührmann, Reinhard ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; RIBONUCLEASE H; RIBONUCLEOPROTEIN; RNA HELICASE; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; ADENOSINE; CDC40 PROTEIN, HUMAN; CELL CYCLE PROTEIN; DEAD BOX PROTEIN; DHX8 PROTEIN, HUMAN; MESSENGER RNA; PRPF8 PROTEIN, HUMAN; RNA BINDING PROTEIN; RNA SPLICING FACTOR;

CATALYSIS; CELLS AND CELL COMPONENTS; ELECTRON MICROSCOPY; ENZYME ACTIVITY; HOMINID; PROTEIN; RNA; YEAST;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; CRYOELECTRON MICROSCOPY; HELA CELL LINE; HUMAN; IN VITRO STUDY; INTRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; RNA STRUCTURE; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SPLICEOSOME; WD REPEAT; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; EXON; GENETICS; METABOLISM; MOLECULAR MODEL; MOVEMENT (PHYSIOLOGY); NUCLEOTIDE SEQUENCE; RNA SPLICING; RNA STABILITY; ULTRASTRUCTURE;

ADENOSINE; BASE SEQUENCE; BIOCATALYSIS; CELL CYCLE PROTEINS; CRYOELECTRON MICROSCOPY; DEAD-BOX RNA HELICASES; EXONS; HUMANS; INTRONS; MODELS, MOLECULAR; MOVEMENT; PROTEIN DOMAINS; RIBONUCLEASE H; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA SPLICING; RNA SPLICING FACTORS; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SPLICEOSOMES;

EID: 85016153737     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21079     Document Type: Article

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