Delirium in critically ill patients

Handbook of Clinical Neurology

Volumn 141, Issue , 2017, Pages 449-466

  Slooter, A J C ^a   Van De Leur, R R ^a   Zaal, I J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

critically ill; delirium; ICU; intensive care unit; outcomes; pathophysiology; prevention; treatment

Indexed keywords

CRITICAL ILLNESS; DELIRIUM; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; PATHOPHYSIOLOGY; PROCEDURES;

CRITICAL CARE; CRITICAL ILLNESS; DELIRIUM; HUMANS; INTENSIVE CARE UNITS;

EID: 85016121938     PISSN: 00729752     EISSN: 22124152     Source Type: Book Series    
DOI: 10.1016/B978-0-444-63599-0.00025-9     Document Type: Chapter

References (169)

1. Adamis, D., Treloar, A., Martin, F.C., et al. A brief review of the history of delirium as a mental disorder. Hist Psychiatry 18 (2007), 459–469.
2. Adamis, D., Meagher, D., Murray, O., et al. Evaluating attention in delirium: a comparison of bedside tests of attention. Geriatr Gerontol Int, 2015, 10.1111/ggi.12592.
3. Almeida, I.C.T., Soares, M., Bozza, F.A., et al. The impact of acute brain dysfunction in the outcomes of mechanically ventilated cancer patients. PLoS One, 9, 2014, e85332.
4. Al-Qadheeb, N.S., Skrobik, Y., Schumaker, G., et al. Preventing ICU subsyndromal delirium conversion to delirium with low-dose IV haloperidol: a double-blind, placebo-controlled pilot study. Crit Care Med 44 (2016), 583–591.
5. Alsop, D.C., Fearing, M.A., Johnson, K., et al. The role of neuroimaging in elucidating delirium pathophysiology. J Gerontol A Biol Sci Med Sci 61 (2006), 1287–1293.
6. American Geriatrics Society Expert Panel on Postoperative Delirium in Older Adults, Postoperative delirium in older adults: best practice statement from the American Geriatrics Society. J Am Coll Surg 220 (2014), 136–148.e1.
7. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. 3rd edn., 1980, American Psychiatric Publishing, Washington, DC.
8. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. 5th edn., 2013, American Psychiatric Publishing, Arlington, VA.
9. Aurell, J., Elmqvist, D., Sleep in the surgical intensive care unit: continuous polygraphic recording of sleep in nine patients receiving postoperative care. BMJ 290 (1985), 1029–1032.
10. Balas, M.C., Vasilevskis, E.E., Olsen, K.M., et al. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med 42 (2014), 1024–1036.
11. Barr, J., Fraser, G.L., Puntillo, K., et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 41 (2013), 263–306.
12. Bergeron, N., Dubois, M.-J., Dumont, M., et al. Intensive care delirium screening checklist: evaluation of a new screening tool. Intensive Care Med 27 (2001), 859–864.
13. Boyer, E.W., Shannon, M., The serotonin syndrome. N Engl J Med 352 (2005), 1112–1120.
14. Breitbart, W., Gibson, C., Tremblay, A., The delirium experience: delirium recall and delirium-related distress in hospitalized patients with cancer, their spouses/caregivers, and their nurses. Psychosomatics 43 (2002), 183–194.
15. Brown, E.N., Lydic, R., Schiff, N.D., General anesthesia, sleep, and coma. N Engl J Med 363 (2010), 2638–2650.
16. Brummel, N.E., Jackson, J.C., Pandharipande, P.P., et al. Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med 42 (2014), 369–377.
17. Carnahan, R.M., Lund, B.C., Perry, P.J., et al. The Anticholinergic Drug Scale as a measure of drug-related anticholinergic burden: associations with serum anticholinergic activity. J Clin Pharmacol 46 (2006), 1481–1486.
18. Caruso, P., Guardian, L., Tiengo, T., et al. ICU architectural design affects the delirium prevalence. Crit Care Med 42 (2014), 2204–2210.
19. Casarin, A., McAuley, D.F., Alce, T.M., et al. Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial. Trials, 16, 2015, 218.
20. Choi, S.-H.H., Lee, H., Chung, T.-S.S., et al. Neural network functional connectivity during and after an episode of delirium. Am J Psychiatry 169 (2012), 498–507.
21. Colombo, R., Corona, A., Praga, F., et al. A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study. Minerva Anestesiol 78 (2012), 1026–1033.
22. Dale, C.R., Kannas, D.A., Fan, V.S., et al. Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation. Ann Am Thorac Soc 11 (2014), 367–374.
23. Davydow, D.S., Symptoms of depression and anxiety after delirium. Psychosomatics 50 (2009), 309–316.
24. De Rooij, S.E., van Munster, B.C., Korevaar, J.C., et al. Cytokines and acute phase response in delirium. J Psychosom Res 62 (2007), 521–525.
25. Devlin, J.W., Roberts, R.J., Fong, J.J., et al. Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study. Crit Care Med 38 (2010), 419–427.
26. Devlin, J.W., Bhat, S., Roberts, R.J., et al. Current perceptions and practices surrounding the recognition and treatment of delirium in the intensive care unit: a survey of 250 critical care pharmacists from eight states. Ann Pharmacother 45 (2011), 1217–1229.
27. Dubois, M.J., Bergeron, N., Dumont, M., et al. Delirium in an intensive care unit: a study of risk factors. Intensive Care Med 27 (2001), 1297–1304.
28. Durán, C.E., Azermai, M., Vander Stichele, R.H., Systematic review of anticholinergic risk scales in older adults. Eur J Clin Pharmacol 69 (2013), 1485–1496.
29. Ebersoldt, M., Sharshar, T., Annane, D., Sepsis-associated delirium. Intensive Care Med 33 (2007), 941–950.
30. Ely, E.W., Gautam, S., Margolin, R., et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 27 (2001), 1892–1900.
31. Ely, E.W., Margolin, R., Francis, J., et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 29 (2001), 1370–1379.
32. Ely, E.W., Shintani, A., Truman, B., et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291 (2004), 1753–1762.
33. Ely, E.W., Girard, T.D., Shintani, A.K., et al. Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med 35 (2007), 112–117.
34. Field, R.H., Gossen, A., Cunningham, C., Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. J Neurosci 32 (2012), 6288–6294.
35. Fischer, P., Successful treatment of nonanticholinergic delirium with a cholinesterase inhibitor. J Clin Psychopharmacol, 21, 2001, 118.
36. Fok, M.C., Sepehry, A.A., Frisch, L., et al. Do antipsychotics prevent postoperative delirium? A systematic review and meta-analysis. Int J Geriatr Psychiatry 30 (2015), 333–344.
37. Fong, T.G., Bogardus, S.T., Daftary, A., et al. Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. J Gerontol A Biol Sci Med Sci 61 (2006), 1294–1299.
38. Fong, T.G., Davis, D., Growdon, M.E., et al. The interface between delirium and dementia in elderly adults. Lancet Neurol 14 (2015), 823–832.
39. Gagnon, B., Low, G., Schreier, G., Methylphenidate hydrochloride improves cognitive function in patients with advanced cancer and hypoactive delirium: a prospective clinical study. J Psychiatry Neurosci 30 (2005), 100–107.
40. Gagnon, D.J., Riker, R.R., Glisic, E.K., et al. Transition from dexmedetomidine to enteral clonidine for ICU sedation: an observational pilot study. Pharmacother J Hum Pharmacol Drug Ther 35 (2015), 251–259.
41. Gamberini, M., Bolliger, D., Lurati Buse, G.A., et al. Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery – a randomized controlled trial. Crit Care Med 37 (2009), 1762–1768.
42. Girard, T.D., Jackson, J.C., Pandharipande, P.P., et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 38 (2010), 1513–1520.
43. Girard, T.D., Pandharipande, P.P., Carson, S.S., et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med 38 (2010), 428–437.
44. Gross, G., Geyer, M.A., Current antipsychotics. 2012, Springer, Berlin.
45. Gunther, M.L., Morandi, A., Krauskopf, E., et al. The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study. Crit Care Med 40 (2012), 2022–2032.
46. Gusmao-Flores, D., Salluh, J.I.F., Chalhub, R.Á., et al. The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care Med, 16, 2012, R115.
47. Hakim, S.M., Othman, A.I., Naoum, D.O., Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly. Anesthesiology 116 (2012), 987–997.
48. Han, L., McCusker, J., Cole, M., et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch Intern Med 161 (2001), 1099–1105.
49. Hatta, K., Kishi, Y., Wada, K., et al. Preventive effects of ramelteon on delirium. JAMA Psychiat, 71, 2014, 397.
50. Heymann, A., Radtke, F., Schiemann, A., et al. Delayed treatment of delirium increases mortality rate in intensive care unit patients. J Int Med Res 38 (2010), 1584–1595.
51. Hill, A.B., The environment and disease: association or causation?. Proc R Soc Med 58 (1965), 295–300.
52. Holbrook, A.M., Crowther, R., Lotter, A., et al. Meta-analysis of benzodiazepine use in the treatment of acute alcohol withdrawal. CMAJ 160 (1999), 649–655.
53. Hshieh, T.T., Fong, T.G., Marcantonio, E.R., et al. Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. J Gerontol A Biol Sci Med Sci 63 (2008), 764–772.
54. Hshieh, T.T., Yue, J., Oh, E., et al. Effectiveness of multicomponent nonpharmacological delirium interventions. JAMA Intern Med, 175, 2015, 512.
55. Hsieh, S.J., Ely, E.W., Gong, M.N., Can intensive care unit delirium be prevented and reduced? Lessons learned and future directions. Ann Am Thorac Soc 10 (2013), 648–656.
56. Inouye, S.K., Bogardus, S.T., Charpentier, P.A., et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 340 (1999), 669–676.
57. Jackson, J.C., Pandharipande, P.P., Girard, T.D., et al. Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study. Lancet Respir Med 2 (2014), 369–379.
58. Jackson, J.C., Morandi, A., Girard, T.D., et al. Functional brain imaging in survivors of critical illness: a prospective feasibility study and exploration of the association between delirium and brain activation patterns. J Crit Care 30 (2015), 653.e1–653.e7.
59. Jacobi, J., Fraser, G.L., Coursin, D.B., et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 30 (2002), 119–141.
60. Janz, D.R., Abel, T.W., Jackson, J.C., et al. Brain autopsy findings in intensive care unit patients previously suffering from delirium: a pilot study. J Crit Care 25 (2010), 538.e7–538.e12.
61. Kamdar, B.B., King, L.M., Collop, N.A., et al. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med 41 (2013), 800–809.
62. Kamdar, B.B., Niessen, T., Colantuoni, E., et al. Delirium transitions in the medical ICU: exploring the role of sleep quality and other factors. Crit Care Med 43 (2015), 135–141.
63. Kaplan, P.W., Rossetti, A.O., EEG patterns and imaging correlations in encephalopathy: encephalopathy part II. J Clin Neurophysiol 28 (2011), 233–251.
64. Katznelson, R., Djaiani, G.N., Borger, M.A., et al. Preoperative use of statins is associated with reduced early delirium rates after cardiac surgery. Anesthesiology 110 (2009), 67–73.
65. Klein Klouwenberg, P.M.C., Zaal, I.J., Spitoni, C., et al. The attributable mortality of delirium in critically ill patients: prospective cohort study. BMJ, 349, 2014, g6652.
66. Leucht, S., Corves, C., Arbter, D., et al. Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373 (2009), 31–41.
67. Lipowski, Z., Delirium: acute confusional states. 1990, Oxford University Press, New York.
68. Maclullich, A.M.J., Ferguson, K.J., Miller, T., et al. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 65 (2008), 229–238.
69. Maldonado, J.R., Neuropathogenesis of delirium: review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 21 (2013), 1190–1222.
70. Maldonado, J.R., Wysong, A., van der Starre, P.J.A., et al. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics 50 (2009), 206–217.
71. Marcantonio, E.R., Flacker, J.M., Wright, R.J., et al. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 49 (2001), 516–522.
72. Marcantonio, E.R., Palihnich, K., Appleton, P., et al. Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture. J Am Geriatr Soc 59 (2011), 282–288.
73. Marquis, F., Ouimet, S., Riker, R., et al. Individual delirium symptoms: do they matter?. Crit Care Med 35 (2007), 2533–2537.
74. Martin, J., Heymann, A., Bäsell, K., et al. Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care – short version. Ger Med Sci, 8, 2010 Doc02.
75. Martinez, F.T., Tobar, C., Beddings, C.I., et al. Preventing delirium in an acute hospital using a non-pharmacological intervention. Age Ageing 41 (2012), 629–634.
76. McGrane, S., Girard, T.D., Thompson, J.L., et al. Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Crit Care Med, 15, 2011, R78.
77. McNicoll, L., Pisani, M.A., Zhang, Y., et al. Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc 51 (2003), 591–598.
78. Meagher, D.J., Motor subtypes of delirium: Past, present and future. Int Rev Psychiatry 21 (2009), 59–73.
79. Meagher, D.J., O'Hanlon, D., O'Mahony, E., et al. Relationship between symptoms and motoric subtype of delirium. J Neuropsychiatry Clin Neurosci 12 (2000), 51–56.
80. Meagher, D.J., McLoughlin, L., Leonard, M., et al. What do we really know about the treatment of delirium with antipsychotics? Ten key issues for delirium pharmacotherapy. Am J Geriatr Psychiatry 21 (2013), 1223–1238.
81. Milbrandt, E.B., Deppen, S., Harrison, P.L., et al. Costs associated with delirium in mechanically ventilated patients. Crit Care Med 32 (2004), 955–962.
82. Mo, Y., Scheer, C.E., Abdallah, G.T., Emerging role of melatonin and melatonin receptor agonists in sleep and delirium in intensive care unit patients. J Intensive Care Med: 2015, 1–5.
83. Morandi, A., Pandharipande, P., Trabucchi, M., et al. Understanding international differences in terminology for delirium and other types of acute brain dysfunction in critically ill patients. Intensive Care Med 34 (2008), 1907–1915.
84. Morandi, A., Rogers, B.P., Gunther, M.L., et al. The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging. Crit Care Med 40 (2012), 2182–2189.
85. Morandi, A., Hughes, C.G., Thompson, J.L., et al. Statins and delirium during critical illness: a multicenter, prospective cohort study. Crit Care Med 42 (2014), 1899–1909.
86. Morrison, R.S., Magaziner, J., Gilbert, M., et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci 58 (2003), 76–81.
87. Mu, D.-L., Wang, D.-X., Li, L.-H., et al. High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study. Crit Care Med, 14, 2010, R238.
88. Neto, A.S., Nassar, A.P., Cardoso, S.O., et al. Delirium screening in critically ill patients: a systematic review and meta-analysis. Crit Care Med 40 (2012), 1946–1951.
89. Oddo, M., Carrera, E., Claassen, J., et al. Continuous electroencephalography in the medical intensive care unit. Crit Care Med 37 (2009), 2051–2056.
90. Omiya, H., Yoshitani, K., Yamada, N., et al. Preoperative brain magnetic resonance imaging and postoperative delirium after off-pump coronary artery bypass grafting: a prospective cohort study. Can J Anesth 62 (2015), 595–602.
91. Ouimet, S., Kavanagh, B.P., Gottfried, S.B., et al. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med 33 (2007), 66–73.
92. Ouimet, S., Riker, R., Bergeon, N., et al. Subsyndromal delirium in the ICU: evidence for a disease spectrum. Intensive Care Med 33 (2007), 1007–1013.
93. Overshott, R., Vernon, M., Morris, J., et al. Rivastigmine in the treatment of delirium in older people: a pilot study. Int Psychogeriatr 22 (2010), 812–818.
94. Page, V.J., Ely, E.W., Gates, S., et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 1 (2013), 515–523.
95. Page, V.J., Davis, D., Zhao, X.B., et al. Statin use and risk of delirium in the critically ill. Am J Respir Crit Care Med 189 (2014), 666–673.
96. Pandharipande, P.P., Shintani, A., Peterson, J., et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104 (2006), 21–26.
97. Pandharipande, P.P., Cotton, B.A., Shintani, A., et al. Motoric subtypes of delirium in mechanically ventilated surgical and trauma intensive care unit patients. Intensive Care Med 33 (2007), 1726–1731.
98. Pandharipande, P.P., Pun, B.T., Herr, D.L., et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA 298 (2007), 2644–2653.
99. Pandharipande, P.P., Cotton, B.A., Shintani, A., et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 65 (2008), 34–41.
100. Pandharipande, P.P., Girard, T.D., Jackson, J.C., et al. Long-term cognitive impairment after critical illness. N Engl J Med 369 (2013), 1306–1316.
101. Parker, A.M., Sricharoenchai, T., Raparla, S., et al. Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med 43 (2015), 1121–1129.
102. Patel, R.P., Gambrell, M., Speroff, T., et al. Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med 37 (2009), 825–832.
103. Peterson, J.F., Pun, B.T., Dittus, R.S., et al. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc 54 (2006), 479–484.
104. Pfister, D., Siegemund, M., Dell-Kuster, S., et al. Cerebral perfusion in sepsis-associated delirium. Crit Care Med, 12, 2008, R63.
105. Pisani, M.A., Kong, S.Y.J., Kasl, S.V., et al. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 180 (2009), 1092–1097.
106. Pisani, M.A., Murphey, T.E., Araujo, K.L.B., et al. Benzodiazepine and opoid use and the duration of ICU delirium in an older population. Crit Care Med 37 (2009), 177–183.
107. Pisani, M.A., Araujo, K.L.B., Murphy, T.E., Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients. Crit Care Med 43 (2015), 996–1002.
108. Pitkälä, K.H., Laurila, J.V., Strandberg, T.E., et al. Multicomponent geriatric intervention for elderly inpatients with delirium: a randomized, controlled trial. J Gerontol A Biol Sci Med Sci 61 (2006), 176–181.
109. Plaschke, K., Fichtenkamm, P., Schramm, C., et al. Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Intensive Care Med 36 (2010), 2081–2089.
110. Prakanrattana, U., Prapaitrakool, S., Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care 35 (2007), 714–719.
111. Qin, L., Wu, X., Block, M.L., et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55 (2007), 453–462.
112. Radboud University, Effects of prophylactic use of haloperidol in critically ill patients with a high risk for delirium. ClinicalTrials.gov, 2013 https://clinicaltrials.gov/show/NCT01785290 Accessed 4 Oct 2015.
113. Reade, M.C., Eastwood, G.M., Bellomo, R., et al. Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium: a randomized clinical trial. JAMA 315 (2016), 1460–1480.
114. Reade, M.C., O'Sullivan, K., Bates, S., et al. Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Crit Care Med, 13, 2009, R75.
115. Riker, R.R., Shehabi, Y., Bokesch, P.M., et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 301 (2009), 489–499.
116. Root, J.C., Pryor, K.O., Downey, R., et al. Association of pre-operative brain pathology with post-operative delirium in a cohort of non-small cell lung cancer patients undergoing surgical resection. Psychooncology 22 (2013), 2087–2094.
117. Rudolph, J.L., The anticholinergic risk scale and anticholinergic adverse effects in older persons. Arch Intern Med, 168, 2008, 508.
118. Salluh, J.I.F., Wang, H., Schneider, E.B., et al. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ, 350, 2015, h2538.
119. Schreiber, M.P., Colantuoni, E., Bienvenu, O.J., et al. Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med 42 (2014), 1480–1486.
120. Schweickert, W.D., Pohlman, M.C., Pohlman, A.S., et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373 (2009), 1874–1882.
121. Sechi, G., Serra, A., Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol 6 (2007), 442–455.
122. Serafim, R.B., Dutra, M.F., Saddy, F., et al. Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes. Ann Intensive Care, 2, 2012, 51.
123. Serafim, R.B., Bozza, F.A., Soares, M., et al. Pharmacologic prevention and treatment of delirium in intensive care patients: A systematic review. J Crit Care 30 (2015), 799–807.
124. Shioiri, A., Kurumaji, A., Takeuchi, T., et al. White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging. Am J Geriatr Psychiatry 18 (2010), 743–753.
125. Skrobik, Y.K., Bergeron, N., Dumont, M., et al. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med 30 (2004), 444–449.
126. Slooter, A.J.C., Neurocritical care: critical illness, delirium and cognitive impairment. Nat Rev Neurol 9 (2013), 666–667.
127. Soiza, R.L., Sharma, V., Ferguson, K., et al. Neuroimaging studies of delirium: a systematic review. J Psychosom Res 65 (2008), 239–248.
128. Stoicea, N., McVicker, S., Quinones, A., et al. Delirium-biomarkers and genetic variance. Front Pharmacol, 5, 2014, 75.
129. Tieges, Z., Stíobhairt, A., Scott, K., et al. Development of a smartphone application for the objective detection of attentional deficits in delirium. Int Psychogeriatr 27 (2015), 1251–1262.
130. Trogrlić, Z., van der Jagt, M., Bakker, J., et al. A systematic review of implementation strategies for assessment, prevention, and management of ICU delirium and their effect on clinical outcomes. Crit Care Med, 19, 2015, 157.
131. Trzepacz, P.T., Update on the neuropathogenesis of delirium. Dement Geriatr Cogn Disord 10 (1999), 330–334.
132. Tune, L.E., Anticholinergic effects of medication in elderly patients. J Clin Psychiatry 62:Suppl 2 (2001), 11–14.
133. Turunen, H., Jakob, S.M., Ruokonen, E., et al. Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation. Crit Care Med, 19, 2015, 67.
134. Van Dellen, E., van der Kooi, A.W., Numan, T., et al. Decreased functional connectivity and disturbed electroencephalography of intensive care unit patients with delirium after cardiac surgery. Anesthesiology 121 (2014), 328–335.
135. Van den Boogaard, M., Kox, M., Quinn, K.L., et al. Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients. Crit Care Med, 15, 2011, R297.
136. Van den Boogaard, M., Pickkers, P., Slooter, A.J.C., et al. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ, 344, 2012, e420.
137. Van den Boogaard, M., Schoonhoven, L., Evers, A.W.M., et al. Delirium in critically ill patients: impact on long-term health-related quality of life and cognitive functioning. Crit Care Med 40 (2012), 112–118.
138. Van den Boogaard, M., Schoonhoven, L., van der Hoeven, J.G., et al. Incidence and short-term consequences of delirium in critically ill patients: a prospective observational cohort study. Int J Nurs Stud 49 (2012), 775–783.
139. Van den Boogaard, M., Schoonhoven, L., van Achterberg, T., et al. Haloperidol prophylaxis in critically ill patients with a high risk for delirium. Crit Care Med, 17, 2013, R9.
140. Van den Boogaard, M., Slooter, A.J., Brüggemann, R.J., et al. Prevention of ICU delirium and delirium-related outcome with haloperidol: a study protocol for a multicenter randomized controlled trial. Trials, 14, 2013, 400.
141. Van den Boogaard, M., Schoonhoven, L., Maseda, E., et al. Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study. Intensive Care Med 40 (2014), 361–369.
142. Van der Kooi, A.W., Leijten, F.S., Van der Wekken, R.J., et al. Electroencephalography-based monitoring of delirium in the ICU: what are the opportunities?. Crit Care Med, 16, 2012, P338.
143. Van der Kooi, A.W., Kappen, T.H., Raijmakers, R.J., et al. Temperature variability during delirium in ICU patients: an observational study. PLoS One, 8, 2013, e78923.
144. Van der Kooi, A.W., Rots, M.L., Huiskamp, G., et al. Delirium detection based on monitoring of blinks and eye movements. Am J Geriatr Psychiatry 22 (2014), 1575–1582.
145. Van Eijk, M.M., Slooter, A.J.C., Delirium in intensive care unit patients. Semin Cardiothorac Vasc Anesth 14 (2010), 141–147.
146. Van Eijk, M.M.J., van Marum, R.J., Klijn, I.A.M., et al. Comparison of delirium assessment tools in a mixed intensive care unit. Crit Care Med 37 (2009), 1881–1885.
147. Van Eijk, M.M., Roes, K.C., Honing, M.L., et al. Effect of rivastigmine as an adjunct to usual care with haloperidol on duration of delirium and mortality in critically ill patients: a multicentre, double-blind, placebo-controlled randomised trial. Lancet 376 (2010), 1829–1837.
148. Van Eijk, M.M., van den Boogaard, M., van Marum, R.J., et al. Routine use of the confusion assessment method for the intensive care unit: a multicenter study. Am J Respir Crit Care Med 184 (2011), 340–344.
149. Van Gool, W.A., van de Beek, D., Eikelenboom, P., Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet 375 (2010), 773–775.
150. van Munster, B.C., Aronica, E., Zwinderman, A.H., et al. Neuroinflammation in delirium: a postmortem case-control study. Rejuvenation Res 14 (2011), 615–622.
151. Van Rompaey, B., Schuurmans, M.J., Shortridge-Baggett, L.M., et al. A comparison of the CAM-ICU and the NEECHAM Confusion Scale in intensive care delirium assessment: an observational study in non-intubated patients. Crit Care Med, 12, 2008, R16.
152. Van Rompaey, B., Elseviers, M.M., Schuurmans, M.J., et al. Risk factors for delirium in intensive care patients: a prospective cohort study. Crit Care Med, 13, 2009, R77.
153. Van Rompaey, B., Elseviers, M.M., Van Drom, W., et al. The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients. Crit Care Med, 16, 2012, R73.
154. Vanderbilt University, The MENDSII study, maximizing the efficacy of sedation and reducing neurological dysfunction and mortality in septic patients with acute respiratory failure. ClinicalTrials.gov, 2014 https://clinicaltrials.gov/show/NCT01739933 Accessed 4 Oct 2015.
155. Vanderbilt University, The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) study. ClinicalTrials.gov, 2014.
156. Waage, A., Halstensen, A., Shalaby, R., et al. Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response. J Exp Med 170 (1989), 1859–1867.
157. Wang, W., Li, H.-L., Wang, D.-X., et al. Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med 40 (2012), 731–739.
158. Wassenaar, A., van den Boogaard, M., van Achterberg, T., et al. Multinational development and validation of an early prediction model for delirium in ICU patients. Intensive Care Med: 2015, 1048–1056.
159. Wolters, A.E., van Dijk, D., Pasma, W., et al. Long-term outcome of delirium during intensive care unit stay in survivors of critical illness: a prospective cohort study. Crit Care Med, 18, 2014, R125.
160. Wolters, A.E., Veldhuijzen, D.S., Zaal, I.J., et al. Systemic corticosteroids and transition to delirium in critically ill patients. Crit Care Med, 1, 2015.
161. Wolters, A.E., Zaal, I.J., Veldhuijzen, D.S., et al. Anticholinergic medication use and transition to delirium in critically ill patients: a prospective cohort study. Crit Care Med 43 (2015), 1846–1852.
162. Yokota, H., Ogawa, S., Kurokawa, A., et al. Regional cerebral blood flow in delirium patients. Psychiatry Clin Neurosci 57 (2003), 337–339.
163. Young, J., Murthy, L., Westby, M., et al. Diagnosis, prevention, and management of delirium: summary of NICE guidance. BMJ, 341, 2010, c3704.
164. Zaal, I.J., Spruyt, C.F., Peelen, L.M., et al. Intensive care unit environment may affect the course of delirium. Intensive Care Med 39 (2013), 481–488.
165. Zaal, I.J., Slooter, A.J., Light levels of sedation and DSM-5 criteria for delirium. Intensive Care Med 40 (2014), 300–301.
166. Zaal, I.J., Devlin, J.W., Hazelbag, M., et al. Benzodiazepine-associated delirium in critically ill adults. Intensive Care Med 41 (2015), 2130–2137.
167. Zaal, I.J., Devlin, J.W., Peelen, L.M., et al. A systematic review of risk factors for delirium in the ICU. Crit Care Med 43 (2015), 40–47.
168. Zaal, I.J., Tekatli, H., van der Kooi, A.W., et al. Classification of daily mental status in critically ill patients for research purposes. J Crit Care 30 (2015), 375–380.
169. Zhang, Z., Pan, L., Ni, H., Impact of delirium on clinical outcome in critically ill patients: a meta-analysis. Gen Hosp Psychiatry 35 (2013), 105–111.