Corticosteroids and transition to delirium in patients with acute lung injury

Critical Care Medicine

Volumn 42, Issue 6, 2014, Pages 1480-1486

  Schreiber, Matthew P ^a   Colantuoni, Elizabeth ^b   Bienvenu, Oscar J ^b,c   Neufeld, Karin J ^b,c   Chen, Kuan Fu ^d   Shanholtz, Carl ^e   Mendez Tellez, Pedro A ^b,c   Needham, Dale M ^b,c  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Acute lung injury; delirium; intensive care; Markov chains; steroids; treatment outcome

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CORTICOSTEROID; MIDAZOLAM; MORPHINE; OPIATE; PREDNISONE;

ACUTE LUNG INJURY; ADULT; APACHE; ARTICLE; CORTICOSTEROID THERAPY; DELIRIUM; FEMALE; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SYSTEMIC THERAPY; TREATMENT OUTCOME; VENTILATED PATIENT;

ACUTE LUNG INJURY; ADRENAL CORTEX HORMONES; ADULT; AGE FACTORS; APACHE; CRITICAL ILLNESS; DELIRIUM; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MARKOV CHAINS; MIDDLE AGED; ORGAN DYSFUNCTION SCORES; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84901480340     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000247     Document Type: Article

References (64)

1. Ely EW, Shintani A, Truman B, et al: Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291:1753-1762
2. Rockwood K, Cosway S, Carver D, et al: The risk of dementia and death after delirium. Age Ageing 1999; 28:551-556
3. Milbrandt EB, Deppen S, Harrison PL, et al: Costs associated with delirium in mechanically ventilated patients. Crit Care Med 2004; 32:955-962
4. Pisani MA, Kong SY, Ka sl SV, et al: Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 2009; 180:1092-1097
5. Girard TD, Jackson JC, Pandharipan de PP, et al: Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 2010; 38:1513-1520
6. Saczynski JS, Marcantonio ER, Quach L, et al: Cognitive trajectories after postoperative delirium. N Engl J Med 2012; 367:30-39
7. Schweickert WD, Pohlman MC, Pohlman AS, et al: Early physical and occupational therapy in mechanically ven tilated, critically ill patients: A randomised controlled trial. Lancet 2009; 373:1874-1882
8. Needham DM, Korupolu R, Zanni JM, et al: Early physical medicine and rehabilitation for patients wit h acute respiratory failure: A quality improvement project. Arch Phys Med Rehabil 2010; 91:536-542
9. Inouye SK, Bogardus ST Jr, Charpentier PA, et al: A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med 1999; 340:669-676
10. Koster S, Hensens AG, Schuurmans MJ, et al: Risk factors of delirium after cardiac surgery: A systematic review. Eur J Cardiovasc Nurs 2011; 10:197-204
11. Barr J, Fraser GL, Puntillo K, et al; American College of Critical Care Medicine: Clinical practice guidelines for the management of pain, agitation, and del irium in adult patients in the intensive care unit. Crit Care Med 2013; 41:263-306
12. Riker RR, Shehabi Y, Bokesch PM, et al; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group: Dexmedetomidine vs midazolam for sedation of critically ill patients: A randomized trial. JAMA 2009; 301:489-499
13. Kamdar BB, King LM, Collop NA, et al: The effect of a quality improve ment intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med 2013; 41:800-809
14. Hager DN, Dinglas VD, Subhas S, et al: Reducing deep sedation and delirium in acute lung injury patients: A quality improvement project. Crit Care Med 2013; 41:1435-1442
15. Stoudemire A,Anfinson T,Edwards J, Corticosteroid-induced delirium and dependency, Gen Hosp Psychiatry, 1996,18,196-202
16. Kenna HA, Poon AW, de los Angeles CP, et al: Psychiatric complications of treatment with corticosteroids: Review with case report. Psychiatry Clin Neurosci 2011; 65:549-560
17. Breitbart W, Gibson C, Tremblay A: The delirium experience: Delirium recall and delirium-related distress in hospitalized patients with cancer, their spouses/caregivers, and their nurses. Psychosomatics 2002; 43:183-194
18. Lewis DA, Smith RE: Steroid-induced psychiatric syndromes. A report of 14 cases and a review of the literature. J Affect Disord 1983; 5:319-332
19. Sprung CL, Annane D, Keh D, et al; CORTICUS Study Group: Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358:111-124.
20. Meduri GU, Headley AS, Golden E, et al: Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: A randomized controlled trial. JAMA 1998; 280:159-165
21. Tang BM, Craig JC, Eslick GD, et al: Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis. Crit Care Med 2009; 37:1594-1 603
22. Steinberg KP, Hudson LD, Goodman RB, et al; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network: Efficacy and safety of corticosteroids for persistent acut e respiratory distress syndrome. N Engl J Med 2006; 354:1671-1684
23. Annane D, Bellissant E, Bollaert PE, et al: Corticosteroids for severe sepsis and septic shock: A systematic review and meta-analysis. BMJ 2004; 329:480
24. Karir V, Cooke CR, Andersson L, et al: Practice variability in the assessment and treatment of critical illness-related corticosteroid insufficiency. J Crit C are 2010; 25:363.e9-363.e14
25. Sarnes E, Crofford L, Watson M, et al: Incidence and US costs of corticosteroid-associated adverse events: A systematic literature review. Clin Ther 2011; 33:1413-1432
26. Desai SV, Law TJ, Needham DM: Long-term complications of critical care. Crit Care Med 2011; 39:371-379
27. Davydow DS, Desai SV, Needham DM, et al: Psychiatric morbidity in survivors of the acute respiratory distress syndrome: A systematic review. Psychosom Med 2008; 70:512-519
28. Salgado DR, Favory R, Goulart M, et al: Toward less sedation in the intensive care unit: A prospective observational study. J Crit Care 2011; 26:113-121
29. Needham DM, Wang W, Desai SV, et al: Intensive care unit exposures for long-term outcomes research: Development and description of exposures for 150 patients with acute lung injury. J Crit Care 2007; 22:275-284
30. Bernard GR, Artigas A, Brigham KL, et al: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149:818-824
31. Needham DM, Dennison CR, Dowdy DW, et al: Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) study. Crit Care 2006; 10:R9
32. Ely EW, Inouye SK, Bernard GR, et al: Delirium in mechanically ventilated patients: Validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001; 286:2703-2710
33. Ely EW, Truman B, Shintani A, et al: Monitoring sedation status over time in ICU patients: Reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 2003; 289:2983-2991
34. Brunton L, Lazo J, Parker K: Goodman & Gilman?s The Pharmacological Basis of Therapeutics. Eleventh Edition. New York, McGraw-Hill, 2005
35. Charlson M, Szatrowski TP, Peterson J, et al: Validation of a combined comorbidity index. J Clin Epidemiol 1994; 47:1245-1251
36. Pandharipande P, Shintani A, Peterson J, et al: Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006; 104:21-26
37. Pandharipande P, Ely EW: Sedative and analgesic medications: Risk factors for delirium and sleep disturbances in the critically ill. Crit Care Clin 2006; 22:313 -327, vii
38. Greer N, Rossom R, Anderson P, et al: Delirium: Screening, Prevention, and Diagnosis-A Systematic Review of the Evidence. Washington, DC, Department of Veterans Affairs (US), 2011
39. Noimark D: Predicting the onset of delirium in the post-operative patient. Age Ageing 2009; 38:368-373
40. Aghanwa HS, Nd ububa D: Specific psychiatric morbidity in liver cirrhosis in a Nigerian general hospital setting. Gen Hosp Psychiatry 2002; 24:436-441
41. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
42. Ferreira FL, Bota DP, Bross A, et al: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286:1754-1758
43. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensu s Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655
44. Wilson WC, Smedira NG, Fink C, et al: Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients. JAMA 1992; 267: 949-953
45. Marshall J, Finn CA, Theodore AC: Impact of a clinical pharmacist-enforced intensive care unit sedation protocol on duration of mechanical ventilation and hospital stay. Crit Care Med 2008; 36:427-433
46. Chambers JM, Cleveland WS, Kleiner B, et al: Graphical Methods for Data Analysis. Boston, MA, Duxbury Press, 1983
47. Meyan S: Markov Chains and Stochastic Stability. Second Edition. New York, Cambridge University Press, 2009
48. Hosmer D, Laemeshow S: Applied Logistic Regression. New York, Wiley, 2000
49. van den Boogaard M, Pickke rs P, Slooter AJ, et al: Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: Observational multicentre study. BMJ 2012; 344:e420
50. Fardet L, Flahault A, Kettaneh A, et al: Corticosteroid-induced clinical adverse events: Frequency, risk factors and patient?s opinion. Br J Dermatol 2007; 157:142-148
51. Fa rdet L, Petersen I, Nazareth I: Suicidal behavior and severe neuropsychiatric disorders following glucocorticoid therapy in primary care. Am J Psychiatry 2012; 169:491-497
52. Ushida T, Yokoyama T, Kishida Y, et al: Incidence and risk factors of postoperative delirium in cervical spine surgery. Spine (Phila Pa 1976) 2009; 34:2500-2504
53. Lin SM, Huang CD, Liu CY, et al: Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients. J Crit Care 2008; 23:372-379
54. Micek ST, Anand NJ, Laible BR, et al: Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients. Crit Care Med 2005; 33:1260-1265
55. Pandharipande P, Cotton BA, Shintani A, et al: Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 2008; 65:34-41
56. Lat I, McMillian W, Taylor S, et al: The impact of delirium on clinical outcomes in mechanically ventilated surgical and trauma patients. Crit Care Med 2009; 37:1898-1905
57. Pisani MA, Murphy TE, Araujo KL, et al: Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med 2009; 37:177-183
58. Schor J.D., Levkoff S.E., Lipsitz L.A., et al.: Risk factors for delirium in hospitalized elderly. JAMA 1992; 267:827-831
59. Pandharipande PP, Pun BT, Herr DL, et al: Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: The MENDS randomized controlled trial. JAMA 2007; 298:2644-2653
60. McPherson JA, Wagner CE, Boehm LM, et al: Delirium in the cardiovascular ICU: Exploring modifiable risk factors. Crit Care Med 2013; 41:405-413
61. Skrobik Y, Leger C, Cossette M, et al: Factors predis posing to coma and delirium: Fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. Crit Care Med 2013; 41:999-1008
62. Bienvenu OJ, Gellar J, Althouse BM, et al: Post-traumatic stress disorder symptoms after acute lung injury: A 2-year prospective longitudinal study. Psychol Med 2013; 43:2657-2671
63. Maldonado J, Wysong A, van der Starre P, et al: Postoperative sedation can dramatically alter the development of delirium after cardiac surgery. Psychosomatics 2005; 46:185-186
64. Pandharipande PP, Sanders RD, Girard TD, et al; MENDS investigators: Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: An a priori-designed analysis of the MENDS randomized controlled trial. Crit Care 2010; 14:R38