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Volumn 42, Issue 8, 2014, Pages 1899-1909

Statins and delirium during critical illness: A multicenter, prospective cohort study

Author keywords

cognition; critical illness; delirium; hydroxymethylglutaryl CoA reductase inhibitors; intensive care units; sepsis

Indexed keywords

ADRENALIN; ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTIDEPRESSANT AGENT; ATORVASTATIN; DEXMEDETOMIDINE; DOBUTAMINE; DOPAMINE; FENTANYL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MIDAZOLAM; MILRINONE; NEUROLEPTIC AGENT; NORADRENALIN; PHENYLEPHRINE; PRAVASTATIN; PROPOFOL; ROSUVASTATIN; VASOPRESSIN;

EID: 84904752943     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000398     Document Type: Article
Times cited : (85)

References (57)
  • 1
    • 77958108729 scopus 로고    scopus 로고
    • Critical care and the global burden of critical illness in adults
    • Adhikari NK, Fowler RA, Bhagwanjee S, et al: Critical care and the global burden of critical illness in adults. Lancet 2010; 376:1339-1346
    • (2010) Lancet , vol.376 , pp. 1339-1346
    • Adhikari, N.K.1    Fowler, R.A.2    Bhagwanjee, S.3
  • 2
    • 77954088532 scopus 로고    scopus 로고
    • Delirium as a predictor of long-term cognitive impairment in survivors of critical illness
    • Girard TD, Jackson JC, Pandharipande PP, et al: Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 2010; 38:1513-1520
    • (2010) Crit Care Med , vol.38 , pp. 1513-1520
    • Girard, T.D.1    Jackson, J.C.2    Pandharipande, P.P.3
  • 3
    • 23744460868 scopus 로고    scopus 로고
    • Intensive care unit delirium is an independent predictor of longer hospital stay: A prospective analysis of 261 non-ventilated patients
    • Thomason JW, Shintani A, Peterson J F, et al: Intensive care unit delirium is an independent predictor of longer hospital stay: A prospective analysis of 261 non-ventilated patients. Crit Care 2005; 9:R375-R381
    • (2005) Crit Care , vol.9
    • Thomason, J.W.1    Shintani, A.2    Peterson, J.F.3
  • 5
    • 1842867052 scopus 로고    scopus 로고
    • Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    • Ely EW, Shintani A, Truman B, et al: Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291:1753-1762
    • (2004) JAMA , vol.291 , pp. 1753-1762
    • Ely, E.W.1    Shintani, A.2    Truman, B.3
  • 6
    • 72749113044 scopus 로고    scopus 로고
    • Days of delirium are associated with 1-year mortality in an older intensive care unit population
    • Pisani MA, Kong SY, Kasl SV, et al: Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 2009; 180:1092-1097
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 1092-1097
    • Pisani, M.A.1    Kong, S.Y.2    Kasl, S.V.3
  • 7
    • 11144358457 scopus 로고    scopus 로고
    • Costs associated with delirium in mechanically ventilated patients
    • Milbrandt EB, Deppen S, Harrison PL, et al: Costs associated with delirium in mechanically ventilated patients. Crit Care Med 2004; 32:955-962
    • (2004) Crit Care Med , vol.32 , pp. 955-962
    • Milbrandt, E.B.1    Deppen, S.2    Harrison, P.L.3
  • 8
    • 84858836975 scopus 로고    scopus 로고
    • National Center for Health Statistics: Health, United States Hyattsville MD, National Center for Health Statistics
    • National Center for Health Statistics: Health, United States, 2010: With Special Feature on Death and Dying. Hyattsville, MD, National Center for Health Statistics, 2011
    • (2011) 2010: With Special Feature on Death and Dying
  • 9
    • 0033586472 scopus 로고    scopus 로고
    • Inhibition of proinfammatory cytokine production by pravastatin
    • Rosenson RS, Tangney CC, Casey LC: Inhibition of proinfammatory cytokine production by pravastatin. Lancet 1999; 353:983-984
    • (1999) Lancet , vol.353 , pp. 983-984
    • Rosenson, R.S.1    Tangney, C.C.2    Casey, L.C.3
  • 10
    • 0037233913 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors regulate infammatory transcription factors in human endothelial and vascular smooth muscle cells
    • Dichtl W, Dulak J, Frick M, et al: HMG-CoA reductase inhibitors regulate infammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23:58-63
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 58-63
    • Dichtl, W.1    Dulak, J.2    Frick, M.3
  • 11
    • 9344256068 scopus 로고    scopus 로고
    • Simvastatin prevents vascular hyporeactivity during infammation
    • Pleiner J, Schaller G, Mittermayer F, et al: Simvastatin prevents vascular hyporeactivity during infammation. Circulation 2004; 110:3349-3354
    • (2004) Circulation , vol.110 , pp. 3349-3354
    • Pleiner, J.1    Schaller, G.2    Mittermayer, F.3
  • 12
    • 76749152023 scopus 로고    scopus 로고
    • Benefcial microvascu-lar and anti-infammatory effects of pravastatin during sepsis involve nitric oxide synthase III
    • McGown CC, Brown NJ, Hellewell PG, et al: Benefcial microvascu-lar and anti-infammatory effects of pravastatin during sepsis involve nitric oxide synthase III. Br J Anaesth 2010; 104:183-190
    • (2010) Br J Anaesth , vol.104 , pp. 183-190
    • McGown, C.C.1    Brown, N.J.2    Hellewell, P.G.3
  • 13
    • 0033966049 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitors reduce plas-minogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
    • Bourcier T, Libby P: HMG CoA reductase inhibitors reduce plas-minogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol 2000; 20:556-562
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 556-562
    • Bourcier, T.1    Libby, P.2
  • 14
    • 20244378532 scopus 로고    scopus 로고
    • Simvastatin blunts endo-toxin-induced tissue factor in vivo
    • Steiner S, Speidl WS, Pleiner J, et al: Simvastatin blunts endo-toxin-induced tissue factor in vivo. Circulation 2005; 111: 1841-1846
    • (2005) Circulation , vol.111 , pp. 1841-1846
    • Steiner, S.1    Speidl, W.S.2    Pleiner, J.3
  • 15
    • 80052685575 scopus 로고    scopus 로고
    • Statins and brain dysfunction: A hypothesis to reduce the burden of cognitive impairment in patients who are critically ill
    • Morandi A, Hughes CG, Girard TD, et al: Statins and brain dysfunction: A hypothesis to reduce the burden of cognitive impairment in patients who are critically ill. Chest 2011; 140:580-585
    • (2011) Chest , vol.140 , pp. 580-585
    • Morandi, A.1    Hughes, C.G.2    Girard, T.D.3
  • 16
    • 49149119577 scopus 로고    scopus 로고
    • Unravelling the pathophysi-ology of delirium: A focus on the role of aberrant stress responses
    • Maclullich AM, Ferguson KJ, Miller T, et al: Unravelling the pathophysi-ology of delirium: A focus on the role of aberrant stress responses. J Psychosom Res 2008; 65:229-238
    • (2008) J Psychosom Res , vol.65 , pp. 229-238
    • Maclullich, A.M.1    Ferguson, K.J.2    Miller, T.3
  • 17
    • 38649126579 scopus 로고    scopus 로고
    • Pathophysiology of delirium in the intensive care unit
    • viii
    • Gunther ML, Morandi A, Ely EW: Pathophysiology of delirium in the intensive care unit. Crit Care Clin 2008; 24:45-65, viii
    • (2008) Crit Care Clin , vol.24 , pp. 45-65
    • Gunther, M.L.1    Morandi, A.2    Ely, E.W.3
  • 18
    • 65449179667 scopus 로고    scopus 로고
    • Simvastatin decreases lipopolysaccharide-induced pulmonary infamma-tion in healthy volunteers
    • Shyamsundar M, McKeown ST, O'Kane CM, et al: Simvastatin decreases lipopolysaccharide-induced pulmonary infamma-tion in healthy volunteers. Am J Respir Crit Care Med 2009; 179: 1107-1114
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 1107-1114
    • Shyamsundar, M.1    McKeown, S.T.2    O'Kane, C.M.3
  • 19
    • 79952240186 scopus 로고    scopus 로고
    • A randomized clinical trial of hydroxymethylglutaryl-coenzyme a reductase inhibition for acute lung injury (the HARP study)
    • Craig TR, Duffy MJ, Shyamsundar M, et al: A randomized clinical trial of hydroxymethylglutaryl-coenzyme a reductase inhibition for acute lung injury (the HARP study). Am J Respir Crit Care Med 2011; 183:620-626
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 620-626
    • Craig, T.R.1    Duffy, M.J.2    Shyamsundar, M.3
  • 20
    • 84875818387 scopus 로고    scopus 로고
    • A multicenter randomized trial of ator-vastatin therapy in intensive care patients with severe sepsis
    • ANZ-STATInS Investigators-ANZICS Clinical Trials Group
    • Kruger P, Bailey M, Bellomo R, et al; ANZ-STATInS Investigators-ANZICS Clinical Trials Group: A multicenter randomized trial of ator-vastatin therapy in intensive care patients with severe sepsis. Am J Respir Crit Care Med 2013; 187:743-750
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 743-750
    • Kruger, P.1    Bailey, M.2    Bellomo, R.3
  • 21
    • 70350572370 scopus 로고    scopus 로고
    • Rebound infammatory response during the acute phase of myocardial infarction after simvastatin withdrawal
    • Brasilia Heart Study Group
    • Sposito AC, Carvalho LS, Cintra RM, et al; Brasilia Heart Study Group: Rebound infammatory response during the acute phase of myocardial infarction after simvastatin withdrawal. Atherosclerosis 2009; 207:191-194
    • (2009) Atherosclerosis , vol.207 , pp. 191-194
    • Sposito, A.C.1    Carvalho, L.S.2    Cintra, R.M.3
  • 22
    • 0037177167 scopus 로고    scopus 로고
    • Withdrawal of statins increases event rates in patients with acute coronary syndromes
    • Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Investigators
    • Heeschen C, Hamm CW, Laufs U, et al; Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Investigators: Withdrawal of statins increases event rates in patients with acute coronary syndromes. Circulation 2002; 105:1446-1452
    • (2002) Circulation , vol.105 , pp. 1446-1452
    • Heeschen, C.1    Hamm, C.W.2    Laufs, U.3
  • 23
    • 23244432198 scopus 로고    scopus 로고
    • Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic defcits after aneurysmal subarachnoid hemorrhage: A phase II randomized placebo-controlled trial
    • Tseng MY, Czosnyka M, Richards H, et al: Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic defcits after aneurysmal subarachnoid hemorrhage: A phase II randomized placebo-controlled trial. Stroke 2005; 36: 1627-1632
    • (2005) Stroke , vol.36 , pp. 1627-1632
    • Tseng, M.Y.1    Czosnyka, M.2    Richards, H.3
  • 24
    • 34548278923 scopus 로고    scopus 로고
    • Statin treatment withdrawal in ischemic stroke: A controlled randomized study
    • Blanco M, Nombela F, Castellanos M, et al: Statin treatment withdrawal in ischemic stroke: A controlled randomized study. Neurology 2007; 69:904-910
    • (2007) Neurology , vol.69 , pp. 904-910
    • Blanco, M.1    Nombela, F.2    Castellanos, M.3
  • 25
    • 34249106454 scopus 로고    scopus 로고
    • The impact of postoperative discontinuation or continuation of chronic statin therapy on cardiac outcome after major vascular surgery
    • Le Manach Y, Godet G, Coriat P, et al: The impact of postoperative discontinuation or continuation of chronic statin therapy on cardiac outcome after major vascular surgery. Anesth Analg 2007; 104: 1326-1333
    • (2007) Anesth Analg , vol.104 , pp. 1326-1333
    • Le Manach, Y.1    Godet, G.2    Coriat, P.3
  • 26
    • 80052073777 scopus 로고    scopus 로고
    • Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases
    • Bell CM, Brener SS, Gunraj N, et al: Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases. JAMA 2011; 306:840-847
    • (2011) JAMA , vol.306 , pp. 840-847
    • Bell, C.M.1    Brener, S.S.2    Gunraj, N.3
  • 27
    • 52449134280 scopus 로고    scopus 로고
    • Delirium after elective surgery among elderly patients taking statins
    • Redelmeier DA, Thiruchelvam D, Daneman N: Delirium after elective surgery among elderly patients taking statins. CMAJ 2008; 179:645-652
    • (2008) CMAJ , vol.179 , pp. 645-652
    • Redelmeier, D.A.1    Thiruchelvam, D.2    Daneman, N.3
  • 28
    • 58749110360 scopus 로고    scopus 로고
    • Preoperative use of statins is associated with reduced early delirium rates after cardiac surgery
    • Katznelson R, Djaiani GN, Borger MA, et al: Preoperative use of statins is associated with reduced early delirium rates after cardiac surgery. Anesthesiology 2009; 110:67-73
    • (2009) Anesthesiology , vol.110 , pp. 67-73
    • Katznelson, R.1    Djaiani, G.N.2    Borger, M.A.3
  • 29
    • 84860262229 scopus 로고    scopus 로고
    • Preoperative statin therapy is not associated with a decrease in the incidence of delirium after cardiac operations
    • Mariscalco G, Cottini M, Zanobini M, et al: Preoperative statin therapy is not associated with a decrease in the incidence of delirium after cardiac operations. Ann Thorac Surg 2012; 93: 1439-1447
    • (2012) Ann Thorac Surg , vol.93 , pp. 1439-1447
    • Mariscalco, G.1    Cottini, M.2    Zanobini, M.3
  • 30
    • 0020040238 scopus 로고
    • A new clinical scale for the staging of dementia
    • Hughes CP, Berg L, Danziger WL, et al: A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140: 566-572
    • (1982) Br J Psychiatry , vol.140 , pp. 566-572
    • Hughes, C.P.1    Berg, L.2    Danziger, W.L.3
  • 31
    • 84884950975 scopus 로고    scopus 로고
    • Long-term cognitive impairment after critical illness
    • BRAIN-ICU Study Investigators
    • Pandharipande PP, Girard TD, Jackson JC, et al; BRAIN-ICU Study Investigators: Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369:1306-1316
    • (2013) N Engl J Med , vol.369 , pp. 1306-1316
    • Pandharipande, P.P.1    Girard, T.D.2    Jackson, J.C.3
  • 32
    • 0035814368 scopus 로고    scopus 로고
    • Delirium in mechanically ventilated patients: Validity and reliability of the Confusion Assessment Method for the intensive care unit (CAM-ICU)
    • Ely EW, Inouye SK, Bernard GR, et al: Delirium in mechanically ventilated patients: Validity and reliability of the Confusion Assessment Method for the intensive care unit (CAM-ICU). JAMA 2001; 286:2703-2710
    • (2001) JAMA , vol.286 , pp. 2703-2710
    • Ely, E.W.1    Inouye, S.K.2    Bernard, G.R.3
  • 33
    • 0034948268 scopus 로고    scopus 로고
    • Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)
    • Ely EW, Margolin R, Francis J, et al: Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001; 29: 1370-1379
    • (2001) Crit Care Med , vol.29 , pp. 1370-1379
    • Ely, E.W.1    Margolin, R.2    Francis, J.3
  • 34
    • 77049092290 scopus 로고    scopus 로고
    • Validity and reliability of the CAM-ICU Flowsheet to diagnose delirium in surgical ICU patients
    • Guenther U, Popp J, Koecher L, et al: Validity and reliability of the CAM-ICU Flowsheet to diagnose delirium in surgical ICU patients. J Crit Care 2010; 25:144-151
    • (2010) J Crit Care , vol.25 , pp. 144-151
    • Guenther, U.1    Popp, J.2    Koecher, L.3
  • 36
    • 0028345244 scopus 로고
    • A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Development and cross-validation
    • Jorm AF: A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Development and cross-validation. Psychol Med 1994; 24:145-153
    • (1994) Psychol Med , vol.24 , pp. 145-153
    • Jorm, A.F.1
  • 37
    • 0025799827 scopus 로고
    • Performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening test for dementia
    • Jorm AF, Scott R, Cullen JS, et al: Performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening test for dementia. Psychol Med 1991; 21:785-790
    • (1991) Psychol Med , vol.21 , pp. 785-790
    • Jorm, A.F.1    Scott, R.2    Cullen, J.S.3
  • 39
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure
    • Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996; 22:707-710
    • (1996) Intensive Care Med , vol.22 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3
  • 40
    • 0026639706 scopus 로고
    • Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
    • Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-619
    • (1992) J Clin Epidemiol , vol.45 , pp. 613-619
    • Deyo, R.A.1    Cherkin, D.C.2    Ma, C.3
  • 42
    • 0020075038 scopus 로고
    • Measurement of functional activities in older adults in the community
    • Pfeffer RI, Kurosaki TT, Harrah CH Jr, et al: Measurement of functional activities in older adults in the community. J Gerontol 1982; 37: 323-329
    • (1982) J Gerontol , vol.37 , pp. 323-329
    • Pfeffer, R.I.1    Kurosaki, T.T.2    Harrah Jr., C.H.3
  • 44
    • 0030305457 scopus 로고    scopus 로고
    • R: A language for data analysis and graphics
    • Ihaka R, Gentleman R: R: A language for data analysis and graphics. J Comput Graph Stat 1996; 5:299-314
    • (1996) J Comput Graph Stat , vol.5 , pp. 299-314
    • Ihaka, R.1    Gentleman, R.2
  • 45
    • 84896519801 scopus 로고    scopus 로고
    • Statin use and risk of delirium in the critically ill
    • Page VJ, Davis D, Zhao XB, et al: Statin use and risk of delirium in the critically ill. Am J Respir Crit Care Med 2014; 189:666-673
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 666-673
    • Page, V.J.1    Davis, D.2    Zhao, X.B.3
  • 46
    • 53149142765 scopus 로고    scopus 로고
    • Sepsis causes neuro-infammation and concomitant decrease of cerebral metabolism
    • Semmler A, Hermann S, Mormann F, et al: Sepsis causes neuro-infammation and concomitant decrease of cerebral metabolism. J Neuroinfammation 2008; 5:38
    • (2008) J Neuroinfammation , vol.5 , pp. 38
    • Semmler, A.1    Hermann, S.2    Mormann, F.3
  • 47
    • 77449084057 scopus 로고    scopus 로고
    • Systemic infection and delirium: When cytokines and acetylcholine collide
    • van Gool WA, van de Beek D, Eikelenboom P: Systemic infection and delirium: When cytokines and acetylcholine collide. Lancet 2010; 375:773-775
    • (2010) Lancet , vol.375 , pp. 773-775
    • Van Gool, W.A.1    Van De Beek, D.2    Eikelenboom, P.3
  • 48
    • 84872072002 scopus 로고    scopus 로고
    • Associations of markers of infammation and coagulation with delirium during critical illness
    • Girard TD, Ware LB, Bernard GR, et al: Associations of markers of infammation and coagulation with delirium during critical illness. Intensive Care Med 2012; 38:1965-1973
    • (2012) Intensive Care Med , vol.38 , pp. 1965-1973
    • Girard, T.D.1    Ware, L.B.2    Bernard, G.R.3
  • 49
    • 0032912159 scopus 로고    scopus 로고
    • Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex
    • Papadopoulos MC, Lamb FJ, Moss RF, et al: Faecal peritonitis causes oedema and neuronal injury in pig cerebral cortex. Clin Sci (Lond) 1999; 96:461-466
    • (1999) Clin Sci (Lond) , vol.96 , pp. 461-466
    • Papadopoulos, M.C.1    Lamb, F.J.2    Moss, R.F.3
  • 50
    • 44249122189 scopus 로고    scopus 로고
    • Cerebral perfusion in sepsis-associated delirium
    • Pfster D, Siegemund M, Dell-Kuster S, et al: Cerebral perfusion in sepsis-associated delirium. Crit Care 2008; 12:R63
    • (2008) Crit Care , vol.12
    • Pfster, D.1    Siegemund, M.2    Dell-Kuster, S.3
  • 51
    • 25144435958 scopus 로고    scopus 로고
    • Systemic infammation induces apoptosis with variable vulnerability of different brain regions
    • Semmler A, Okulla T, Sastre M, et al: Systemic infammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neuroanat 2005; 30:144-157
    • (2005) J Chem Neuroanat , vol.30 , pp. 144-157
    • Semmler, A.1    Okulla, T.2    Sastre, M.3
  • 52
    • 0346749450 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl coen-zyme A reductase inhibitors protect cortical neurons from excitotoxic-ity
    • Zacco A, Togo J, Spence K, et al: 3-hydroxy-3-methylglutaryl coen-zyme A reductase inhibitors protect cortical neurons from excitotoxic-ity. J Neurosci 2003; 23:11104-11111
    • (2003) J Neurosci , vol.23 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3
  • 53
    • 41149132355 scopus 로고    scopus 로고
    • Simvastatin reduces the association of NMDA receptors to lipid rafts: A cholesterol-mediated effect in neuroprotection
    • Ponce J, de la Ossa N P, Hurtado O, et al: Simvastatin reduces the association of NMDA receptors to lipid rafts: A cholesterol-mediated effect in neuroprotection. Stroke 2008; 39: 1269-1275
    • (2008) Stroke , vol.39 , pp. 1269-1275
    • Ponce, J.1    De La Ossa, N.P.2    Hurtado, O.3
  • 54
    • 84874648949 scopus 로고    scopus 로고
    • Association between endo-thelial dysfunction and acute brain dysfunction during critical illness
    • Hughes CG, Morandi A, Girard TD, et al: Association between endo-thelial dysfunction and acute brain dysfunction during critical illness. Anesthesiology 2013; 118:631-639
    • (2013) Anesthesiology , vol.118 , pp. 631-639
    • Hughes, C.G.1    Morandi, A.2    Girard, T.D.3
  • 55
    • 0032513736 scopus 로고    scopus 로고
    • Persistence of use of lipid-lowering medications: A cross-national study
    • Avorn J, Monette J, Lacour A, et al: Persistence of use of lipid-lowering medications: A cross-national study. JAMA 1998; 279: 1458-1462
    • (1998) JAMA , vol.279 , pp. 1458-1462
    • Avorn, J.1    Monette, J.2    Lacour, A.3
  • 56
    • 20444468851 scopus 로고    scopus 로고
    • Adherence to statins, beta-blockers and angiotensin-converting enzyme inhibitors following a frst cardiovascular event: A retrospective cohort study
    • Blackburn DF, Dobson RT, Blackburn JL, et al: Adherence to statins, beta-blockers and angiotensin-converting enzyme inhibitors following a frst cardiovascular event: A retrospective cohort study. Can J Cardiol 2005; 21:485-488
    • (2005) Can J Cardiol , vol.21 , pp. 485-488
    • Blackburn, D.F.1    Dobson, R.T.2    Blackburn, J.L.3
  • 57
    • 0031765551 scopus 로고    scopus 로고
    • Factors affecting patient compliance with antihyperlipidemic medications in an HMO population
    • Sung JC, Nichol MB, Venturini F, et al: Factors affecting patient compliance with antihyperlipidemic medications in an HMO population. Am J Manag Care 1998; 4:1421-1430
    • (1998) Am J Manag Care , vol.4 , pp. 1421-1430
    • Sung, J.C.1    Nichol, M.B.2    Venturini, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.