Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk

Cell

Volumn 169, Issue 1, 2017, Pages 72-84.e13

  Galarza Muñoz, Gaddiel ^a,b,c   Briggs, Farren B S ^d   Evsyukova, Irina ^b   Schott Lerner, Geraldine ^c   Kennedy, Edward M ^a   Nyanhete, Tinashe ^e   Wang, Liuyang ^a   Bergamaschi, Laura ^e   Widen, Steven G ^c   Tomaras, Georgia D ^a,e   Ko, Dennis C ^a   Bradrick, Shelton S ^a,b,c   Barcellos, Lisa F ^f   Gregory, Simon G ^a,e   Garcia Blanco, Mariano A ^a,b,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

alternative splicing; autoimmune disorders; DDX39B; epistasis; genetic association; IL7R; multiple sclerosis

Indexed keywords

DDX39B PROTEIN; HLA A ANTIGEN; HLA B ANTIGEN; HLA DRB1 ANTIGEN; INTERLEUKIN 7 RECEPTOR; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 4; RNA HELICASE; UNCLASSIFIED DRUG; DDX39B PROTEIN, HUMAN; DEAD BOX PROTEIN; IL7R PROTEIN, HUMAN; INTERLEUKIN 7 RECEPTOR ALPHA; SMALL INTERFERING RNA;

5' UNTRANSLATED REGION; ALLELE; ALTERNATIVE RNA SPLICING; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EPISTASIS; EXON; EXON SKIPPING; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENE LOCUS; GENE SILENCING; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; RNA TRANSLATION; SINGLE NUCLEOTIDE POLYMORPHISM; GENETICS; HELA CELL LINE; IMMUNOLOGY; METABOLISM; PROTEIN SYNTHESIS; RNA SPLICING; T LYMPHOCYTE;

DEAD-BOX RNA HELICASES; EPISTASIS, GENETIC; EXONS; HELA CELLS; HUMANS; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; MULTIPLE SCLEROSIS; PROTEIN BIOSYNTHESIS; RNA SPLICING; RNA, SMALL INTERFERING; T-LYMPHOCYTES;

EID: 85016065319     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.03.007     Document Type: Article

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