Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

Nature Genetics

Volumn 44, Issue 3, 2012, Pages 291-296

  Raychaudhuri, Soumya ^a,c   Sandor, Cynthia ^a,c   Stahl, Eli A ^a,c   Freudenberg, Jan ^d   Lee, Hye Soon ^e   Jia, Xiaoming ^a,c   Alfredsson, Lars ^f   Padyukov, Leonid ^g   Klareskog, Lars ^g   Worthington, Jane ^h   Siminovitch, Katherine A ⁱ   Bae, Sang Cheol ^b,e   Plenge, Robert M ^a,c   Gregersen, Peter K ^d   De Bakker, Paul I W ^a,c,j  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b LABORATORY FOR MOLECULAR MEDICINE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e Hanyang University Hospital for Rheumatic Diseases   (South Korea)

^f KAROLINSKA INSTITUTE   (Sweden)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ UNIVERSITY HEALTH NETWORK   (Canada)

^j UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

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Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DPB1 ANTIGEN; HLA DQA1 ANTIGEN; HLA DRB1 ANTIGEN;

ALLELE; ARTICLE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HAPLOTYPE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HLA-B ANTIGENS; HLA-DP BETA-CHAINS; HLA-DRB1 CHAINS; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, MOLECULAR; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84862776511     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.1076     Document Type: Article

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