Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193);DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions

Nature

Volumn 528, Issue 7583, 2015, Pages 517-522

  Huang, Wendy ^a   Thomas, Benjamin ^b   Flynn, Ryan A ^c   Gavzy, Samuel J ^a   Wu, Lin ^a   Kim, Sangwon V ^a   Hall, Jason A ^a   Miraldi, Emily R ^a,d,e,f   Ng, Charles P ^a   Rigo, Frank W ^g   Meadows, Sarah ^h   Montoya, Nina R ^a   Herrera, Natalia G ^a   Domingos, Ana I ⁱ   Rastinejad, Fraydoon ^j   Myers, Richard M ^h   Fuller Pace, Frances V ^k   Bonneau, Richard ^d,e,f   Chang, Howard Y ^c   Acuto, Oreste ^b   Littman, Dan R ^a   more..

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c STANFORD UNIVERSITY   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e NEW YORK UNIVERSITY   (United States)

^f Simons Center for Data Analysis   (United States)

^g ISIS PHARMACEUTICALS   (United States)

^h HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

ⁱ INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^j BURNHAM INSTITUTE   (United States)

^k UNIVERSITY OF DUNDEE   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANTISENSE OLIGONUCLEOTIDE; CELL NUCLEUS RECEPTOR; DEAD BOX PROTEIN 5; ESTROGEN RECEPTOR; GAMMA INTERFERON; HISTONE H3; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 17; INTERLEUKIN 17F; LONG UNTRANSLATED RNA; RNA HELICASE; STAT3 PROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; CHROMATIN; DDX5 PROTEIN, MOUSE; DEAD BOX PROTEIN; PROTEIN BINDING; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

CELLS AND CELL COMPONENTS; CHROMATE; CHRONIC WASTING DISEASE; DIFFERENTIATION; GENE EXPRESSION; GENETIC ANALYSIS; LIGAND; MUTATION; PROTEIN; RNA;

ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; COMPLEX FORMATION; CONTROLLED CLINICAL TRIAL (TOPIC); EFFECTOR CELL; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; IMMUNOMODULATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM; TH17 CELL; THYMOCYTE; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CHROMATIN; CONGENITAL MALFORMATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HAIR; HIRSCHSPRUNG DISEASE; IMMUNE DEFICIENCY; IMMUNOLOGY; INFLAMMATION; MALE; METABOLISM; MOUSE; MUTATION; OSTEOCHONDRODYSPLASIAS; PATHOLOGY;

MUS;

ANIMALS; CHROMATIN; DEAD-BOX RNA HELICASES; FEMALE; GENE EXPRESSION REGULATION; HAIR; HIRSCHSPRUNG DISEASE; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MUTATION; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; ORGAN SPECIFICITY; OSTEOCHONDRODYSPLASIAS; PROTEIN BINDING; RNA, LONG NONCODING; TH17 CELLS; TRANSCRIPTION, GENETIC;

EID: 84951288125     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/s41586-018-0311-z     Document Type: Erratum

References (60)

1. Weaver, C. T., Hatton, R. D., Mangan, P. R. & Harrington, L. E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821-852 (2007).
2. + T helper cells. Cell 126, 1121-1133 (2006).
3. Leppkes, M. et al. RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136, 257-267 (2009).
4. Genovese, M. C. et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 62, 929-939 (2010).
5. H17 cell differentiation by antagonizing RORγt activity. Nature 472, 486-490 (2011).
6. Kondo, Y. et al. Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice. Arthritis Res. Ther. 17, 105 (2015).
7. Gaffen, S. L., Jain, R., Garg, A. V. & Cua, D. J. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nature Rev. Immunol. 14, 585-600 (2014).
8. Ciofani, M. et al. A validated regulatory network for Th17 cell specification. Cell 151, 289-303 (2012).
9. O'Malley, B. W. & Kumar, R. Nuclear receptor coregulators in cancer biology. Cancer Res. 69, 8217-8222 (2009).
10. Huang, Y. & Liu, Z. R. The ATPase, RNA unwinding, and RNA binding activities of recombinant p68 RNA helicase. J. Biol. Chem. 277, 12810-12815 (2002).
11. Fuller-Pace, F. V. & Moore, H. C. RNA helicases p68 and p72: multifunctional proteins with important implications for cancer development. Future Oncol. 7, 239-251 (2011).
12. Clark, E. L. et al. The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Res. 68, 7938-7946 (2008).
13. Linder, P. & Jankowsky, E. From unwinding to clamping - the DEAD box RNA helicase family. Nature Rev. Mol. Cell Biol. 12, 505-516 (2011).
14. Arun, G., Akhade, V. S., Donakonda, S. & Rao, M. R. mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Mol. Cell. Biol. 32, 3140-3152 (2012).
15. Caretti, G. et al. The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. Dev. Cell 11, 547-560 (2006).
16. Lin, C., Yang, L., Yang, J. J., Huang, Y. & Liu, Z. R. ATPase/helicase activities of p68 RNA helicase are required for pre-mRNA splicing but not for assembly of the spliceosome. Mol. Cell. Biol. 25, 7484-7493 (2005).
17. Jalal, C., Uhlmann-Schiffler, H. & Stahl, H. Redundant role of DEAD box proteins p68 (Ddx5) and p72/p82 (Ddx17) in ribosome biogenesis and cell proliferation. Nucleic Acids Res. 35, 3590-3601 (2007).
18. Rosenbluh, J. et al. RMRP is a non-coding RNA essential for early murine development. PLoS ONE 6, e26270 (2011).
19. Hsieh, C. L. et al. The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human chromosome 9p and on mouse chromosome 4. Genomics 6, 540-544 (1990).
20. Esakova, O. & Krasilnikov, A. S. Of proteins and RNA: the RNase P/MRP family. RNA 16, 1725-1747 (2010).
21. Mäkitie, O., Kaitila, I. & Savilahti, E. Susceptibility to infections and in vitro immune functions in cartilage-hair hypoplasia. Eur. J. Pediatr. 157, 816-820 (1998).
22. Bonafé, L. et al. Evolutionary comparison provides evidence for pathogenicity of RMRP mutations. PLoS Genet. 1, e47 (2005).
23. Bacchetta, J. et al. Autoimmune hypoparathyroidism in a 12-year-old girl with McKusick cartilage hair hypoplasia. Pediatr. Nephrol. 24, 2449-2453 (2009).
24. Jensen, E. D. et al. p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation. J. Cell. Biochem. 103, 1438-1451 (2008).
25. Dardenne, E. et al. RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep. 7, 1900-1913 (2014).
26. Wortham, N. C. et al. The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer. Oncogene 28, 4053-4064 (2009).
27. Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
28. + T cells. Immunity 1, 553-562 (1994).
29. Hirota, K. et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nature Immunol. 12, 255-263 (2011).
30. Wang, Y. et al. The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. Immunity 40, 355-366 (2014).
31. Sun, Z. et al. Requirement for RORγ in thymocyte survival and lymphoid organ development. Science 288, 2369-2373 (2000).
32. Chu, C., Quinn, J. & Chang, H. Y. Chromatin isolation by RNA purification (ChIRP). J. Vis. Exp. (2012).
33. Bonasio, R. & Shiekhattar, R. Regulation of transcription by long noncoding RNAs. Annu. Rev. Genet. 48, 433-455 (2014).
34. Gomez, J. A. et al. The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell 152, 743-754 (2013).
35. Carpenter, S. et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science 341, 789-792 (2013).
36. Maenner, S., Muller, M., Frohlich, J., Langer, D. & Becker, P. B. ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins. Mol. Cell 51, 174-184 (2013).
37. Ilik, I. A. et al. Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila. Mol. Cell 51, 156-173 (2013).
38. Calo, E. et al. RNA helicase DDX21 coordinates transcription and ribosomal RNA processing. Nature 518, 249-253 (2015).
39. Yang, J., Sundrud, M. S., Skepner, J. & Yamagata, T. Targeting Th17 cells in autoimmune diseases. Trends Pharmacol. Sci. 35, 493-500 (2014).
40. Lee, Y. J., Holzapfel, K. L., Zhu, J., Jameson, S. C. & Hogquist, K. A. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nature Immunol. 14, 1146-1154 (2013).
41. Takatori, H. et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206, 35-41 (2009).
42. + cell populations in gut and skin. Nature Immunol. 10, 75-82 (2009).
43. Chien, Y. H., Zeng, X. & Prinz, I. The natural and the inducible: interleukin (IL)-17-producing γδ T cells. Trends Immunol. 34, 151-154 (2013).
44. Kang, H. S. et al. Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism. Physiol. Genomics 31, 281-294 (2007).
45. H17 cells towards commensal bacterial antigens. Nature 510, 152-156 (2014).
46. Sano, T. et al. An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. Cell (2015).
47. Stanley, S. et al. Profiling of glucose-sensing neurons reveals that GHRH neurons are activated by hypoglycemia. Cell Metab. 18, 596-607 (2013).
48. Nicol, S. M. et al. The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage. Oncogene 32, 3461-3469 (2013).
49. Croswell, A., Amir, E., Teggatz, P., Barman, M. & Salzman, N. H. Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection. Infect. Immun. 77, 2741-2753 (2009).
50. Ostanin, D. V. et al. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G135-G146 (2009).
51. Kim, S. V. et al. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science 340, 1456-1459 (2013).
52. H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORgammat. Nature Immunol. 9, 641-649 (2008).
53. Meng, L. et al. Towards a therapy for Angelman syndrome by targeting a long non-coding RNA. Nature 518, 409-412 (2015).
54. Bates, G. J. et al. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. EMBO J. 24, 543-553 (2005).
55. Morita, S., Kojima, T. & Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066 (2000).
56. Santori, F. R. et al. Identification of natural RORγ ligands that regulate the development of lymphoid cells. Cell Metab. 21, 286-297 (2015).
57. Huh, J. R. et al. Identification of potent and selective diphenylpropanamide RORgamma Inhibitors. ACS Med. Chem. Lett. 4, 79-84, (2013).
58. Chu, C., Qu, K., Zhong, F. L., Artandi, S. E. & Chang, H. Y. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol. Cell 44, 667-678 (2011).
59. Flynn, R. A. et al. Dissecting noncoding and pathogen RNA-protein interactomes. RNA 21, 135-143 (2015).
60. Buenrostro, J. D., Wu, B., Chang, H. Y. & Greenleaf, W. J. ATAC-seq: a method for assaying chromatin accessibility genome-wide. Curr. Protoc. Mol. Biol. 109, 21.29.1-21.29.9. (2015).