Concentration and activity of the soluble form of the interleukin-7 receptor a in type 1 diabetes identifies an interplay between hyperglycemia and immune function

Diabetes

Volumn 62, Issue 7, 2013, Pages 2500-2508

  Monti, Paolo ^a   Brigatti, Cristina ^a   Krasmann, Miriam ^b   Ziegler, Anette G ^b   Bonifacio, Ezio ^c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUCOSE; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; SOLUBLE INTERLEUKIN 7 RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL EXPANSION; CHILD; CYTOKINE RELEASE; FEMALE; GENE; GENOTYPE; GLYCATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNOREGULATION; INSULIN DEPENDENT DIABETES MELLITUS; INTERLEUKIN 7 RECEPTOR ALPHA GENE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; UPREGULATION; ADOLESCENT; GENETICS; IMMUNITY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PRESCHOOL CHILD; SIGNAL TRANSDUCTION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; GENOTYPE; HUMANS; HYPERGLYCEMIA; IMMUNITY; INTERLEUKIN-7; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION;

EID: 84881483958     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1726     Document Type: Article

References (29)

1. Monti P, Scirpoli M, Maffi P, et al. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest 2008;118:1806-1814
2. Hartgring SA, van Roon JA, Wenting-van Wijk M, et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum 2009;60:2595- 2605
3. Lundmark F, Duvefelt K, Iacobaeus E, et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007;39:1108-1113
4. Laakso SM, Kekäläinen E, Rossi LH, et al. IL-7 dysregulation and loss of CD8+ T cell homeostasis in the monogenic human disease autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. J Immunol 2011; 187:2023-2030
5. Calzascia T, Pellegrini M, Lin A, et al. CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci USA 2008;105: 2999-3004
6. Penaranda C, Kuswanto W, Hofmann J, et al. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci USA 2012;109:12668-12673
7. Lee LF, Logronio K, Tu GH, et al. Anti-IL-7 receptor-a reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci USA 2012;109:12674-12679
8. Goodwin RG, Friend D, Ziegler SF, et al. Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 1990;60:941-951
9. Teutsch SM, Booth DR, Bennetts BH, Heard RNS, Stewart GJ. Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. Eur J Hum Genet 2003;11:509-515
10. McKay FC, Swain LI, Schibeci SD, et al. Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun 2008;9:1-6
11. Selinsky CL, Howell MD. Soluble tumor necrosis factor receptor type 1 enhances tumor development and persistence in vivo. Cell Immunol 2000; 200:81-87
12. Rose-John S, Scheller J, Elson G, Jones SA. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol 2006;80:227-236
13. Stoklasek TA, Schluns KS, Lefrancois L. Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol 2006;177:6072- 6080
14. Thümer L, Adler K, Bonifacio E, et al. German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results. Rev Diabet Stud 2010;7:202-208
15. Ziegler A-G, Meier-Stiegen F, Winkler C, Bonifacio E; TEENDIAB Study Group. Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty-TEENDIAB: study design. Pediatr Diabetes 2012;13:419-424
16. Monti P, Scirpoli M, Rigamonti A, Mayr A, Jaeger A, Bonfanti R, et al Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol 2007;179:5785-5792
17. Kumar PA, Kumar MS, Reddy GB. Effect of glycation on alpha-crystallin structure and chaperone-like function. Biochem J 2007;408:251-258
18. Monti P, Brigatti C, Heninger AK, Scirpoli M, Bonifacio E. Disengaging the IL-2 receptor with daclizumab enhances IL-7-mediated proliferation of CD4(+) and CD8(+) T cells. Am J Transplant 2009;9:2727-2735
19. McElroy CA, Dohm JA, Walsh ST. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure 2009;17:54-65
20. Schmidt AM, Yan SD, Yan SF, Stern DM. The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. 2001;108:949-955
21. Todd JA, Walker NM, Cooper JD, et al.; Genetics of Type 1 Diabetes in Finland; Wellcome Trust Case Control Consortium. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007;39:857-864
22. Hoe E, McKay FC, Schibeci SD, et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol 2010;184:2512-2517
23. Mazzucchelli R, Durum SK. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 2007;7:144-154
24. Rose T, Lambotte O, Pallier C, Delfraissy J-F, Colle J-H. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol 2009;182:7389-7397
25. Noguchi M, Nakamura Y, Russell SM, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 1993; 262:1877-1880
26. Wong HL, Pfeiffer RM, Fears TR, Vermeulen R, Ji S, Rabkin CS. Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons. Cancer Epidemiol Biomarkers Prev 2008;17:3450-3456
27. Esposito K, Nappo F, Marfella R, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002;106:2067-2072
28. Ramasamy R, Yan SF, Schmidt AM. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann NY Acad Sci 2011;1243:88-102
29. Hunter SJ, Boyd AC, O'Harte FPM, et al. Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycemic-hyperinsulinemic clamp technique in humans. Diabetes 2003; 52:492-498