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Volumn 18, Issue 11, 2016, Pages 674-688

Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; ELAV LIKE PROTEIN 1; FLUOROURACIL; LAPATINIB; MESSENGER RNA; MICRORNA; TAMOXIFEN; ANTINEOPLASTIC AGENT; PROTEIN BINDING;

EID: 85016022999     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2016.09.002     Document Type: Review
Times cited : (46)

References (123)
  • 1
    • 0029873536 scopus 로고    scopus 로고
    • Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
    • [1] Ma, W.J., Cheng, S., Campbell, C., Wright, A., Furneaux, H., Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem 271 (1996), 8144–8151.
    • (1996) J Biol Chem , vol.271 , pp. 8144-8151
    • Ma, W.J.1    Cheng, S.2    Campbell, C.3    Wright, A.4    Furneaux, H.5
  • 2
    • 0028129989 scopus 로고
    • Conserved structures and diversity of functions of RNA-binding proteins
    • [2] Burd, C.G., Dreyfuss, G., Conserved structures and diversity of functions of RNA-binding proteins. Science 265 (1994), 615–621.
    • (1994) Science , vol.265 , pp. 615-621
    • Burd, C.G.1    Dreyfuss, G.2
  • 3
    • 0027314350 scopus 로고
    • Hel-N1: an autoimmune RNA-binding protein with specificity for 3’ uridylate-rich untranslated regions of growth factor mRNAs
    • [3] Levine, T.D., Gao, F., King, P.H., Andrews, L.G., Keene, J.D., Hel-N1: an autoimmune RNA-binding protein with specificity for 3’ uridylate-rich untranslated regions of growth factor mRNAs. Mol Cell Biol 13 (1993), 3494–3504.
    • (1993) Mol Cell Biol , vol.13 , pp. 3494-3504
    • Levine, T.D.1    Gao, F.2    King, P.H.3    Andrews, L.G.4    Keene, J.D.5
  • 6
    • 0030933006 scopus 로고    scopus 로고
    • Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay
    • [6] Myer, V.E., Fan, X.C., Steitz, J.A., Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J 16 (1997), 2130–2139.
    • (1997) EMBO J , vol.16 , pp. 2130-2139
    • Myer, V.E.1    Fan, X.C.2    Steitz, J.A.3
  • 7
    • 0032526427 scopus 로고    scopus 로고
    • Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
    • [7] Fan, X.C., Steitz, J.A., Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J 17 (1998), 3448–3460.
    • (1998) EMBO J , vol.17 , pp. 3448-3460
    • Fan, X.C.1    Steitz, J.A.2
  • 8
    • 0032526417 scopus 로고    scopus 로고
    • RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
    • [8] Peng, S.S., Chen, C.Y., Xu, N., Shyu, A.B., RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 17 (1998), 3461–3470.
    • (1998) EMBO J , vol.17 , pp. 3461-3470
    • Peng, S.S.1    Chen, C.Y.2    Xu, N.3    Shyu, A.B.4
  • 9
    • 0036894711 scopus 로고    scopus 로고
    • ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR
    • [9] Kullmann, M., Gopfert, U., Siewe, B., Hengst, L., ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev 16 (2002), 3087–3099.
    • (2002) Genes Dev , vol.16 , pp. 3087-3099
    • Kullmann, M.1    Gopfert, U.2    Siewe, B.3    Hengst, L.4
  • 11
    • 33847076533 scopus 로고    scopus 로고
    • Hu proteins regulate polyadenylation by blocking sites containing U-rich sequences
    • [11] Zhu, H., Zhou, H.L., Hasman, R.A., Lou, H., Hu proteins regulate polyadenylation by blocking sites containing U-rich sequences. J Biol Chem 282 (2007), 2203–2210.
    • (2007) J Biol Chem , vol.282 , pp. 2203-2210
    • Zhu, H.1    Zhou, H.L.2    Hasman, R.A.3    Lou, H.4
  • 12
    • 49649128843 scopus 로고    scopus 로고
    • Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
    • [12] Izquierdo, J.M., Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition. J Biol Chem 283 (2008), 19077–19084.
    • (2008) J Biol Chem , vol.283 , pp. 19077-19084
    • Izquierdo, J.M.1
  • 15
    • 0032431026 scopus 로고    scopus 로고
    • HNS, a nuclear-cytoplasmic shuttling sequence in HuR
    • [15] Fan, X.C., Steitz, J.A., HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc Natl Acad Sci U S A 95 (1998), 15293–15298.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15293-15298
    • Fan, X.C.1    Steitz, J.A.2
  • 16
    • 0033524475 scopus 로고    scopus 로고
    • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets
    • [16] Keene, J.D., Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. Proc Natl Acad Sci U S A 96 (1999), 5–7.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5-7
    • Keene, J.D.1
  • 17
    • 0348150716 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase
    • [17] Li, H., Park, S., Kilburn, B., Jelinek, M.A., Henschen-Edman, A., Aswad, D.W., Stallcup, M.R., Laird-Offringa, I.A., Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem 277 (2002), 44623–44630.
    • (2002) J Biol Chem , vol.277 , pp. 44623-44630
    • Li, H.1    Park, S.2    Kilburn, B.3    Jelinek, M.A.4    Henschen-Edman, A.5    Aswad, D.W.6    Stallcup, M.R.7    Laird-Offringa, I.A.8
  • 18
    • 58149511991 scopus 로고    scopus 로고
    • miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
    • [18] Abdelmohsen, K., Srikantan, S., Kuwano, Y., Gorospe, M., miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci U S A 105 (2008), 20297–20302.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20297-20302
    • Abdelmohsen, K.1    Srikantan, S.2    Kuwano, Y.3    Gorospe, M.4
  • 19
    • 84555203329 scopus 로고    scopus 로고
    • Nitric oxide-sensitive guanylyl cyclase is differentially regulated by nuclear and non-nuclear estrogen pathways in anterior pituitary gland
    • [19] Cabilla, J.P., Nudler, S.I., Ronchetti, S.A., Quinteros, F.A., Lasaga, M., Duvilanski, B.H., Nitric oxide-sensitive guanylyl cyclase is differentially regulated by nuclear and non-nuclear estrogen pathways in anterior pituitary gland. PLoS One, 6, 2011, e29402.
    • (2011) PLoS One , vol.6
    • Cabilla, J.P.1    Nudler, S.I.2    Ronchetti, S.A.3    Quinteros, F.A.4    Lasaga, M.5    Duvilanski, B.H.6
  • 20
    • 0038788884 scopus 로고    scopus 로고
    • Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR
    • [20] Akool, E.-S., Kleinert, H., Hamada, F.M., Abdelwahab, M.H., Forstermann, U., Pfeilschifter, J., Eberhardt, W., Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR. Mol Cell Biol 23 (2003), 4901–4916.
    • (2003) Mol Cell Biol , vol.23 , pp. 4901-4916
    • Akool, E.-S.1    Kleinert, H.2    Hamada, F.M.3    Abdelwahab, M.H.4    Forstermann, U.5    Pfeilschifter, J.6    Eberhardt, W.7
  • 23
    • 84855465218 scopus 로고    scopus 로고
    • Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis
    • [23] Yiakouvaki, A., Dimitriou, M., Karakasiliotis, I., Eftychi, C., Theocharis, S., Kontoyiannis, D.L., Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest 122 (2012), 48–61.
    • (2012) J Clin Invest , vol.122 , pp. 48-61
    • Yiakouvaki, A.1    Dimitriou, M.2    Karakasiliotis, I.3    Eftychi, C.4    Theocharis, S.5    Kontoyiannis, D.L.6
  • 24
    • 77951030151 scopus 로고    scopus 로고
    • HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells
    • [24] Rhee, W.J., Ni, C.W., Zheng, Z., Chang, K., Jo, H., Bao, G., HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A 107 (2010), 6858–6863.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6858-6863
    • Rhee, W.J.1    Ni, C.W.2    Zheng, Z.3    Chang, K.4    Jo, H.5    Bao, G.6
  • 25
    • 84859055291 scopus 로고    scopus 로고
    • Macrophage beta2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis
    • [25] Zhang, J., Modi, Y., Yarovinsky, T., Yu, J., Collinge, M., Kyriakides, T., Zhu, Y., Sessa, W.C., Pardi, R., Bender, J.R., Macrophage beta2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Am J Pathol 180 (2012), 1751–1760.
    • (2012) Am J Pathol , vol.180 , pp. 1751-1760
    • Zhang, J.1    Modi, Y.2    Yarovinsky, T.3    Yu, J.4    Collinge, M.5    Kyriakides, T.6    Zhu, Y.7    Sessa, W.C.8    Pardi, R.9    Bender, J.R.10
  • 26
    • 27744520451 scopus 로고    scopus 로고
    • HuR: post-transcriptional paths to malignancy
    • [26] Lopez de Silanes, I., Lal, A., Gorospe, M., HuR: post-transcriptional paths to malignancy. RNA Biol 2 (2005), 11–13.
    • (2005) RNA Biol , vol.2 , pp. 11-13
    • Lopez de Silanes, I.1    Lal, A.2    Gorospe, M.3
  • 27
    • 65449184997 scopus 로고    scopus 로고
    • The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis
    • [27] Wang, J., Zhao, W., Guo, Y., Zhang, B., Xie, Q., Xiang, D., Gao, J., Wang, B., Chen, Z., The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis. Oncology 76 (2009), 420–429.
    • (2009) Oncology , vol.76 , pp. 420-429
    • Wang, J.1    Zhao, W.2    Guo, Y.3    Zhang, B.4    Xie, Q.5    Xiang, D.6    Gao, J.7    Wang, B.8    Chen, Z.9
  • 30
    • 34547651351 scopus 로고    scopus 로고
    • Posttranscriptional orchestration of an anti-apoptotic program by HuR
    • [30] Abdelmohsen, K., Lal, A., Kim, H.H., Gorospe, M., Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle 6 (2007), 1288–1292.
    • (2007) Cell Cycle , vol.6 , pp. 1288-1292
    • Abdelmohsen, K.1    Lal, A.2    Kim, H.H.3    Gorospe, M.4
  • 32
    • 0043092174 scopus 로고    scopus 로고
    • The RNA-binding protein HuR regulates the expression of cyclooxygenase-2
    • [32] Sengupta, S., Jang, B.C., Wu, M.T., Paik, J.H., Furneaux, H., Hla, T., The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem 278 (2003), 25227–25233.
    • (2003) J Biol Chem , vol.278 , pp. 25227-25233
    • Sengupta, S.1    Jang, B.C.2    Wu, M.T.3    Paik, J.H.4    Furneaux, H.5    Hla, T.6
  • 33
    • 0034657686 scopus 로고    scopus 로고
    • HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
    • [33] Wang, W., Caldwell, M.C., Lin, S., Furneaux, H., Gorospe, M., HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 19 (2000), 2340–2350.
    • (2000) EMBO J , vol.19 , pp. 2340-2350
    • Wang, W.1    Caldwell, M.C.2    Lin, S.3    Furneaux, H.4    Gorospe, M.5
  • 34
    • 84905528326 scopus 로고    scopus 로고
    • Clinical significance of HuR expression in human malignancy
    • [34] Kotta-Loizou, I., Giaginis, C., Theocharis, S., Clinical significance of HuR expression in human malignancy. Med Oncol, 31, 2014, 161.
    • (2014) Med Oncol , vol.31 , pp. 161
    • Kotta-Loizou, I.1    Giaginis, C.2    Theocharis, S.3
  • 35
    • 84945487572 scopus 로고    scopus 로고
    • The origin of breast tumor heterogeneity
    • [35] Skibinski, A., Kuperwasser, C., The origin of breast tumor heterogeneity. Oncogene, 2015.
    • (2015) Oncogene
    • Skibinski, A.1    Kuperwasser, C.2
  • 36
    • 84884318201 scopus 로고    scopus 로고
    • Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis
    • [36] Wang, L., Gallo, K.A., Conrad, S.E., Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Oncotarget 4 (2013), 1158–1171.
    • (2013) Oncotarget , vol.4 , pp. 1158-1171
    • Wang, L.1    Gallo, K.A.2    Conrad, S.E.3
  • 37
    • 58149172080 scopus 로고    scopus 로고
    • Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    • [37] Hostetter, C., Licata, L.A., Witkiewicz, A., Costantino, C.L., Yeo, C.J., Brody, J.R., Keen, J.C., Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells. Cancer Biol Ther 7 (2008), 1496–1506.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1496-1506
    • Hostetter, C.1    Licata, L.A.2    Witkiewicz, A.3    Costantino, C.L.4    Yeo, C.J.5    Brody, J.R.6    Keen, J.C.7
  • 38
    • 51649126046 scopus 로고    scopus 로고
    • Destabilization of ERBB2 transcripts by targeting 3’ untranslated region messenger RNA associated HuR and histone deacetylase-6
    • [38] Scott, G.K., Marx, C., Berger, C.E., Saunders, L.R., Verdin, E., Schafer, S., Jung, M., Benz, C.C., Destabilization of ERBB2 transcripts by targeting 3’ untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res 6 (2008), 1250–1258.
    • (2008) Mol Cancer Res , vol.6 , pp. 1250-1258
    • Scott, G.K.1    Marx, C.2    Berger, C.E.3    Saunders, L.R.4    Verdin, E.5    Schafer, S.6    Jung, M.7    Benz, C.C.8
  • 40
    • 80455129693 scopus 로고    scopus 로고
    • Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function
    • [40] Yu, T.X., Wang, P.Y., Rao, J.N., Zou, T., Liu, L., Xiao, L., Gorospe, M., Wang, J.Y., Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. Nucleic Acids Res 39 (2011), 8472–8487.
    • (2011) Nucleic Acids Res , vol.39 , pp. 8472-8487
    • Yu, T.X.1    Wang, P.Y.2    Rao, J.N.3    Zou, T.4    Liu, L.5    Xiao, L.6    Gorospe, M.7    Wang, J.Y.8
  • 41
    • 68949161769 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
    • [41] Lafarga, V., Cuadrado, A., Lopez de Silanes, I., Bengoechea, R., Fernandez-Capetillo, O., Nebreda, A.R., p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. Mol Cell Biol 29 (2009), 4341–4351.
    • (2009) Mol Cell Biol , vol.29 , pp. 4341-4351
    • Lafarga, V.1    Cuadrado, A.2    Lopez de Silanes, I.3    Bengoechea, R.4    Fernandez-Capetillo, O.5    Nebreda, A.R.6
  • 42
    • 84884322780 scopus 로고    scopus 로고
    • Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR
    • [42] Schulz, S., Doller, A., Pendini, N.R., Wilce, J.A., Pfeilschifter, J., Eberhardt, W., Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR. Cell Signal 25 (2013), 2485–2495.
    • (2013) Cell Signal , vol.25 , pp. 2485-2495
    • Schulz, S.1    Doller, A.2    Pendini, N.R.3    Wilce, J.A.4    Pfeilschifter, J.5    Eberhardt, W.6
  • 43
    • 34250362729 scopus 로고    scopus 로고
    • Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2
    • [43] Doller, A., Huwiler, A., Muller, R., Radeke, H.H., Pfeilschifter, J., Eberhardt, W., Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell 18 (2007), 2137–2148.
    • (2007) Mol Biol Cell , vol.18 , pp. 2137-2148
    • Doller, A.1    Huwiler, A.2    Muller, R.3    Radeke, H.H.4    Pfeilschifter, J.5    Eberhardt, W.6
  • 44
    • 84893219580 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
    • [44] Yoon, J.H., Abdelmohsen, K., Srikantan, S., Guo, R., Yang, X., Martindale, J.L., Gorospe, M., Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res 42 (2014), 1196–1208.
    • (2014) Nucleic Acids Res , vol.42 , pp. 1196-1208
    • Yoon, J.H.1    Abdelmohsen, K.2    Srikantan, S.3    Guo, R.4    Yang, X.5    Martindale, J.L.6    Gorospe, M.7
  • 46
    • 77749334696 scopus 로고    scopus 로고
    • Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR
    • [46] Doller, A., Schlepckow, K., Schwalbe, H., Pfeilschifter, J., Eberhardt, W., Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR. Mol Cell Biol 30 (2010), 1397–1410.
    • (2010) Mol Cell Biol , vol.30 , pp. 1397-1410
    • Doller, A.1    Schlepckow, K.2    Schwalbe, H.3    Pfeilschifter, J.4    Eberhardt, W.5
  • 47
    • 42149150455 scopus 로고    scopus 로고
    • Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
    • [47] Doller, A., Akool el, S., Huwiler, A., Muller, R., Radeke, H.H., Pfeilschifter, J., Eberhardt, W., Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol Cell Biol 28 (2008), 2608–2625.
    • (2008) Mol Cell Biol , vol.28 , pp. 2608-2625
    • Doller, A.1    Akool el, S.2    Huwiler, A.3    Muller, R.4    Radeke, H.H.5    Pfeilschifter, J.6    Eberhardt, W.7
  • 48
    • 79955780590 scopus 로고    scopus 로고
    • High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells
    • [48] Doller, A., Winkler, C., Azrilian, I., Schulz, S., Hartmann, S., Pfeilschifter, J., Eberhardt, W., High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells. Carcinogenesis 32 (2011), 676–685.
    • (2011) Carcinogenesis , vol.32 , pp. 676-685
    • Doller, A.1    Winkler, C.2    Azrilian, I.3    Schulz, S.4    Hartmann, S.5    Pfeilschifter, J.6    Eberhardt, W.7
  • 49
    • 84876154977 scopus 로고    scopus 로고
    • miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer
    • [49] Al-Ahmadi, W., Al-Ghamdi, M., Al-Souhibani, N., Khabar, K.S., miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer. J Pathol 230 (2013), 28–38.
    • (2013) J Pathol , vol.230 , pp. 28-38
    • Al-Ahmadi, W.1    Al-Ghamdi, M.2    Al-Souhibani, N.3    Khabar, K.S.4
  • 50
    • 33748575589 scopus 로고    scopus 로고
    • Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells
    • [50] Leandersson, K., Riesbeck, K., Andersson, T., Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells. Nucleic Acids Res 34 (2006), 3988–3999.
    • (2006) Nucleic Acids Res , vol.34 , pp. 3988-3999
    • Leandersson, K.1    Riesbeck, K.2    Andersson, T.3
  • 52
    • 77950527724 scopus 로고    scopus 로고
    • The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer
    • [52] Calaluce, R., Gubin, M.M., Davis, J.W., Magee, J.D., Chen, J., Kuwano, Y., Gorospe, M., Atasoy, U., The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer. BMC Cancer, 10, 2010, 126.
    • (2010) BMC Cancer , vol.10 , pp. 126
    • Calaluce, R.1    Gubin, M.M.2    Davis, J.W.3    Magee, J.D.4    Chen, J.5    Kuwano, Y.6    Gorospe, M.7    Atasoy, U.8
  • 53
    • 33748078455 scopus 로고    scopus 로고
    • HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells
    • [53] Guo, X., Hartley, R.S., HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells. Cancer Res 66 (2006), 7948–7956.
    • (2006) Cancer Res , vol.66 , pp. 7948-7956
    • Guo, X.1    Hartley, R.S.2
  • 54
    • 77950584927 scopus 로고    scopus 로고
    • MicroRNA-125a represses cell growth by targeting HuR in breast cancer
    • [54] Guo, X., Wu, Y., Hartley, R.S., MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 6 (2009), 575–583.
    • (2009) RNA Biol , vol.6 , pp. 575-583
    • Guo, X.1    Wu, Y.2    Hartley, R.S.3
  • 55
    • 49649092885 scopus 로고    scopus 로고
    • Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells
    • [55] Meng, Z., Jackson, N.L., Choi, H., King, P.H., Emanuel, P.D., Blume, S.W., Alterations in RNA-binding activities of IRES-regulatory proteins as a mechanism for physiological variability and pathological dysregulation of IGF-IR translational control in human breast tumor cells. J Cell Physiol 217 (2008), 172–183.
    • (2008) J Cell Physiol , vol.217 , pp. 172-183
    • Meng, Z.1    Jackson, N.L.2    Choi, H.3    King, P.H.4    Emanuel, P.D.5    Blume, S.W.6
  • 57
    • 79851498863 scopus 로고    scopus 로고
    • Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis
    • [57] Yuan, Z., Sanders, A.J., Ye, L., Wang, Y., Jiang, W.G., Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis. Anticancer Res 31 (2011), 303–310.
    • (2011) Anticancer Res , vol.31 , pp. 303-310
    • Yuan, Z.1    Sanders, A.J.2    Ye, L.3    Wang, Y.4    Jiang, W.G.5
  • 58
    • 11844291394 scopus 로고    scopus 로고
    • IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3’ untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR
    • [58] Suswam, E.A., Nabors, L.B., Huang, Y., Yang, X., King, P.H., IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3’ untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. Int J Cancer 113 (2005), 911–919.
    • (2005) Int J Cancer , vol.113 , pp. 911-919
    • Suswam, E.A.1    Nabors, L.B.2    Huang, Y.3    Yang, X.4    King, P.H.5
  • 59
    • 84857169594 scopus 로고    scopus 로고
    • Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
    • [59] Gabai, V.L., Meng, L., Kim, G., Mills, T.A., Benjamin, I.J., Sherman, M.Y., Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol 32 (2012), 929–940.
    • (2012) Mol Cell Biol , vol.32 , pp. 929-940
    • Gabai, V.L.1    Meng, L.2    Kim, G.3    Mills, T.A.4    Benjamin, I.J.5    Sherman, M.Y.6
  • 60
    • 77957122863 scopus 로고    scopus 로고
    • BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells
    • [60] Chock, K., Allison, J.M., Elshamy, W.M., BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells. Oncogene 29 (2010), 5274–5285.
    • (2010) Oncogene , vol.29 , pp. 5274-5285
    • Chock, K.1    Allison, J.M.2    Elshamy, W.M.3
  • 61
    • 84896445788 scopus 로고    scopus 로고
    • Loss of protein kinase Cdelta/HuR interaction is necessary to doxorubicin resistance in breast cancer cell lines
    • [61] Latorre, E., Castiglioni, I., Gatto, P., Carelli, S., Quattrone, A., Provenzani, A., Loss of protein kinase Cdelta/HuR interaction is necessary to doxorubicin resistance in breast cancer cell lines. J Pharmacol Exp Ther 349 (2014), 99–106.
    • (2014) J Pharmacol Exp Ther , vol.349 , pp. 99-106
    • Latorre, E.1    Castiglioni, I.2    Gatto, P.3    Carelli, S.4    Quattrone, A.5    Provenzani, A.6
  • 62
    • 56049123873 scopus 로고    scopus 로고
    • HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence
    • [62] Ortega, A.D., Sala, S., Espinosa, E., Gonzalez-Baron, M., Cuezva, J.M., HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence. Carcinogenesis 29 (2008), 2053–2061.
    • (2008) Carcinogenesis , vol.29 , pp. 2053-2061
    • Ortega, A.D.1    Sala, S.2    Espinosa, E.3    Gonzalez-Baron, M.4    Cuezva, J.M.5
  • 63
    • 78549256935 scopus 로고    scopus 로고
    • Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma
    • [63] Xu, F., Zhang, X., Lei, Y., Liu, X., Liu, Z., Tong, T., Wang, W., Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma. J Cell Biochem 111 (2010), 727–734.
    • (2010) J Cell Biochem , vol.111 , pp. 727-734
    • Xu, F.1    Zhang, X.2    Lei, Y.3    Liu, X.4    Liu, Z.5    Tong, T.6    Wang, W.7
  • 65
    • 84881480646 scopus 로고    scopus 로고
    • Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
    • [65] Zhu, Z., Wang, B., Bi, J., Zhang, C., Guo, Y., Chu, H., Liang, X., Zhong, C., Wang, J., Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer. Tumour Biol 34 (2013), 2299–2308.
    • (2013) Tumour Biol , vol.34 , pp. 2299-2308
    • Zhu, Z.1    Wang, B.2    Bi, J.3    Zhang, C.4    Guo, Y.5    Chu, H.6    Liang, X.7    Zhong, C.8    Wang, J.9
  • 66
    • 4143134276 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    • [66] Denkert, C., Weichert, W., Winzer, K.J., Muller, B.M., Noske, A., Niesporek, S., Kristiansen, G., Guski, H., Dietel, M., Hauptmann, S., Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res 10 (2004), 5580–5586.
    • (2004) Clin Cancer Res , vol.10 , pp. 5580-5586
    • Denkert, C.1    Weichert, W.2    Winzer, K.J.3    Muller, B.M.4    Noske, A.5    Niesporek, S.6    Kristiansen, G.7    Guski, H.8    Dietel, M.9    Hauptmann, S.10
  • 68
    • 84885327889 scopus 로고    scopus 로고
    • Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy
    • [68] Wang, J., Li, D., Wang, B., Wu, Y., Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy. Breast Cancer Res Treat 141 (2013), 213–224.
    • (2013) Breast Cancer Res Treat , vol.141 , pp. 213-224
    • Wang, J.1    Li, D.2    Wang, B.3    Wu, Y.4
  • 69
    • 84866516368 scopus 로고    scopus 로고
    • HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via DeltaNp63
    • [69] Yan, W., Zhang, Y., Zhang, J., Cho, S.J., Chen, X., HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via DeltaNp63. PLoS One, 7, 2012, e45336.
    • (2012) PLoS One , vol.7 , pp. e45336
    • Yan, W.1    Zhang, Y.2    Zhang, J.3    Cho, S.J.4    Chen, X.5
  • 70
    • 54249097458 scopus 로고    scopus 로고
    • Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach
    • [70] Mazan-Mamczarz, K., Hagner, P.R., Dai, B., Wood, W.H., Zhang, Y., Becker, K.G., Liu, Z., Gartenhaus, R.B., Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach. Cancer Res 68 (2008), 7730–7735.
    • (2008) Cancer Res , vol.68 , pp. 7730-7735
    • Mazan-Mamczarz, K.1    Hagner, P.R.2    Dai, B.3    Wood, W.H.4    Zhang, Y.5    Becker, K.G.6    Liu, Z.7    Gartenhaus, R.B.8
  • 71
    • 77953541017 scopus 로고    scopus 로고
    • The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines
    • [71] Licata, L.A., Hostetter, C.L., Crismale, J., Sheth, A., Keen, J.C., The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines. Breast Cancer Res Treat 122 (2010), 55–63.
    • (2010) Breast Cancer Res Treat , vol.122 , pp. 55-63
    • Licata, L.A.1    Hostetter, C.L.2    Crismale, J.3    Sheth, A.4    Keen, J.C.5
  • 72
    • 77955750366 scopus 로고    scopus 로고
    • Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis
    • [72] Gubin, M.M., Calaluce, R., Davis, J.W., Magee, J.D., Strouse, C.S., Shaw, D.P., Ma, L., Brown, A., Hoffman, T., Rold, T.L., et al. Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis. Cell Cycle 9 (2010), 3337–3346.
    • (2010) Cell Cycle , vol.9 , pp. 3337-3346
    • Gubin, M.M.1    Calaluce, R.2    Davis, J.W.3    Magee, J.D.4    Strouse, C.S.5    Shaw, D.P.6    Ma, L.7    Brown, A.8    Hoffman, T.9    Rold, T.L.10
  • 73
    • 78751695662 scopus 로고    scopus 로고
    • Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer
    • [73] Woo, H.H., Yi, X., Lamb, T., Menzl, I., Baker, T., Shapiro, D.J., Chambers, S.K., Posttranscriptional suppression of proto-oncogene c-fms expression by vigilin in breast cancer. Mol Cell Biol 31 (2011), 215–225.
    • (2011) Mol Cell Biol , vol.31 , pp. 215-225
    • Woo, H.H.1    Yi, X.2    Lamb, T.3    Menzl, I.4    Baker, T.5    Shapiro, D.J.6    Chambers, S.K.7
  • 74
    • 0034687794 scopus 로고    scopus 로고
    • Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays
    • [74] Tenenbaum, S.A., Carson, C.C., Lager, P.J., Keene, J.D., Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. Proc Natl Acad Sci U S A 97 (2000), 14085–14090.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 14085-14090
    • Tenenbaum, S.A.1    Carson, C.C.2    Lager, P.J.3    Keene, J.D.4
  • 76
    • 47549097004 scopus 로고    scopus 로고
    • Trichostatin A and 5 Aza-2’ deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR
    • [76] Pryzbylkowski, P., Obajimi, O., Keen, J.C., Trichostatin A and 5 Aza-2’ deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. Breast Cancer Res Treat 111 (2008), 15–25.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 15-25
    • Pryzbylkowski, P.1    Obajimi, O.2    Keen, J.C.3
  • 77
    • 84878324195 scopus 로고    scopus 로고
    • Involvement of post-transcriptional regulation of FOXO1 by HuR in 5-FU-induced apoptosis in breast cancer cells
    • [77] Li, Y., Yu, J., Du, D., Fu, S., Chen, Y., Yu, F., Gao, P., Involvement of post-transcriptional regulation of FOXO1 by HuR in 5-FU-induced apoptosis in breast cancer cells. Oncol Lett 6 (2013), 156–160.
    • (2013) Oncol Lett , vol.6 , pp. 156-160
    • Li, Y.1    Yu, J.2    Du, D.3    Fu, S.4    Chen, Y.5    Yu, F.6    Gao, P.7
  • 78
    • 84876347286 scopus 로고    scopus 로고
    • Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a
    • [78] Yang, F., Miao, L., Mei, Y., Wu, M., Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a. Cell Signal 25 (2013), 1476–1485.
    • (2013) Cell Signal , vol.25 , pp. 1476-1485
    • Yang, F.1    Miao, L.2    Mei, Y.3    Wu, M.4
  • 79
    • 84858598980 scopus 로고    scopus 로고
    • Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
    • [79] Latorre, E., Tebaldi, T., Viero, G., Sparta, A.M., Quattrone, A., Provenzani, A., Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol Cancer, 11, 2012, 13.
    • (2012) Mol Cancer , vol.11 , pp. 13
    • Latorre, E.1    Tebaldi, T.2    Viero, G.3    Sparta, A.M.4    Quattrone, A.5    Provenzani, A.6
  • 80
    • 27744592137 scopus 로고    scopus 로고
    • The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells
    • [80] Sommer, S., Cui, Y., Brewer, G., Fuqua, S.A., The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells. J Steroid Biochem Mol Biol 97 (2005), 219–229.
    • (2005) J Steroid Biochem Mol Biol , vol.97 , pp. 219-229
    • Sommer, S.1    Cui, Y.2    Brewer, G.3    Fuqua, S.A.4
  • 81
    • 84906837700 scopus 로고    scopus 로고
    • Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells
    • [81] Al-Souhibani, N., Al-Ghamdi, M., Al-Ahmadi, W., Khabar, K.S., Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells. Carcinogenesis 35 (2014), 1983–1992.
    • (2014) Carcinogenesis , vol.35 , pp. 1983-1992
    • Al-Souhibani, N.1    Al-Ghamdi, M.2    Al-Ahmadi, W.3    Khabar, K.S.4
  • 82
    • 0037474203 scopus 로고    scopus 로고
    • The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein
    • [82] Giles, K.M., Daly, J.M., Beveridge, D.J., Thomson, A.M., Voon, D.C., Furneaux, H.M., Jazayeri, J.A., Leedman, P.J., The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein. J Biol Chem 278 (2003), 2937–2946.
    • (2003) J Biol Chem , vol.278 , pp. 2937-2946
    • Giles, K.M.1    Daly, J.M.2    Beveridge, D.J.3    Thomson, A.M.4    Voon, D.C.5    Furneaux, H.M.6    Jazayeri, J.A.7    Leedman, P.J.8
  • 83
    • 84875408831 scopus 로고    scopus 로고
    • Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells
    • [83] Hsia, T.C., Tu, C.Y., Chen, Y.J., Wei, Y.L., Yu, M.C., Hsu, S.C., Tsai, S.L., Chen, W.S., Yeh, M.H., Yen, C.J., et al. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Mol Pharmacol 83 (2013), 857–869.
    • (2013) Mol Pharmacol , vol.83 , pp. 857-869
    • Hsia, T.C.1    Tu, C.Y.2    Chen, Y.J.3    Wei, Y.L.4    Yu, M.C.5    Hsu, S.C.6    Tsai, S.L.7    Chen, W.S.8    Yeh, M.H.9    Yen, C.J.10
  • 84
    • 84910107534 scopus 로고    scopus 로고
    • Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer
    • [84] Luo, N.A., Qu, Y.Q., Yang, G.D., Wang, T., Li, R.L., Jia, L.T., Dong, R., Post-transcriptional up-regulation of PDGF-C by HuR in advanced and stressed breast cancer. Int J Mol Sci 15 (2014), 20306–20320.
    • (2014) Int J Mol Sci , vol.15 , pp. 20306-20320
    • Luo, N.A.1    Qu, Y.Q.2    Yang, G.D.3    Wang, T.4    Li, R.L.5    Jia, L.T.6    Dong, R.7
  • 85
    • 15544376261 scopus 로고    scopus 로고
    • Lessons in estrogen biology from knockout and transgenic animals
    • [85] Hewitt, S.C., Harrell, J.C., Korach, K.S., Lessons in estrogen biology from knockout and transgenic animals. Annu Rev Physiol 67 (2005), 285–308.
    • (2005) Annu Rev Physiol , vol.67 , pp. 285-308
    • Hewitt, S.C.1    Harrell, J.C.2    Korach, K.S.3
  • 86
    • 0032971250 scopus 로고    scopus 로고
    • GATA-3 is expressed in association with estrogen receptor in breast cancer
    • [86] Hoch, R.V., Thompson, D.A., Baker, R.J., Weigel, R.J., GATA-3 is expressed in association with estrogen receptor in breast cancer. Int J Cancer 84 (1999), 122–128.
    • (1999) Int J Cancer , vol.84 , pp. 122-128
    • Hoch, R.V.1    Thompson, D.A.2    Baker, R.J.3    Weigel, R.J.4
  • 89
    • 48449104880 scopus 로고    scopus 로고
    • Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells
    • [89] Gallo, D., Jacquot, Y., Laurent, G., Leclercq, G., Calmodulin, a regulatory partner of the estrogen receptor alpha in breast cancer cells. Mol Cell Endocrinol 291 (2008), 20–26.
    • (2008) Mol Cell Endocrinol , vol.291 , pp. 20-26
    • Gallo, D.1    Jacquot, Y.2    Laurent, G.3    Leclercq, G.4
  • 90
    • 48649103713 scopus 로고    scopus 로고
    • Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4
    • [90] Rzymski, T., Paantjens, A., Bod, J., Harris, A.L., Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4. Oncogene 27 (2008), 4532–4543.
    • (2008) Oncogene , vol.27 , pp. 4532-4543
    • Rzymski, T.1    Paantjens, A.2    Bod, J.3    Harris, A.L.4
  • 92
    • 75849118831 scopus 로고    scopus 로고
    • Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer
    • [92] Guo, X., Wu, Y., Hartley, R.S., Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer. Mol Carcinog 49 (2010), 130–140.
    • (2010) Mol Carcinog , vol.49 , pp. 130-140
    • Guo, X.1    Wu, Y.2    Hartley, R.S.3
  • 93
    • 84927607111 scopus 로고    scopus 로고
    • MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells
    • [93] Guo, X., Connick, M.C., Vanderhoof, J., Ishak, M.A., Hartley, R.S., MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells. Int J Mol Sci 16 (2015), 7112–7132.
    • (2015) Int J Mol Sci , vol.16 , pp. 7112-7132
    • Guo, X.1    Connick, M.C.2    Vanderhoof, J.3    Ishak, M.A.4    Hartley, R.S.5
  • 97
    • 84918813152 scopus 로고    scopus 로고
    • The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor
    • [97] Swierczak, A., Cook, A.D., Lenzo, J.C., Restall, C.M., Doherty, J.P., Anderson, R.L., Hamilton, J.A., The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor. Cancer Immunol Res 2 (2014), 765–776.
    • (2014) Cancer Immunol Res , vol.2 , pp. 765-776
    • Swierczak, A.1    Cook, A.D.2    Lenzo, J.C.3    Restall, C.M.4    Doherty, J.P.5    Anderson, R.L.6    Hamilton, J.A.7
  • 98
    • 84857763650 scopus 로고    scopus 로고
    • Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components
    • [98] Ioachim, E., Damala, K., Tsanou, E., Briasoulis, E., Papadiotis, E., Mitselou, A., Charhanti, A., Doukas, M., Lampri, L., Arvanitis, D.L., Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components. Histol Histopathol 27 (2012), 209–216.
    • (2012) Histol Histopathol , vol.27 , pp. 209-216
    • Ioachim, E.1    Damala, K.2    Tsanou, E.3    Briasoulis, E.4    Papadiotis, E.5    Mitselou, A.6    Charhanti, A.7    Doukas, M.8    Lampri, L.9    Arvanitis, D.L.10
  • 99
    • 84863149986 scopus 로고    scopus 로고
    • Comparative profiling of plasma proteome from breast cancer patients reveals thrombospondin-1 and BRWD3 as serological biomarkers
    • [99] Suh, E.J., Kabir, M.H., Kang, U.B., Lee, J.W., Yu, J., Noh, D.Y., Lee, C., Comparative profiling of plasma proteome from breast cancer patients reveals thrombospondin-1 and BRWD3 as serological biomarkers. Exp Mol Med 44 (2012), 36–44.
    • (2012) Exp Mol Med , vol.44 , pp. 36-44
    • Suh, E.J.1    Kabir, M.H.2    Kang, U.B.3    Lee, J.W.4    Yu, J.5    Noh, D.Y.6    Lee, C.7
  • 100
    • 84901191680 scopus 로고    scopus 로고
    • Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer
    • [100] Mehner, C., Hockla, A., Miller, E., Ran, S., Radisky, D.C., Radisky, E.S., Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer. Oncotarget 5 (2014), 2736–2749.
    • (2014) Oncotarget , vol.5 , pp. 2736-2749
    • Mehner, C.1    Hockla, A.2    Miller, E.3    Ran, S.4    Radisky, D.C.5    Radisky, E.S.6
  • 102
    • 59349106138 scopus 로고    scopus 로고
    • Timing is everything: order of administration of 5-aza 2’ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity
    • [102] Hostetter, C.L., Licata, L.A., Keen, J.C., Timing is everything: order of administration of 5-aza 2’ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity. Cancer Lett 275 (2009), 178–184.
    • (2009) Cancer Lett , vol.275 , pp. 178-184
    • Hostetter, C.L.1    Licata, L.A.2    Keen, J.C.3
  • 104
    • 57249104900 scopus 로고    scopus 로고
    • NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis
    • [104] Kang, M.J., Ryu, B.K., Lee, M.G., Han, J., Lee, J.H., Ha, T.K., Byun, D.S., Chae, K.S., Lee, B.H., Chun, H.S., et al. NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis. Gastroenterology 135:2030-2042 (2008), 2042.e2031–2042.e2033.
    • (2008) Gastroenterology , vol.135 , Issue.2030-2042 , pp. 2042.e2031-2042.e2033
    • Kang, M.J.1    Ryu, B.K.2    Lee, M.G.3    Han, J.4    Lee, J.H.5    Ha, T.K.6    Byun, D.S.7    Chae, K.S.8    Lee, B.H.9    Chun, H.S.10
  • 106
    • 34548658230 scopus 로고    scopus 로고
    • Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
    • [106] Dai, C., Whitesell, L., Rogers, A.B., Lindquist, S., Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130 (2007), 1005–1018.
    • (2007) Cell , vol.130 , pp. 1005-1018
    • Dai, C.1    Whitesell, L.2    Rogers, A.B.3    Lindquist, S.4
  • 107
    • 9744223645 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines
    • [107] Alao, J.P., Lam, E.W., Ali, S., Buluwela, L., Bordogna, W., Lockey, P., Varshochi, R., Stavropoulou, A.V., Coombes, R.C., Vigushin, D.M., Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res 10 (2004), 8094–8104.
    • (2004) Clin Cancer Res , vol.10 , pp. 8094-8104
    • Alao, J.P.1    Lam, E.W.2    Ali, S.3    Buluwela, L.4    Bordogna, W.5    Lockey, P.6    Varshochi, R.7    Stavropoulou, A.V.8    Coombes, R.C.9    Vigushin, D.M.10
  • 108
    • 69849105168 scopus 로고    scopus 로고
    • Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer
    • [108] Finn, R.S., Press, M.F., Dering, J., Arbushites, M., Koehler, M., Oliva, C., Williams, L.S., Di Leo, A., Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer. J Clin Oncol 27 (2009), 3908–3915.
    • (2009) J Clin Oncol , vol.27 , pp. 3908-3915
    • Finn, R.S.1    Press, M.F.2    Dering, J.3    Arbushites, M.4    Koehler, M.5    Oliva, C.6    Williams, L.S.7    Di Leo, A.8
  • 109
    • 0141640857 scopus 로고    scopus 로고
    • Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    • [109] Tran, H., Maurer, F., Nagamine, Y., Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol 23 (2003), 7177–7188.
    • (2003) Mol Cell Biol , vol.23 , pp. 7177-7188
    • Tran, H.1    Maurer, F.2    Nagamine, Y.3
  • 110
    • 6044269455 scopus 로고    scopus 로고
    • Androgens regulate the binding of endogenous HuR to the AU-rich 3'UTRs of HIF-1alpha and EGF mRNA
    • [110] Sheflin, L.G., Zou, A.P., Spaulding, S.W., Androgens regulate the binding of endogenous HuR to the AU-rich 3'UTRs of HIF-1alpha and EGF mRNA. Biochem Biophys Res Commun 322 (2004), 644–651.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 644-651
    • Sheflin, L.G.1    Zou, A.P.2    Spaulding, S.W.3
  • 112
    • 0032513043 scopus 로고    scopus 로고
    • Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
    • [112] Levy, N.S., Chung, S., Furneaux, H., Levy, A.P., Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 273 (1998), 6417–6423.
    • (1998) J Biol Chem , vol.273 , pp. 6417-6423
    • Levy, N.S.1    Chung, S.2    Furneaux, H.3    Levy, A.P.4
  • 113
    • 23044508946 scopus 로고    scopus 로고
    • Cyclin D1 in breast cancer pathogenesis
    • [113] Arnold, A., Papanikolaou, A., Cyclin D1 in breast cancer pathogenesis. J Clin Oncol 23 (2005), 4215–4224.
    • (2005) J Clin Oncol , vol.23 , pp. 4215-4224
    • Arnold, A.1    Papanikolaou, A.2
  • 114
    • 84892448216 scopus 로고    scopus 로고
    • Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
    • [114] Kang, J., Sergio, C.M., Sutherland, R.L., Musgrove, E.A., Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells. BMC Cancer, 14, 2014, 32.
    • (2014) BMC Cancer , vol.14 , pp. 32
    • Kang, J.1    Sergio, C.M.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 115
    • 84875974093 scopus 로고    scopus 로고
    • Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration
    • [115] Wang, Y., Liu, F., Mao, F., Hang, Q., Huang, X., He, S., Cheng, C., Wang, H., Xu, G., Zhang, T., et al. Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration. J Biol Chem 288 (2013), 9028–9034.
    • (2013) J Biol Chem , vol.288 , pp. 9028-9034
    • Wang, Y.1    Liu, F.2    Mao, F.3    Hang, Q.4    Huang, X.5    He, S.6    Cheng, C.7    Wang, H.8    Xu, G.9    Zhang, T.10
  • 116
    • 77951709842 scopus 로고    scopus 로고
    • Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface
    • [116] Nannuru, K.C., Futakuchi, M., Varney, M.L., Vincent, T.M., Marcusson, E.G., Singh, R.K., Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface. Cancer Res 70 (2010), 3494–3504.
    • (2010) Cancer Res , vol.70 , pp. 3494-3504
    • Nannuru, K.C.1    Futakuchi, M.2    Varney, M.L.3    Vincent, T.M.4    Marcusson, E.G.5    Singh, R.K.6
  • 120
    • 84946549216 scopus 로고    scopus 로고
    • Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation
    • [120] Wang, Z., Bhattacharya, A., Ivanov, D.N., Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation. PLoS One, 10, 2015, e0138780.
    • (2015) PLoS One , vol.10
    • Wang, Z.1    Bhattacharya, A.2    Ivanov, D.N.3
  • 121
    • 84881501527 scopus 로고    scopus 로고
    • A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation
    • [121] D'Agostino, V.G., Adami, V., Provenzani, A., A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation. PLoS One, 8, 2013, e72426.
    • (2013) PLoS One , vol.8
    • D'Agostino, V.G.1    Adami, V.2    Provenzani, A.3
  • 122
    • 73649138927 scopus 로고    scopus 로고
    • Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA
    • [122] Chae, M.J., Sung, H.Y., Kim, E.H., Lee, M., Kwak, H., Chae, C.H., Kim, S., Park, W.Y., Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA. Exp Mol Med 41 (2009), 824–831.
    • (2009) Exp Mol Med , vol.41 , pp. 824-831
    • Chae, M.J.1    Sung, H.Y.2    Kim, E.H.3    Lee, M.4    Kwak, H.5    Chae, C.H.6    Kim, S.7    Park, W.Y.8


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