메뉴 건너뛰기




Volumn 141, Issue 2, 2013, Pages 213-224

Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy

Author keywords

Breast cancer; HuR; Neoadjuvant chemotherapy; Pathologic complete remission; Prognosis

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROURACIL; HUR PROTEIN; PACLITAXEL;

EID: 84885327889     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-013-2679-7     Document Type: Article
Times cited : (26)

References (39)
  • 4
    • 12444309319 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy in breast cancer
    • 15635596 10.1002/bjs.4840 1:STN:280:DC%2BD2M%2Fhs1egsg%3D%3D
    • Charfare H, Limongelli S, Purushotham AD (2005) Neoadjuvant chemotherapy in breast cancer. Br J Surg 92:14-23
    • (2005) Br J Surg , vol.92 , pp. 14-23
    • Charfare, H.1    Limongelli, S.2    Purushotham, A.D.3
  • 5
    • 78649825336 scopus 로고    scopus 로고
    • Current and emerging biomarkers in breast cancer: Prognosis and prediction
    • 20647302 10.1677/ERC-10-0136 1:CAS:528:DC%2BC3MXislyms7w%3D
    • Weigel MT, Dowsett M (2010) Current and emerging biomarkers in breast cancer: prognosis and prediction. Endocr Relat Cancer 17:R245-R262
    • (2010) Endocr Relat Cancer , vol.17
    • Weigel, M.T.1    Dowsett, M.2
  • 7
    • 79959518743 scopus 로고    scopus 로고
    • Prediction of pathologic complete response to sequential paclitaxel and 5-fluorouracil/epirubicin/cyclophosphamide therapy using a 70-gene classifier for breast cancers
    • 21305539 10.1002/cncr.25953 1:CAS:528:DC%2BC3MXps12gu7w%3D
    • Naoi Y, Kishi K, Tanei T, Tsunashima R, Tominaga N, Baba Y, Kim SJ, Taguchi T, Tamaki Y, Noguchi S (2011) Prediction of pathologic complete response to sequential paclitaxel and 5-fluorouracil/epirubicin/cyclophosphamide therapy using a 70-gene classifier for breast cancers. Cancer 117:3682-3690
    • (2011) Cancer , vol.117 , pp. 3682-3690
    • Naoi, Y.1    Kishi, K.2    Tanei, T.3    Tsunashima, R.4    Tominaga, N.5    Baba, Y.6    Kim, S.J.7    Taguchi, T.8    Tamaki, Y.9    Noguchi, S.10
  • 8
    • 79952116721 scopus 로고    scopus 로고
    • A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy
    • 19967557 10.1007/s10549-009-0664-y 1:CAS:528:DC%2BC3cXhtFOqtL%2FO
    • Lin Y, Lin S, Watson M, Trinkaus KM, Kuo S, Naughton MJ, Weilbaecher K, Fleming TP, Aft RL (2010) A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy. Breast Cancer Res Treat 123:691-699
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 691-699
    • Lin, Y.1    Lin, S.2    Watson, M.3    Trinkaus, K.M.4    Kuo, S.5    Naughton, M.J.6    Weilbaecher, K.7    Fleming, T.P.8    Aft, R.L.9
  • 11
    • 84879796288 scopus 로고    scopus 로고
    • Molecular subtyping of early-stage breast cancer identifies a group of patients who do not benefit from neoadjuvant chemotherapy
    • 23756626 10.1007/s10549-013-2572-4
    • Gluck S, de Snoo F, Peeters J, Stork-Sloots L, Somlo G (2013) Molecular subtyping of early-stage breast cancer identifies a group of patients who do not benefit from neoadjuvant chemotherapy. Breast Cancer Res Treat 139:759-767
    • (2013) Breast Cancer Res Treat , vol.139 , pp. 759-767
    • Gluck, S.1    De Snoo, F.2    Peeters, J.3    Stork-Sloots, L.4    Somlo, G.5
  • 13
    • 84877821108 scopus 로고    scopus 로고
    • Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis
    • 23665903 10.3390/ijms140510015 1:CAS:528:DC%2BC3sXhtVSktL7K
    • Wang J, Guo Y, Chu H, Guan Y, Bi J, Wang B (2013) Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis. Int J Mol Sci 14:10015-10041
    • (2013) Int J Mol Sci , vol.14 , pp. 10015-10041
    • Wang, J.1    Guo, Y.2    Chu, H.3    Guan, Y.4    Bi, J.5    Wang, B.6
  • 14
    • 0035213198 scopus 로고    scopus 로고
    • Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells
    • 11733561 1:CAS:528:DC%2BD3MXovVCgsLk%3D
    • Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA, Prescott SM (2001) Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest 108:1657-1665
    • (2001) J Clin Invest , vol.108 , pp. 1657-1665
    • Dixon, D.A.1    Tolley, N.D.2    King, P.H.3    Nabors, L.B.4    McIntyre, T.M.5    Zimmerman, G.A.6    Prescott, S.M.7
  • 15
    • 33947305279 scopus 로고    scopus 로고
    • Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation
    • 17383427 10.1053/j.gastro.2006.12.031 1:CAS:528:DC%2BD2sXkslCisrY%3D
    • Sureban SM, Murmu N, Rodriguez P, May R, Maheshwari R, Dieckgraefe BK, Houchen CW, Anant S (2007) Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation. Gastroenterology 132:1055-1065
    • (2007) Gastroenterology , vol.132 , pp. 1055-1065
    • Sureban, S.M.1    Murmu, N.2    Rodriguez, P.3    May, R.4    Maheshwari, R.5    Dieckgraefe, B.K.6    Houchen, C.W.7    Anant, S.8
  • 16
    • 84856008627 scopus 로고    scopus 로고
    • The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2
    • 22049153 10.1158/1541-7786.MCR-11-0337 1:CAS:528:DC%2BC38Xoslarug%3D%3D
    • Young LE, Moore AE, Sokol L, Meisner-Kober N, Dixon DA (2012) The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. Mol Cancer Res 10:167-180
    • (2012) Mol Cancer Res , vol.10 , pp. 167-180
    • Young, L.E.1    Moore, A.E.2    Sokol, L.3    Meisner-Kober, N.4    Dixon, D.A.5
  • 17
    • 79955854286 scopus 로고    scopus 로고
    • Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9
    • 21503589 1:CAS:528:DC%2BC3MXotlegtbc%3D
    • Yuan Z, Sanders AJ, Ye L, Wang Y, Jiang WG (2011) Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncol Rep 26:237-245
    • (2011) Oncol Rep , vol.26 , pp. 237-245
    • Yuan, Z.1    Sanders, A.J.2    Ye, L.3    Wang, Y.4    Jiang, W.G.5
  • 18
    • 84874897020 scopus 로고    scopus 로고
    • High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer
    • 23516604 10.1371/journal.pone.0059095 1:CAS:528:DC%2BC3sXks1Wnurg%3D
    • Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K, Sakai H (2013) High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer. PLoS ONE 8:e59095
    • (2013) PLoS ONE , vol.8 , pp. 59095
    • Miyata, Y.1    Watanabe, S.2    Sagara, Y.3    Mitsunari, K.4    Matsuo, T.5    Ohba, K.6    Sakai, H.7
  • 19
    • 65449184997 scopus 로고    scopus 로고
    • The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis
    • 19420963 10.1159/000216837 1:CAS:528:DC%2BD1MXmtFCis70%3D
    • Wang J, Zhao W, Guo Y, Zhang B, Xie Q, Xiang D, Gao J, Wang B, Chen Z (2009) The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis. Oncology 76:420-429
    • (2009) Oncology , vol.76 , pp. 420-429
    • Wang, J.1    Zhao, W.2    Guo, Y.3    Zhang, B.4    Xie, Q.5    Xiang, D.6    Gao, J.7    Wang, B.8    Chen, Z.9
  • 20
    • 79960157540 scopus 로고    scopus 로고
    • Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer
    • 21046284 10.1007/s12032-010-9734-6
    • Wang J, Wang B, Bi J, Zhang C (2011) Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer. Med Oncol 28(Suppl 1):S577-S585
    • (2011) Med Oncol , vol.28 , Issue.SUPPL. 1
    • Wang, J.1    Wang, B.2    Bi, J.3    Zhang, C.4
  • 21
    • 33747601610 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR in human colon cancer: Association with tumor stage and cyclooxygenase-2
    • 16799479 10.1038/modpathol.3800645 1:CAS:528:DC%2BD28XotlCgu74%3D
    • Denkert C, Koch I, von Keyserlingk N, Noske A, Niesporek S, Dietel M, Weichert W (2006) Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. Mod Pathol 19:1261-1269
    • (2006) Mod Pathol , vol.19 , pp. 1261-1269
    • Denkert, C.1    Koch, I.2    Von Keyserlingk, N.3    Noske, A.4    Niesporek, S.5    Dietel, M.6    Weichert, W.7
  • 22
    • 84893809652 scopus 로고    scopus 로고
    • Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma
    • doi: 10.1007/s13277-013-1008-4
    • Zhang C, Xue G, Bi J, Geng M, Chu H, Guan Y, Wang J, Wang B (2013) Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma. Tumour Biol. doi: 10.1007/s13277-013-1008-4
    • (2013) Tumour Biol
    • Zhang, C.1    Xue, G.2    Bi, J.3    Geng, M.4    Chu, H.5    Guan, Y.6    Wang, J.7    Wang, B.8
  • 23
    • 0345707583 scopus 로고    scopus 로고
    • Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma
    • 14633672 1:CAS:528:DC%2BD3sXptFOls7w%3D
    • Erkinheimo TL, Lassus H, Sivula A, Sengupta S, Furneaux H, Hla T, Haglund C, Butzow R, Ristimaki A (2003) Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res 63:7591-7594
    • (2003) Cancer Res , vol.63 , pp. 7591-7594
    • Erkinheimo, T.L.1    Lassus, H.2    Sivula, A.3    Sengupta, S.4    Furneaux, H.5    Hla, T.6    Haglund, C.7    Butzow, R.8    Ristimaki, A.9
  • 24
    • 4143134276 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    • 15328200 10.1158/1078-0432.CCR-04-0070 1:CAS:528:DC%2BD2cXmvFSlur0%3D
    • Denkert C, Weichert W, Winzer KJ, Muller BM, Noske A, Niesporek S, Kristiansen G, Guski H, Dietel M, Hauptmann S (2004) Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res 10:5580-5586
    • (2004) Clin Cancer Res , vol.10 , pp. 5580-5586
    • Denkert, C.1    Weichert, W.2    Winzer, K.J.3    Muller, B.M.4    Noske, A.5    Niesporek, S.6    Kristiansen, G.7    Guski, H.8    Dietel, M.9    Hauptmann, S.10
  • 26
    • 84881480646 scopus 로고    scopus 로고
    • Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer
    • 23605320 10.1007/s13277-013-0774-3 1:CAS:528:DC%2BC3sXhtFWjsr%2FF
    • Zhu Z, Wang B, Bi J, Zhang C, Guo Y, Chu H, Liang X, Zhong C, Wang J (2013) Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer. Tumour Biol 34:2299-2308
    • (2013) Tumour Biol , vol.34 , pp. 2299-2308
    • Zhu, Z.1    Wang, B.2    Bi, J.3    Zhang, C.4    Guo, Y.5    Chu, H.6    Liang, X.7    Zhong, C.8    Wang, J.9
  • 27
    • 66349114705 scopus 로고    scopus 로고
    • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    • 19487279 10.1158/0008-5472.CAN-09-0371 1:CAS:528:DC%2BD1MXmsFGltLg%3D
    • Costantino CL, Witkiewicz AK, Kuwano Y, Cozzitorto JA, Kennedy EP, Dasgupta A, Keen JC, Yeo CJ, Gorospe M, Brody JR (2009) The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res 69:4567-4572
    • (2009) Cancer Res , vol.69 , pp. 4567-4572
    • Costantino, C.L.1    Witkiewicz, A.K.2    Kuwano, Y.3    Cozzitorto, J.A.4    Kennedy, E.P.5    Dasgupta, A.6    Keen, J.C.7    Yeo, C.J.8    Gorospe, M.9    Brody, J.R.10
  • 31
    • 84858598980 scopus 로고    scopus 로고
    • Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
    • 22436134 10.1186/1476-4598-11-13 1:CAS:528:DC%2BC38XmtlyqurY%3D
    • Latorre E, Tebaldi T, Viero G, Sparta AM, Quattrone A, Provenzani A (2012) Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol Cancer 11:13
    • (2012) Mol Cancer , vol.11 , pp. 13
    • Latorre, E.1    Tebaldi, T.2    Viero, G.3    Sparta, A.M.4    Quattrone, A.5    Provenzani, A.6
  • 32
    • 58149172080 scopus 로고    scopus 로고
    • Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    • 18769129 10.4161/cbt.7.9.6490 1:CAS:528:DC%2BD1cXhsVKms7rO
    • Hostetter C, Licata LA, Witkiewicz A, Costantino CL, Yeo CJ, Brody JR, Keen JC (2008) Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells. Cancer Biol Ther 7:1496-1506
    • (2008) Cancer Biol Ther , vol.7 , pp. 1496-1506
    • Hostetter, C.1    Licata, L.A.2    Witkiewicz, A.3    Costantino, C.L.4    Yeo, C.J.5    Brody, J.R.6    Keen, J.C.7
  • 35
    • 56049123873 scopus 로고    scopus 로고
    • HuR and the bioenergetic signature of breast cancer: A low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence
    • 18687667 10.1093/carcin/bgn185 1:CAS:528:DC%2BD1cXhtlalsLnO
    • Ortega AD, Sala S, Espinosa E, Gonzalez-Baron M, Cuezva JM (2008) HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence. Carcinogenesis 29:2053-2061
    • (2008) Carcinogenesis , vol.29 , pp. 2053-2061
    • Ortega, A.D.1    Sala, S.2    Espinosa, E.3    Gonzalez-Baron, M.4    Cuezva, J.M.5
  • 36
    • 79851498863 scopus 로고    scopus 로고
    • Prognostic value of the human antigen R (HuR) in human breast cancer: High level predicts a favourable prognosis
    • 21273615 1:CAS:528:DC%2BC3MXisVams7g%3D
    • Yuan Z, Sanders AJ, Ye L, Wang Y, Jiang WG (2011) Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis. Anticancer Res 31:303-310
    • (2011) Anticancer Res , vol.31 , pp. 303-310
    • Yuan, Z.1    Sanders, A.J.2    Ye, L.3    Wang, Y.4    Jiang, W.G.5
  • 37
    • 84876154977 scopus 로고    scopus 로고
    • MiR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer
    • 23401122 10.1002/path.4178 1:CAS:528:DC%2BC3sXlvVekurs%3D
    • Al-Ahmadi W, Al-Ghamdi M, Al-Souhibani N, Khabar KS (2013) miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer. J Pathol 230:28-38
    • (2013) J Pathol , vol.230 , pp. 28-38
    • Al-Ahmadi, W.1    Al-Ghamdi, M.2    Al-Souhibani, N.3    Khabar, K.S.4
  • 38
    • 77950584927 scopus 로고    scopus 로고
    • MicroRNA-125a represses cell growth by targeting HuR in breast cancer
    • 19875930 10.4161/rna.6.5.10079 1:CAS:528:DC%2BC3cXmtlWitL0%3D
    • Guo X, Wu Y, Hartley RS (2009) MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 6:575-583
    • (2009) RNA Biol , vol.6 , pp. 575-583
    • Guo, X.1    Wu, Y.2    Hartley, R.S.3
  • 39
    • 77955750366 scopus 로고    scopus 로고
    • Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis
    • 20724828 10.4161/cc.9.16.12711 1:CAS:528:DC%2BC3MXhs12mtw%3D%3D
    • Gubin MM, Calaluce R, Davis JW, Magee JD, Strouse CS, Shaw DP, Ma L, Brown A, Hoffman T, Rold TL, Atasoy U (2010) Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis. Cell Cycle 9:3337-3346
    • (2010) Cell Cycle , vol.9 , pp. 3337-3346
    • Gubin, M.M.1    Calaluce, R.2    Davis, J.W.3    Magee, J.D.4    Strouse, C.S.5    Shaw, D.P.6    Ma, L.7    Brown, A.8    Hoffman, T.9    Rold, T.L.10    Atasoy, U.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.