Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma

Journal of Cellular Biochemistry

Volumn 111, Issue 3, 2010, Pages 727-734

  Xu, Fang ^a   Zhang, Xiaotian ^a   Lei, Yutao ^b   Liu, Xinwen ^a   Liu, Zhenyun ^a   Tong, Tanjun ^a   Wang, Wengong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Breast Carcinoma; Hur; Mir 16; Translational Regulation

Indexed keywords

HUR PROTEIN; LUCIFERASE; MESSENGER RNA; MICRORNA; MICRORNA 16; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER CELL CULTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ANTIGENS, SURFACE; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 78549256935     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22762     Document Type: Article

References (30)

1. Abdelmohsen K, Pullmann R, Jr., Lal A, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. 2007. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 25(4):543-557.
2. Abdelmohsen K, Srikantan S, Kuwano Y, Gorospe M. 2008. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci USA 105(51):20297-20302.
3. Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, Hasan L, Kappeler A, Brunner T, Vassella E. 2009. miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or downregulated in non-small cell lung cancer. Cancer Res 69(13):5553-5559.
4. Bonci D, Coppola V, Musumeci M, Addario A, Giuffrida R, Memeo L, D'Urso L, Pagliuca A, Biffoni M, Labbaye C, Bartucci M, Muto G, Peschle C, De Maria R. 2008. The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 14(11):1271-1277.
5. Bottoni A, Piccin D, Tagliati F, Luchin A, Zatelli MC, degli Uberti EC. 2005. miR-15a and miR-16-1 down-regulation in pituitary adenomas. J Cell Physiol 204:280-285.
6. Brennan CM, Gallouzi IE, Steitz JA. 2000. Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J Cell Biol 151(1):1-14.
7. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM. 2008. miR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci USA 105:5166-5171.
8. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, Wojcik SE, Aqeilan RI, Zupo S, Dono M, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. 2006. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 102(39):13944-13949.
9. Dean JL, Wait R, Mahtani KR, Sully G, Clark AR, Saklatvala J. 2002. The 30 untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol 21(3):721-730.
10. Denkert C, Weichert W, Winzer KJ, Mü ller BM, Noske A, Niesporek S, Kristiansen G, Guski H, Dietel M, Hauptmann S. 2004a. Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res 10(16):5580-5586.
11. Denkert C, Weichert W, Pest S, Koch I, Licht D, Köbel M, Reles A, Sehouli J, Dietel M, Hauptmann S. 2004b. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res 64(1):189-195.
12. Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA, Prescott SM. 2001. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest 108(11):1657-1665.
13. Dormoy-Raclet V, Ménard I, Clair E, Kurban G, Mazroui R, Di Marco S, von Roretz C, Pause A, Gallouzi IE. 2007. The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol 27(15):5365-5380.
14. Erkinheimo TL, Lassus H, Sivula A, Sengupta S, Furneaux H, Hla T, Haglund C, Butzow R, Ristimäki A. 2003. Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res 63(22):7591-7594.
15. Gouble A, Grazide S, Meggetto F, Mercier P, Delsol G, Morello D. 2002. A new player in oncogenesis: AUF1/hnRNPD overexpression leads to tumorigenesis in transgenic mice. Cancer Res 62(5):1489-1495.
16. Guo X, Hartley RS. 2006. HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells. Cancer Res 66(16):7948-7956.
17. Guo X, Wu Y, Hartley R. 2009. MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 6(5):575-583.
18. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J. 2005. Involvement of microRNA in AU-rich elementmediated mRNA instability. Cell 120(5):623-634.
19. Kim HH, Kuwano Y, Srikantan S, Lee EK, Martindale JL, Gorospe M. 2009. HuR recruits let-7/RISC to repress c-Myc expression. Genes Dev 23(15): 1743-1748.
20. Levy NS, Chung S, Furneaux H, Levy AP. 1998. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 273(11):6417-6423.
21. Mazan-Mamczarz K, Galbán S, López de Silanes I, Martindale JL, Atasoy U, Keene JD, Gorospe M. 2003. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci USA 100(14):8354-8359.
22. Natarajan G, Ramalingam S, Ramachandran I, May R, Queimado L, Houchen CW, Anant S. 2008. CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. Am J Physiol Gastrointest Liver Physiol 294(5):G1235-G1244.
23. Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H, Hla T. 2003. The RNAbinding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem 278(27):25227-25233.
24. Suswam EA, Nabors LB, Huang Y, Yang X, King PH. 2005. IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. Int J Cancer 113(6):911-919.
25. Suswam E, Li Y, Zhang X, Gillespie GY, Li X, Shacka JJ, Lu L, Zheng L, King PH. 2008. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res 68(3):674-682.
26. Wang W, Furneaux H, Cheng H, Caldwell MC, Hutter D, Liu Y, Holbrook N, Gorospe M. 2000. HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol 20(3):760-769.
27. Wang W, Yang X, Cristofalo VJ, Holbrook NJ, Gorospe M. 2001. Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol Cell Biol 21(17):5889-5898.
28. Wang W, Yang X, López de Silanes I, Carling D, Gorospe M. 2003. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem 278(29):27016-27023.
29. Wijdan A, Al-Ghamdi M, Al-Haj L, Al-Saif M, Khabar KSA. 2009. Alternative polyadenylation variants of the RNA binding protein, HuR: Abundance, role of AU-rich elements and auto-Regulation. Nucleic Acids Res 37(11):3612-3624.
30. Yi J, Chang N, Liu X, Guo G, Xue L, Tong T, Gorospe M, Wang W. 2010. Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence. Nucleic Acids Res 38(5):1547-1558.