Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes

Human Molecular Genetics

Volumn 25, Issue 13, 2016, Pages 2681-2697

  Busch, Johanna I ^a   Unger, Travis L ^a   Jain, Nimansha ^a   Skrinak, R Tyler ^a   Charan, Rakshita A ^a   Chen Plotkin, Alice S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; LACTATE DEHYDROGENASE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; TAR DNA BINDING PROTEIN; TRANSMEMBRANE PROTEIN 106B; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; DNA BINDING PROTEIN; NERVE PROTEIN; PROTEIN; TMEM106B PROTEIN, HUMAN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COS-7 CELL LINE; CYTOTOXICITY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; FRONTOTEMPORAL DEMENTIA; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GENETIC VARIABILITY; HEK293 CELL LINE; HELA CELL LINE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; LYSOSOME; MOUSE; NONHUMAN; RISK FACTOR; TMEM106B GENE; TONOPLAST; TUNEL ASSAY; ANIMAL; CELL CULTURE TECHNIQUE; CELL INCLUSION; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; MALE; METABOLISM; NERVE CELL; ONSET AGE; PHYSIOLOGY; PRIMARY CELL CULTURE; PROTEIN TRANSPORT; REGULATOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGE OF ONSET; ANIMALS; CELL CULTURE TECHNIQUES; DNA-BINDING PROTEINS; FEMALE; FRONTOTEMPORAL DEMENTIA; FRONTOTEMPORAL LOBAR DEGENERATION; GENES, REGULATOR; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INCLUSION BODIES; LYSOSOMES; MALE; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIMARY CELL CULTURE; PROTEIN TRANSPORT; PROTEINS; RISK FACTORS;

EID: 85015992433     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw127     Document Type: Article

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