Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis

Acta Neuropathologica

Volumn 121, Issue 3, 2011, Pages 373-380

  Vass, Ryan ^a   Ashbridge, Emily ^a,d   Geser, Felix ^a,b   Hu, William T ^c   Grossman, Murray ^a   Clay Falcone, Dana ^a,b   Elman, Lauren ^a   McCluskey, Leo ^a   Lee, Virginia M Y ^a,b   Van Deerlin, Vivianna M ^a   Trojanowski, John Q ^a,b   Chen Plotkin, Alice S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Julia R Masterman School   (United States)

Author keywords

ALS; Amyotrophic lateral sclerosis; Cognitive impairment; Frontotemporal dementia; Frontotemporal lobar degeneration; FTLD TDP; TDP 43; TMEM106B

Indexed keywords

DNA; GENE PRODUCT; PROTEIN TMEM106B; TAR DNA BINDING PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; AMYGDALOID NUCLEUS; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; AUTOPSY; BRAAK STAGE; BRAIN STEM; CINGULATE GYRUS; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE DURATION; DOMINANT GENE; EXECUTIVE FUNCTION; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HIPPOCAMPAL CA1 REGION; HISTOPATHOLOGY; HOMOZYGOTE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MIDDLE FRONTAL GYRUS; MIDDLE TEMPORAL GYRUS; NEUROFIBRILLARY TANGLE; NEUROPSYCHOLOGICAL TEST; ONSET AGE; PHONEMIC VERBAL FLUENCY TEST; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SPINAL CORD; SUBICULUM; SUPERIOR TEMPORAL GYRUS;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; AUTOPSY; CASE-CONTROL STUDIES; COGNITION DISORDERS; COMORBIDITY; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINEAR MODELS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 79954436511     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0782-y     Document Type: Article

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