Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Wang, Jingbo ^a   Liu, Rui ^a   Liu, Baoxiu ^a   Yang, Yan ^a   Xie, Jun ^a   Zhu, Naishuo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CORDYCEPIN; CYTOKINE; DEOXYADENOSINE DERIVATIVE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; HERBACEOUS AGENT; IMMUNOLOGICAL ADJUVANT; VIRUS ANTIBODY;

ANIMAL; ANTIBODY PRODUCTION; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CELL DIFFERENTIATION; CELL PROLIFERATION; CHINESE MEDICINE; CYTOLOGY; DRUG EFFECT; FEMALE; IMMUNIZATION; IMMUNOLOGY; PRECLINICAL STUDY; SPLEEN; SYSTEMS BIOLOGY;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, VIRAL; ANTIBODY FORMATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOKINES; DEOXYADENOSINES; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VACCINES; IMMUNIZATION; MEDICINE, CHINESE TRADITIONAL; MICE, INBRED BALB C; SPLEEN; SYSTEMS BIOLOGY;

EID: 85015858518     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep44788     Document Type: Article

References (70)

1. Pyo, K. H., Lee, Y. W., Lim, S. M., Shin, E. H. Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice. Oncotarget, doi: 10. 18632/oncotarget. 12316 (2016).
2. Agger, E. M. Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates. Advanced drug delivery reviews 102, 73-82, doi: 10. 1016j.addr/2015. 11. 012 (2016).
3. Spiegel, D., et al. Acute Toxicity in Patients With HER2-Positive Breast Cancer Treated With Adjuvant Radiation Therapy and Concurrent Trastuzumab and Pertuzumab. Int J Radiat Oncol Biol Phys 96, E9-E10, doi: 10. 1016j.ijrobp/2016. 06. 619 (2016).
4. Alijotas-Reig, J. Human adjuvant-related syndrome or autoimmune/inflammatory syndrome induced by adjuvants. Where have we come from? Where are we going? A proposal for new diagnostic criteria. Lupus 24, 1012-1018, doi: 10. 1177/0961203315579092 (2015).
5. Huang, C., et al. Systems pharmacology in drug discovery and therapeutic insight for herbal medicines. Briefings in bioinformatics 15, 710-733, doi: 10. 1093/bib/bbt035 (2014).
6. Li, B., et al. A systems biology approach to understanding the mechanisms of action of chinese herbs for treatment of cardiovascular disease. International journal of molecular sciences 13, 13501-13520, doi: 10. 3390/ijms131013501 (2012).
7. Liu, J., et al. Systems-Pharmacology Dissection of Traditional Chinese Medicine Compound Saffron Formula Reveals Multi-scale Treatment Strategy for Cardiovascular Diseases. Scientific reports 6, 19809, doi: 10. 1038/srep19809 (2016).
8. Li, J., Zhao, P., Li, Y., Tian, Y., Wang, Y. Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease. Scientific reports 5, 15290, doi: 10. 1038/srep15290 (2015).
9. Zhou, W., et al. A systematic identification of multiple toxin-target interactions based on chemical, genomic and toxicological data. Toxicology 304, 173-184, doi: 10. 1016j.tox/2012. 12. 012 (2013).
10. Yao, Y., et al. Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction. Journal of ethnopharmacology 150, 619-638, doi: 10. 1016j.jep/2013. 09. 018 (2013).
11. Zhang, J., et al. Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae. International journal of molecular sciences 16, 2913-2941, doi: 10. 3390/ijms16022913 (2015).
12. Block, T. M., Rawat, S., Brosgart, C. L. Chronic hepatitis B: A wave of new therapies on the horizon. Antiviral research 121, 69-81, doi: 10. 1016j.antiviral/2015. 06. 014 (2015).
13. Hadler, S. C., et al. Long-Term Immunogenicity And Efficacy Of Hepatitis-B Vaccine In Homosexual Men. New Engl J Med 315, 209-214, doi: Doi 10. 1056/Nejm198607243150401 (1986).
14. Singh, M., O'Hagan, D. T. Recent advances in vaccine adjuvants. Pharmaceutical research 19, 715-728, doi: Unsp 0724-8741/02/0600-0715/010. 1023/A:1016104910582 (2002).
15. Ottone, S., et al. Expression of hepatitis B surface antigen major subtypes in Pichia pastoris and purification for in vitro diagnosis. Protein expression and purification 56, 177-188, doi: 10. 1016j.pep/2007. 07. 008 (2007).
16. Thoelen, S., et al. Safety and immunogenicity of a hepatitis B vaccine formulated with a novel adjuvant system. Vaccine 16, 708-714, doi: Doi 10. 1016/S0264-410x(97)00254-5 (1998).
17. Li, Y., et al. Complete mitochondrial genome of the medicinal fungus Ophiocordyceps sinensis. Scientific reports 5, 13892, doi: 10. 1038/srep13892 (2015).
18. Chen, P. X., Wang, S., Nie, S., Marcone, M. Properties of Cordyceps Sinensis: A review. Journal of Functional Foods 5, 550-569, doi: 10. 1016j.jff/2013. 01. 034 (2013).
19. Dalla Rosa, L., et al. Cordycepin (3?-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi. Parasitology 140, 663-671, doi: 10. 1017/S0031182012001990 (2013).
20. Chen, X., Wu, J.-y., Gui, X. Production and characterization of exopolysaccharides in mycelial culture of Cordyceps sinensis fungus Cs-HK1 with different carbon sources. Chinese Journal of Chemical Engineering 24, 158-162, doi: 10. 1016j.cjche/2015. 06. 016 (2016).
21. Hu, T., Jiang, C., Huang, Q., Sun, F. A comb-like branched beta-d-glucan produced by a Cordyceps sinensis fungus and its protective effect against cyclophosphamide-induced immunosuppression in mice. Carbohydrate polymers 142, 259-267, doi: 10. 1016j.carbpol/2016. 01. 036 (2016).
22. Wang, Y., et al. Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydrate polymers 125, 135-145, doi: 10. 1016j.carbpol/2015. 02. 012 (2015).
23. Wang, B.-S., Lee, C. P., Chen, Z.-T., Yu, H. M., Duh, P.-D. Comparison of the hepatoprotective activity between cultured Cordyceps militaris and natural Cordyceps sinensis. Journal of Functional Foods 4, 489-495, doi: 10. 1016j.jff/2012. 02. 009 (2012).
24. Wang, B.-J., Won, S.-J., Yu, Z.-R., Su, C.-L. Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide. Food and Chemical Toxicology 43, 543-552, doi: 10. 1016j.fct/2004. 12. 008 (2005).
25. Jing, Y., et al. Elucidation and biological activities of a new polysaccharide from cultured Cordyceps militaris. Carbohydrate polymers 102, 288-296, doi: 10. 1016j.carbpol/2013. 11. 061 (2014).
26. Zhang, J., Zhong, X., Li, S., Zhang, G., Liu, X. Metabolic characterization of natural and cultured Ophicordyceps sinensis from different origins by 1H NMR spectroscopy. Journal of pharmaceutical and biomedical analysis 115, 395-401, doi: 10. 1016j.jpba/2015. 07. 035 (2015).
27. Zhang, J., et al. Systems pharmacology dissection of multi-scale mechanisms of action for herbal medicines in stroke treatment and prevention. PloS One 9, e102506, doi: 10. 1371/journal. pone. 0102506 (2014).
28. Ru, J., et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 6, 13, doi: 10. 1186/1758-2946-6-13 (2014).
29. Tao, W., et al. CancerHSP: anticancer herbs database of systems pharmacology. Scientific reports 5, 11481, doi: 10. 1038/srep11481 (2015).
30. Cheng, L., et al. Yindanxinnaotong, a Chinese compound medicine, synergistically attenuates atherosclerosis progress. Scientific reports 5, 12333, doi: 10. 1038/srep12333 (2015).
31. Lu, M. Y., Chen, C. C., Lee, L. Y., Lin, T. W., Kuo, C. F. N(6)-(2-Hydroxyethyl)adenosine in the Medicinal Mushroom Cordyceps cicadae Attenuates Lipopolysaccharide-Stimulated Pro-inflammatory Responses by Suppressing TLR4-Mediated NF-kappaB Signaling Pathways. J Nat Prod 78, 2452-2460, doi: 10. 1021/acs. jnatprod. 5b00573 (2015).
32. Moon, D. O., Lee, K. J., Choi, Y. H., Kim, G. Y. Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells. International immunopharmacology 7, 1044-1053, doi: 10. 1016j.intimp/2007. 03. 010 (2007).
33. Machado, N. J., et al. Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses. Mol Neurobiol, doi: 10. 1007/s12035-016-9774-9 (2016).
34. Garscha, U., et al. BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly. Biochemical pharmacology 119, 17-26, doi: 10. 1016j.bcp/2016. 08. 023 (2016).
35. Nakamura, K., et al. Antitumor effect of cordycepin (3?-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer research 26, 43-47 (2006).
36. Thomadaki, H., Tsiapalis, C. M., Scorilas, A. Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction. Biological chemistry 386, 471-480 (2005).
37. Yang, Q., et al. A novel protein with anti-metastasis activity on 4T1 carcinoma from medicinal fungus Cordyceps militaris. International journal of biological macromolecules 80, 385-391, doi: 10. 1016j.ijbiomac/2015. 06. 050 (2015).
38. Pan, B. S., Wang, Y. K., Lai, M. S., Mu, Y. F., Huang, B. M. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Scientific reports 5 (2015).
39. Ren, Z., et al. Cordycepin suppresses TNF-alpha-induced NF-kappaB activation by reducing p65 transcriptional activity, inhibiting IkappaBalpha phosphorylation, blocking IKKgamma ubiquitination. International immunopharmacology 14, 698-703, doi: 10. 1016j.intimp/2012. 10. 008 (2012).
40. Jen, C. Y., Lin, C. Y., Huang, B. M., Leu, S. F. Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway. Evidence-based complementary and alternative medicine: eCAM 2011, 984537, doi: 10. 1093/ecam/nen084 (2011).
41. Jeong, J. W., et al. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. International immunopharmacology 10, 1580-1586 (2010).
42. Cho, H. J., Cho, J. Y., Rhee, M. H., Park, H. J. Cordycepin (3?-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP-and cyclic GMP-dependent manner. European journal of pharmacology 558, 43-51 (2007).
43. Li, Y., et al. A systems pharmacology approach to investigate the mechanisms of action of Semen Strychni and Tripterygium wilfordii Hook F for treatment of rheumatoid arthritis. Journal of ethnopharmacology 175, 301-314, doi: 10. 1016j.jep/2015. 09. 016 (2015).
44. Liu, J., et al. Pathway as a pharmacological target for herbal medicines: an investigation from reduning injection. PloS one 10, e0123109, doi: 10. 1371/journal. pone. 0123109 (2015).
45. Zheng, C., et al. Large-scale Direct Targeting for Drug Repositioning and Discovery. Scientific reports 5, 11970, doi: 10. 1038/srep11970 (2015).
46. Zhang, B., et al. New strategy for drug discovery by large-scale association analysis of molecular networks of different species. Scientific reports 6, 21872, doi: 10. 1038/srep21872 (2016).
47. Jeong, M. H., et al. Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growth delay in mousederived breast cancer. Oncology reports 30, 1996-2002, doi: 10. 3892/or/2013. 2660 (2013).
48. Lee, S., et al. Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7. 5 cells. Journal of microbiology 53, 468-474, doi: 10. 1007/s12275-015-5198-x (2015).
49. Shashidhar, M. G., Giridhar, P., Udaya Sankar, K., Manohar, B. Bioactive principles from Cordyceps sinensis: A potent food supplement-A review. Journal of Functional Foods 5, 1013-1030, doi: 10. 1016j.jff/2013. 04. 018 (2013).
50. Hall, S., et al. A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression. Food Research International 76, 626-636, doi: 10. 1016j.foodres/2015. 07. 027 (2015).
51. Gupte, A. S., Gupta, D., Ravichandran, S., Ma, M. M., Chouthai, N. S. Effect of early caffeine on neurodevelopmental outcome of very low-birth weight newborns. J Matern-Fetal Neo M 29, 1233-1237, doi: 10. 3109/14767058/2015. 1041493 (2016).
52. Richards, G., Smith, A. Caffeine consumption and self-assessed stress, anxiety, depression in secondary school children. Journal of psychopharmacology 29, 1236-1247, doi: 10. 1177/0269881115612404 (2015).
53. Wang, L., Shen, X., Wu, Y., Zhang, D. Coffee and caffeine consumption and depression: A meta-analysis of observational studies. The Australian and New Zealand journal of psychiatry 50, 228-242, doi: 10. 1177/0004867415603131 (2016).
54. Leon-Carmona, J. R., Galano, A. Is caffeine a good scavenger of oxygenated free radicals? The journal of physical chemistry. B 115, 4538-4546, doi: 10. 1021/jp201383y (2011).
55. Chen, X.-W., Guo, J., Wang, J.-M., Yin, S.-W., Yang, X.-Q. Controlled volatile release of structured emulsions based on phytosterols crystallization. Food Hydrocolloids 56, 170-179, doi: 10. 1016j.foodhyd/2015. 11. 035 (2016).
56. Hac-Wydro, K. The effect of beta-sitosterol on the properties of cholesterol/phosphatidylcholine/ganglioside monolayers-the impact of monolayer fluidity. Colloids and surfaces. B, Biointerfaces 110, 113-119, doi: 10. 1016j.colsurfb/2013. 04. 041 (2013).
57. Shi, C., et al. beta-sitosterol inhibits high cholesterol-induced platelet beta-amyloid release. Journal of bioenergetics and biomembranes 43, 691-697, doi: 10. 1007/s10863-011-9383-2 (2011).
58. Farshori, N. N., Banday, M. R., Zahoor, Z., Rauf, A. DCC/DMAP mediated esterification of hydroxy and non-hydroxy olefinic fatty acids with beta-sitosterol: In vitro antimicrobial activity. Chinese Chem Lett 21, 646-650 (2010).
59. Kawanabe, A., Okamura, Y. Effects of unsaturated fatty acids on the kinetics of voltage-gated proton channels heterologously expressed in cultured cells. The Journal of physiology 594, 595-610, doi: 10. 1113/JP271274 (2016).
60. Li, Y., et al. Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc. PeerJ 4, e1992, doi: 10. 7717/peerj. 1992 (2016).
61. Wang, Z., et al. Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR. Molecules 21, doi: 10. 3390/molecules21101267 (2016).
62. Tao, X., Ning, Y., Zhao, X., Pan, T. The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460. J Pharm Pharmacol 68, 901-911, doi: 10. 1111/jphp. 12544 (2016).
63. Galson, J. D., et al. Erratum to: B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation. Genome Med 8, 81, doi: 10. 1186/s13073-016-0337-5 (2016).
64. Su, X., Pei, Z., Hu, S. Ginsenoside Re as an adjuvant to enhance the immune response to the inactivated rabies virus vaccine in mice. International immunopharmacology 20, 283-289, doi: 10. 1016j.intimp/2014. 03. 008 (2014).
65. Xu, P., Sun, Z., Wang, Y., Miao, C. Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway to inhibit TNF-alpha and IFN-gamma in hepatocellular carcinoma. Experimental cell research 337, 53-60, doi: 10. 1016j.yexcr/2015. 07. 007 (2015).
66. Boehm, U., Klamp, T., Groot, M., Howard, J. C. Cellular responses to interferon-gamma. Annual review of immunology 15, 749-795 (1997).
67. Paul, W. E. History of interleukin-4. Cytokine 75, 3-7, doi: 10. 1016j.cyto/2015. 01. 038 (2015).
68. Qiu, Y., et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157, 1292-1308, doi: 10. 1016j.cell/2014. 03. 066 (2014).
69. Jeong, M. H., et al. Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes. Journal of microbiology and biotechnology 22, 1161-1164 (2012).
70. Shannon, P., et al. Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome research 13, 2498-2504 (2003).