Cordycepin induces apoptosis and inhibits proliferation of human lung cancer cell line H1975 via inhibiting the phosphorylation of EGFR

Molecules

Volumn 21, Issue 10, 2016, Pages

  Wang, Zheng ^a   Wu, Xue ^b   Liang, Yan Ni ^a   Wang, Li ^a   Song, Zhong Xing ^a   Liu, Jian Li ^c   Tang, Zhi Shu ^a  

^a SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c NORTHWEST UNIVERSITY   (China)

Author keywords

Apoptosis; Cordycepin; EGFR; H1975 cell line; Proliferation

Indexed keywords

EID: 84988983064     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21101267     Document Type: Article

References (25)

1. Wang, S.; Cang, S.; Liu, D. Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer. J. Hematol. Oncol. 2016, 9.
2. Yang, Y.; Zhang, B.; Li, R.; Liu, B.; Wang, L. EGFR-tyrosine kinase inhibitor treatment in a patient with advanced non-small cell lung cancer and concurrent exon 19 and 21 EGFR mutations: A case report and review of the literature. Oncol. Lett. 2016, 11, 3546-3550.
3. Wang, Z.; Wang, C.; Sun, Y.; Zhang, N.; Liu, Z.; Liu, J. A novel strategy to the synthesis of 4-anilinoquinazoline derivatives. Tetrahedron 2014, 70, 906-913.
4. Baselga, J.; Averbuch, S.D. ZD1839 ('Iressa') as an anticancer agent. Drugs 2000, 60, 33-40.
5. Ryan, A.J.; Wedge, S.R. ZD6474 - A novel inhibitor of VEGFR and EGFR tyrosine kinase activity. Br. J. Cancer 2005, 92, S6-S13.
6. Wang, Z.; Wu, X.; Wang, L.; Zhang, J.; Liu, J.; Song, Z.; Tang, Z. Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors. Bioorg. Med. Chem. Lett. 2016, 26, 2589-2593.
7. Chen, Y.M. Update of epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer. J. Chin. Med. Assoc. 2013, 76, 249-257.
8. Sequist, L.V.; Waltman, B.A.; Dias-Santagata, D.; Digumarthy, S.; Turke, A.B.; Fidias, P.; Bergethon, K.; Shaw, A.T.; Gettinger, S.; Cosper, A.K.; et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci. Transl. Med. 2011, 3.
9. Yun, C.H.; Mengwasser, K.E.; Toms, A.V.; Woo, M.S.; Greulich, H.; Wong, K.K.; Meyerson, M.; Eck, M.J. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc. Natl. Acad. Sci. USA 2008, 105, 2070-2075.
10. Kobayashi, S.; Boggon, T.J.; Dayaram, T.; Janne, P.A.; Kocher, O.; Meyerson, M.; Johnson, B.E.; Eck, M.J.; Tenen, D.G.; Halmos, B. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2005, 352, 786-792.
11. Zhou, W.; Ercan, D.; Chen, L.; Yun, C.H.; Li, D.; Capelletti, M.; Cortot, A.B.; Chirieac, L.; Iacob, R.E.; Padera, R.; et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462, 1070-1074.
12. Walter, A.O.; Sjin, R.T.; Haringsma, H.J.; Ohashi, K.; Sun, J.; Lee, K.; Dubrovskiy, A.; Labenski, M.; Zhu, Z.; Wang, Z.; et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013, 3, 1404-1415.
13. Tuli, H.S.; Sharma, A.K.; Sandhu, S.S.; Kashyap, D. Cordycepin: A bioactive metabolite with therapeutic potential. Life Sci. 2013, 93, 863-869.
14. Wang, Z.; Wu, X.; Liu, J.L.; Tang, Z.S. Advances in research on Antitumor Activities of Cordycepin. Chin. Pharm. J. 2015, 50, 1365-1368.
15. Vodnala, S.K.; Lundback, T.; Yeheskieli, E.; Sjoberg, B.; Gustavsson, A.L.; Svensson, R.; Olivera, G.C.; Eze, A.A.; de Koning, H.P.; Hammarstrom, L.G.; et al. Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. J. Med. Chem. 2013, 56, 9861-9873.
16. Li, G.; Nakagome, L.; Hirono, S.; Itoh, T.; Fujiwara, R. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Pharmacol. Res. Perspect. 2015, 3.
17. Thomadaki, H.; Tsiapalis, C.M.; Scorilas, A. The effect of the polyadenylation inhibitor cordycepin on human Molt-4 and Daudi leukaemia and lymphoma cell lines. Cancer Chemother. Pharmacol. 2008, 61, 703-711.
18. Nakamura, K.; Yoshikawa, N.; Yamaguchi, Y.; Kagota, S.; Shinozuka, K.; Kunitomo, M. Antitumor effect of cordycepin (3′-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res. 2006, 26, 43-47.
19. Yao, W.L.; Ko, B.S.; Liu, T.A.; Liang, S.M.; Liu, C.C.; Lu, Y.J.; Tzean, S.S.; Shen, T.L.; Liou, J.Y. Cordycepin suppresses integrin/FAK signaling and epithelial-mesenchymal transition in hepatocellular carcinoma. Anticancer Agents Med. Chem. 2014, 14, 29-34.
20. Lee, H.H.; Park, C.; Jeong, J.W.; Kim, M.J.; Seo, M.J.; Kang, B.W.; Park, J.U.; Kim, G.Y.; Choi, B.T.; Choi, Y.H.; et al. Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species mediated mitochondrial death pathway. Int. J. Oncol. 2013, 42, 1036-1044.
21. Chen, Y.; Yang, S.H.; Hueng, D.Y.; Syu, J.P.; Liao, C.C.; Wu, Y.C. Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway. Chem. Biol. Interact. 2014, 216, 17-25.
22. Muller, W.E.; Seibert, G.; Beyer, R.; Breter, H.J.; Maidhof, A.; Zahn, R.K. Effect of cordycepin on nucleic acid metabolism in L5178Y cells and on nucleic acid-synthesizing enzyme systems. Cancer Res. 1977, 37, 3824-3833.
23. Rodman, L.E.; Farnell, D.R.; Coyne, J.M.; Allan, P.W.; Hill, D.L.; Duncan, K.L.; Tomaszewski, J.E.; Smith, A.C.; Page, J.G. Toxicity of cordycepin in combination with the adenosine deaminase inhibitor 2′-deoxycoformycin in beagle dogs. Toxicol. Appl. Pharmacol. 1997, 147, 39-45.
24. Wang, Z.; Wang, C.L.; Li, J.L.; Zhang, N.; Sun, Y.N.; Liu, Z.L.; Tang, Z.S.; Liu, J.L. Synthesis of new 4-anilinoquinazoline analogues and evaluation of their EGFR inhibitor activity. Yao Xue Xue Bao 2015, 50, 1613-1621.
25. Wang, X.A.; Xiang, S.S.; Li, H.F.; Wu, X.S.; Li, M.L.; Shu, Y.J.; Zhang, F.; Cao, Y.; Ye, Y.Y.; Bao, R.F.; et al. Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells. Molecules 2014, 19, 11350-11365.