The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460

Journal of Pharmacy and Pharmacology

Volumn , Issue , 2016, Pages 901-911

  Tao, Xiandong ^a   Ning, Ye ^a   Zhao, Xuewei ^a   Pan, Tiewen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis cordycepin; lung cancer; migration; proliferation

Indexed keywords

CASPASE 3; CORDYCEPIN; CYCLIN B; CYCLIN D; CYCLIN E; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PROTEIN BCL 2; UVOMORULIN; VIMENTIN;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG PURIFICATION; EPITHELIAL MESENCHYMAL TRANSITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG CANCER CELL LINE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84975263650     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12544     Document Type: Article

References (31)

1. Jemal A et al. Global cancer statistics. CA Cancer J Clin 2011; 61: 69–90.
2. Siegel R et al. Cancer statistics, 2014. CA Cancer J Clin 2014; 64: 9–29.
3. Boulikas T, Vougiouka M. Recent clinical trials using cisplatin, carboplatin and their combination chemotherapy drugs (review). Oncol Rep 2004; 11: 559–595.
4. Smith IE et al. Duration of chemotherapy in advanced non–small-cell lung cancer: a randomized trial of three versus six courses of mitomycin, vinblastine, and cisplatin. J Clin Oncol 2001; 19: 1336–1343.
5. Desantis CE et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin 2014; 64: 252–271.
6. Holbein S et al. Cordycepin interferes with 3′ end formation in yeast independently of its potential to terminate RNA chain elongation. RNA 2009; 15: 837–849.
7. Tuli HS et al. Cordycepin: a bioactive metabolite with therapeutic potential. Life Sci 2013; 93: 863–869.
8. Wong YY et al. Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem 2010; 285: 2610–2621.
9. Lee SJ et al. Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. Arch Biochem Biophys 2009; 490: 103–109.
10. Jeong J-W et al. Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt. Int J Oncol 2012; 40: 1697–1704.
11. He W et al. Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules. J Zhejiang Univ Sci B 2010; 11: 654–660.
12. Nakamura K et al. Antitumor effect of cordycepin (3′-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation. Anticancer Res 2006; 26: 43–47.
13. Nakamura K et al. Effect of cordycepin (3′-deoxyadenosine) on hematogenic lung metastatic model mice. In Vivo 2005; 19: 137–141.
14. Wlodkowic D et al. Flow Cytometry-Based Apoptosis Detection, in Apoptosis. Clifton, NJ. Springer, 2009.
15. Schiller JH et al. Comparison of four chemotherapy regimens for advanced non–small-cell lung cancer. N Engl J Med 2002; 346: 92–98.
16. Stinchcombe TE, Bogart JA. Novel approaches of chemoradiotherapy in unresectable stage IIIA and stage IIIB non-small cell lung cancer. Oncologist 2012; 17: 682–693.
17. Ju-Hyon L et al. Anti-cancer effects of cordycepin on oral squamous cell carcinoma proliferation and apoptosis in vitro. J Cancer Ther 2011; 2011: 224–234.
18. Imesch P et al. Cordycepin (3′-deoxyadenosine), an inhibitor of mRNA polyadenylation, suppresses proliferation and activates apoptosis in human epithelial endometriotic cells in vitro. Gynecol Obstet Invest 2010; 72: 43–49.
19. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14: 818–829.
20. Thompson EW, Newgreen DF. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 2005; 65: 5991–5995.
21. Hunter KW et al. Mechanisms of metastasis. Breast Cancer Res 2008; 10(Suppl 1): S2.
22. Nakamura K et al. Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. J Pharmacol Sci 2015; 127: 53–56.
23. Canel M et al. E-cadherin–integrin crosstalk in cancer invasion and metastasis. J Cell Sci 2013; 126: 393–401.
24. Kidd ME et al. The role of vimentin intermediate filaments in the progression of lung cancer. Am J Respir Cell Mol Biol 2014; 50: 1–6.
25. Luo W et al. Aberrant expression of nuclear vimentin and related epithelial–mesenchymal transition markers in nasopharyngeal carcinoma. Int J Cancer 2012; 131: 1863–1873.
26. Aramwit P et al. Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity. Nanoscale Res Lett 2015; 10: 1–10.
27. Park SE et al. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem Toxicol 2009; 47: 1667–1675.
28. Thakur A et al. Pro-apoptotic effects of Paecilomyces hepiali, a Cordyceps sinensis extract on human lung adenocarcinoma A549 cells in vitro. J Cancer Res Ther 2011; 7: 421.
29. Tuli HS et al. Apoptotic effect of cordycepin on A549 human lung cancer cell line. Turk J Biol 2015; 39: 306–311.
30. Choi S et al. Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor. Toxicol Appl Pharmacol 2011; 257: 165–173.
31. Baik J-S et al. Cordycepin induces apoptosis in human neuroblastoma SK-N-BE (2)-C and melanoma SK-MEL-2 cells. 2012.