Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Pan, Bo Syong ^a   Wang, Yang Kao ^a   Lai, Meng Shao ^a   Mu, Yi Fen ^a   Huang, Bu Miin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CORDYCEPIN; DEOXYADENOSINE DERIVATIVE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL; APOPTOSIS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; LEYDIG CELL TUMOR; MALE; METABOLISM; MOUSE; PATHOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DEOXYADENOSINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; LEYDIG CELL TUMOR; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, SCID; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASE; TREATMENT OUTCOME;

EID: 84940041796     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13372     Document Type: Article

References (51)

1. Wagner, E. F. & Nebreda, A. R. Signal integration by JNK and p38 MAPK pathways in cancer development. Nature reviews. Cancer 9, 537-549 (2009).
2. Kyriakis, J. M. & Avruch, J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. Physiological reviews 92, 689-737 (2012).
3. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
4. Fang, J. Y. & Richardson, B. C. The MAPK signalling pathways and colorectal cancer. The lancet oncology 6, 322-327 (2005).
5. Porras, A. et al. P38 alpha mitogen-Activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Molecular biology of the cell 15, 922-933 (2004).
6. Sui, X. et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer letters 344, 174-179 (2014).
7. de la Cruz-Morcillo, M. A. et al. P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance. Oncogene 31, 1073-1085 (2012).
8. Chipuk, J. E. & Green, D. R. Dissecting p53-dependent apoptosis. Cell death and differentiation 13, 994-1002 (2006).
9. Satyanarayana, A., Hilton, M. B. & Kaldis, P. p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint. Molecular biology of the cell 19, 65-77 (2008).
10. Beuvink, I. et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120, 747-759 (2005).
11. Jemal, A. et al. Cancer statistics, 2007. CA Cancer J Clin 57, 43-66 (2007).
12. Kim, I., Young, R. H. & Scully, R. E. Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature. The American journal of surgical pathology 9, 177-192 (1985).
13. Cancer incidence in five continents. Volume VIII. IARC scientific publications, 1-781 (2002).
14. Bertram, K. A., Bratloff, B., Hodges, G. F. & Davidson, H. Treatment of malignant Leydig cell tumor. Cancer 68, 2324-2329 (1991).
15. Bosl, G. J. & Motzer, R. J. Testicular germ-cell cancer. The New England journal of medicine 337, 242-253 (1997).
16. Bokemeyer, C., Berger, C. C., Kuczyk, M. A. & Schmoll, H. J. Evaluation of long-term toxicity after chemotherapy for testicular cancer. J Clin Oncol 14, 2923-2932 (1996).
17. Pont, J. & Albrecht, W. Fertility after chemotherapy for testicular germ cell cancer. Fertility and sterility 68, 1-5 (1997).
18. Lampe, H., Horwich, A., Norman, A., Nicholls, J. & Dearnaley, D. P. Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol 15, 239-245 (1997).
19. Stephenson, W. T., Poirier, S. M., Rubin, L. & Einhorn, L. H. Evaluation of reproductive capacity in germ cell tumor patients following treatment with cisplatin, etoposide, and bleomycin. J Clin Oncol 13, 2278-2280 (1995).
20. Petersen, P. M., Skakkebaek, N. E., Rorth, M. & Giwercman, A. Semen quality and reproductive hormones before and after orchiectomy in men with testicular cancer. The Journal of urology 161, 822-826 (1999).
21. Gerl, A., Muhlbayer, D., Hansmann, G., Mraz, W. & Hiddemann, W. The impact of chemotherapy on Leydig cell function in long term survivors of germ cell tumors. Cancer 91, 1297-1303 (2001).
22. Leu, S. F., Poon, S. L., Pao, H. Y. & Huang, B. M. The in vivo and in vitro stimulatory effects of cordycepin on mouse leydig cell steroidogenesis. Biosci Biotechnol Biochem 75, 723-731 (2011).
23. Pan, B. S., Lin, C. Y. & Huang, B. M. The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells. Evid Based Complement Alternat Med 2011, doi: 750468 (2011).
24. Pao, H. Y., Pan, B. S., Leu, S. F. & Huang, B. M. Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C Pathway. J Agric Food Chem 60, 4905-4913 (2012).
25. Jeong, J. W. et al. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. International immunopharmacology 10, 1580-1586 (2010).
26. Cho, H. J., Cho, J. Y., Rhee, M. H. & Park, H. J. Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP-And cyclic GMP-dependent manner. European journal of pharmacology 558, 43-51 (2007).
27. Wu, W. C., Hsiao, J. R., Lian, Y. Y., Lin, C. Y. & Huang, B. M. The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line. Cancer Chemother Pharmacol 60, 103-111 (2007).
28. Jen, C. Y., Lin, C. Y., Huang, B. M. & Leu, S. F. Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway. Evid Based Complement Alternat Med 2011, doi: 984537 (2011).
29. Zhang, P. et al. Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b. Oncotarget 6, 9834-9853 (2015).
30. Liao, Y. et al. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells. Cell cycle 14, 761-771 (2015).
31. Oosterhuis, J. W. & Looijenga, L. H. Testicular germ-cell tumours in a broader perspective. Nature reviews. Cancer 5, 210-222 (2005).
32. Albers, P. et al. EAU guidelines on testicular cancer: 2011 update. Eur Urol 60, 304-319 (2011).
33. Efeyan, A. et al. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 493, 679-683 (2013).
34. Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nature reviews. Drug discovery 8, 579-591 (2009).
35. Nicol, S. M. et al. The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage. Oncogene 32, 3461-3469 (2013).
36. Massague, J., Blain, S. W. & Lo, R. S. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309 (2000).
37. Rudner, J. et al. Type I and type II reactions in TRAIL-induced apoptosis-results from dose-response studies. Oncogene 24, 130-140 (2005).
38. Sabnis, G., Schayowitz, A., Goloubeva, O., Macedo, L. & Brodie, A. Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen. Cancer research 69, 1416-1428 (2009).
39. Oskouian, B. et al. Sphingosine-1-phosphate lyase potentiates apoptosis via p53-And p38-dependent pathways and is downregulated in colon cancer. Proceedings of the National Academy of Sciences of the United States of America 103, 17384-17389 (2006).
40. Engelman, J. A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nature reviews. Cancer 9, 550-562 (2009).
41. Mathew, R., Karantza-Wadsworth, V. & White, E. Role of autophagy in cancer. Nature reviews. Cancer 7, 961-967 (2007).
42. Lu, J., Sharma, L. K. & Bai, Y. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell research 19, 802-815 (2009).
43. Fujiwara, K. et al. Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy. The Journal of biological chemistry 283, 388-397 (2008).
44. Bauer, J., Sporn, J. C., Cabral, J., Gomez, J. & Jung, B. Effects of activin and TGFbeta on p21 in colon cancer. PloS one 7, doi: e39381 (2012).
45. Wu, Y. C. et al. Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4. Cancer research 72, 4963-4973 (2012).
46. Nitzsche, B. et al. Anti-tumour activity of two novel compounds in cisplatin-resistant testicular germ cell cancer. British journal of cancer 107, 1853-1863 (2012).
47. Yang, H. et al. Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. Cancer research 72, 779-789 (2012).
48. Ascoli, M. Characterization of several clonal lines of cultured Leydig tumor cells: gonadotropin receptors and steroidogenic responses. Endocrinology 108, 88-95 (1981).
49. Mather, J. P. Establishment and characterization of two distinct mouse testicular epithelial cell lines. Biology of reproduction 23, 243-252 (1980).
50. Huang, B. M., Stocco, D. M. & Norman, R. L. The cellular mechanisms of corticotropin-releasing hormone (CRH)-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH. Journal of andrology 18, 528-534 (1997).
51. Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS biology 8, doi: e1000412 (2010).