The cancer epigenome: Concepts, challenges, and therapeutic opportunities

Science

Volumn 355, Issue 6330, 2017, Pages 1147-1152

  Dawson, Mark A ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CELLS AND CELL COMPONENTS; GENETIC ANALYSIS; GENOME; LITERATURE REVIEW; MOLECULAR ANALYSIS; PLASTICITY;

CHROMATIN; EPIGENETICS; GENE MUTATION; HUMAN; MALIGNANT NEOPLASM; METABOLISM; PLASTICITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; THERAPY; ANTAGONISTS AND INHIBITORS; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; DRUG DESIGN; DRUG EFFECTS; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; MOLECULAR LIBRARY; MOLECULARLY TARGETED THERAPY; MUTATION; NEOPLASMS; PHARMACOLOGY; PROTEIN DOMAIN; THERAPEUTIC USE;

IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN; MOLECULAR LIBRARY;

CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; DRUG DESIGN; EPIGENESIS, GENETIC; HUMANS; ISOCITRATE DEHYDROGENASE; MOLECULAR TARGETED THERAPY; MUTATION; NEOPLASMS; PROTEIN DOMAINS; SMALL MOLECULE LIBRARIES; TRANSCRIPTION, GENETIC;

EID: 85015289156     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aam7304     Document Type: Review

References (74)

1. K. Luger, M. L. Dechassa, D. J. Tremethick, Nat. Rev. Mol. Cell Biol. 13, 436-447 (2012).
2. E. Segal, J. Widom, Trends Genet. 25, 335-343 (2009).
3. C. D. Allis, M.-L. Caparros, T. Jenuwein, D. Reinberg, Epigenetics (Cold Spring Harbor Laboratory Press, ed. 2, 2015).
4. A. J. Bannister, T. Kouzarides, Cell Res. 21, 381-395 (2011).
5. Z. Gao et al., Mol. Cell 45, 344-356 (2012).
6. A. Piunti, A. Shilatifard, Science 352, aad9780 (2016).
7. L. Di Croce, K. Helin, Nat. Struct. Mol. Biol. 20, 1147-1155 (2013).
8. K. Klauke et al., Nat. Cell Biol. 15, 353-362 (2013).
9. L. Morey et al., Cell Stem Cell 10, 47-62 (2012).
10. A. M. Schmitt, H. Y. Chang, Cancer Cell 29, 452-463 (2016).
11. K. V. Morris, J. S. Mattick, Nat. Rev. Genet. 15, 423-437 (2014).
12. L. A. Garraway, E. S. Lander, Cell 153, 17-37 (2013).
13. M. A. Dawson, T. Kouzarides, Cell 150, 12-27 (2012).
14. B. Vogelstein et al., Science 339, 1546-1558 (2013).
15. C. Kadoch, G. R. Crabtree, Sci. Adv. 1, e1500447 (2015).
16. D. Sturm et al., Nat. Rev. Cancer 14, 92-107 (2014).
17. C. Lu et al., Science 352, 844-849 (2016).
18. R. P. Halley-Stott, J. B. Gurdon, Brief. Funct. Genomics 12, 164-173 (2013).
19. G. Q. Daley, Cell 151, 1151-1154 (2012).
20. A. Sánchez Alvarado, S. Yamanaka, Cell 157, 110-119 (2014).
21. J. P. Thiery, H. Acloque, R. Y. Huang, M. A. Nieto, Cell 139, 871-890 (2009).
22. W. L. Tam, R. A. Weinberg, Nat. Med. 19, 1438-1449 (2013).
23. P. Voigt, W. W. Tee, D. Reinberg, Genes Dev. 27, 1318-1338 (2013).
24. K. Basso, R. Dalla-Favera, Nat. Rev. Immunol. 15, 172-184 (2015).
25. M. Xie et al., Nat. Med. 20, 1472-1478 (2014).
26. S. Jaiswal et al., N. Engl. J. Med. 371, 2488-2498 (2014).
27. G. Genovese et al., N. Engl. J. Med. 371, 2477-2487 (2014).
28. B. A. Woods, R. L. Levine, Immunol. Rev. 263, 22-35 (2015).
29. L. I. Shlush et al., Nature 506, 328-333 (2014).
30. N. Weinhold, A. Jacobsen, N. Schultz, C. Sander, W. Lee, Nat. Genet. 46, 1160-1165 (2014).
31. D. Perera et al., Nature 532, 259-263 (2016).
32. R. Katainen et al., Nat. Genet. 47, 818-821 (2015).
33. F. W. Huang et al., Science 339, 957-959 (2013).
34. S. Horn et al., Science 339, 959-961 (2013).
35. S. Gröschel et al., Cell 157, 369-381 (2014).
36. H. Yamazaki et al., Cancer Cell 25, 415-427 (2014).
37. J. Lovén et al., Cell 153, 320-334 (2013).
38. O. Gilan et al., Nat. Struct. Mol. Biol. 23, 673-681 (2016).
39. M. R. Mansour et al., Science 346, 1373-1377 (2014).
40. D. A. Oldridge et al., Nature 528, 418-421 (2015).
41. N. N. Pavlova, C. B. Thompson, Cell Metab. 23, 27-47 (2016).
42. W. A. Flavahan et al., Nature 529, 110-114 (2016).
43. M. Sciacovelli et al., Nature 537, 544-547 (2016).
44. N. Shyh-Chang et al., Science 339, 222-226 (2013).
45. L. Cai, B. M. Sutter, B. Li, B. P. Tu, Mol. Cell 42, 426-437 (2011).
46. R. Deplus et al., EMBO J. 32, 645-655 (2013).
47. P. A. Jones, J. P. Issa, S. Baylin, Nat. Rev. Genet. 17, 630-641 (2016).
48. K. J. Falkenberg, R. W. Johnstone, Nat. Rev. Drug Discov. 13, 673-691 (2014).
49. S. C. Mack et al., Nature 506, 445-450 (2014).
50. L. Cerchietti, A. Melnick, J. Clin. Oncol. JCO2016710616 (2017).
51. P. Fenaux et al., Lancet Oncol. 10, 223-232 (2009).
52. L. Pleyer, R. Greil, Drug Metab. Rev. 47, 252-279 (2015).
53. K. B. Chiappinelli et al., Cell 162, 974-986 (2015).
54. D. Roulois et al., Cell 162, 961-973 (2015).
55. L. Sigalotti, E. Fratta, S. Coral, M. Maio, Pharmacol. Ther. 142, 339-350 (2014).
56. P. Filippakopoulos et al., Nature 468, 1067-1073 (2010).
57. E. M. Stein, M. S. Tallman, Blood 127, 71-78 (2016).
58. S. R. Daigle et al., Cancer Cell 20, 53-65 (2011).
59. M. A. Dawson et al., Nature 478, 529-533 (2011).
60. J. Zuber et al., Nature 478, 524-528 (2011).
61. W. J. Harris et al., Cancer Cell 21, 473-487 (2012).
62. C. Berthon et al., Lancet Haematol. 3, e186-e195 (2016).
63. R. Rodriguez, K. M. Miller, Nat. Rev. Genet. 15, 783-796 (2014).
64. C. Y. Fong et al., Nature 525, 538-542 (2015).
65. P. Rathert et al., Nature 525, 543-547 (2015).
66. B. Knoechel et al., Nat. Genet. 46, 364-370 (2014).
67. T. Prebet et al., J. Clin. Oncol. 32, 1242-1248 (2014).
68. J. P. Issa et al., Cancer 121, 556-561 (2015).
69. S. M. Chan et al., Nat. Med. 21, 178-184 (2015).
70. C. Fellmann, S. W. Lowe, Nat. Cell Biol. 16, 10-18 (2014).
71. F. J. Sánchez-Rivera, T. Jacks, Nat. Rev. Cancer 15, 387-395 (2015).
72. J. Shi et al., Nat. Biotechnol. 33, 661-667 (2015).
73. Y. Kagoya et al., J. Clin. Invest. 126, 3479-3494 (2016).
74. H. Zhu et al., Cell Rep. 16, 2829-2837 (2016).