Cancer: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

Science

Volumn 352, Issue 6287, 2016, Pages 844-849

  Lu, Chao ^a   Jain, Siddhant U ^b,c   Hoelper, Dominik ^b,c   Bechet, Denise ^d   Molden, Rosalynn C ^e,f,q   Ran, Leili ^g   Murphy, Devan ^g   Venneti, Sriram ^h   Hameed, Meera ^g   Pawel, Bruce R ⁱ   Wunder, Jay S ^j,k   Dickson, Brendan C ^j,l   Lundgren, Stefan M ^b,c   Jani, Krupa S ^f   De Jay, Nicolas ^d   Papillon Cavanagh, Simon ^d   Andrulis, Irene L ^j,l,m   Sawyer, Sarah L ⁿ   Grynspan, David ⁿ   Turcotte, Robert E ^o   Nadaf, Javad ^d   Fahiminiyah, Somayyeh ^d   Muir, Tom W ^f   Majewski, Jacek ^d   Thompson, Craig B ^g   Chi, Ping ^g,p   Garcia, Benjamin A ^e   Allis, C David ^a   Jabado, Nada ^d   Lewis, Peter W ^b,c   more..

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f PRINCETON UNIVERSITY   (United States)

^g MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^h UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

ⁱ UNIVERSITY OF PENNSYLVANIA   (United States)

^j MOUNT SINAI HOSPITAL   (Canada)

^k UNIVERSITY OF TORONTO   (Canada)

^l UNIVERSITY OF TORONTO   (Canada)

^m MOUNT SINAI HOSPITAL   (Canada)

ⁿ CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^o MONTREAL GENERAL HOSPITAL   (Canada)

^p WEILL CORNELL MEDICAL COLLEGE   (United States)

^q REGENERON PHARMACEUTICALS INC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; HISTONE H3; HISTONE; LYSINE; METHIONINE; METHYLTRANSFERASE; NUCLEOSOME;

CANCER; GENE EXPRESSION; GENOME; INHIBITION; METHYLATION; MUTATION; PROTEIN;

ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CHONDROBLASTOMA; CHONDROSARCOMA; ENZYME INHIBITION; GENE MUTATION; GENE REPRESSION; GLIOMA; HISTONE METHYLATION; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; SARCOMA; SARCOMAGENESIS; SOFT TISSUE SARCOMA; ANIMAL; BONE TUMOR; CANCER STEM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MESENCHYMAL STROMA CELL; METABOLISM; METHYLATION; MISSENSE MUTATION; MOUSE; MUTATION; NUCLEOSOME; PATHOLOGY; PRESCHOOL CHILD;

ANIMALS; BONE NEOPLASMS; CARCINOGENESIS; CHILD, PRESCHOOL; CHONDROBLASTOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; LYSINE; MESENCHYMAL STROMAL CELLS; METHIONINE; METHYLATION; METHYLTRANSFERASES; MICE; MUTATION; MUTATION, MISSENSE; NEOPLASTIC STEM CELLS; NUCLEOSOMES; POLYCOMB REPRESSIVE COMPLEX 1; SARCOMA;

EID: 84969204062     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7272     Document Type: Article

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