Health benefits of aerobic training programs in adults aged 70 and over: a systematic review

Archives of Gerontology and Geriatrics

Volumn 69, Issue , 2017, Pages 110-127

  Bouaziz, Walid ^a,b   Vogel, Thomas ^a,b   Schmitt, Elise ^a,b   Kaltenbach, Georges ^a   Geny, Bernard ^a,b   Lang, Pierre Olivier ^c,d  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c ANGLIA RUSKIN UNIVERSITY   (United Kingdom)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Active aging; Aerobic training; Health benefits; Healthy aging; Older adults; Senior fitness

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

AEROBIC EXERCISE; AGING; BODY COMPOSITION; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR FUNCTION; CHOLESTEROL BLOOD LEVEL; COGNITION; DIASTOLIC BLOOD PRESSURE; GLUCOSE METABOLISM; HEALTH PROGRAM; HUMAN; INTERVENTION STUDY; MUSCLE STRENGTH; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PEER REVIEW; PHYSICAL ACTIVITY; POPULATION RESEARCH; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; TRAINING; TRIACYLGLYCEROL BLOOD LEVEL; AGED; EXERCISE TOLERANCE; FITNESS; KINESIOTHERAPY; PHYSIOLOGY; PROCEDURES;

AGED; AGING; COGNITION; EXERCISE THERAPY; EXERCISE TOLERANCE; HUMANS; MUSCLE STRENGTH; PHYSICAL FITNESS; QUALITY OF LIFE;

EID: 84998699254     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2016.10.012     Document Type: Review

References (86)

1. Albinet, C.T., Boucard, G., Bouquet, C.A., Audiffren, M., Increased heart rate variability and executive performance after aerobic training in the elderly. Eur J Appl Physiol. 109 (2010), 617–624, 10.1007/s00421-010-1393-y.
2. American College of Sports Medicine, Chodzko-Zajko, W.J., Proctor, D.N., Fiatarone Singh, M.A., Minson, C.T., Nigg, C.R., et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc. 41 (2009), 1510–1530, 10.1249/MSS.0b013e3181a0c95c.
3. Babcock, M.A., Paterson, D.H., Cunningham, D.A., Effects of aerobic endurance training on gas exchange kinetics of older men. Med Sci Sports Exerc. 26 (1994), 447–452.
4. Baker, M.K., Atlantis, E., Fiatarone Singh, M.A., Multimodal exercise programs for older adults. Age Ageing. 36 (2007), 375–381.
5. Bouaziz, W., Lang, P.O., Schmitt, E., Kaltenbach, G., Geny, B., Vogel, T., Health benefits of multicomponent training programmes in seniors: a systematic review. Int J Clin Pract. 70 (2016), 520–536, 10.1111/ijcp.12822.
6. Bouaziz, W., Schmitt, E., Kaltenbach, G., Geny, B., Vogel, T., Health benefits of endurance training alone or combined with diet for obese patients over 60: a review. Int J Clin Pract. 69 (2015), 1032–1049, 10.1111/ijcp.12648.
7. Bouaziz, W., Schmitt, E., Kaltenbach, G., Geny, B., Vogel, T., Health benefits of cycle ergometer training for older adults over 70: a review. Eur Rev Aging Phys Act, 12, 2015, 8, 10.1186/s11556-015-0152-9.
8. Buchner, D.M., Cress, M.E., de Lateur, B.J., Esselman, P.C., Margherita, A.J., Price, R., et al. The effect of strength and endurance training on gait, balance, fall risk, and health services use in community-living older adults. J Gerontol A Biol Sci Med Sci. 52 (1997), M218–224.
9. Buford, T.W., Manini, T.M., Hsu, F.-C., Cesari, M., Anton, S.D., Nayfield, S., et al. Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise. J Am Geriatr Soc. 60 (2012), 1244–1252, 10.1111/j.1532-5415.2012.04045.x.
10. Charifi, N., Kadi, F., Féasson, L., Costes, F., Geyssant, A., Denis, C., Enhancement of microvessel tortuosity in the vastus lateralis muscle of old men in response to endurance training. J Physiol. 554 (2004), 559–569, 10.1113/jphysiol.2003.046953.
11. Coker, R.H., Hays, N.P., Williams, R.H., Brown, A.D., Freeling, S.A., Kortebein, P.M., et al. Exercise-induced changes in insulin action and glycogen metabolism in elderly adults. Med Sci Sports Exerc. 38 (2006), 433–438, 10.1249/01.mss.0000191417.48710.11.
12. Coker, R.H., Williams, R.H., Kortebein, P.M., Sullivan, D.H., Evans, W.J., Influence of exercise intensity on abdominal fat and adiponectin in elderly adults. Metab Syndr Relat Disord. 7 (2009), 363–368, 10.1089/met.2008.0060.
13. Cononie, C.C., Graves, J.E., Pollock, M.L., Phillips, M.I., Sumners, C., Hagberg, J.M., Effect of exercise training on blood pressure in 70- to 79-yr-old men and women. Med Sci Sports Exerc. 23 (1991), 505–511.
14. de Labra, C., Guimaraes-Pinheiro, C., Maseda, A., Lorenzo, T., Millán-Calenti, J.C., Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trials. BMC Geriatr., 15, 2015, 154, 10.1186/s12877-015-0155-4.
15. de Souto Barreto, P., Morley, J.E., Chodzko-Zajko, W., Pitkala, K.H., Weening-Djiksterhuis, E., Rodriguez-Mañas, L., et al. Recommendations on Physical Activity and Exercise for Older Adults Living in Long-Term Care Facilities: A Taskforce Report. J Am Med Dir Assoc., 2016, 10.1016/j.jamda.2016.01.021.
16. Denison, H.J., Syddall, H.E., Dodds, R., Martin, H.J., Finucane, F.M., Griffin, S.J., et al. Effects of aerobic exercise on muscle strength and physical performance in community-dwelling older people from the Hertfordshire cohort study: a randomized controlled trial. J Am Geriatr Soc. 61 (2013), 1034–1036, 10.1111/jgs.12286.
17. Denton, F.T., Spencer, B.G., Chronic health conditions: changing prevalence in an aging population and some implications for the delivery of health care services. Can J Aging. 29 (2010), 11–21, 10.1017/S0714980809990390.
18. DiPietro, L., Dziura, J., Yeckel, C.W., Neufer, P.D., Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol (1985) 100 (2006), 142–149, 10.1152/japplphysiol.00474.2005.
19. DiPietro, L., Seeman, T.E., Stachenfeld, N.S., Katz, L.D., Nadel, E.R., Moderate-intensity aerobic training improves glucose tolerance in aging independent of abdominal adiposity. J Am Geriatr Soc. 46 (1998), 875–879.
20. Enette L., Vogel T., Fanon J. L., & Lang P. O., Interval or continuous training to impact BDNF level in health and disease: A systematic review. Rejuvenation Res. in press.
21. Evans, E.M., Racette, S.B., Peterson, L.R., Villareal, D.T., Greiwe, J.S., Holloszy, J.O., Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds. J Appl Physiol (1985) 98 (2005), 40–45, 10.1152/japplphysiol.00928.2004.
22. Fahlman, M.M., Boardley, D., Lambert, C.P., Flynn, M.G., Effects of endurance training and resistance training on plasma lipoprotein profiles in elderly women. J Gerontol A Biol Sci Med Sci. 57 (2002), B54–60.
23. Finucane, F.M., Sharp, S.J., Purslow, L.R., Horton, K., Horton, J., Savage, D.B., et al. The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial. Diabetologia 53 (2010), 624–631, 10.1007/s00125-009-1641-z.
24. Foster, V.L., Hume, G.J., Byrnes, W.C., Dickinson, A.L., Chatfield, S.J., Endurance training for elderly women: moderate vs low intensity. J Gerontol. 44 (1989), M184–188.
25. Franco, M.R., Tong, A., Howard, K., Sherrington, C., Ferreira, P.H., Pinto, R.Z., Ferreira, M.L., Older people's perspectives on participation in physical activity: a systematic review and thematic synthesis of qualitative literature. Br J Sports Med. 49 (2015), 1268–1276, 10.1136/bjsports-2014-094015.
26. Gordon, N.F., Gulanick, M., Costa, F., Fletcher, G., Franklin, B.A., Roth, E.J., Shephard, T., American Heart Association Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation and Prevention, The Council on Cardiovascular Nursing, The Council on Nutrition, Physical Activity, and Metabolism, The Stroke Council, Physical activity and exercise recommendations for stroke survivors: an American heart association scientific statement from the council on clinical cardiology, subcommittee on exercise, cardiac rehabilitation, and prevention; the council on cardiovascular nursing; the council on nutrition, physical activity, and metabolism; and the stroke council. Stoke 35 (2004), 1230–1240, 10.1161/01.STR.0000127303.19261.19.
27. Höfer, S., Lim, L., Guyatt, G., Oldridge, N., The MacNew Heart Disease health-related quality of life instrument: a summary. Health Qual Life Outcomes, 2, 2004, 3, 10.1186/1477-7525-2-3.
28. Haber, P., Höniger, B., Klicpera, M., Niederberger, M., Effects in elderly people 67-76 years of age of three-month endurance training on a bicycle ergometer. Eur Heart J. 5:Suppl. E (1984), 37–39.
29. Harber, M.P., Konopka, A.R., Douglass, M.D., Minchev, K., Kaminsky, L.A., Trappe, T.A., et al. Aerobic exercise training improves whole muscle and single myofiber size and function in older women. Am J Physiol Regul Integr Comp Physiol. 297 (2009), R1452–1459, 10.1152/ajpregu.00354.2009.
30. Hersey, W.C., Graves, J.E., Pollock, M.L., Gingerich, R., Shireman, R.B., Heath, G.W., et al. Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women. Metabolism 43 (1994), 847–854.
31. Huang, G., Thompson, C., Osness, W., Influence of a 10-Week Controlled Exercise Program on Resting Blood Pressure in Sedentary Older Adults. J Appl Res. 3 (2006), 188–195.
32. Hutton, I., Gamble, G., Mclean, G., Butcher, H., Gow, P., Dalbeth, N., Obstacles to action in arthritis: a community case-control study. International Int J Rheum Dis. 12 (2009), 107–117.
33. Kemoun, G., Thibaud, M., Roumagne, N., Carette, P., Albinet, C., Toussaint, L., et al. Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dement Geriatr Cogn Disord. 29 (2010), 109–114, 10.1159/000272435.
34. Keogh, J.W.L., Kilding, A., Pidgeon, P., Ashley, L., Gillis, D., Physical benefits of dancing for healthy older adults: a review. J Aging Phys Act. 17 (2009), 479–500.
35. Kitzman, D.W., Brubaker, P.H., Herrington, D.M., Morgan, T.M., Stewart, K.P., Hundley, W.G., et al. Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol. 62 (2013), 584–592, 10.1016/j.jacc.2013.04.033.
36. Koo, J.P., Moon, O.K., Effect of Aerobic Exercise on Cognitive Function in the Elderly persons. J Int Acad Phys Ther Res 3 (2012), 453–457, 10.5854/JIAPTR.2012.10.30.453.
37. Lang, P.O., Bréchat, P.H., Vogel, T., Lebreton, C., Bellanger, M., Rivière, D., Regnard, J., Leprêtre, P.M., Lonsdorfer, J., Determinants of the benefits of a short-term personalized intermittent work exercise program (IWEP) among seniors: Results from the CAPS program. Eur Geriatr Med. 7 (2016), 333–339, 10.1016/j.eurger.2016.05.004.
38. Lang, P.O., Dramé, M., Demographical ageing: How can we measure the quality of our future. Neurol Psychiatr Geriatr. 13 (2013), 256–266.
39. Lang, P.O., Govind, S., Aspinall, R., Reversing T cell immunosenescence: why, who, and how. Age Dordr Neth. 35 (2013), 609–620, 10.1007/s11357-012-9393-y.
40. Lang, P.O., Mahmoudi, R., Novella, J.-L., Tardieu, E., Bertholon, L.-A., Nazeyrollas, P., et al. Is obesity a marker of robustness in vulnerable hospitalized aged populations? Prospective, multicenter cohort study of 1 306 acutely ill patients. J Nutr Health Aging. 18 (2014), 66–74, 10.1007/s12603-013-0352-9.
41. Lang, P.O., Trivalle, C., Vogel, T., Proust, J., Papazian, J.-P., Markers of metabolic and cardiovascular health in adults: Comparative analysis of DEXA-based body composition components and BMI categories. J Cardiol 65 (2015), 42–49, 10.1016/j.jjcc.2014.03.010.
42. Lee, L.L., Arthur, A., Avis, M., Evaluating a community-based walking intervention for hypertensive older people in Taiwan: a randomized controlled trial. Prev Med. 44 (2007), 160–166, 10.1016/j.ypmed.2006.09.001.
43. Loprinzi, P.D., Multimorbidity cognitive function, and physical activity. Age Dordr Neth., 38, 2016, 8, 10.1007/s11357-016-9874-5.
44. Lovell, D.I., Cuneo, R., Gass, G.C., Can aerobic training improve muscle strength and power in older men?. J Aging Phys Act. 18 (2010), 14–26.
45. Lovell, D.I., Cuneo, R., Wallace, J., McLellan, C., The hormonal response of older men to sub-maximum aerobic exercise: the effect of training and detraining. Steroids 77 (2012), 413–418, 10.1016/j.steroids.2011.12.022.
46. Madden, K.M., Lockhart, C., Cuff, D., Potter, T.F., Meneilly, G.S., Short-term aerobic exercise reduces arterial stiffness in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. Diabetes Care 32 (2009), 1531–1535, 10.2337/dc09-0149.
47. Madden, K.M., Lockhart, C., Potter, T.F., Cuff, D., Aerobic training restores arterial baroreflex sensitivity in older adults with type 2 diabetes, hypertension, and hypercholesterolemia. Clin J Sport Med. 20 (2010), 312–317, 10.1097/JSM.0b013e3181ea8454.
48. Malbut, K.E., Dinan, S., Young, A., Aerobic training in the oldest old: the effect of 24 weeks of training. Age Ageing. 31 (2002), 255–260.
49. Mangione, K.K., McCully, K., Gloviak, A., Lefebvre, I., Hofmann, M., Craik, R., The effects of high-intensity and low-intensity cycle ergometry in older adults with knee osteoarthritis. J Gerontol A Biol Sci Med Sci. 54 (1999), M184–190.
50. Martins, R.A., Neves, A.P., Coelho-Silva, M.J., Veríssimo, M.T., Teixeira, A.M., The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults. Eur J Appl Physiol. 110 (2010), 161–169, 10.1007/s00421-010-1488-5.
51. McHorney, C.A., Ware, J.E. Jr., Raczek, A.E., The MOS 36-Item Short-Form Health Survey (SF-36): II: Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care 31 (1993), 247–263.
52. McMurray, R.G., Hackney, A.C., Interactions of metabolic hormones, adipose tissue and exercise. Sports Med. 35 (2005), 393–412.
53. Miu, D.K.Y., Szeto, S.L., Mak, Y.F., A randomised controlled trial on the effect of exercise on physical, cognitive and affective function in dementia subjects. Asian J Gerontol Geriatr 3 (2008), 8–16.
54. Motoyama, M., Sunami, Y., Kinoshita, F., Irie, T., Sasaki, J., Arakawa, K., et al. The effects of long-term low intensity aerobic training and detraining on serum lipid and lipoprotein concentrations in elderly men and women. Eur J Appl Physiol. 70 (1995), 126–131.
55. Motoyama, M., Sunami, Y., Kinoshita, F., Kiyonaga, A., Tanaka, H., Shindo, M., et al. Blood pressure lowering effect of low intensity aerobic training in elderly hypertensive patients. Med Sci Sports Exerc. 30 (1998), 818–823.
56. Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., Atwood, J.E., Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 346 (2002), 793–801, 10.1056/NEJMoa011858.
57. Ozkaya, G.Y., Aydin, H., Toraman, F.N., Kizilay, F., Ozdemir, O., Cetinkaya, V., Effect of Strength and Endurance Training on Cognition in Older People. J Sports Sci Med. 4 (2005), 300–313.
58. Palleschi, L., Vetta, F., De Gennaro, E., Idone, G., Sottosanti, G., Gianni, W., et al. Effect of aerobic training on the cognitive performance of elderly patients with senile dementia of Alzheimer type. Arch Gerontol Geriatr. 22:Suppl. 1 (1996), 47–50, 10.1016/0167-4943(96)86912-3.
59. Pedersen, B.K., Saltin, B., Exercise as medicine − evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports 25 (2015), 1–72, 10.1111/sms.12581.
60. Perini, R., Fisher, N., Veicsteinas, A., Pendergast, D.R., Aerobic training and cardiovascular responses at rest and during exercise in older men and women. Med Sci Sports Exerc. 34 (2002), 700–708.
61. Petter, M., Blanchard, C., Kemp, K.A., Mazoff, A.S., Ferrier, S.N., Correlates of exercise among coronary heart disease patients: review, implications and future directions. Eur J Cardiovascular Prev Rehabil 16 (2009), 515–526, 10.1097/HJR.0b013e3283299585.
62. Pichot, V., Roche, F., Denis, C., Garet, M., Duverney, D., Costes, F., et al. Interval training in elderly men increases both heart rate variability and baroreflex activity. Clin Auton Res. 15 (2005), 107–115, 10.1007/s10286-005-0251-1.
63. Pothirat, C., Chaiwong, W., Phetsuk, N., Liwsrisakun, C., Bumroongkit, C., Deesomchok, A., et al. Long-term efficacy of intensive cycle ergometer exercise training program for advanced COPD patients. Int J Chron Obstruct Pulmon Dis. 10 (2015), 133–144, 10.2147/COPD.S73398.
64. Probart, C.K., Notelovitz, M., Martin, D., Khan, F.Y., Fields, C., The effect of moderate aerobic exercise on physical fitness among women 70 years and older. Maturitas 14 (1991), 49–56.
65. Ryan, D.J., Stebbings, G.K., Onambele, G.L., The emergence of sedentary behaviour physiology and its effects on the cardiometabolic profile in young and older adults. Age Dordr Neth., 37, 2015, 89, 10.1007/s11357-015-9832-7.
66. Scherder, E.J.A., Van Paasschen, J., Deijen, J.-B., Van Der Knokke, S., Orlebeke, J.F.K., Burgers, I., et al. Physical activity and executive functions in the elderly with mild cognitive impairment. Aging Ment Health 9 (2005), 272–280, 10.1080/13607860500089930.
67. Shigematsu, R., Chang, M., Yabushita, N., Sakai, T., Nakagaichi, M., Nho, H., et al. Dance-based aerobic exercise may improve indices of falling risk in older women. Age Ageing 31 (2002), 261–266.
68. Sial, S., Coggan, A.R., Hickner, R.C., Klein, S., Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects. Am J Physiol. 274 (1998), E785–790.
69. Sipila, S., Multanen, J., Kallinen, M., Era, P., Suominen, H., Effects of strength and endurance training on isometric muscle strength and walking speed in elderly women. Acta Physiol Scand. 156 (1996), 457–464, 10.1046/j.1365-201X.1996.461177000.x.
70. St Sauver, J.L., Boyd, C.M., Grossardt, B.R., Bobo, W.V., Finney Rutten, L.J., Roger, V.L., et al. Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity. BMJ Open, 5, 2015, e006413, 10.1136/bmjopen-2014-006413.
71. Strasser, B., Keinrad, M., Haber, P., Schobersberger, W., Efficacy of systematic endurance and resistance training on muscle strength and endurance performance in elderly adults-a randomized controlled trial. Wien Klin Wochenschr 121 (2009), 757–764, 10.1007/s00508-009-1273-9.
72. Sung, K., Bae, S., Effects of a regular walking exercise program on behavioral and biochemical aspects in elderly people with type II diabetes. Nurs Health Sci. 14 (2012), 438–445, 10.1111/j.1442-2018.2012.00690.x.
73. Temfemo, A., Chlif, M., Mandengue, S.H., Lelard, T., Choquet, D., Ahmaidi, S., Is there a beneficial effect difference between age, gender, and different cardiac pathology groups of exercise training at ventilatory threshold in cardiac patients?. Cardiol J. 18 (2011), 632–638.
74. Tsai, J.C., Chan, P., Wang, C.H., Jeng, C., Hsieh, M.H., Kao, P.F., et al. The effects of exercise training on walking function and perception of health status in elderly patients with peripheral arterial occlusive disease. J Intern Med. 252 (2002), 448–455.
75. Vaitkevicius, P.V., Ebersold, C., Shah, M.S., Gill, N.S., Katz, R.L., Narrett, M.J., et al. Effects of aerobic exercise training in community-based subjects aged 80 and older: a pilot study. J Am Geriatr Soc. 50 (2002), 2009–2013.
76. Valenzuela, T., Efficacy of progressive resistance training interventions in older adults in nursing homes: a systematic review. J Am Med Dir Assoc. 13 (2012), 418–428, 10.1016/j.jamda.2011.11.001.
77. Varela, S., Ayán, C., Cancela, J.M., Martín, V., Effects of two different intensities of aerobic exercise on elderly people with mild cognitive impairment: a randomized pilot study. Clin Rehabil. 26 (2012), 442–450, 10.1177/0269215511425835.
78. Venturelli, M., Scarsini, R., Schena, F., Six-month walking program changes cognitive and ADL performance in patients with Alzheimer. Am J Alzheimers Dis Other Demen 26 (2011), 381–388, 10.1177/1533317511418956.
79. Verissimo, M.T., Aragão, A., Sousa, A., Barbosa, B., Ribeiro, H., Costa, D., et al. Effect of physical exercise on lipid metabolism in the elderly. Rev Port Cardiol. 21 (2002), 1099–1112.
80. Vogel, T., Brechat, P.-H., Leprêtre, P.-M., Kaltenbach, G., Berthel, M., Lonsdorfer, J., Health benefits of physical activity in older patients: a review. Int J Clin Pract. 63 (2009), 303–320, 10.1111/j.1742-1241.2008.01957.x.
81. Vogel, T., Leprêtre, P.-M., Brechat, P.-H., Lonsdorfer, E., Benetos, A., Kaltenbach, G., et al. Effects of a short-term personalized Intermittent Work Exercise Program (IWEP) on maximal cardio-respiratory function and endurance parameters among healthy young and older seniors. J Nutr Health Aging 15 (2011), 905–911.
82. Wanderley, F.A.C., Oliveira, J., Mota, J., Carvalho, J., Effects of a moderate-intensity walking program on blood pressure, body composition and functional fitness in older women: results of a pilot study. Arch Exerc Health Dis. 1 (2010), 50–57, 10.5628/aehd.v1i2.87.
83. Westhoff, T.H., Franke, N., Schmidt, S., Vallbracht-Israng, K., Zidek, W., Dimeo, F., et al. Beta-blockers do not impair the cardiovascular benefits of endurance training in hypertensives. J Hum Hypertens 21 (2007), 486–493, 10.1038/sj.jhh.1002173.
84. Wisloff, U., Stoylen, A., Loennechen, J.P., Bruvold, M., Rognmo, O., Haram, P.M., et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115 (2007), 3086–3094, 10.1161/CIRCULATIONAHA.106.675041.
85. World Health Organization (WHO), Global status report on non-communicable diseases., 2010, World Health Organization (WHO), Geneva, Switzerland http://www.who.int/nmh/publications/ncd_report_full_en.pdf.
86. Young, J., Angevaren, M., Rusted, J., Tabet, N., Aerobic exercise to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev., 4, 2015, 10.1002/14651858 CD005381.pub4.