Exercise, Autophagy, and Apoptosis

Progress in Molecular Biology and Translational Science

Volumn 135, Issue , 2015, Pages 407-422

  Mooren, Frank C ^a   Krüger, Karsten ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Adaptation process; Cell death; Cell stress; Inflammation; Protein degradation; Signaling; Tissue damage

Indexed keywords

ADAPTATION; APOPTOSIS; AUTOPHAGY; CELL STRUCTURE; CONFERENCE PAPER; EXERCISE; HUMAN; LEUKOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; BIOLOGICAL MODEL; PHYSIOLOGY;

ANIMALS; APOPTOSIS; AUTOPHAGY; EXERCISE; HUMANS; MODELS, BIOLOGICAL;

EID: 84940707273     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/bs.pmbts.2015.07.023     Document Type: Conference Paper

References (56)

1. P.H. Krammer, R. Arnold, and I.N. Lavrik Life and death in peripheral T cells Nat Rev Immunol 7 7 2007 532 542
2. S.J. Korsmeyer Programmed cell death and the regulation of homeostasis Harvey Lect 95 1999-2000 21 41
3. J.F. Curtin, and T.G. Cotter Live and let die: regulatory mechanisms in Fas-mediated apoptosis Cell Signal 15 11 2003 983 992
4. J.F. Kerr, A.H. Wyllie, and A.R. Currie Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics Br J Cancer 26 1972 239 257
5. J.M. Blander A long-awaited merger of the pathways mediating host defence and programmed cell death Nat Rev Immunol 14 9 2014 601 618
6. Y. Ishizaki, L. Cheng, A.W. Mudge, and M.C. Raff Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells Mol Biol Cell 6 11 1995 1443 1458
7. H. Wajant Principles and mechanisms of CD95 activation Biol Chem 395 12 2014 1401 1416
8. S. Cory, and J.M. Adams The Bcl2 family: regulators of the cellular life-or-death switch Nat Rev Cancer 2 2002 647 656
9. K. Krüger, and F.C. Mooren Exercise-induced leukocyte apoptosis Exerc Immunol Rev 20 2014 117 134
10. N.V. Vorobjeva, and B.V. Pinegin Neutrophil extracellular traps: mechanisms of formation and role in health and disease Biochemistry (Mosc) 79 12 2014 1286 1296
11. J. Atamaniuk, K.M. Stuhlmeier, C. Vidotto, H. Tschan, A. Dossenbach-Glaninger, and M. Mueller Effects of ultra-marathon on circulating DNA and mRNA expression of pro- and anti-apoptotic genes in mononuclear cells Eur J Appl Physiol 104 4 2008 711 717
12. F.C. Mooren, A. Lechtermann, and K. Völker Exercise-induced apoptosis of lymphocytes depends on training status Med Sci Sports Exerc 36 9 2004 1476 1483
13. F.C. Mooren, D. Bloming, A. Lechtermann, M.M. Lerch, and K. Volker Lymphocyte apoptosis after exhaustive and moderate exercise J Appl Physiol 93 1 2002 147 153
14. A.C. Levada-Pires, M.F. Cury-Boaventura, R. Gorjão, and et al. Induction of lymphocyte death by short- and long-duration triathlon competitions Med Sci Sports Exerc 41 10 2009 1896 1901
15. J.W. Navalta, D.A. Sedlock, and K.S. Park Effect of exercise intensity on exercise induced lymphocyte apoptosis Int J Sports Med 28 6 2007 539 542
16. K. Krüger, S. Agnischock, A. Lechtermann, and et al. Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways J Appl Physiol 110 5 2011 1226 1232
17. K. Krüger, S. Frost, E. Most, K. Völker, J. Pallauf, and F.C. Mooren Exercise affects tissue lymphocyte apoptosis via redox-sensitive and Fas-dependent signaling pathways Am J Physiol Regul Integr Comp Physiol 296 5 2009 R1518 R1527
18. J. Quadrilatero, and L. Hoffman-Goetz N-Acetyl-L-cysteine prevents exercise-induced intestinal lymphocyte apoptosis by maintaining intracellular glutathione levels and reducing mitochondrial membrane depolarization Biochem Biophys Res Commun 319 3 2004 894 901
19. G.D. Syu, H.I. Chen, and C.J. Jen Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status PLoS One 6 9 2011 e24385
20. F.C. Mooren, K. Völker, R. Klocke, S. Nikol, J. Waltenberger, and K. Krüger Exercise delays neutrophil apoptosis by a G-CSF-dependent mechanism J Appl Physiol 113 7 2012 1082 1090
21. T. Beiter, A. Fragasso, D. Hartl, and A.M. Nieß Neutrophil extracellular traps: a walk on the wild side of exercise immunology Sports Med 45 5 2015 625 640
22. J. Tower Programmed cell death in aging Ageing Res Rev 23 pt A 2015 90 100
23. N.E. Brooks, and K.H. Myburgh Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways Front Physiol 5 2014 99
24. G. Paulsen, U.R. Mikkelsen, T. Raastad, and J.M. Peake Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise? Exerc Immunol Rev 18 2012 42 97
25. E. Marzetti, G. Privitera, V. Simili, and et al. Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging Sci World J 10 2010 340 349
26. E. Marzetti, R. Calvani, R. Bernabei, and C. Leeuwenburgh Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review Gerontology 58 2 2012 99 106
27. W. Song, H.B. Kwak, and J.M. Lawler Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle Antioxid Redox Signal 8 3-4 2006 517 528
28. D.C. Nieman Exercise, infection, and immunity Int J Sports Med 15 suppl 3 1994 S131 S141
29. R.J. Simpson Aging, persistent viral infections, and immunosenescence: can exercise "make space"? Exerc Sport Sci Rev 39 1 2011 23 33
30. F.C. Mooren, and K. Krüger Apoptotic lymphocytes induce progenitor cell mobilization after exercise J Appl Physiol (1985) 119 2 2015 135 139 10.1152/japplphysiol.00287.2015
31. A. Vainshtein, P. Grumati, M. Sandri, and P. Bonaldo Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease J Mol Med (Berl) 92 2 2014 127 137
32. J. Lim, M.L. Lachenmayer, S. Wu, and et al. Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates PLoS Genet 11 2 2015 e1004987
33. E. Masiero, L. Agatea, C. Mammucari, and et al. Autophagy is required to maintain muscle mass Cell Metab 10 6 2009 507 515
34. M. Sandri Autophagy in skeletal muscle FEBS Lett 584 7 2010 1411 1416
35. J. Zhang, J. Kim, A. Alexander, and et al. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS Nat Cell Biol 15 10 2013 1186 1196
36. D.C. Rubinsztein, T. Shpilka, and Z. Elazar Mechanisms of autophagosome biogenesis Curr Biol 22 1 2012 R29 R34
37. J. Zhang Teaching the basics of autophagy and mitophagy to redox biologists - mechanisms and experimental approaches Redox Biol 4 2015 242 259
38. E.A. Dunlop, and A.R. Tee mTOR and autophagy: a dynamic relationship governed by nutrients and energy Semin Cell Dev Biol 36 2014 121 129
39. R.C. Russell, Y. Tian, H. Yuan, and et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase Nat Cell Biol 15 7 2013 741 750
40. T. Johansen, and T. Lamark Selective autophagy mediated by autophagic adapter proteins Autophagy 7 3 2011 279 296
41. S. Mostowy, V. Sancho-Shimizu, M.A. Hamon, and et al. p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways J Biol Chem 286 30 2011 26987 26995
42. J. Kim, Y.C. Kim, C. Fang, and et al. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy Cell 152 1-2 2013 290 303
43. C. Mammucari, G. Milan, V. Romanello, and et al. FoxO3 controls autophagy in skeletal muscle in vivo Cell Metab 6 6 2007 458 471
44. P. Grumati, L. Coletto, A. Schiavinato, and et al. Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles Autophagy 7 12 2011 1415 1423
45. C. Jamart, M. Francaux, G.Y. Millet, L. Deldicque, D. Frère, and L. Féasson Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running J Appl Physiol (1985) 112 9 2012 1529 1537
46. C. Jamart, N. Benoit, J.M. Raymackers, H.J. Kim, C.K. Kim, and M. Francaux Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise Eur J Appl Physiol 112 8 2012 3173 3177
47. C. He, M.C. Bassik, V. Moresi, and et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis Nature 481 7382 2012 511 515
48. Y.A. Kim, Y.S. Kim, and W. Song Autophagic response to a single bout of moderate exercise in murine skeletal muscle J Physiol Biochem 68 2 2012 229 235
49. C. Schwalm, C. Jamart, N. Benoit, and et al. Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation FASEB J 29 8 2015 3515 3526
50. C.S. Fry, M.J. Drummond, E.L. Glynn, and et al. Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults J Gerontol A Biol Sci Med Sci 68 5 2013 599 607
51. A.J. Smuder, A.N. Kavazis, K. Min, and S.K. Powers Exercise protects against doxorubicin-induced markers of autophagy signaling in skeletal muscle J Appl Physiol (1985) 111 4 2011 1190 1198
52. Z. Feng, L. Bai, J. Yan, and et al. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol Free Radic Biol Med 50 10 2011 1437 1446
53. V.A. Lira, M. Okutsu, M. Zhang, and et al. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance FASEB J 27 10 2013 4184 4193
54. L. Luo, A.M. Lu, Y. Wang, and et al. Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats Exp Gerontol 48 4 2013 427 436
55. L.M. Lindqvist, M. Heinlein, D.C. Huang, and D.L. Vaux Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak Proc Natl Acad Sci USA 111 23 2014 8512 8517
56. A.D. Rubinstein, M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis Mol Cell 44 5 2011 698 709