β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/interferon γ-induced MuRF-1 expression in C2C12 cells

Nutrition Research

Volumn 34, Issue 4, 2014, Pages 368-374

  Kimura, Kaoru ^a   Cheng, Xian Wu ^a   Inoue, Aiko ^a   Hu, Lina ^a   Koike, Teruhiko ^a   Kuzuya, Masafumi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

C2C12; Forkhead box class O; Phosphoinositide 3 kinase; Ubiquitin ligase; Hydroxy methylbutyrate

Indexed keywords

ATROGIN 1; BETA HYDROXY BETA METHYLBUTYRIC ACID; ESSENTIAL AMINO ACID; GAMMA INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE RING FINGER 1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BETA-HYDROXYISOVALERIC ACID; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; MESSENGER RNA; MTOR PROTEIN, HUMAN; MUSCLE PROTEIN; TARGET OF RAPAMYCIN KINASE; TRIM63 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE; VALERIC ACID DERIVATIVE;

AGING; ANIMAL CELL; ARTICLE; ATROGIN 1 GENE; CELL DIFFERENTIATION; CELL STRESS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; CELL LINE; DRUG EFFECTS; GENETICS; INFLAMMATION; METABOLISM; MUSCLE ATROPHY; PHOSPHORYLATION; SKELETAL MUSCLE;

MAMMALIA;

AGING; CELL LINE; FORKHEAD TRANSCRIPTION FACTORS; INFLAMMATION; INTERFERON-GAMMA; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION; VALERATES;

EID: 84899648581     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2014.02.003     Document Type: Article

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