-
2
-
-
84940953781
-
The 'Big Bang' in obese fat: Events initiating obesity-induced adipose tissue inflammation
-
Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B: The 'Big Bang' in obese fat: events initiating obesity-induced adipose tissue inflammation. Eur J Immunol 2015; 45: 2446-2456.
-
(2015)
Eur J Immunol
, vol.45
, pp. 2446-2456
-
-
Wensveen, F.M.1
Valentić, S.2
Šestan, M.3
Turk, W.T.4
Polić, B.5
-
3
-
-
84960106182
-
Adipose tissue macrophages: Going off track during obesity
-
Boutens L, Stienstra R: Adipose tissue macrophages: going off track during obesity. Diabetologia 2016; 59: 879-894.
-
(2016)
Diabetologia
, vol.59
, pp. 879-894
-
-
Boutens, L.1
Stienstra, R.2
-
4
-
-
0028108409
-
Glycine and taurine conjugation of bile acids by a single enzyme Molecular cloning and expression of human liver bile acid CoA:Amino acid N-acyltransferase
-
Falany CN, Johnson MR, Barnes S, Diasio RB: Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem 1994; 269: 19375-19379.
-
(1994)
J Biol Chem
, vol.269
, pp. 19375-19379
-
-
Falany, C.N.1
Johnson, M.R.2
Barnes, S.3
Diasio, R.B.4
-
5
-
-
84904742368
-
Beyond intestinal soap-bile acids in metabolic control
-
Kuipers F, Bloks VW, Groen AK: Beyond intestinal soap-bile acids in metabolic control. Nat Rev Endocrinol 2014; 10: 488-498.
-
(2014)
Nat Rev Endocrinol
, vol.10
, pp. 488-498
-
-
Kuipers, F.1
Bloks, V.W.2
Groen, A.K.3
-
6
-
-
0029046931
-
Identification of a nuclear receptor that is activated by farnesol metabolites
-
Forman BM, et al: Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 1995; 81: 687-693.
-
(1995)
Cell
, vol.81
, pp. 687-693
-
-
Forman, B.M.1
-
7
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima M, et al: Identification of a nuclear receptor for bile acids. Science 1999; 284: 1362-1365.
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
-
8
-
-
0033591387
-
Bile acids: Natural ligands for an orphan nuclear receptor
-
Parks DJ, et al: Bile acids: natural ligands for an orphan nuclear receptor. Science 1999; 284: 1365-1368.
-
(1999)
Science
, vol.284
, pp. 1365-1368
-
-
Parks, D.J.1
-
9
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H, Chen J, Hollister K, Sowers LC, Forman BM: Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3: 543-553.
-
(1999)
Mol Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
10
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki T, et al: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2: 217-225.
-
(2005)
Cell Metab
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
-
11
-
-
37249015421
-
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
-
Kim I, et al: Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 2007; 48: 2664-2672.
-
(2007)
J Lipid Res
, vol.48
, pp. 2664-2672
-
-
Kim, I.1
-
12
-
-
0037827787
-
Liver receptor homologue-1 mediates species-and cell line-specific bile aciddependent negative feedback regulation of the apical sodium-dependent bile acid transporter
-
Chen F, et al: Liver receptor homologue-1 mediates species-and cell line-specific bile aciddependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem 2003; 278: 19909-19916.
-
(2003)
J Biol Chem
, vol.278
, pp. 19909-19916
-
-
Chen, F.1
-
13
-
-
0036238073
-
Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor
-
Hwang ST, Urizar NL, Moore DD, Henning SJ: Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor. Gastroenterology 2002; 122: 1483-1492.
-
(2002)
Gastroenterology
, vol.122
, pp. 1483-1492
-
-
Hwang, S.T.1
Urizar, N.L.2
Moore, D.D.3
Henning, S.J.4
-
14
-
-
33646871585
-
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents
-
Boyer JL, et al: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver physiol 2006; 290:G1124-G1130.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, pp. G1124-G1130
-
-
Boyer, J.L.1
-
15
-
-
0021961432
-
Glucuronidation of bile acids in human liver, intestine and kidney An in vitro study on hyodeoxycholic acid
-
Parquet M, et al: Glucuronidation of bile acids in human liver, intestine and kidney. An in vitro study on hyodeoxycholic acid. FEBS Lett 1985; 189: 183-187.
-
(1985)
FEBS Lett
, vol.189
, pp. 183-187
-
-
Parquet, M.1
-
16
-
-
64349115740
-
Bile acid sulfation: A pathway of bile acid elimination and detoxification
-
Alnouti Y: Bile acid sulfation: a pathway of bile acid elimination and detoxification. Toxicol Sci 2009; 108: 225-246.
-
(2009)
Toxicol Sci
, vol.108
, pp. 225-246
-
-
Alnouti, Y.1
-
17
-
-
33644748143
-
Fxr(-/-) mice adapt to biliary obstruction by enhanced phase i detoxification and renal elimination of bile acids
-
Marschall HU, et al: Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. J Lipid Res 2006; 47: 582-592.
-
(2006)
J Lipid Res
, vol.47
, pp. 582-592
-
-
Marschall, H.U.1
-
18
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal CJ, et al: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000; 102: 731-744.
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
-
19
-
-
30844436795
-
Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice
-
Hanniman EA, Lambert G, McCarthy TC, Sinal CJ: Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J Lipid Res 2005; 46: 2595-2604.
-
(2005)
J Lipid Res
, vol.46
, pp. 2595-2604
-
-
Hanniman, E.A.1
Lambert, G.2
McCarthy, T.C.3
Sinal, C.J.4
-
20
-
-
1842527650
-
Glucose regulates the expression of the farnesoid X receptor in liver
-
Duran-Sandoval, D, et al: Glucose regulates the expression of the farnesoid X receptor in liver. Diabetes 2004; 53: 890-898.
-
(2004)
Diabetes
, vol.53
, pp. 890-898
-
-
Duran-Sandoval, D.1
-
21
-
-
22544452537
-
The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition
-
Duran-Sandoval D, et al: The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition. J Biol Chem 2005; 280: 29971-29979.
-
(2005)
J Biol Chem
, vol.280
, pp. 29971-29979
-
-
Duran-Sandoval, D.1
-
22
-
-
32244447570
-
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
-
Zhang Y, et al: Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 2006; 103: 1006-1011.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1006-1011
-
-
Zhang, Y.1
-
23
-
-
33645531297
-
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
-
Cariou B, et al: The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem 2006; 281: 11039-11049.
-
(2006)
J Biol Chem
, vol.281
, pp. 11039-11049
-
-
Cariou, B.1
-
24
-
-
79960838523
-
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
-
Prawitt J, et al: Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 2011; 60: 1861-1871.
-
(2011)
Diabetes
, vol.60
, pp. 1861-1871
-
-
Prawitt, J.1
-
25
-
-
84863067866
-
Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice
-
Zhang Y, et al: Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. Mol Endocrinol 2012; 26: 272-280.
-
(2012)
Mol Endocrinol
, vol.26
, pp. 272-280
-
-
Zhang, Y.1
-
26
-
-
0142211282
-
Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
-
Kok T, et al: Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem 2003; 278: 41930-41937.
-
(2003)
J Biol Chem
, vol.278
, pp. 41930-41937
-
-
Kok, T.1
-
27
-
-
67449102914
-
An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/-mice
-
van Dijk TH, et al: An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/-mice. J Biol Chem 2009; 284: 10315-10323.
-
(2009)
J Biol Chem
, vol.284
, pp. 10315-10323
-
-
Van Dijk, T.H.1
-
28
-
-
84877916062
-
Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH
-
Bjursell M, et al: Ageing Fxr deficient mice develop increased energy expenditure, improved glucose control and liver damage resembling NASH. PLoS One 2013; 8:e64721.
-
(2013)
PLoS One
, vol.8
, pp. e64721
-
-
Bjursell, M.1
-
29
-
-
0034632762
-
Identification of a chemical tool for the orphan nuclear receptor FXR
-
Maloney PR, et al: Identification of a chemical tool for the orphan nuclear receptor FXR. J Med Chem 2000; 43: 2971-2974.
-
(2000)
J Med Chem
, vol.43
, pp. 2971-2974
-
-
Maloney, P.R.1
-
30
-
-
84876477803
-
Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance
-
Ma Y, Huang Y, Yan L, Gao M, Liu D: Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance. Pharm Res 2013; 30: 1447-1457.
-
(2013)
Pharm Res
, vol.30
, pp. 1447-1457
-
-
Ma, Y.1
Huang, Y.2
Yan, L.3
Gao, M.4
Liu, D.5
-
31
-
-
0037101810
-
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
-
Pellicciari R, et al: 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002; 45: 3569-3572.
-
(2002)
J Med Chem
, vol.45
, pp. 3569-3572
-
-
Pellicciari, R.1
-
32
-
-
20944450029
-
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis
-
Fiorucci S, et al: Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther 2005; 313: 604-612.
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 604-612
-
-
Fiorucci, S.1
-
33
-
-
0346690402
-
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis
-
Liu Y, et al: Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis. J Clin Invest 2003; 112: 1678-1687.
-
(2003)
J Clin Invest
, vol.112
, pp. 1678-1687
-
-
Liu, Y.1
-
34
-
-
77950613528
-
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
-
Cipriani S, Mencarelli A, Palladino G, Fiorucci S: FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats. J Lipid Res 2010; 51: 771-784.
-
(2010)
J Lipid Res
, vol.51
, pp. 771-784
-
-
Cipriani, S.1
Mencarelli, A.2
Palladino, G.3
Fiorucci, S.4
-
36
-
-
84880664792
-
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
-
Mudaliar S, et al: Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574-582.e1.
-
(2013)
Gastroenterology
, vol.145
, pp. 574e1-582e1
-
-
Mudaliar, S.1
-
37
-
-
84865499656
-
Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
-
Adorini L, Pruzanski M, Shapiro D: Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today 2012; 17: 988-997.
-
(2012)
Drug Discov Today
, vol.17
, pp. 988-997
-
-
Adorini, L.1
Pruzanski, M.2
Shapiro, D.3
-
38
-
-
84929266699
-
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
-
Neuschwander-Tetri BA, et al: Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015; 385: 956-965.
-
(2015)
Lancet
, vol.385
, pp. 956-965
-
-
Neuschwander-Tetri, B.A.1
-
39
-
-
84925362562
-
Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
-
e8
-
Hirschfield GM, et al: Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology 2015; 148: 751-761.e8.
-
(2015)
Gastroenterology
, vol.148
, pp. 751-761
-
-
Hirschfield, G.M.1
-
40
-
-
0037738531
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
-
Downes M, et al: A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell 2003; 11: 1079-1092.
-
(2003)
Mol Cell
, vol.11
, pp. 1079-1092
-
-
Downes, M.1
-
41
-
-
84925507991
-
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
-
Fang S, et al: Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 2015; 21: 159-165.
-
(2015)
Nat Med
, vol.21
, pp. 159-165
-
-
Fang, S.1
-
42
-
-
18344394556
-
Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
-
Tomlinson E, et al: Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 2002; 143: 1741-1747.
-
(2002)
Endocrinology
, vol.143
, pp. 1741-1747
-
-
Tomlinson, E.1
-
43
-
-
2542505481
-
Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
-
Fu L, et al: Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 2004; 145: 2594-2603.
-
(2004)
Endocrinology
, vol.145
, pp. 2594-2603
-
-
Fu, L.1
-
44
-
-
79958066536
-
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREBPGC-1α pathway
-
Potthoff MJ, et al: FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREBPGC-1α pathway. Cell Metab 2011; 13: 729-738.
-
(2011)
Cell Metab
, vol.13
, pp. 729-738
-
-
Potthoff, M.J.1
-
45
-
-
84856159269
-
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
-
e1-e4
-
Modica S, et al: Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012; 142: 355-365.e1-e4.
-
(2012)
Gastroenterology
, vol.142
, pp. 355-365
-
-
Modica, S.1
-
46
-
-
33644867569
-
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
-
Inagaki T, et al: Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 2006; 103: 3920-3925.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3920-3925
-
-
Inagaki, T.1
-
47
-
-
79952535597
-
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
-
Gadaleta RM, et al: Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011; 60: 463-472.
-
(2011)
Gut
, vol.60
, pp. 463-472
-
-
Gadaleta, R.M.1
-
48
-
-
0028931071
-
Bacterial translocation from the gastrointestinal tract
-
Berg RD: Bacterial translocation from the gastrointestinal tract. Trends Microbiol 1995; 3: 149-154.
-
(1995)
Trends Microbiol
, vol.3
, pp. 149-154
-
-
Berg, R.D.1
-
49
-
-
84864394573
-
The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control
-
Pournaras DJ, et al: The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology 2012; 153: 3613-3619.
-
(2012)
Endocrinology
, vol.153
, pp. 3613-3619
-
-
Pournaras, D.J.1
|