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Volumn 8, Issue 5, 2013, Pages

Ageing Fxr Deficient Mice Develop Increased Energy Expenditure, Improved Glucose Control and Liver Damage Resembling NASH

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOID X RECEPTOR; GLUCOSE; INSULIN;

EID: 84877916062     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064721     Document Type: Article
Times cited : (60)

References (49)
  • 1
    • 0029046931 scopus 로고
    • Identification of a nuclear receptor that is activated by farnesol metabolites
    • Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, et al. (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81: 687-693.
    • (1995) Cell , vol.81 , pp. 687-693
    • Forman, B.M.1    Goode, E.2    Chen, J.3    Oro, A.E.4    Bradley, D.J.5
  • 3
    • 0037462815 scopus 로고    scopus 로고
    • The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
    • Lambert G, Amar MJ, Guo G, Brewer HB Jr, Gonzalez FJ, et al. (2003) The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. J Biol Chem 278: 2563-2570.
    • (2003) J Biol Chem , vol.278 , pp. 2563-2570
    • Lambert, G.1    Amar, M.J.2    Guo, G.3    Brewer Jr., H.B.4    Gonzalez, F.J.5
  • 4
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD, (2006) Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 116: 1102-1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 5
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, et al. (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102: 731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5
  • 6
    • 84863067866 scopus 로고    scopus 로고
    • Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice
    • Zhang Y, Ge X, Heemstra LA, Chen WD, Xu J, et al. (2012) Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. Mol Endocrinol 26: 272-280.
    • (2012) Mol Endocrinol , vol.26 , pp. 272-280
    • Zhang, Y.1    Ge, X.2    Heemstra, L.A.3    Chen, W.D.4    Xu, J.5
  • 7
    • 33645531297 scopus 로고    scopus 로고
    • The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
    • Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, et al. (2006) The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem 281: 11039-11049.
    • (2006) J Biol Chem , vol.281 , pp. 11039-11049
    • Cariou, B.1    van Harmelen, K.2    Duran-Sandoval, D.3    van Dijk, T.H.4    Grefhorst, A.5
  • 8
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, et al. (2000) A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6: 517-526.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3    Watson, M.A.4    McKee, D.D.5
  • 9
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • Kim I, Ahn SH, Inagaki T, Choi M, Ito S, et al. (2007) Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 48: 2664-2672.
    • (2007) J Lipid Res , vol.48 , pp. 2664-2672
    • Kim, I.1    Ahn, S.H.2    Inagaki, T.3    Choi, M.4    Ito, S.5
  • 10
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2: 217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5
  • 11
    • 58949097425 scopus 로고    scopus 로고
    • Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
    • Song KH, Li T, Owsley E, Strom S, Chiang JY, (2009) Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49: 297-305.
    • (2009) Hepatology , vol.49 , pp. 297-305
    • Song, K.H.1    Li, T.2    Owsley, E.3    Strom, S.4    Chiang, J.Y.5
  • 12
    • 0142211282 scopus 로고    scopus 로고
    • Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein
    • Kok T, Hulzebos CV, Wolters H, Havinga R, Agellon LB, et al. (2003) Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: Efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem 278: 41930-41937.
    • (2003) J Biol Chem , vol.278 , pp. 41930-41937
    • Kok, T.1    Hulzebos, C.V.2    Wolters, H.3    Havinga, R.4    Agellon, L.B.5
  • 13
    • 67449102914 scopus 로고    scopus 로고
    • An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in fxr-/- mice
    • van Dijk TH, Grefhorst A, Oosterveer MH, Bloks VW, Staels B, et al. (2009) An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in fxr-/- mice. J Biol Chem 284: 10315-10323.
    • (2009) J Biol Chem , vol.284 , pp. 10315-10323
    • van Dijk, T.H.1    Grefhorst, A.2    Oosterveer, M.H.3    Bloks, V.W.4    Staels, B.5
  • 15
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, et al. (2006) Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 103: 1006-1011.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5
  • 16
    • 33847044019 scopus 로고    scopus 로고
    • Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    • Yang F, Huang X, Yi T, Yen Y, Moore DD, et al. (2007) Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 67: 863-867.
    • (2007) Cancer Res , vol.67 , pp. 863-867
    • Yang, F.1    Huang, X.2    Yi, T.3    Yen, Y.4    Moore, D.D.5
  • 17
    • 77954837070 scopus 로고    scopus 로고
    • FXR regulates liver repair after CCl4-induced toxic injury
    • Meng Z, Wang Y, Wang L, Jin W, Liu N, et al. (2010) FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol 24: 886-897.
    • (2010) Mol Endocrinol , vol.24 , pp. 886-897
    • Meng, Z.1    Wang, Y.2    Wang, L.3    Jin, W.4    Liu, N.5
  • 18
    • 33645821043 scopus 로고    scopus 로고
    • Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    • Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, et al. (2006) Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312: 233-236.
    • (2006) Science , vol.312 , pp. 233-236
    • Huang, W.1    Ma, K.2    Zhang, J.3    Qatanani, M.4    Cuvillier, J.5
  • 19
    • 80053137993 scopus 로고    scopus 로고
    • Consumption of soy protein isolate reduces hepatic SREBP-1c and lipogenic gene expression in wild-type mice, but not in FXR-deficient mice
    • Hashidume T, Sasaki T, Inoue J, Sato R, (2011) Consumption of soy protein isolate reduces hepatic SREBP-1c and lipogenic gene expression in wild-type mice, but not in FXR-deficient mice. Biosci Biotechnol Biochem 75: 1702-1707.
    • (2011) Biosci Biotechnol Biochem , vol.75 , pp. 1702-1707
    • Hashidume, T.1    Sasaki, T.2    Inoue, J.3    Sato, R.4
  • 20
    • 80051703916 scopus 로고    scopus 로고
    • Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage
    • Lian F, Xing X, Yuan G, Schafer C, Rauser S, et al. (2011) Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage. Biochem J 438: 315-323.
    • (2011) Biochem J , vol.438 , pp. 315-323
    • Lian, F.1    Xing, X.2    Yuan, G.3    Schafer, C.4    Rauser, S.5
  • 21
    • 84861880073 scopus 로고    scopus 로고
    • Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and K(ATP) channel inhibition
    • Dufer M, Horth K, Wagner R, Schittenhelm B, Prowald S, et al. (2012) Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes 61: 1479-1489.
    • (2012) Diabetes , vol.61 , pp. 1479-1489
    • Dufer, M.1    Horth, K.2    Wagner, R.3    Schittenhelm, B.4    Prowald, S.5
  • 22
    • 79960838523 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
    • Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, et al. (2011) Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 60: 1861-1871.
    • (2011) Diabetes , vol.60 , pp. 1861-1871
    • Prawitt, J.1    Abdelkarim, M.2    Stroeve, J.H.3    Popescu, I.4    Duez, H.5
  • 23
    • 78049299629 scopus 로고    scopus 로고
    • Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model
    • Wang XX, Jiang T, Shen Y, Caldas Y, Miyazaki-Anzai S, et al. (2010) Diabetic nephropathy is accelerated by farnesoid X receptor deficiency and inhibited by farnesoid X receptor activation in a type 1 diabetes model. Diabetes 59: 2916-2927.
    • (2010) Diabetes , vol.59 , pp. 2916-2927
    • Wang, X.X.1    Jiang, T.2    Shen, Y.3    Caldas, Y.4    Miyazaki-Anzai, S.5
  • 24
    • 59149106502 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    • Kong B, Luyendyk JP, Tawfik O, Guo GL, (2009) Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther 328: 116-122.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 116-122
    • Kong, B.1    Luyendyk, J.P.2    Tawfik, O.3    Guo, G.L.4
  • 25
    • 59649084903 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development
    • Maran RR, Thomas A, Roth M, Sheng Z, Esterly N, et al. (2009) Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther 328: 469-477.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 469-477
    • Maran, R.R.1    Thomas, A.2    Roth, M.3    Sheng, Z.4    Esterly, N.5
  • 26
    • 22544474215 scopus 로고    scopus 로고
    • Transient impairment of the adaptive response to fasting in FXR-deficient mice
    • Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk T, Grefhorst A, et al. (2005) Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett 579: 4076-4080.
    • (2005) FEBS Lett , vol.579 , pp. 4076-4080
    • Cariou, B.1    van Harmelen, K.2    Duran-Sandoval, D.3    van Dijk, T.4    Grefhorst, A.5
  • 27
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 cre reporter strain
    • Soriano P, (1999) Generalized lacZ expression with the ROSA26 cre reporter strain. Nat Genet 21: 70-71.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 30
    • 78650800467 scopus 로고    scopus 로고
    • Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
    • Bjursell M, Admyre T, Goransson M, Marley AE, Smith DM, et al. (2011) Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am J Physiol Endocrinol Metab 300: E211-20.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Bjursell, M.1    Admyre, T.2    Goransson, M.3    Marley, A.E.4    Smith, D.M.5
  • 32
    • 33244494398 scopus 로고    scopus 로고
    • PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes
    • Edvardsson U, Ljungberg A, Linden D, William-Olsson L, Peilot-Sjogren H, et al. (2006) PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes. J Lipid Res 47: 329-340.
    • (2006) J Lipid Res , vol.47 , pp. 329-340
    • Edvardsson, U.1    Ljungberg, A.2    Linden, D.3    William-Olsson, L.4    Peilot-Sjogren, H.5
  • 33
    • 33646192257 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice
    • Srivastava RA, Jahagirdar R, Azhar S, Sharma S, Bisgaier CL, (2006) Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice. Mol Cell Biochem 285: 35-50.
    • (2006) Mol Cell Biochem , vol.285 , pp. 35-50
    • Srivastava, R.A.1    Jahagirdar, R.2    Azhar, S.3    Sharma, S.4    Bisgaier, C.L.5
  • 34
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, et al. (2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439: 484-489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3    Christoffolete, M.A.4    Kim, B.W.5
  • 35
    • 84857408775 scopus 로고    scopus 로고
    • Reversal of type 1 diabetes in mice by brown adipose tissue transplant
    • Gunawardana SC, Piston DW, (2012) Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 61: 674-682.
    • (2012) Diabetes , vol.61 , pp. 674-682
    • Gunawardana, S.C.1    Piston, D.W.2
  • 36
    • 77951181327 scopus 로고    scopus 로고
    • Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure
    • Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, et al. (2010) Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem 285: 4637-4644.
    • (2010) J Biol Chem , vol.285 , pp. 4637-4644
    • Tang, T.1    Zhang, J.2    Yin, J.3    Staszkiewicz, J.4    Gawronska-Kozak, B.5
  • 37
    • 34047097326 scopus 로고    scopus 로고
    • Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation
    • Binczek E, Jenke B, Holz B, Gunter RH, Thevis M, et al. (2007) Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1-/-) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation. Biol Chem 388: 405-418.
    • (2007) Biol Chem , vol.388 , pp. 405-418
    • Binczek, E.1    Jenke, B.2    Holz, B.3    Gunter, R.H.4    Thevis, M.5
  • 38
    • 0030835838 scopus 로고    scopus 로고
    • Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier
    • Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, et al. (1997) Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. J Clin Invest 100: 705-712.
    • (1997) J Clin Invest , vol.100 , pp. 705-712
    • Hanley, K.1    Jiang, Y.2    Crumrine, D.3    Bass, N.M.4    Appel, R.5
  • 39
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    • Moschetta A, Bookout AL, Mangelsdorf DJ, (2004) Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 10: 1352-1358.
    • (2004) Nat Med , vol.10 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Mangelsdorf, D.J.3
  • 40
    • 10744227867 scopus 로고    scopus 로고
    • Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity
    • Chen F, Ananthanarayanan M, Emre S, Neimark E, Bull LN, et al. (2004) Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity. Gastroenterology 126: 756-764.
    • (2004) Gastroenterology , vol.126 , pp. 756-764
    • Chen, F.1    Ananthanarayanan, M.2    Emre, S.3    Neimark, E.4    Bull, L.N.5
  • 41
    • 17344366172 scopus 로고    scopus 로고
    • A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
    • Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, et al. (1998) A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet 20: 233-238.
    • (1998) Nat Genet , vol.20 , pp. 233-238
    • Strautnieks, S.S.1    Bull, L.N.2    Knisely, A.S.3    Kocoshis, S.A.4    Dahl, N.5
  • 42
    • 9144241623 scopus 로고    scopus 로고
    • Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis
    • Figge A, Lammert F, Paigen B, Henkel A, Matern S, et al. (2004) Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J Biol Chem 279: 2790-2799.
    • (2004) J Biol Chem , vol.279 , pp. 2790-2799
    • Figge, A.1    Lammert, F.2    Paigen, B.3    Henkel, A.4    Matern, S.5
  • 43
    • 84861738395 scopus 로고    scopus 로고
    • Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Takahashi Y, Soejima Y, Fukusato T, (2012) Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol 18: 2300-2308.
    • (2012) World J Gastroenterol , vol.18 , pp. 2300-2308
    • Takahashi, Y.1    Soejima, Y.2    Fukusato, T.3
  • 44
    • 14844288046 scopus 로고    scopus 로고
    • Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients
    • Malaguarnera L, Madeddu R, Palio E, Arena N, Malaguarnera M, (2005) Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients. J Hepatol 42: 585-591.
    • (2005) J Hepatol , vol.42 , pp. 585-591
    • Malaguarnera, L.1    Madeddu, R.2    Palio, E.3    Arena, N.4    Malaguarnera, M.5
  • 45
    • 79952425249 scopus 로고    scopus 로고
    • Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model
    • Inoue M, Tazuma S, Kanno K, Hyogo H, Igarashi K, et al. (2011) Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model. J Clin Biochem Nutr 48: 161-166.
    • (2011) J Clin Biochem Nutr , vol.48 , pp. 161-166
    • Inoue, M.1    Tazuma, S.2    Kanno, K.3    Hyogo, H.4    Igarashi, K.5
  • 47
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T, Moschetta A, Lee YK, Peng L, Zhao G, et al. (2006) Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 103: 3920-3925.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.K.3    Peng, L.4    Zhao, G.5
  • 48
    • 84861547908 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice
    • Ye D, Li FY, Lam KS, Li H, Jia W, et al. (2012) Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut 61: 1058-1067.
    • (2012) Gut , vol.61 , pp. 1058-1067
    • Ye, D.1    Li, F.Y.2    Lam, K.S.3    Li, H.4    Jia, W.5
  • 49
    • 81355127623 scopus 로고    scopus 로고
    • Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts
    • Id Boufker H, Lagneaux L, Fayyad-Kazan H, Badran B, Najar M, et al. (2011) Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts. Bone 49: 1219-1231.
    • (2011) Bone , vol.49 , pp. 1219-1231
    • Id Boufker, H.1    Lagneaux, L.2    Fayyad-Kazan, H.3    Badran, B.4    Najar, M.5


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