Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy

Molecular Brain Research

Volumn 76, Issue 2, 2000, Pages 429-435

  López Redondo, Fernando ^a   Nakajima, Kazuyuki ^a,b   Honda, Shizuyo ^a   Kohsaka, Shinichi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b SOKA UNIVERSITY   (Japan)

Author keywords

Astrocytes; Facial nerve axotomy; Facial nucleus; GLT 1; Glutamate transporter; Microglia; Rat

Indexed keywords

GLUTAMATE TRANSPORTER; GLUTAMIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; FACIAL NERVE; FACIAL NERVE NUCLEUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; AXOTOMY; BRAIN; CELLS, CULTURED; EXCITATORY AMINO ACID TRANSPORTER 2; FACIAL NERVE; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HUMANS; MALE; MICROGLIA; NEURONS; RATS; RATS, WISTAR; RECEPTORS, NEUROTRANSMITTER; TIME FACTORS;

RODENTIA;

EID: 0034728639     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00022-X     Document Type: Article

References (38)

1. J.L. Arriza, S. Eliasof, M.P. Kavanaugh, S.G. Amara, Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance, Proc. Natl. Acad. Sci. USA A 94 (1997) 4155-4160.
2. J.L. Arriza, W.A. Fairman, J.I. Wadiche, G.H. Murdoch, M.P. Kavanaugh, S.G. Amara, Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex, J. Neurosci. 14 (1994) 5559-5569.
3. L.A. Bristol, J.D. Rothstein, Use of antisense oligodeoxynucleotides to inhibit expression of glutamate transporter subtypes, Ann. Neurol. 39 (1996) 676-679.
4. D.W. Choi, Glutamate neurotoxicity and diseases of the nervous system, Neuron 1 (1988) 623-634.
5. I. Choi, S.Y. Chiu, Expression of high-affinity neuronal and glial glutamate transporters in the rat optic nerve, Glia 20 (1997) 184-192.
6. R. Dingledine, C.J. McBain, J.O. McNamara, Excitatory amino acid receptors in epilepsy, Trends Pharmacol. Sci. 11 (1990) 334-338.
7. W.A. Fairman, R.J. Vandenberg, J.L. Arriza, M.P. Kavanaugh, S.G. Amara, An excitatory amino-acid transporter with properties of a ligand-gated chloride channel, Nature 375 (1995) 599-603.
8. M.B. Graeber, W. Tetzlaff, W.J. Streit, G.W. Kreutzberg, Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy, Neurosci. Lett. 85 (1988) 317-321.
9. M.B. Graeber, F. López-Redondo, E. Ikoma, M. Ishikawa, Y. Imai, K. Nakajina, G.W. Kreutzberg, S. Kohsaka, The microglia/macrophage response in the neonatal rat facial nucleus following axotomy, Brain Res. 813 (1998) 241-253.
10. M.B. Graeber, G.W. Kreutzberg, Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons, J. Neurocytol. 15 (1986) 363-373.
11. D. Ito, Y. Imai, K. Ohsawa, K. Nakajima, Y. Fukuuchi, S. Kohsaka, Microglia-specific localisation of a novel calcium binding protein, Iba1, Mol. Brain Res. 57 (1998) 1-9.
12. Y. Kanai, M.A. Hediger, Primary structure and functional characterization of a high-affinity glutamate transporter, Nature 360 (1992) 467-471.
13. B.I. Kanner, S. Schuldiner, Mechanism of transport and storage of neurotransmitters, CRC Crit. Rev. Biochem. 22 (1987) 1-38.
14. K. Kondo, H. Hashimoto, J. Kitanaka, M. Sawada, A. Suzumura, T. Marunouchi, A. Baba, Expression of glutamate transporters in cultured glial cells, Neurosci. Lett. 188 (1995) 140-142.
15. K.P. Lehre, L.M. Levy, O.P. Ottersen, J. Storm-Mathisen, N.C. Danbolt, Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations, J. Neurosci. 15 (1995) 1835-1853.
16. D. Lekieffre, J. Callebert, M. Plotkine, R.G. Boulu, Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia, Neurosci. Lett. 137 (1992) 78-82.
17. L.M. Levy, K.P. Lehre, S.I. Walaas, J. Storm-Mathisen, N.C. Danbolt, Down-regulation of glial glutamate transporters after glutamatergic denervation in the rat brain, Eur. J. Neurosci. 7 (1995) 2036-2041.
18. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, R.J. Randall, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
19. L.J. Martin, A.M. Brambrink, C. Lehmann, C. Portera-Cailliau, R. Koehler, J. Rothstein, R.J. Traystman, Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum, Ann. Neurol. 42 (1997) 335-348.
20. B. Meldrum, J. Garthwaite, Excitatory amino acid neurotoxicity and neurodegenerative disease, Trends Pharmacol. Sci. 11 (1990) 379-387.
21. T. Mennini, A. Bastone, D. Crespi, D. Comoletti, C. Manzoni, Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice, J. Neurol. Sci. 157 (1998) 31-36.
22. K. Nakajima, M. Hamanoue, M. Shimojo, N. Takei, S. Kohsaka, Characterization of microglia isolated from a primary culture of embryonic rat brain by a simplified method, Biomed. Res. 10 (1989) 411-423.
23. K. Nakajima, Y. Kikuchi, E. Ikoma, S. Honda, M. Ishikawa, Y. Liu, S. Kohsaka, Neurotrophins regulate the function of cultured microglia, Glia 24 (1998) 272-289.
24. K. Nakajima, S. Reddington, S. Kohsaka, G.W. Kreutzberg, Induction of urokinase-type plasminogen activator in rat facial nucleus by axotomy of the facial nerve, J. Neurochem. 66 (1996) 2500-2505.
25. K. Nakajima, M. Shimojo, M. Hamanoue, S. Ishiura, H. Sugita, S. Kohsaka, Identification of elastase as a secretory protease from cultured rat microglia, J. Neurochem. 58 (1992) 1401-1408.
26. F.J. Northington, R.J. Traystman, R.C. Koehler, J.D. Rothstein, L.J. Martin, Regional and cellular expression of glial (GLT1) and neuronal (EAAC1) glutamate transporter proteins in ovine fetal brain, Neuroscience 85 (1998) 1183-1194.
27. G. Pines, N.C. Danbolt, M. Bjørås, Y. Zhang, A. Bendahan, L. Eide, H. Koepsell, J. Storm-Mathisen, E. Seeberg, B.I. Kanner, Cloning and expression of a rat brain L-glutamate transporter, Nature 360 (1992) 464-467.
28. M.B. Robinson, The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype, Neurochem. Int. 33 (1999) 479-491.
29. J.D. Rothstein, M. Dykes-Hoberg, C.A. Pardo, L.A. Bristol, L. Jin, R.W. Kuncl, Y. Kanai, M.A. Hediger, Y. Wang, J.P. Schielke, D.F. Welty, Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate, Neuron 16 (1996) 675-686.
30. J.D. Rothstein, L. Martin, A.I. Levey, M. Dykes-Hoberg, L. Jin, D. Wu, N. Nash, R.W. Kuncl, Localization of neuronal and glial glutamate transporters, Neuron 13 (1994) 713-725.
31. J.D. Rothstein, M. Van Kammen, A.I. Levey, L.J. Martin, R.W. Kuncl, Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis, Ann. Neurol. 38 (1995) 73-84.
32. E. Senba, T. Kaneko, N. Mizuno, M. Tohyama, Somato-, branchio-and viscero-motor neurons contain glutaminase-like immunoreactivity, Brain Res. Bull. 26 (1991) 85-97.
33. T. Storck, S. Schulte, K. Hofmann, W. Stoffel, Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain, Proc. Natl. Acad. Sci. USA 89 (1992) 10955-10959.
34. W.J. Streit, G.W. Kreutzberg, Heterogeneity of microglial and perivascular cell populations: insights gained from the facial nucleus paradigm, Glia 7 (1993) 68-74.
35. R.A. Swanson, J. Liu, J.W. Miller, J.D. Rothstein, K. Farrell, B.A. Stein, M.C. Longuemare, Neuronal regulation of glutamate transporter subtype expression in astrocytes, J. Neurosci. 17 (1997) 932-940.
36. K. Tanaka, K. Watase, T. Manabe, K. Yamada, M. Watanabe, K. Takahashi, H. Iwama, T. Nishikawa, N. Ichihara, T. Kikuchi, S. Okuyama, N. Kawashima, S. Hori, M. Takimoto, K. Wada, Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1, Science 276 (1997) 1699-1702.
37. R. Torp, D. Lekieffre, L.M. Levy, F.M. Haug, N.C. Danbolt, B.S. Meldrum, O.P. Ottersen, Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus, Exp. Brain Res. 103 (1995) 51-58.
38. K. Yamada, M. Watanabe, T. Shibata, M. Nagashima, K. Tanaka, Y. Inoue, Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression, J. Neurosci. 18 (1998) 5706-5713.