N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

Cellular Immunology

Volumn 278, Issue 1-2, 2012, Pages 84-90

  Liu, Hong Cui ^a,b   Zheng, Min Hua ^a   Du, Yan Ling ^a,b   Wang, Li ^a   Kuang, Fang ^a   Qin, Hong Yan ^a   Zhang, Bing Fang ^b   Han, Hua ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

IL4; LPS; Macrophage polarization; Microglia; Notch signaling

Indexed keywords

I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NOTCH1 RECEPTOR; PROTEIN P50; TRANSCRIPTION FACTOR HES 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; EPIGENETICS; MACROPHAGE; MICROGLIA; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; UPREGULATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; EPIGENESIS, GENETIC; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NITRIC OXIDE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84868288704     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2012.06.001     Document Type: Article

References (46)

1. de Lau L.M., Breteler M.M. Epidemiology of Parkinson's disease. Lancet Neurol. 2006, 5:525-535.
2. Nussbaum R.L., Ellis C.E. Alzheimer's disease and Parkinson's disease. N. Engl. J. Med. 2003, 348:1356-1364.
3. Toulouse A., Sullivan A.M. Progress in Parkinson's disease - where do we stand?. Prog. Neurobiol. 2008, 85:376-392.
4. Block M.L., Zecca L., Hong J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 2007, 8:57-69.
5. McGeer P.L., McGeer E.G. Glial reactions in Parkinson's disease. Mov. Disord. 2008, 23:474-483.
6. Nagatsu T., Sawada M. Inflammatory process in Parkinson's disease: role for cytokines. Curr. Pharm. Des. 2005, 11:999-1016.
7. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
8. Kawanokuchi J., Mizuno T., Kato H., Mitsuma N., Suzumura A. Effects of interferon-beta on microglial functions as inflammatory and antigen presenting cells in the central nervous system. Neuropharmacology 2004, 46:734-742.
9. Sondag C.M., Combs C.K. Amyloid precursor protein cross-linking stimulates beta amyloid production and pro-inflammatory cytokine release in monocytic lineage cells. J. Neurochem. 2006, 97:449-461.
10. Xie Z., Morgan T.E., Rozovsky I., Finch C.E. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Exp. Neurol. 2003, 182:135-141.
11. Martinez F.O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization. Front. Biosci. 2008, 13:453-461.
12. Stein M., Keshav S., Harris N., Gordon S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 1992, 176:287-292.
13. Goerdt S., Orfanos C.E. Other functions, other genes: alternative activation of antigen presenting cells. Immunity 1999, 10:137-142.
14. Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
15. Varin A., Gordon S. Alternative activation of macrophages: immune function and cellular biology. Immunobiology 2009, 214:630-641.
16. Chizzolini C., Rezzonico R., De Luca C., Burger D., Dayer J.M. Th2 cell membrane factors in association with IL-4 enhance matrix metalloproteinase-1 (MMP-1) while decreasing MMP-9 production by granulocyte-macrophage colony-stimulating factor-differentiated human monocytes. J. Immunol. 2000, 164:5952-5960.
17. Cua D.J., Stohlman S.A. In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets. J. Immunol. 1997, 159:5834-5840.
18. Gratchev A., Kzhyshkowska J., Utikal J., Goerdt S. Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages. Scan. J. Immunol. 2005, 61:10-17.
19. Mantovani A., Bottazzi B., Colotta F., Sozzani S., Ruco L. The origin and function of tumor-associated macrophages. Immunol. Today 1992, 13:265-270.
20. Mantovani A., Sozzani S., Locati M., Allavena P., Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002, 23:549-555.
21. Sica A., Larghi P., Mancino A., Rubino L., Porta C., Totaro M.G., Rimoldi M., Biswas S.K., Allavena P., Mantovani A. Macrophage polarization in tumour progression. Sem. Cancer Biol. 2008, 18:349-355.
22. Anderson C.F., Mosser D.M. A novel phenotype for an activated macrophage: the type 2 activated macrophage. J. Leukoc. Biol. 2002, 72:101-106.
23. Gerber J.S., Mosser D.M. Reversing lipopolysaccharide toxicity by ligating the macrophage Fcγ receptors. J. Immunol. 2001, 166:6861-6868.
24. Michelucci A., Heurtaux T., Grandbarbe L., Morga E., Heuschling P. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-beta. J. Neuroimmunol. 2009, 210:3-12.
25. Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776.
26. Arumugam T.V., Chan S.L., Jo D.G., Yilmaz G., Tang S.C., Cheng A., Gleichmann M., Okun E., Dixit V.D., Chigurupati S., Mughal M.R., Ouyang X., Miele L., Magnus T., Poosala S., Granger D.N., Mattson M.P. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nat. Med. 2006, 12:621-623.
27. Goh F., Irvine K.M., Lovelace E., Donnelly S., Jones M.K., Brion K., Hume D.A., Kotze A.C., Dalton J.P., Ingham A., Sweet M.J. Selective induction of the Notch ligand Jagged-1 in macropages by soluble egg antigen from Schistosoma mansoni involves ERK signaling. Immunology 2009, 127:326-337.
28. Nilsson R., Bajic V.B., Suzuki H., di Bernardo D., Björkegren J., Katayama S., Reid J.F., Sweet M.J., Gariboldi M., Carninci P., Hayashizaki Y., Hume D.A., Tegner J., Ravasi T. Transcriptional network dynamics in macrophage activation. Genomics 2006, 88:133-142.
29. Grandbarbe L., Michelucci A., Heurtaux T., Hemmer K., Morga E., Heuschling P. Notch signaling modulates the activation of microglial cells. Glia 2007, 55:1519-1530.
30. Wang Y.C., He H., Feng F., Liu X.W., Dong G.Y., Qin H.Y., Hu X.B., Zheng M.H., Liang L., Feng L., Liang Y.M., Han H. Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer Res. 2010, 70:4840-4849.
31. Stout R.D., Jiang C., Matta B., Tietzel I., Watkins S.K., Suttles J. Macrophages sequentially change their functional phenotype in response to change in microenvironmental influences. J. Immunol. 2005, 175:342-349.
32. Righi M., Mori L., De Libero G., Sironi M., Biondi A., Mantovani A., Donini S.D., Ricciardi-Castagnoli P. Monokine production by microglial cell clones. Eur. J. Immunol. 1989, 19:1443-1448.
33. Barger S.W., Harmon A.D. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 1997, 388:878-881.
34. Zhang W., Xu W., Xiong S. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J. Immunol. 2010, 184:6465-6478.
35. Dai J.-N., Zong Y., Zhong L.-M., Li Y.-M., Zhang W., Bian L.-G., Ai Q.-L., Liu Y.-D., Sun J., Lu D. Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One 2011, 6:e21891.
36. Ling E.A., Wong W.C. The origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia 1993, 7:9-18.
37. Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
38. Zhang S.C., Goetz B.D., Carré J.L., Duncan I.D. Reactive microglia in dysmyelination and demyelination. Glia 2001, 34:101-109.
39. Butovsky O., Ziv Y., Schwartz A., Landa G., Talpalar A.E., Pluchino S., Martino G., Schwartz M. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci. 2006, 31:149-160.
40. Butovsky O., Talpalar A.E., Ben-Yaakov K., Schwartz M. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol. Cell. Neurosci. 2005, 29:381-393.
41. Schwartz M., Butovsky O., Bruck W., Hanisch U.K. Microglial phenotype: is the commitment reversible?. Trends Neurosci. 2006, 29:68-74.
42. Foldi J., Chung A.Y., Xu H., Zhu J., Outtz H.H., Kitajewski J., Li Y., Hu X., Ivashkiv L.B. Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J. Immunol. 2010, 185:5023-5031.
43. Cao Q., Lu J., Kaur C., Sivakumar V., Li F., Cheah P.S., Dheen S.T., Linq E.A. Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. Glia 2008, 56:1224-1237.
44. Cao Q., Li P., Lu J., Dheen S.T., Kaur C., Linq E.A. Nuclear factor-kappaB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the gamma-secretase complex blocker DAPT. J. Neurosci. Res. 2010, 88:2701-2714.
45. Jayadev S., Case A., Eastman A.J., Nguyen H., Pollak J., Wiley J.C., Möller T., Morrison R.S., Garden G.A. Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release. PLoS One 2010, 5:e15743.
46. Kopan R., Ilagan M.X. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009, 137:216-233.