Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity

Stem Cell Reports

Volumn 8, Issue 3, 2017, Pages 548-560

  Abad, Maria ^a,b   Hashimoto, Hisayuki ^a   Zhou, Huanyu ^a   Morales, Maria Gabriela ^a   Chen, Beibei ^a   Bassel Duby, Rhonda ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VALL D HEBRON UNIVERSITY HOSPITAL   (Spain)

Author keywords

cardiomyocytes; cell fate conversion; DAPT; direct cellular reprogramming; heart regeneration; Notch signaling; regenerative medicine; transdifferentiation

Indexed keywords

NOTCH RECEPTOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HAND2; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG; 24-DIAMINO-5-PHENYLTHIAZOLE; AKT1 PROTEIN, MOUSE; DIAMINE; MYOCYTE ENHANCER FACTOR 2; THIAZOLE DERIVATIVE; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CARDIAC MUSCLE CELL; CELL DIFFERENTIATION; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; RECEPTOR UPREGULATION; RNA SEQUENCE; SARCOMERE; STRUCTURAL GENE; ANIMAL; CALCIUM SIGNALING; CYTOLOGY; DRUG EFFECTS; ELECTROPHYSIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELLULAR REPROGRAMMING; DIAMINES; ELECTROPHYSIOLOGICAL PHENOMENA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MEF2 TRANSCRIPTION FACTORS; MICE; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, NOTCH; SARCOMERES; SIGNAL TRANSDUCTION; THIAZOLES; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTOME;

EID: 85014097486     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2017.01.025     Document Type: Article

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