Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain

Cardiovascular Research

Volumn 100, Issue 1, 2013, Pages 105-113

  Hirai, Hiroyuki ^a,b   Katoku Kikyo, Nobuko ^a,b   Keirstead, Susan A ^a,b   Kikyo, Nobuaki ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cardiomyocytes; Direct reprogramming; Transcription factors

Indexed keywords

CATION CHANNEL; HYPERPOLARIZATION ACTIVATED CATION CHANNEL 4; MYOD PROTEIN; SODIUM CHANNEL NAV1.5; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HAND2; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR TBX5; TROPONIN T; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL BETA 1 SUBUNIT;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE EXPRESSION; GENE FUSION; GENETIC TRANSDUCTION; HEART MUSCLE CELL; IMMUNOFLUORESCENCE TEST; MOUSE; NEWBORN; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; WILD TYPE;

CARDIOMYOCYTES; DIRECT REPROGRAMMING; TRANSCRIPTION FACTORS;

ANIMALS; CELL DIFFERENTIATION; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; INDUCED PLURIPOTENT STEM CELLS; MEF2 TRANSCRIPTION FACTORS; MICE; MYOCYTES, CARDIAC; MYOD PROTEIN; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTIONAL ACTIVATION;

EID: 84887887555     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt167     Document Type: Article

References (36)

1. Kikuchi K, Poss KD. Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol 2012; 28: 719-741.
2. Burridge PW, Keller G, Gold J.D., Wu JC. Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell 2012; 10: 16-28.
3. Sancho-Martinez I., Baek SH, Izpisua Belmonte JC. Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol 2012; 14: 892-899.
4. Ieda M, Fu J-D, Delgado-Olguin P, Vedantham V., Hayashi Y, Bruneau BG et al. Direct reprogramming offibroblasts into functional cardiomyocytes bydefined factors. Cell 2010; 142: 375-386.
5. Chen JX, Krane M, Deutsch M.A., Wang L., Rav-Acha M, Gregoire S et al. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res 2012; 111: 50-55.
6. Song K, Nam YJ, Luo X, Qi X., Tan W, Huang GN et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 2012; 485: 599-604.
7. Qian L, Huang Y, Spencer C.I., Foley A., Vedantham V, Liu L et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 2012; 485: 593-598.
8. Inagawa K, Miyamoto K, Yamakawa H., Muraoka N, Sadahiro T, Umei T et al. Induction of cardiomyocyte-like cells ininfarct heartsby gene transfer of Gata4, Mef2c, and Tbx5. Circ Res 2012; 111: 1147-1156.
9. Hirai H, Tani T, Katoku-Kikyo N, Kellner S., Karian P, Firpo M et al. Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells 2011; 29: 1349-1361.
10. Hirai H, Katoku-Kikyo N, Karian P., Firpo M, Kikyo N. Efficient iPS cell production with the MyoD transactivation domain in serum-free culture. PloS One 2012; 7:e34149.
11. Hirai H, Tani T, Kikyo N. Structure and functions of powerful transactivators: VP16, MyoD and FoxA. Int J Dev Biol 2010; 54: 1589-1596.
12. Kitamura T, Koshino Y, Shibata F., Oki T, Nakajima H, Nosaka T et al. Retrovirus-mediated gene transfer and expression cloning: Powerful toolsinfunctional genomics. Exp Hematol 2003; 31: 1007-1014.
13. Morita S, Kojima T, Kitamura T. Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther 2000; 7: 1063-1066.
14. Wang Y, Chen J, Hu J.L., Wei XX, Qin D, Gao J et al. Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep 2011; 12: 373-378.
15. Hammachi F, Morrison GM, Sharov A.A., Livigni A., Narayan S, Papapetrou EP et al. Tran-scriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency. Cell Rep 2012; 1: 99-109.
16. Schram G, Pourrier M, Melnyk P., Nattel S. Differential distribution of cardiacion channel expression as a basis for regional specialization in electrical function. Circ Res 2002; 90: 939-950.
17. Watanabe H, Darbar D, Kaiser D.W., Jiramongkolchai K., Chopra S, Donahue BS et al. Mutations in sodium channel b1- and b2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2009; 2: 268-275.
18. Shi W, Wymore R, Yu H., Wu J, Wymore RT, Pan Z et al. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expressionin cardiac tissues. Circ Res 1999; 85:e1-e6.
19. Stadtfeld M, Maherali N, Borkent M., Hochedlinger K. A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat Methods 2010; 7: 53-55.
20. Islas JF, Liu Y, Weng K.C., Robertson MJ, Zhang S, Prejusa A et al. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci USA 2012; 109: 13016-13021.
21. Eminli S, Foudi A, Stadtfeld M., Maherali N, Ahfeldt T, Mostoslavsky G et al. Differentiation stage determines potential ofhematopoietic cells for reprogramming into induced pluri-potent stem cells. Nat Genet 2009; 41: 968-976.
22. Buganim Y, Faddah DA, Cheng A.W., Itskovich E., Markoulaki S, Ganz K et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012; 150: 1209-1222.
23. Morrisey EE, Ip HS, Tang Z, Parmacek MS. Gata-4 activates transcription via two novel domains that are conserved within the Gata-4/5/6 subfamily. J Biol Chem 1997; 272: 8515-8524.
24. Tremblay JJ, Hamel F, Viger RS. Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity. Endocrinology 2002; 143: 3935-3945.
25. Zaragoza MV, Lewis LE, Sun G, Wang E., Li L, Said-Salman I et al. Identification of the Tbx5 transactivating domain and the nuclear localization signal. Gene 2004; 330: 9-18.
26. Ma K, Chan JK, Zhu G, Wu Z. Myocyte enhancer factor 2acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol Cell Biol 2005; 25: 3575-3582.
27. Morin S, Charron F, Robitaille L., Nemer M. Gata-dependent recruitment of Mef2 proteins to target promoters. EMBO J 2000; 19: 2046-2055.
28. Ghosh TK, Song FF, Packham E.A., Buxton S., Robinson TE, Ronksley J et al. Physical interaction between Tbx5 and Mef2c is required for early heart development. Mol Cell Biol 2009; 29: 2205-2218.
29. Latchman DS. Transcription factors and transcription control. Gene Control. New York: Garland Science, 2010:pp. 133-173.
30. Jayawardena TM, Egemnazarov B, Finch E.A., Zhang L., Payne JA, Pandya K et al. Microrna-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes. Circ Res 2012; 110: 1465-1473.
31. Nam YJ, Song K, Luo X., Daniel E, Lambeth K, West K et al. Reprogramming of human fibroblasts toward a cardiac fate. Proc Natl Acad Sci USA 2013; 110: 5588-5593.
32. Kim K, Doi A, Wen B., Ng K, Zhao R, Cahan P et al. Epigenetic memory in induced pluri-potent stem cells. Nature 2010; 467: 285-290.
33. Ohi Y, Qin H, Hong C., Blouin L, Polo JM, Guo T et al. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human ips cells. Nat Cell Biol 2011; 13: 541-549.
34. Polo JM, Liu S, Figueroa M.E., Kulalert W., Eminli S, Tan KY et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol 2010; 28: 848-855.
35. Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell 2011; 145: 835-850.
36. Papp B, Plath K. Epigenetics of reprogramming to induced pluripotency. Cell 2013; 152: 1324-1343.