Conversion of human fibroblasts into functional cardiomyocytes by small molecules

Science

Volumn 352, Issue 6290, 2016, Pages 1216-1220

  Cao, Nan ^a,b   Huang, Yu ^a   Zheng, Jiashun ^b,d   Spencer, C Ian ^a   Zhang, Yu ^a,b   Fu, Ji Dong ^e   Nie, Baoming ^a,b   Xie, Min ^a,b   Zhang, Mingliang ^a,b   Wang, Haixia ^a,b   Ma, Tianhua ^a,b   Xu, Tao ^a,b   Shi, Guilai ^a,b   Srivastava, Deepak ^a,b,c   Ding, Sheng ^a,b  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; 6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ACTIVIN A; ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN 4; FORSKOLIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTOME; TRANYLCYPROMINE; VASCULOTROPIN; VENTRICULAR MYOSIN; CHROMATIN; MOLECULAR LIBRARY; MYOSIN HEAVY CHAIN;

CARDIOVASCULAR SYSTEM; CELLS AND CELL COMPONENTS; CYTOGENETICS; ELECTRICAL PROPERTY; GENE; OPTIMIZATION; PHYSIOLOGY; RODENT;

ARTICLE; CARDIAC MUSCLE CELL; CELL LINE; CELL TRANSDIFFERENTIATION; CONFORMATIONAL TRANSITION; DEVELOPMENTAL GENE; ELECTROPHYSIOLOGY; ENHANCER REGION; EPIGENETICS; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CELL LINEAGE; CELL REPROGRAMMING TECHNIQUE; CHEMISTRY; CHROMATIN; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; EMBRYOLOGY; GENETIC TRANSDUCTION; GENETICS; HEART; MALE; METABOLISM; MOLECULAR LIBRARY; MOUSE; MYOCARDIAL INFARCTION; NONOBESE DIABETIC MOUSE; ORGANOGENESIS; PHARMACOLOGY; PROTEIN CONFORMATION; SKIN; TRANSPLANTATION;

ANIMALS; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CELLULAR REPROGRAMMING; CELLULAR REPROGRAMMING TECHNIQUES; CHROMATIN; DISEASE MODELS, ANIMAL; FIBROBLASTS; HEART; HUMANS; MALE; MICE; MICE, INBRED NOD; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; ORGANOGENESIS; PROTEIN CONFORMATION; SKIN; SMALL MOLECULE LIBRARIES; TRANSCRIPTOME; TRANSDUCTION, GENETIC;

EID: 84965036159     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf1502     Document Type: Article

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