Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success

Journal of Molecular and Cellular Cardiology

Volumn 60, Issue 1, 2013, Pages 97-106

  Addis, Russell C ^a   Ifkovits, Jamie L ^a   Pinto, Filipa ^a   Kellam, Lori D ^a   Esteso, Paul ^a   Rentschler, Stacey ^b   Christoforou, Nicolas ^c   Epstein, Jonathan A ^a   Gearhart, John D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Duke University   (United States)

Author keywords

Calcium imaging; Direct reprogramming; Induced cardiomyocytes; Regenerative medicine; Transdifferentiation

Indexed keywords

ALPHA ACTININ; CALCIUM; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2C; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR HAND2; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR TBX5; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; FIBROBLAST; FLOW CYTOMETRY; FUNCTIONAL ASSESSMENT; HEART EXCITATION; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN FOLDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; CELL LINE; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; MICE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; TRANSCRIPTION FACTORS;

EID: 84878646315     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.04.004     Document Type: Article

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