Identification of Oct4-activating compounds that enhance reprogramming efficiency

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 51, 2012, Pages 20853-20858

  Li, Wendong ^a   Tian, E ^a   Chen, Zhao Xia ^a   Sun, GuoQiang ^a   Ye, Peng ^a   Yang, Su ^a   Lu, Dave ^a   Xie, Jun ^a   Ho, Thach Vu ^a   Tsark, Walter M ^a   Wang, Charles ^a   Horne, David A ^a   Riggs, Arthur D ^a   Yip, M L Richard ^a   Shi, Yanhong ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DNA; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL BASED HIGH THROUGHPUT SCREENING; CELL STRUCTURE; DEMETHYLATION; EMBRYONIC STEM CELL; GENE; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; MOLECULE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; WNT SIGNALING PATHWAY;

ANIMALS; BENZAMIDES; CELL DIFFERENTIATION; CHEMISTRY, PHARMACEUTICAL; DNA METHYLATION; DNA-BINDING PROTEINS; DRUG DESIGN; EMBRYONIC STEM CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; NUCLEAR REPROGRAMMING; OCTAMER TRANSCRIPTION FACTOR-3; PROTO-ONCOGENE PROTEINS; PYRIDINES; PYRROLES; SOXB1 TRANSCRIPTION FACTORS;

EID: 84871385001     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219181110     Document Type: Article

References (52)

1. Takahashi K, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861-872.
2. Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663-676.
3. Yamanaka S (2007) Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1(1):39-49.
4. Huangfu D, et al. (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 26(7):795-797.
5. Huangfu D, et al. (2008) Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 26(11):1269-1275.
6. Shi Y, et al. (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2(6):525-528.
7. Shi Y, et al. (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5):568-574.
8. Lin T, et al. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods 6(11):805-808.
9. Ichida JK, et al. (2009) A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 5(5):491-503.
10. Zhu S, et al. (2010) Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 7(6):651-655.
11. Li Y, et al. (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res 21(1):196-204.
12. Esteban MA, et al. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6(1):71-79.
13. Mali P, et al. (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluri-potency- associated genes. Stem Cells 28(4):713-720.
14. Lyssiotis CA, et al. (2009) Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci USA 106 (22):8912-8917.
15. Silva J, et al. (2008) Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol 6(10):e253.
16. Wang Q, et al. (2011) Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res 21(10):1424-1435.
17. Wang W, et al. (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc Natl Acad Sci USA 108(45):18283-18288.
18. Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24(4):372-376.
19. Marson A, et al. (2008) Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 3(2):132-135.
20. Silva J,etal. (2009)Nanogis thegateway to thepluripotentgroundstate. Cell 138(4):722-737.
21. Judson RL, Babiarz JE, Venere M, Blelloch R (2009) Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 27(5):459-461.
22. Warren L, et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7(5):618-630.
23. Anokye-Danso F, et al. (2011) Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 8(4):376-388.
24. Loewer S, et al. (2010) Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet 42(12):1113-1117.
25. Liao B, et al. (2011) MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem 286(19):17359-17364.
26. Zhao Y, et al. (2008) Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3(5):475-479.
27. Banito A, et al. (2009) Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev 23(18):2134-2139.
28. Hong H, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460(7259):1132-1135.
29. Kawamura T, et al. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460(7259):1140-1144.
30. Li H, et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460 (7259):1136-1139.
31. Utikal J, et al. (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460(7259):1145-1148.
32. Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S (2009) Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell 5(3):237-241.
33. Heng JC, et al. (2010) The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 6(2):167-174.
34. Miyoshi N, et al. (2011) Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 8(6):633-638.
35. Kim JB, et al. (2009) Oct4-induced pluripotency in adult neural stemcells. Cell 136(3):411-419.
36. Kim JB, et al. (2009) Direct reprogramming of human neural stem cells by OCT4. Nature 461(7264):649-3.
37. Boyer LA, et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122(6):947-956.
38. Jaenisch R, Young R (2008) Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 132(4):567-582.
39. Chen J, et al. (2010) Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem 285(40):31066-31072.
40. Szabó PE, Hübner K, Schöler H, Mann JR (2002) Allele-specific expression of imprinted genes in mouse migratory primordial germ cells. Mech Dev 115(1-2):157-160.
41. Marión RM, et al. (2009) A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460(7259):1149-1153.
42. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10(1):55-63.
43. Li W, et al. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27(12):2992-3000.
44. Ito S, et al. (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466(7310):1129-1133.
45. Freudenberg JM, et al. (2012) Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity. Nucleic Acids Res 40(8):3364-3377.
46. Chambers I, et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113(5):643-655.
47. Mitsui K, et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113(5):631-642.
48. Nichols J, et al. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95(3):379-391.
49. Thompson PA, et al. (2008) Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods. Assay Drug Dev Technol 6(1):69-81.
50. Koh KP, et al. (2011) Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8(2):200-213.
51. Dawlaty MM, et al. (2011) Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell 9(2):166-175.
52. González F, Boué S, Izpisúa Belmonte JC (2011) Methods for making induced pluripotent stem cells: Reprogramming à la carte. Nat Rev Genet 12(4):231-242.