Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis

Arthritis Research and Therapy

Volumn 17, Issue 1, 2015, Pages

  Cai, Dawei ^a   Yin, Shasha ^a   Yang, Jun ^a   Jiang, Qing ^a,b   Cao, Wangsen ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; HISTONE DEACETYLASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; IODOACETIC ACID; MONOSODIUM IODOACETATE; STROMELYSIN; TRANSCRIPTION FACTOR NRF2; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; NFE2L2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE INJURY; CHONDROPROTECTION; CHONDROSARCOMA CELL LINE; CONTROLLED STUDY; ENZYME INHIBITION; HISTONE ACETYLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MALE; MOUSE; MOUSE MODEL; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SW1353 CELL LINE; WILD TYPE MOUSE; ANIMAL; ARTICULAR CARTILAGE; CELL LINE; CHONDROCYTE; DEFICIENCY; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELL LINE; CHONDROCYTES; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; MALE; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION;

EID: 84942163002     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0774-3     Document Type: Article

References (42)

1. Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:2115-26. doi: 10.1016/S0140-6736(11)60243-2.
2. Sellam J, Berenbaum F. Is osteoarthritis a metabolic disease? Joint Bone Spine. 2013;80:568-73. doi: 10.1016/j.jbspin.2013.09.007.
3. Su SC, Tanimoto K, Tanne Y, Kunimatsu R, Hirose N, Mitsuyoshi T, et al. Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress. Osteoarthritis Cartilage. 2014;22:845-51. doi: 10.1016/j.joca.2014.03.011.
4. de Vries HE, Witte M, Hondius D, Rozemuller AJ, Drukarch B, Hoozemans J, et al. Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic Biol Med. 2008;45:1375-83. doi: 10.1016/j.freeradbiomed.2008.09.001.
5. Zhao J, Zhang B, Li S, Zeng L, Chen Y, Fang J. Mangiferin increases Nrf2 protein stability by inhibiting its ubiquitination and degradation in human HL60 myeloid leukemia cells. Int J Mol Med. 2014;33:1348-54. doi: 10.3892/ijmm.2014.1696.
6. Apopa PL, He X, Ma Q. Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. J Biochem Mol Toxicol. 2008;22:63-76. doi: 10.1002/jbt.20212.
7. Sun Z, Chin YE, Zhang DD. Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol. 2009;29:2658-72. doi: 10.1128/MCB.01639-08.
8. Kawai Y, Garduno L, Theodore M, Yang J, Arinze IJ. Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem. 2011;286:7629-40. doi: 10.1074/jbc.M110.208173.
9. Patra N, De U, Kim TH, Lee YJ, Ahn MY, Kim ND, et al. A novel histone deacetylase (HDAC) inhibitor MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. Biomed Pharmacother. 2013;67:407-15. doi: 10.1016/j.biopha.2013.01.006.
10. Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, et al. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. Eur J Med Chem. 2014;82:204-13. doi: 10.1016/j.ejmech.2014.05.050.
11. Foti SB, Chou A, Moll AD, Roskams AJ. HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain. Int J Dev Neurosci. 2013;31:434-47. doi: 10.1016/j.ijdevneu.2013.03.008.
12. Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, et al. The histone-deacetylase inhibitor trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol. 2002;36:233-40.
13. Culley KL, Hui W, Barter MJ, Davidson RK, Swingler TE, Destrument AP, et al. Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. Arthritis Rheum. 2013;65:1822-30. doi: 10.1002/art.37965.
14. Chen WP, Bao JP, Hu PF, Feng J, Wu LD. Alleviation of osteoarthritis by trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. Mol Biol Rep. 2010;37:3967-72. doi: 10.1007/s11033-010-0055-9.
15. Li M, Liu X, Sun X, Wang Z, Guo W, Hu F, et al. Therapeutic effects of NK-HDAC-1, a novel histone deacetylase inhibitor, on collagen-induced arthritis through the induction of apoptosis of fibroblast-like synoviocytes. Inflammation. 2013;36:888-96. doi: 10.1007/s10753-013-9616-0.
16. Joosten LA, Leoni F, Meghji S, Mascagni P. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis. Mol Med. 2011;17:391-6. doi: 10.2119/molmed.2011.00058.
17. Ogbonna AC, Clark AK, Gentry C, Hobbs C, Malcangio M. Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice. Eur J Pain. 2013;17:514-26. doi: 10.1002/j.1532-2149.2012.00223.x.
18. Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum. 2004;50:2547-58. doi: 10.1002/art.20558.
19. La Porta C, Bura SA, Aracil-Fernández A, Manzanares J, Maldonado R. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. Pain. 2013;154:160-74. doi: 10.1016/j.pain.2012.10.009.
20. Wang B, Zhu X, Kim Y, Li J, Huang S, Saleem S, et al. Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. Free Radic Biol Med. 2012;52:928-36. doi: 10.1016/j.freeradbiomed.2011.12.006.
21. Kawaguchi H. Mechanism of molecular backgrounds of osteoarthritis. Nihon Rinsho. 2014;72:1729-33. Japanese.
22. Jiang L, Li L, Geng C, Gong D, Jiang L, Ishikawa N, et al. Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro. J Orthop Res. 2013;31:364-9. doi: 10.1002/jor.22250.
23. Furuzawa-Carballeda J, Macip-Rodríguez PM, Cabral AR. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clin Exp Rheumatol. 2008;26:554-60.
24. Chorazy-Massalska M, Kontny E, Kornatka A, Rell-Bakalarska M, Marcinkiewicz J, Maslinski W. The effect of taurine chloramine on pro-inflammatory cytokine production by peripheral blood mononuclear cells isolated from rheumatoid arthritis and osteoarthritis patients. Clin Exp Rheumatol. 2004;22:692-8.
25. Anuranjani, Bala M. Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage. Redox Biol. 2014;2:832-46. doi: 10.1016/j.redox.2014.02.008.
26. So H, Kim H, Kim Y, Kim E, Pae HO, Chung HT, et al. Evidence that cisplatin-induced auditory damage is attenuated by downregulation of pro-inflammatory cytokines via Nrf2/HO-1. J Assoc Res Otolaryngol. 2008;9:290-306. doi: 10.1007/s10162-008-0126-y.
27. Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis. 2011;70:844-50. doi: 10.1136/ard.2010.132720.
28. Maicas N, Ferrándiz ML, Brines R, Ibáñez L, Cuadrado A, Koenders MI, et al. Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease. Antioxid Redox Signal. 2011;15:889-901. doi: 10.1089/ars.2010.3835.
29. Hashimoto S, Rai MF, Janiszak KL, Cheverud JM, Sandell LJ. Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice. Osteoarthritis Cartilage. 2012;20:562-71. doi: 10.1016/j.joca.2012.01.022.
30. Little CB, Zaki S. What constitutes an "animal model of osteoarthritis" - the need for consensus? Osteoarthritis Cartilage. 2012;20:261-7. doi: 10.1016/j.joca.2012.01.017.
31. van der Kraan PM, Vitters EL, van de Putte LB, van den Berg WB. Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. Am J Pathol. 1989;135:1001-14.
32. Naveen SV, Ahmad RE, Hui WJ, Suhaeb AM, Murali MR, Shanmugam R, et al. Histology, glycosaminoglycan level and cartilage stiffness in monoiodoacetate-induced osteoarthritis: comparative analysis with anterior cruciate ligament transection in rat model and human osteoarthritis. Int J Med Sci. 2014;11:97-105. doi: 10.7150/ijms.6964.
33. Kaspiris A, Khaldi L, Grivas TB, Vasiliadis E, Kouvaras I, Dagkas S, et al. Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: an immunohistochemical study. Orthop Traumatol Surg Res. 2013;99:523-9. doi: 10.1016/j.otsr.2013.03.019.
34. Ryu JH, Lee A, Huh MS, Chu J, Kim K, Kim BS, et al. Measurement of MMP activity in synovial fluid in cases of osteoarthritis and acute inflammatory conditions of the knee joints using a fluorogenic peptide probe-immobilized diagnostic kit. Theranostics. 2012;2:198-206. doi: 10.7150/thno.3477.
35. Lee YJ, Lee EB, Kwon YE, Lee JJ, Cho WS, Kim HA, et al. Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes. Rheumatol Int. 2003;23:282-8. doi: 10.1007/s00296-003-0312-5.
36. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33-42. doi: 10.1038/nrrheum.2010.196.
37. Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, et al. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. Osteoarthritis Cartilage. 2008;16:723-32. doi: 10.1016/j.joca.2007.10.014.
38. Clérigues V, Murphy CL, Guillén MI, Alcaraz MJ. Haem oxygenase-1 induction reverses the actions of interleukin-1β on hypoxia-inducible transcription factors and human chondrocyte metabolism in hypoxia. Clin Sci (Lond). 2013;125:99-108. doi: 10.1042/CS20120491.
39. Clérigues V, Guillén MI, Castejón MA, Gomar F, Mirabet V, Alcaraz MJ. Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts. Biochem Pharmacol. 2012;83:395-405. doi: 10.1016/j.bcp.2011.11.024.
40. Guillén M, Megías J, Gomar F, Alcaraz M. Haem oxygenase-1 regulates catabolic and anabolic processes in osteoarthritic chondrocytes. J Pathol. 2008;214:515-22. doi: 10.1002/path.2313.
41. Wagener FA, Scharstuhl A, Tyrrell RM, Von den Hoff JW, Jozkowicz A, Dulak J, et al. The heme-heme oxygenase system in wound healing; implications for scar formation. Curr Drug Targets. 2010;11:1571-85.
42. Adcock IM, Lee KY. Abnormal histone acetylase and deacetylase expression and function in lung inflammation. Inflamm Res. 2006;55:311-21. doi: 10.1007/s00011-006-0081-1.