Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis

Osteoarthritis and Cartilage

Volumn 23, Issue 4, 2015, Pages 616-628

  Gardiner, M D ^a   Vincent, T L ^a   Driscoll, C ^a   Burleigh, A ^a,b   Bou Gharios, G ^a,c   Saklatvala, J ^a   Nagase, H ^a   Chanalaris, A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Destabilisation of the medial meniscus (DMM); Fibromodulin; Fibronectin; Microarray; Osteoarthritis; Tenascin

Indexed keywords

FIBRONECTIN; JAGGED1; MYC PROTEIN; TETRASPANIN; TETRASPANIN 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; FIBROMODULIN; MEMBRANE PROTEIN; NBL1 PROTEIN, MOUSE; NDR2 PROTEIN, MOUSE; NERVE PROTEIN; PROTEIN; PROTEOGLYCAN; SCLEROPROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE; TENASCIN; TENASCIN-N PROTEIN, MOUSE; TSPAN2 PROTEIN, MOUSE;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; FOCAL ADHESION; GENE EXPRESSION; MALE; MICRODISSECTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; OVERLAPPING GENE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOMICS; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; GENETIC TRANSCRIPTION; GENETICS; INJURY; KNEE MENISCUS; METABOLISM; MICROARRAY ANALYSIS; OSTEOARTHRITIS, KNEE; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM-BINDING PROTEINS; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MENISCI, TIBIAL; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; NERVE TISSUE PROTEINS; OSTEOARTHRITIS, KNEE; PROTEINS; PROTEOGLYCANS; SIGNAL TRANSDUCTION; TENASCIN; TETRASPANINS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; WOUNDS AND INJURIES;

EID: 84924864232     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.12.014     Document Type: Article

References (47)

1. Loughlin J. Genetics of osteoarthritis. Curr Opin Rheumatol 2011, 23:479-483.
2. Panoutsopoulou K., Southam L., Elliott K.S., Wrayner N., Zhai G., Beazley C., et al. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis 2011, 70:864-867.
3. Reynard L.N., Loughlin J. The genetics and functional analysis of primary osteoarthritis susceptibility. Expert Rev Mol Med 2013, 15:e2.
4. Aigner T., Zien A., Gehrsitz A., Gebhard P.M., McKenna L. Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum 2001, 44:2777-2789.
5. Aigner T., Saas J., Zien A., Zimmer R., Gebhard P.M., Knorr T. Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis. Methods Mol Med 2004, 100:109-128.
6. Sato T., Konomi K., Yamasaki S., Aratani S., Tsuchimochi K., Yokouchi M., et al. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum 2006, 54:808-817.
7. Geyer M., Grassel S., Straub R.H., Schett G., Dinser R., Grifka J., et al. Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage 2009, 17:328-335.
8. van Tienen C., de Silva T.I., Alcantara L.C., Onyango C.O., Jarju S., Goncalves N., et al. Molecular epidemiology of endemic human T-lymphotropic virus type 1 in a rural community in Guinea-Bissau. PLoS Negl Trop Dis 2012, 6:e1690.
9. Cho D.Y., Kim Y.A., Przytycka T.M. Chapter 5: network biology approach to complex diseases. PLoS Comput Biol 2012, 8:e1002820.
10. McNulty M.A., Loeser R.F., Davey C., Callahan M.F., Ferguson C.M., Carlson C.S. Histopathology of naturally occurring and surgically induced osteoarthritis in mice. Osteoarthritis Cartilage 2012, 20:949-956.
11. Burleigh A., Chanalaris A., Gardiner M.D., Driscoll C., Boruc O., Saklatvala J., et al. Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression invivo. Arthritis Rheum 2012, 64:2278-2288.
12. Edgar R., Domrachev M., Lash A.E. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 2002, 30:207-210.
13. Appleton C.T., Pitelka V., Henry J., Beier F. Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 2007, 56:1854-1868.
14. Bateman J.F., Rowley L., Belluoccio D., Chan B., Bell K., Fosang A.J., et al. Transcriptomics of wild type and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum 2013, 65:1547-1560.
15. Wei T., Kulkarni N.H., Zeng Q.Q., Helvering L.M., Lin X., Lawrence F., et al. Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Osteoarthritis Cartilage 2010, 18:992-1000.
16. Karlsson C., Dehne T., Lindahl A., Brittberg M., Pruss A., Sittinger M., et al. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 2010, 18:581-592.
17. Loeser R.F., Olex A.L., McNulty M.A., Carlson C.S., Callahan M., Ferguson C., et al. Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis. PLoS One 2013, 8:e54633.
18. Loza M.J., McCall C.E., Li L., Isaacs W.B., Xu J., Chang B.L. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One 2007, 2:e1035.
19. Oliveros J.C. VENNY. An Interactive Tool for Comparing Lists with Venn Diagrams 2007.
20. Clements K.M., Price J.S., Chambers M.G., Visco D.M., Poole A.R., Mason R.M. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum 2003, 48:3452-3463.
21. Poulet B., Ulici V., Stone T.C., Pead M., Gburcik V., Constantinou E., et al. Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis Rheum 2012, 64:3256-3266.
22. Loeser R.F., Olex A.L., McNulty M.A., Carlson C.S., Callahan M.F., Ferguson C.M., et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum 2012, 64:705-717.
23. Scherberich A., Tucker R.P., Samandari E., Brown-Luedi M., Martin D., Chiquet-Ehrismann R. Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development. JCell Sci 2004, 117:571-581.
24. Mikura A., Okuhara S., Saito M., Ota M., Ueda K., Iseki S. Association of tenascin-W expression with mineralization in mouse calvarial development. Congenit Anom (Kyoto) 2009, 49:77-84.
25. Morgan J.M., Wong A., Yellowley C.E., Genetos D.C. Regulation of tenascin expression in bone. JCell Biochem 2011, 112:3354-3363.
26. Cheng T., Maddox N.C., Wong A.W., Rahnama R., Kuo A.C. Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes. JOrthop Res 2012, 30:234-245.
27. Kalamajski S., Oldberg A. The role of small leucine-rich proteoglycans in collagen fibrillogenesis. Matrix Biol 2010, 29:248-253.
28. Burton-Wurster N., Liu W., Matthews G.L., Lust G., Roughley P.J., Glant T.T., et al. TGF beta 1 and biglycan, decorin, and fibromodulin metabolism in canine cartilage. Osteoarthritis Cartilage 2003, 11:167-176.
29. Cs-Szabo G., Melching L.I., Roughley P.J., Glant T.T. Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples. Arthritis Rheum 1997, 40:1037-1045.
30. Westergren-Thorsson G., Hernnas J., Sarnstrand B., Oldberg A., Heinegard D., Malmstrom A. Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats. JClin Invest 1993, 92:632-637.
31. Jian J., Zheng Z., Zhang K., Rackohn T.M., Hsu C., Levin A., et al. Fibromodulin promoted invitro and invivo angiogenesis. Biochem Biophys Res Commun 2013, 436:530-535.
32. Drews F., Knobel S., Moser M., Muhlack K.G., Mohren S., Stoll C., et al. Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability. Biochim Biophys Acta 2008, 1783:34-48.
33. Leijten J.C., Emons J., Sticht C., van Gool S., Decker E., Uitterlinden A., et al. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum 2012, 64:3302-3312.
34. Uchino M., Izumi T., Tominaga T., Wakita R., Minehara H., Sekiguchi M., et al. Growth factor expression in the osteophytes of the human femoral head in osteoarthritis. Clin Orthop Relat Res 2000, 119-125.
35. Zhen G., Wen C., Jia X., Li Y., Crane J.L., Mears S.C., et al. Inhibition of TGF-beta signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med 2013, 19:704-712.
36. Shen J., Li J., Wang B., Jin H., Wang M., Zhang Y., et al. Deletion of the transforming growth factor beta receptor type II genein articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Arthritis Rheum 2013, 65:3107-3119.
37. James C.G., Appleton C.T., Ulici V., Underhill T.M., Beier F. Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol Biol Cell 2005, 16:5316-5333.
38. Meulenbelt I., Min J.L., Bos S., Riyazi N., Houwing-Duistermaat J.J., van der Wijk H.J., et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 2008, 17:1867-1875.
39. Bos S.D., Bovee J.V., Duijnisveld B.J., Raine E.V., van Dalen W.J., Ramos Y.F., et al. Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis 2012, 71:1254-1258.
40. Zeggini E., Panoutsopoulou K., Southam L., Rayner N.W., Day-Williams A.G., Lopes M.C., et al. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012, 380:815-823.
41. Bomer N., den Hollander W., Ramos Y.F., Bos S.D., van der Breggen R., Lakenberg N., et al. Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis. Ann Rheum Dis 2014, Published online first Apr 2 2014. 10.1136/annrheumdis-2013-204739.
42. Olex A.L., Turkett W.H., Fetrow J.S., Loeser R.F. Integration of gene expression data with network-based analysis to identify signaling and metabolic pathways regulated during the development of osteoarthritis. Gene 2014, 542:38-45.
43. Aigner T., Fundel K., Saas J., Gebhard P.M., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006, 54:3533-3544.
44. Nygaard V., Hovig E. Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling. Nucleic Acids Res 2006, 34:996-1014.
45. Kerkhoven R.M., Sie D., Nieuwland M., Heimerikx M., De Ronde J., Brugman W., et al. The T7-primer is a source of experimental bias and introduces variability between microarray platforms. PLoS One 2008, 3:e1980.
46. Singh R., Maganti R.J., Jabba S.V., Wang M., Deng G., Heath J.D., et al. Microarray-based comparison of three amplification methods for nanogram amounts of total RNA. Am J Physiol Cell Physiol 2005, 288:C1179-C1189.
47. McNamee K.E., Burleigh A., Gompels L.L., Feldmann M., Allen S.J., Williams R.O., et al. Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain 2010, 149:386-392.