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Volumn 65, Issue 3, 2013, Pages 639-649

Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE RICH PROTEIN 61; LENTIVIRUS VECTOR; LUCIFERASE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; SIMVASTATIN; SIRTUIN 1; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84874447190     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37807     Document Type: Article
Times cited : (51)

References (44)
  • 1
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • Bartok B, Firestein GS,. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010; 233: 233-55.
    • (2010) Immunol Rev , vol.233 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2
  • 2
    • 33845906843 scopus 로고    scopus 로고
    • All in the CCN family: Essential matricellular signaling modulators emerge from the bunker
    • Leask A, Abraham DJ,. All in the CCN family: essential matricellular signaling modulators emerge from the bunker. J Cell Sci 2006; 119: 4803-10.
    • (2006) J Cell Sci , vol.119 , pp. 4803-4810
    • Leask, A.1    Abraham, D.J.2
  • 3
    • 0035861590 scopus 로고    scopus 로고
    • The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts
    • Chen CC, Mo FE, Lau LF,. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. J Biol Chem 2001; 276: 47329-37.
    • (2001) J Biol Chem , vol.276 , pp. 47329-47337
    • Chen, C.C.1    Mo, F.E.2    Lau, L.F.3
  • 4
    • 0026925148 scopus 로고
    • Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development
    • O'Brien TP, Lau LF,. Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development. Cell Growth Differ 1992; 3: 645-54.
    • (1992) Cell Growth Differ , vol.3 , pp. 645-654
    • O'Brien, T.P.1    Lau, L.F.2
  • 5
    • 33745905328 scopus 로고    scopus 로고
    • Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins
    • Haas CS, Creighton CJ, Pi X, Maine I, Koch AE, Haines GK III, et al. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. Arthritis Rheum 2006; 54: 2047-60.
    • (2006) Arthritis Rheum , vol.54 , pp. 2047-2060
    • Haas, C.S.1    Creighton, C.J.2    Pi, X.3    Maine, I.4    Koch, A.E.5    Haines Iii, G.K.6
  • 6
    • 79953710552 scopus 로고    scopus 로고
    • Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis
    • Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, et al. Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis. Arthritis Rheum 2011; 63: 1010-20.
    • (2011) Arthritis Rheum , vol.63 , pp. 1010-1020
    • Kok, S.H.1    Hou, K.L.2    Hong, C.Y.3    Wang, J.S.4    Liang, P.C.5    Chang, C.C.6
  • 7
    • 73249143991 scopus 로고    scopus 로고
    • A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis
    • Zhang Q, Wu J, Cao Q, Xiao L, Wang L, He D, et al. A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum 2009; 60: 3602-12.
    • (2009) Arthritis Rheum , vol.60 , pp. 3602-3612
    • Zhang, Q.1    Wu, J.2    Cao, Q.3    Xiao, L.4    Wang, L.5    He, D.6
  • 8
    • 84862095866 scopus 로고    scopus 로고
    • Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis
    • Lin J, Zhou Z, Huo R, Xiao L, Ouyang G, Wang L, et al. Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis. J Immunol 2012; 188: 5776-84.
    • (2012) J Immunol , vol.188 , pp. 5776-5784
    • Lin, J.1    Zhou, Z.2    Huo, R.3    Xiao, L.4    Ouyang, G.5    Wang, L.6
  • 9
    • 36549019912 scopus 로고    scopus 로고
    • Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    • Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 2007; 204: 2803-12.
    • (2007) J Exp Med , vol.204 , pp. 2803-2812
    • Hirota, K.1    Yoshitomi, H.2    Hashimoto, M.3    Maeda, S.4    Teradaira, S.5    Sugimoto, N.6
  • 10
    • 33847020702 scopus 로고    scopus 로고
    • Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia
    • Lee HY, Chung JW, Youn SW, Kim JY, Park KW, Koo BK, et al. Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 2007; 100: 372-80.
    • (2007) Circ Res , vol.100 , pp. 372-380
    • Lee, H.Y.1    Chung, J.W.2    Youn, S.W.3    Kim, J.Y.4    Park, K.W.5    Koo, B.K.6
  • 11
    • 41849114197 scopus 로고    scopus 로고
    • Foxo in the immune system
    • Peng SL,. Foxo in the immune system. Oncogene 2008; 27: 2337-44.
    • (2008) Oncogene , vol.27 , pp. 2337-2344
    • Peng, S.L.1
  • 12
    • 20944443597 scopus 로고    scopus 로고
    • Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis
    • Jonsson H, Allen P, Peng SL,. Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis. Nat Med 2005; 11: 666-71.
    • (2005) Nat Med , vol.11 , pp. 666-671
    • Jonsson, H.1    Allen, P.2    Peng, S.L.3
  • 13
    • 34547408400 scopus 로고    scopus 로고
    • Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue
    • Ludikhuize J, de Launay D, Groot D, Smeets TJ, Vinkenoog M, Sanders ME, et al. Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue. Arthritis Rheum 2007; 56: 2180-91.
    • (2007) Arthritis Rheum , vol.56 , pp. 2180-2191
    • Ludikhuize, J.1    De Launay, D.2    Groot, D.3    Smeets, T.J.4    Vinkenoog, M.5    Sanders, M.E.6
  • 14
    • 36849073263 scopus 로고    scopus 로고
    • Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients
    • Kuo CC, Lin SC,. Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Mol Med 2007; 13: 561-6.
    • (2007) Mol Med , vol.13 , pp. 561-566
    • Kuo, C.C.1    Lin, S.C.2
  • 15
    • 77950335818 scopus 로고    scopus 로고
    • FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue
    • Turrel-Davin F, Tournadre A, Pachot A, Arnaud B, Cazalis MA, Mougin B, et al. FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue. Ann Rheum Dis 2010; 69: 755-60.
    • (2010) Ann Rheum Dis , vol.69 , pp. 755-760
    • Turrel-Davin, F.1    Tournadre, A.2    Pachot, A.3    Arnaud, B.4    Cazalis, M.A.5    Mougin, B.6
  • 16
    • 25444442080 scopus 로고    scopus 로고
    • Triple layer control: Phosphorylation, acetylation and ubiquitination of FOXO proteins
    • Vogt PK, Jiang H, Aoki M,. Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle 2005; 4: 908-13.
    • (2005) Cell Cycle , vol.4 , pp. 908-913
    • Vogt, P.K.1    Jiang, H.2    Aoki, M.3
  • 17
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • Van der Horst A, Burgering BM,. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007; 8: 440-50.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 440-450
    • Van Der Horst, A.1    Burgering, B.M.2
  • 18
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, Mostoslavsky R,. Recent progress in the biology and physiology of sirtuins. Nature 2009; 460: 587-91.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 19
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-5.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 20
    • 2942670131 scopus 로고    scopus 로고
    • Trial of Atorvastatin in Rheumatoid Arthritis (TARA): Double-blind, randomized placebo-controlled trial
    • McCarey DW, McInnes IB, Madhok R, Hampson R, Scherbakov O, Ford I, et al. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomized placebo-controlled trial. Lancet 2004; 363: 2015-21.
    • (2004) Lancet , vol.363 , pp. 2015-2021
    • McCarey, D.W.1    McInnes, I.B.2    Madhok, R.3    Hampson, R.4    Scherbakov, O.5    Ford, I.6
  • 21
    • 79954989313 scopus 로고    scopus 로고
    • Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis
    • Tang TT, Song Y, Ding YJ, Liao YH, Yu X, Du R, et al. Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis. J Lipid Res 2011; 52: 1023-32.
    • (2011) J Lipid Res , vol.52 , pp. 1023-1032
    • Tang, T.T.1    Song, Y.2    Ding, Y.J.3    Liao, Y.H.4    Yu, X.5    Du, R.6
  • 22
    • 0037309378 scopus 로고    scopus 로고
    • A novel anti-inflammatory role for simvastatin in inflammatory arthritis
    • Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H, et al. A novel anti-inflammatory role for simvastatin in inflammatory arthritis. J Immunol 2003; 170: 1524-30.
    • (2003) J Immunol , vol.170 , pp. 1524-1530
    • Leung, B.P.1    Sattar, N.2    Crilly, A.3    Prach, M.4    McCarey, D.W.5    Payne, H.6
  • 23
    • 10444220208 scopus 로고    scopus 로고
    • Assessment of the efficacy of different statins in murine collagen-induced arthritis
    • Palmer G, Chobaz V, Talabot-Ayer D, Taylor S, So A, Gabay C, et al. Assessment of the efficacy of different statins in murine collagen-induced arthritis. Arthritis Rheum 2004; 50: 4051-9.
    • (2004) Arthritis Rheum , vol.50 , pp. 4051-4059
    • Palmer, G.1    Chobaz, V.2    Talabot-Ayer, D.3    Taylor, S.4    So, A.5    Gabay, C.6
  • 25
    • 33750939673 scopus 로고    scopus 로고
    • RhoA-mediated, tumor necrosis factor α-induced activation of NF-κB in rheumatoid synoviocytes: Inhibitory effect of simvastatin
    • Xu H, Liu P, Liang L, Danesh FR, Yang X, Ye Y, et al. RhoA-mediated, tumor necrosis factor α-induced activation of NF-κB in rheumatoid synoviocytes: inhibitory effect of simvastatin. Arthritis Rheum 2006; 54: 3441-51.
    • (2006) Arthritis Rheum , vol.54 , pp. 3441-3451
    • Xu, H.1    Liu, P.2    Liang, L.3    Danesh, F.R.4    Yang, X.5    Ye, Y.6
  • 26
    • 32444440805 scopus 로고    scopus 로고
    • Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: A potential therapeutic approach to rheumatoid arthritis
    • Nagashima T, Okazaki H, Yudoh K, Matsuno H, Minota S,. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis. Arthritis Rheum 2006; 54: 579-86.
    • (2006) Arthritis Rheum , vol.54 , pp. 579-586
    • Nagashima, T.1    Okazaki, H.2    Yudoh, K.3    Matsuno, H.4    Minota, S.5
  • 27
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 28
    • 66049093998 scopus 로고    scopus 로고
    • Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: An implication for the pathogenesis of arthritis
    • Kok SH, Hong CY, Kuo MY, Wang CC, Hou KL, Lin YT, et al. Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis. Arthritis Rheum 2009; 60: 1451-62.
    • (2009) Arthritis Rheum , vol.60 , pp. 1451-1462
    • Kok, S.H.1    Hong, C.Y.2    Kuo, M.Y.3    Wang, C.C.4    Hou, K.L.5    Lin, Y.T.6
  • 29
    • 0034966686 scopus 로고    scopus 로고
    • 5′ flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus
    • Schutze N, Rucker N, Muller J, Adamski J, Jakob F,. 5′ flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus. Mol Pathol 2001; 54: 170-5.
    • (2001) Mol Pathol , vol.54 , pp. 170-175
    • Schutze, N.1    Rucker, N.2    Muller, J.3    Adamski, J.4    Jakob, F.5
  • 30
    • 66149120713 scopus 로고    scopus 로고
    • Th17 cells in rheumatoid arthritis and systemic lupus erythematosus
    • Pernis AB,. Th17 cells in rheumatoid arthritis and systemic lupus erythematosus. J Intern Med 2009; 265: 644-52.
    • (2009) J Intern Med , vol.265 , pp. 644-652
    • Pernis, A.B.1
  • 31
    • 77953256541 scopus 로고    scopus 로고
    • Targeting IL-17 and Th17 cells in rheumatoid arthritis
    • Sarkar S, Fox DA,. Targeting IL-17 and Th17 cells in rheumatoid arthritis. Rheum Dis Clin North Am 2010; 36: 345-66.
    • (2010) Rheum Dis Clin North Am , vol.36 , pp. 345-366
    • Sarkar, S.1    Fox, D.A.2
  • 32
    • 33744725255 scopus 로고    scopus 로고
    • Tumor necrosis factor-α protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction
    • Chen Q, Casali B, Pattacini L, Boiardi L, Salvarani C,. Tumor necrosis factor-α protects synovial cells from nitric oxide induced apoptosis through phosphoinositide 3-kinase Akt signal transduction. J Rheumatol 2006; 33: 1061-8.
    • (2006) J Rheumatol , vol.33 , pp. 1061-1068
    • Chen, Q.1    Casali, B.2    Pattacini, L.3    Boiardi, L.4    Salvarani, C.5
  • 33
    • 34447324890 scopus 로고    scopus 로고
    • Anti-malarial agent artesunate inhibits TNF-α-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes
    • Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, et al. Anti-malarial agent artesunate inhibits TNF-α-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology (Oxford) 2007; 46: 920-6.
    • (2007) Rheumatology (Oxford) , vol.46 , pp. 920-926
    • Xu, H.1    He, Y.2    Yang, X.3    Liang, L.4    Zhan, Z.5    Ye, Y.6
  • 34
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96: 857-68.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3    Lin, M.Z.4    Juo, P.5    Hu, L.S.6
  • 35
    • 13244287966 scopus 로고    scopus 로고
    • Regulation of FoxO activity by CBP/p300-mediated acetylation
    • Van der Heide LP, Smidt MP,. Regulation of FoxO activity by CBP/p300-mediated acetylation. Trends Biochem Sci 2005; 30: 81-6.
    • (2005) Trends Biochem Sci , vol.30 , pp. 81-86
    • Van Der Heide, L.P.1    Smidt, M.P.2
  • 36
    • 0038813706 scopus 로고    scopus 로고
    • Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-α-induced cyclooxygenase-2 promoter activation
    • Deng WG, Zhu Y, Wu KK,. Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-α-induced cyclooxygenase-2 promoter activation. J Biol Chem 2003; 278: 4770-7.
    • (2003) J Biol Chem , vol.278 , pp. 4770-4777
    • Deng, W.G.1    Zhu, Y.2    Wu, K.K.3
  • 37
    • 78751566527 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
    • Barroso E, Eyre E, Palomer X, Vazquez-Carrera M,. The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1. Biochem Pharmacol 2011; 81: 534-43.
    • (2011) Biochem Pharmacol , vol.81 , pp. 534-543
    • Barroso, E.1    Eyre, E.2    Palomer, X.3    Vazquez-Carrera, M.4
  • 38
    • 70350593596 scopus 로고    scopus 로고
    • Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts
    • Connor AM, Berger S, Narendran A, Keystone EC,. Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts. Arthritis Res Ther 2006; 8: R94.
    • (2006) Arthritis Res Ther , vol.8
    • Connor, A.M.1    Berger, S.2    Narendran, A.3    Keystone, E.C.4
  • 40
    • 79551483824 scopus 로고    scopus 로고
    • Sirtuins and inflammation: Friends or foes?
    • Galli M, Van Gool F, Leo O,. Sirtuins and inflammation: friends or foes? Biochem Pharmacol 2011; 81: 569-76.
    • (2011) Biochem Pharmacol , vol.81 , pp. 569-576
    • Galli, M.1    Van Gool, F.2    Leo, O.3
  • 41
    • 80052453175 scopus 로고    scopus 로고
    • SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
    • Niederer F, Ospelt C, Brentano F, Hottiger MO, Gay RE, Gay S, et al. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis 2011; 70: 1866-73.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1866-1873
    • Niederer, F.1    Ospelt, C.2    Brentano, F.3    Hottiger, M.O.4    Gay, R.E.5    Gay, S.6
  • 42
    • 84857109047 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner
    • Nakayama H, Yaguchi T, Yoshiya S, Nishizaki T,. Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner. Rheumatol Int 2012; 32: 151-7.
    • (2012) Rheumatol Int , vol.32 , pp. 151-157
    • Nakayama, H.1    Yaguchi, T.2    Yoshiya, S.3    Nishizaki, T.4
  • 43
    • 79953191835 scopus 로고    scopus 로고
    • Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand (RANKL) activation of NF-κB signaling and inhibit osteoclastogenesis in bone-derived cells
    • Shakibaei M, Buhrmann C, Mobasheri A,. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand (RANKL) activation of NF-κB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem 2011; 286: 11492-505.
    • (2011) J Biol Chem , vol.286 , pp. 11492-11505
    • Shakibaei, M.1    Buhrmann, C.2    Mobasheri, A.3
  • 44
    • 77951717549 scopus 로고    scopus 로고
    • SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    • Gagarina V, Gabay O, Dvir-Ginzberg M, Lee EJ, Brady JK, Quon MJ, et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum 2010; 62: 1383-92.
    • (2010) Arthritis Rheum , vol.62 , pp. 1383-1392
    • Gagarina, V.1    Gabay, O.2    Dvir-Ginzberg, M.3    Lee, E.J.4    Brady, J.K.5    Quon, M.J.6


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