Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

PLoS Pathogens

Volumn 11, Issue 3, 2015, Pages 1-28

  Wiesner, Darin L ^a   Specht, Charles A ^b   Lee, Chrono K ^b   Smith, Kyle D ^a   Mukaremera, Liliane ^a   Lee, S Thera ^a   Lee, Chun G ^c   Elias, Jack A ^d   Nielsen, Judith N ^e   Boulware, David R ^a   Bohjanen, Paul R ^a   Jenkins, Marc K ^a   Levitz, Stuart M ^b   Nielsen, Kirsten ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BROWN UNIVERSITY   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHITIN; CHITOTRIOSIDASE; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; RANTES; TUMOR NECROSIS FACTOR ALPHA; BETA N ACETYLHEXOSAMINIDASE; FUNGUS ANTIGEN;

ANTIGEN RECOGNITION; ARTICLE; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; CRYPTOCOCCOSIS; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; LEUKOCYTE FUNCTION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEROLOGY; TH2 CELL; ANIMAL; C57BL MOUSE; CRYPTOCOCCUS NEOFORMANS; DENDRITIC CELL; DISEASE MODEL; FLUORESCENCE MICROSCOPY; IMMUNOLOGY; LUNG MYCOSIS; LYMPHOCYTE ACTIVATION; MOUSE;

ASPERGILLUS FUMIGATUS; FILOBASIDIELLA NEOFORMANS; MAMMALIA;

ANIMALS; ANTIGENS, FUNGAL; CHITIN; CRYPTOCOCCOSIS; CRYPTOCOCCUS NEOFORMANS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; HEXOSAMINIDASES; LUNG DISEASES, FUNGAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; TH2 CELLS;

EID: 85013719052     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004701     Document Type: Article

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