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Volumn 44, Issue 12, 2014, Pages 3596-3604

CD4+FoxP3+ regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection

Author keywords

Cryptococcus neoformans; Pulmonary fungal infection; Regulatory T (Treg) cells; Th2 immunity

Indexed keywords

DIPHTHERIA TOXIN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GATA3 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE;

EID: 84923598220     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444963     Document Type: Article
Times cited : (37)

References (56)
  • 1
    • 84860797412 scopus 로고    scopus 로고
    • Analysis of cell cycle and replication of mouse macrophages after in vivo and in vitro Cryptococcus neoformans infection using laser scanning cytometry
    • Coelho, C., Tesfa, L., Zhang, J., Rivera, J., Goncalves, T. and Casadevall, A., Analysis of cell cycle and replication of mouse macrophages after in vivo and in vitro Cryptococcus neoformans infection using laser scanning cytometry. Infect. Immun. 2012. 80: 1467-1478.
    • (2012) Infect. Immun. , vol.80 , pp. 1467-1478
    • Coelho, C.1    Tesfa, L.2    Zhang, J.3    Rivera, J.4    Goncalves, T.5    Casadevall, A.6
  • 2
    • 34848905334 scopus 로고    scopus 로고
    • Depletion of alveolar macrophages decreases the dissemination of a glucosylceramidedeficient mutant of Cryptococcus neoformans in immunodeficient mice
    • Kechichian, T. B., Shea, J. and Del, P. M., Depletion of alveolar macrophages decreases the dissemination of a glucosylceramidedeficient mutant of Cryptococcus neoformans in immunodeficient mice. Infect. Immun. 2007. 75: 4792-4798.
    • (2007) Infect. Immun. , vol.75 , pp. 4792-4798
    • Kechichian, T.B.1    Shea, J.2    Del, P.M.3
  • 3
  • 5
    • 62349130224 scopus 로고    scopus 로고
    • Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS
    • Park, B. J., Wannemuehler, K. A., Marston, B. J., Govender, N., Pappas, P. G. and Chiller, T. M., Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 2009. 23: 525-530.
    • (2009) AIDS , vol.23 , pp. 525-530
    • Park, B.J.1    Wannemuehler, K.A.2    Marston, B.J.3    Govender, N.4    Pappas, P.G.5    Chiller, T.M.6
  • 6
    • 0025759044 scopus 로고
    • Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells
    • Huffnagle, G. B., Yates, J. L. and Lipscomb, M. F., Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells. J. Exp. Med. 1991. 173: 793-800.
    • (1991) J. Exp. Med. , vol.173 , pp. 793-800
    • Huffnagle, G.B.1    Yates, J.L.2    Lipscomb, M.F.3
  • 7
    • 33746605600 scopus 로고    scopus 로고
    • Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection
    • Lindell, D. M., Ballinger, M. N., McDonald, R. A., Toews, G. B. and Huffnagle, G. B., Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection. Infect. Immun. 2006. 74: 4538-4548.
    • (2006) Infect. Immun. , vol.74 , pp. 4538-4548
    • Lindell, D.M.1    Ballinger, M.N.2    McDonald, R.A.3    Toews, G.B.4    Huffnagle, G.B.5
  • 8
    • 15544372839 scopus 로고    scopus 로고
    • The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans
    • Chen, G. H., McDonald, R. A., Wells, J. C., Huffnagle, G. B., Lukacs, N. W. and Toews, G. B., The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans. Infect. Immun. 2005. 73: 1788-1796.
    • (2005) Infect. Immun. , vol.73 , pp. 1788-1796
    • Chen, G.H.1    McDonald, R.A.2    Wells, J.C.3    Huffnagle, G.B.4    Lukacs, N.W.5    Toews, G.B.6
  • 9
    • 0031310135 scopus 로고    scopus 로고
    • IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17mice
    • Hoag, K. A., Lipscomb, M. F., Izzo, A. A. and Street, N. E., IL-12 and IFN-gamma are required for initiating the protective Th1 response to pulmonary cryptococcosis in resistant C.B-17mice. Am. J. Respir. Cell Mol. Biol. 1997. 17: 733-739.
    • (1997) Am. J. Respir. Cell Mol. Biol. , vol.17 , pp. 733-739
    • Hoag, K.A.1    Lipscomb, M.F.2    Izzo, A.A.3    Street, N.E.4
  • 10
    • 0346373587 scopus 로고    scopus 로고
    • Role of interleukin-4 in resistance to Cryptococcus neoformans infection
    • Blackstock, R. and Murphy, J. W., Role of interleukin-4 in resistance to Cryptococcus neoformans infection. Am. J. Respir. Cell Mol. Biol. 2004. 30: 109-117.
    • (2004) Am. J. Respir. Cell Mol. Biol. , vol.30 , pp. 109-117
    • Blackstock, R.1    Murphy, J.W.2
  • 11
    • 0031707741 scopus 로고    scopus 로고
    • Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
    • Decken, K., Kohler, G., Palmer-Lehmann, K., Wunderlin, A., Mattner, F., Magram, J., Gately, M. K. et al., Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect. Immun. 1998. 66: 4994-5000.
    • (1998) Infect. Immun. , vol.66 , pp. 4994-5000
    • Decken, K.1    Kohler, G.2    Palmer-Lehmann, K.3    Wunderlin, A.4    Mattner, F.5    Magram, J.6    Gately, M.K.7
  • 12
    • 0033543946 scopus 로고    scopus 로고
    • Interleukin-4weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines
    • Kawakami, K., Hossain, Q. M., Zhang, T., Koguchi, Y., Xie, Q., Kurimoto, M. and Saito, A., Interleukin-4weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines. Cell Immunol. 1999. 197: 55-61.
    • (1999) Cell Immunol. , vol.197 , pp. 55-61
    • Kawakami, K.1    Hossain, Q.M.2    Zhang, T.3    Koguchi, Y.4    Xie, Q.5    Kurimoto, M.6    Saito, A.7
  • 13
    • 38449096612 scopus 로고    scopus 로고
    • IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    • Muller, U., Stenzel, W., Kohler, G., Werner, C., Polte, T., Hansen, G., Schutze, N. et al., IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans. J. Immunol. 2007. 179: 5367-5377.
    • (2007) J. Immunol. , vol.179 , pp. 5367-5377
    • Muller, U.1    Stenzel, W.2    Kohler, G.3    Werner, C.4    Polte, T.5    Hansen, G.6    Schutze, N.7
  • 14
    • 84894283077 scopus 로고    scopus 로고
    • Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production
    • Murdock, B. J., Huffnagle, G. B., Olszewski, M. A. and Osterholzer, J. J., Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production. Infect. Immun. 2014. 82: 937-948.
    • (2014) Infect. Immun. , vol.82 , pp. 937-948
    • Murdock, B.J.1    Huffnagle, G.B.2    Olszewski, M.A.3    Osterholzer, J.J.4
  • 15
    • 84859064942 scopus 로고    scopus 로고
    • IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and-dependent mechanisms
    • Szymczak, W. A., Sellers, R. S. and Pirofski, L. A., IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and-dependent mechanisms. Am. J. Pathol. 2012. 180: 1547-1559.
    • (2012) Am. J. Pathol. , vol.180 , pp. 1547-1559
    • Szymczak, W.A.1    Sellers, R.S.2    Pirofski, L.A.3
  • 16
    • 30744434833 scopus 로고    scopus 로고
    • IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12
    • Kleinschek, M. A., Muller, U., Brodie, S. J., Stenzel, W., Kohler, G., Blumenschein, W. M., Straubinger, R. K. et al., IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J. Immunol. 2006. 176: 1098-1106.
    • (2006) J. Immunol. , vol.176 , pp. 1098-1106
    • Kleinschek, M.A.1    Muller, U.2    Brodie, S.J.3    Stenzel, W.4    Kohler, G.5    Blumenschein, W.M.6    Straubinger, R.K.7
  • 17
    • 77953188589 scopus 로고    scopus 로고
    • Host responses to Candida albicans: Th17 cells and mucosal candidiasis
    • Conti, H. R. and Gaffen, S. L., Host responses to Candida albicans: Th17 cells and mucosal candidiasis. Microbes. Infect. 2010. 12: 518-527.
    • (2010) Microbes. Infect. , vol.12 , pp. 518-527
    • Conti, H.R.1    Gaffen, S.L.2
  • 18
    • 84900329695 scopus 로고    scopus 로고
    • IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection
    • Grahnert, A., Richter, T., Piehler, D., Eschke, M., Schulze, B., Muller, U., Protschka, M. et al., IL-4 receptor-alpha-dependent control of Cryptococcus neoformans in the early phase of pulmonary infection. PLoSOne 2014. 9: e87341.
    • (2014) PLoSOne , vol.9
    • Grahnert, A.1    Richter, T.2    Piehler, D.3    Eschke, M.4    Schulze, B.5    Muller, U.6    Protschka, M.7
  • 19
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y., Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 20
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. and Sakaguchi, S., Control of regulatory T cell development by the transcription factor Foxp3. Science 2003. 299: 1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 22
    • 0036346861 scopus 로고    scopus 로고
    • Clinical andmolecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • Wildin, R. S., Smyk-Pearson, S. and Filipovich, A. H., Clinical andmolecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet. 2002. 39: 537-545.
    • (2002) J. Med. Genet. , vol.39 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 23
    • 77956913784 scopus 로고    scopus 로고
    • Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection
    • Fulton, R. B., Meyerholz, D. K. and Varga, S. M., Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J. Immunol. 2010. 185: 2382-2392.
    • (2010) J. Immunol. , vol.185 , pp. 2382-2392
    • Fulton, R.B.1    Meyerholz, D.K.2    Varga, S.M.3
  • 24
    • 14844367047 scopus 로고    scopus 로고
    • Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    • Haeryfar, S. M., DiPaolo, R. J., Tscharke, D. C., Bennink, J. R. and Yewdell, J. W., Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities. J. Immunol. 2005. 174: 3344-3351.
    • (2005) J. Immunol. , vol.174 , pp. 3344-3351
    • Haeryfar, S.M.1    DiPaolo, R.J.2    Tscharke, D.C.3    Bennink, J.R.4    Yewdell, J.W.5
  • 25
    • 84857225568 scopus 로고    scopus 로고
    • Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection
    • Loebbermann, J., Thornton, H., Durant, L., Sparwasser, T., Webster, K. E., Sprent, J., Culley, F. J. et al., Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal. Immunol. 2012. 5: 161-172.
    • (2012) Mucosal. Immunol. , vol.5 , pp. 161-172
    • Loebbermann, J.1    Thornton, H.2    Durant, L.3    Sparwasser, T.4    Webster, K.E.5    Sprent, J.6    Culley, F.J.7
  • 26
    • 63149132590 scopus 로고    scopus 로고
    • Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities
    • Ruckwardt, T. J., Bonaparte, K. L., Nason, M. C. and Graham, B. S., Regulatory T cells promote early influx of CD8+ T cells in the lungs of respiratory syncytial virus-infected mice and diminish immunodominance disparities. J. Virol. 2009. 83: 3019-3028.
    • (2009) J. Virol. , vol.83 , pp. 3019-3028
    • Ruckwardt, T.J.1    Bonaparte, K.L.2    Nason, M.C.3    Graham, B.S.4
  • 27
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmaniamajor persistence and immunity
    • Belkaid, Y., Piccirillo, C. A., Mendez, S., Shevach, E. M. and Sacks, D. L., CD4+CD25+ regulatory T cells control Leishmaniamajor persistence and immunity. Nature 2002. 420: 502-507.
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 29
    • 84897020113 scopus 로고    scopus 로고
    • The intracellular life of Cryptococcus neoformans
    • Coelho, C., Bocca, A. L. and Casadevall, A., The intracellular life of Cryptococcus neoformans. Annu. Rev. Pathol. 2014. 9: 219-238.
    • (2014) Annu. Rev. Pathol. , vol.9 , pp. 219-238
    • Coelho, C.1    Bocca, A.L.2    Casadevall, A.3
  • 31
    • 84888433394 scopus 로고    scopus 로고
    • Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains
    • Chapman, T. J. and Georas, S. N., Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains. J. Immunol. Methods 2013. 400-401: 122-126.
    • (2013) J. Immunol. Methods , vol.400-401 , pp. 122-126
    • Chapman, T.J.1    Georas, S.N.2
  • 32
    • 84900866491 scopus 로고    scopus 로고
    • Limitations of Foxp3 Treg depletion following viral infection in DEREG mice
    • Christiaansen, A. F., Boggiatto, P. M. and Varga, S. M., Limitations of Foxp3 Treg depletion following viral infection in DEREG mice. J. Immunol. Methods 2014. 406: 58-65.
    • (2014) J. Immunol. Methods , vol.406 , pp. 58-65
    • Christiaansen, A.F.1    Boggiatto, P.M.2    Varga, S.M.3
  • 33
    • 80052447493 scopus 로고    scopus 로고
    • Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis
    • Piehler, D., Stenzel, W., Grahnert, A., Held, J., Richter, L., Kohler, G., Richter, T. et al., Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis. Am. J. Pathol. 2011. 179: 733-744.
    • (2011) Am. J. Pathol. , vol.179 , pp. 733-744
    • Piehler, D.1    Stenzel, W.2    Grahnert, A.3    Held, J.4    Richter, L.5    Kohler, G.6    Richter, T.7
  • 34
  • 35
    • 58849104422 scopus 로고    scopus 로고
    • GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
    • Ho, I. C., Tai, T. S. and Pai, S. Y., GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat. Rev. Immunol. 2009. 9: 125-135.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 125-135
    • Ho, I.C.1    Tai, T.S.2    Pai, S.Y.3
  • 36
    • 79953163170 scopus 로고    scopus 로고
    • Immunity to fungal infections
    • Romani, L., Immunity to fungal infections. Nat. Rev. Immunol. 2011. 11: 275-288.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 275-288
    • Romani, L.1
  • 37
    • 20444484565 scopus 로고    scopus 로고
    • The immune response to fungal infections
    • Shoham, S. and Levitz, S. M., The immune response to fungal infections. Br. J. Haematol. 2005. 129: 569-582.
    • (2005) Br. J. Haematol. , vol.129 , pp. 569-582
    • Shoham, S.1    Levitz, S.M.2
  • 39
    • 0029789684 scopus 로고    scopus 로고
    • Role of cytokines in T cell immunity to a pulmonary Cryptococcus neoformans infection
    • Huffnagle, G. B., Role of cytokines in T cell immunity to a pulmonary Cryptococcus neoformans infection. Biol. Signals 1996. 5: 215-222.
    • (1996) Biol. Signals , vol.5 , pp. 215-222
    • Huffnagle, G.B.1
  • 40
    • 0036628960 scopus 로고    scopus 로고
    • Cryptococcal infection and Th1-Th2 cytokine balance
    • Koguchi, Y. and Kawakami, K., Cryptococcal infection and Th1-Th2 cytokine balance. Int. Rev. Immunol. 2002. 21: 423-438.
    • (2002) Int. Rev. Immunol. , vol.21 , pp. 423-438
    • Koguchi, Y.1    Kawakami, K.2
  • 41
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid, Y. and Rouse, B. T., Natural regulatory T cells in infectious disease. Nat. Immunol. 2005. 6: 353-360.
    • (2005) Nat. Immunol. , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 42
    • 8544242704 scopus 로고    scopus 로고
    • Regulatory T cells: friend or foe in immunity to infection?
    • Mills, K. H., Regulatory T cells: friend or foe in immunity to infection? Nat. Rev. Immunol. 2004. 4: 841-855.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 841-855
    • Mills, K.H.1
  • 43
    • 0036107373 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice
    • Hori, S., Carvalho, T. L. and Demengeot, J., CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur. J. Immunol. 2002. 32: 1282-1291.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1282-1291
    • Hori, S.1    Carvalho, T.L.2    Demengeot, J.3
  • 44
    • 0036884607 scopus 로고    scopus 로고
    • B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans
    • Montagnoli, C., Bacci, A., Bozza, S., Gaziano, R., Mosci, P., Sharpe, A. H. and Romani, L., B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J. Immunol. 2002. 169: 6298-6308.
    • (2002) J. Immunol. , vol.169 , pp. 6298-6308
    • Montagnoli, C.1    Bacci, A.2    Bozza, S.3    Gaziano, R.4    Mosci, P.5    Sharpe, A.H.6    Romani, L.7
  • 45
    • 31144456173 scopus 로고    scopus 로고
    • Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism
    • Montagnoli, C., Fallarino, F., Gaziano, R., Bozza, S., Bellocchio, S., Zelante, T., Kurup, W. P. et al., Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J. Immunol. 2006. 176: 1712-1723.
    • (2006) J. Immunol. , vol.176 , pp. 1712-1723
    • Montagnoli, C.1    Fallarino, F.2    Gaziano, R.3    Bozza, S.4    Bellocchio, S.5    Zelante, T.6    Kurup, W.P.7
  • 46
    • 0023223925 scopus 로고
    • Characterization of a third-order suppressor T cell (Ts3) induced by cryptococcal antigen(s)
    • Khakpour, F. R. and Murphy, J. W., Characterization of a third-order suppressor T cell (Ts3) induced by cryptococcal antigen(s). Infect. Immun. 1987. 55: 1657-1662.
    • (1987) Infect. Immun. , vol.55 , pp. 1657-1662
    • Khakpour, F.R.1    Murphy, J.W.2
  • 47
    • 0020062594 scopus 로고
    • Regulation of cell-mediated immunity in cryptococcosis. I. Induction of specific afferent T suppressor cells by cryptococcal antigen
    • Murphy, J. W. and Moorhead, J. W., Regulation of cell-mediated immunity in cryptococcosis. I. Induction of specific afferent T suppressor cells by cryptococcal antigen. J. Immunol. 1982. 128: 276-283.
    • (1982) J. Immunol. , vol.128 , pp. 276-283
    • Murphy, J.W.1    Moorhead, J.W.2
  • 48
    • 0020560196 scopus 로고
    • Regulation of cellmediated immunity in cryptococcosis. II. Characterization of first-order T suppressor cells (Ts1) and induction of second-order suppressor cells
    • Murphy, J. W., Mosley, R. L. and Moorhead, J. W., Regulation of cellmediated immunity in cryptococcosis. II. Characterization of first-order T suppressor cells (Ts1) and induction of second-order suppressor cells. J. Immunol. 1983. 130: 2876-2881.
    • (1983) J. Immunol. , vol.130 , pp. 2876-2881
    • Murphy, J.W.1    Mosley, R.L.2    Moorhead, J.W.3
  • 49
    • 72949106271 scopus 로고    scopus 로고
    • Glucuronoxylomannan promotes the generation of antigen-specific T regulatory cell that suppresses the antigen-specific Th2 response upon activation
    • Liu, T., Chen, X., Feng, B. S., He, S. H., Zhang, T. Y., Wang, B. Q. and Yang, P. C., Glucuronoxylomannan promotes the generation of antigen-specific T regulatory cell that suppresses the antigen-specific Th2 response upon activation. J. Cell Mol. Med. 2009. 13: 1765-1774.
    • (2009) J. Cell Mol. Med. , vol.13 , pp. 1765-1774
    • Liu, T.1    Chen, X.2    Feng, B.S.3    He, S.H.4    Zhang, T.Y.5    Wang, B.Q.6    Yang, P.C.7
  • 50
    • 43449116057 scopus 로고    scopus 로고
    • Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans inducemacrophage apoptosis mediated by Fas ligand
    • Villena, S. N., Pinheiro, R. O., Pinheiro, C. S., Nunes, M. P., Takiya, C. M., DosReis, G. A., Previato, J. O. et al., Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans inducemacrophage apoptosis mediated by Fas ligand. Cell Microbiol. 2008. 10: 1274-1285.
    • (2008) Cell Microbiol. , vol.10 , pp. 1274-1285
    • Villena, S.N.1    Pinheiro, R.O.2    Pinheiro, C.S.3    Nunes, M.P.4    Takiya, C.M.5    DosReis, G.A.6    Previato, J.O.7
  • 51
    • 79955700323 scopus 로고    scopus 로고
    • In vivo depletion of FoxP3+ Tregs using the DEREG mouse model
    • Lahl, K. and Sparwasser, T., In vivo depletion of FoxP3+ Tregs using the DEREG mouse model. Methods Mol. Biol. 2011. 707: 157-172.
    • (2011) Methods Mol. Biol. , vol.707 , pp. 157-172
    • Lahl, K.1    Sparwasser, T.2
  • 52
    • 70449331259 scopus 로고    scopus 로고
    • Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells
    • Rausch, S., Huehn, J., Loddenkemper, C., Hepworth, M. R., Klotz, C., Sparwasser, T., Hamann, A. et al., Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur. J. Immunol. 2009. 39: 3066-3077.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 3066-3077
    • Rausch, S.1    Huehn, J.2    Loddenkemper, C.3    Hepworth, M.R.4    Klotz, C.5    Sparwasser, T.6    Hamann, A.7
  • 53
    • 80051914562 scopus 로고    scopus 로고
    • Foxp3(+) regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis
    • Tian, L., Altin, J. A., Makaroff, L. E., Franckaert, D., Cook, M. C., Goodnow, C. C., Dooley, J. et al., Foxp3(+) regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood 2011. 118: 1845-1853.
    • (2011) Blood , vol.118 , pp. 1845-1853
    • Tian, L.1    Altin, J.A.2    Makaroff, L.E.3    Franckaert, D.4    Cook, M.C.5    Goodnow, C.C.6    Dooley, J.7
  • 54
    • 84894038785 scopus 로고    scopus 로고
    • Foxp3(+) T(reg) cells in humoral immunity
    • Wing, J. B. and Sakaguchi, S., Foxp3(+) T(reg) cells in humoral immunity. Int. Immunol. 2014. 26: 61-69.
    • (2014) Int. Immunol. , vol.26 , pp. 61-69
    • Wing, J.B.1    Sakaguchi, S.2
  • 55
    • 84871856775 scopus 로고    scopus 로고
    • Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer
    • von Boehmer, H. and Daniel, C., Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer. Nat. Rev. Drug Discov. 2013. 12: 51-63.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 51-63
    • von Boehmer, H.1    Daniel, C.2
  • 56
    • 84867356690 scopus 로고    scopus 로고
    • Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation
    • Baru, A. M., Ganesh, V., Krishnaswamy, J. K., Hesse, C., Untucht, C., Glage, S., Behrens, G. et al., Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation. PLoSOne 2012. 7: e47102.
    • (2012) PLoSOne , vol.7
    • Baru, A.M.1    Ganesh, V.2    Krishnaswamy, J.K.3    Hesse, C.4    Untucht, C.5    Glage, S.6    Behrens, G.7


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