Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin

Cell Chemical Biology

Volumn 24, Issue 3, 2017, Pages 316-325

  Storm, Philip A ^a   Herbst, Dominik A ^b   Maier, Timm ^b   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

C methylation; catalytic programming; citrinin; domain deconstruction; iterative biosynthesis; PKS; polyketide; structure

Indexed keywords

CITRININ; ENZYME PRECURSOR; FUNGAL ENZYME; METHYL GROUP; METHYLTRANSFERASE; POLYKETIDE SYNTHASE; S ADENOSYLMETHIONINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME RECONSTITUTION; ENZYME STRUCTURE; ENZYME SYNTHESIS; HYDROGEN BOND; IN VITRO STUDY; LIGAND BINDING; MOLECULAR CLONING; MOLECULAR PHYLOGENY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METHYLATION; SEQUENCE ANALYSIS; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; CLASSIFICATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME SPECIFICITY; ENZYMOLOGY; FUNGUS; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHYLATION; MOLECULAR DOCKING; MONASCUS; PHYLOGENY; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRININ; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; FUNGI; METHYLATION; MOLECULAR DOCKING SIMULATION; MONASCUS; PHYLOGENY; POLYKETIDE SYNTHASES; S-ADENOSYLMETHIONINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY;

EID: 85013675178     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2017.01.008     Document Type: Article

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