Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products

Angewandte Chemie - International Edition

Volumn 52, Issue 6, 2013, Pages 1718-1721

  Vagstad, Anna L ^a   Newman, Adam G ^a   Storm, Philip A ^a   Belecki, Katherine ^a   Crawford, Jason M ^b   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

domain swapping; natural products; pathway engineering; polyketides

Indexed keywords

CATALYTIC DOMAINS; DOMAIN SWAPPING; NATURAL PRODUCTS; NON-NATIVE; POLYKETIDE SYNTHASES; POLYKETIDES; PRODUCT ASSEMBLY; RATIONAL SYNTHESIS;

CATALYSIS; CHEMISTRY;

PLANTS (BOTANY);

POLYKETIDE SYNTHASE; TRANSALDOLASE;

ARTICLE; CHEMISTRY; CYCLIZATION; ENZYME ACTIVE SITE; ENZYMOLOGY; FUNGUS; METABOLIC ENGINEERING; METABOLISM;

CATALYTIC DOMAIN; CYCLIZATION; FUNGI; METABOLIC ENGINEERING; POLYKETIDE SYNTHASES; TRANSALDOLASE;

EID: 84873385451     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201208550     Document Type: Article

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