Structural basis of substrate recognition in human nicotinamide N-methyltransferase

Biochemistry

Volumn 50, Issue 36, 2011, Pages 7800-7808

  Peng, Yi ^a   Sartini, Davide ^b   Pozzi, Valentina ^b   Wilk, Dennis ^a   Emanuelli, Monica ^b   Yee, Vivien C ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; AMIDE GROUPS; AROMATIC RINGS; CANCER THERAPY; CONFORMATIONAL EFFECT; KINETICS ANALYSIS; MD SIMULATION; METABOLIC PATHWAYS; MOLECULAR TARGETS; N-METHYLATION; ORDERS OF MAGNITUDE; S ADENOSYL L METHIONINES; SIDE-CHAINS; STRUCTURAL BASIS; SUBSTRATE RECOGNITION; TERNARY COMPLEX;

ALKYLATION; AMINO ACIDS; CARBOXYLATION; CATALYSIS; CRYSTAL STRUCTURE; DISEASES; ENZYME ACTIVITY; ENZYME KINETICS;

AMIDES;

AMINO ACID; NICOTINAMIDE METHYLTRANSFERASE; RNA;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; MOLECULAR CLONING; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE;

BINDING SITES; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; NIACINAMIDE; NICOTINAMIDE N-METHYLTRANSFERASE; PROTEIN CONFORMATION; S-ADENOSYLMETHIONINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052428125     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2007614     Document Type: Article

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