Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae

Biochemistry

Volumn 47, Issue 26, 2008, Pages 6851-6858

  Qian, Jinghua ^a   Khandogin, Jana ^a   West, Ann H ^a   Cook, Paul F ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONDENSATION; ENZYME ACTIVITY; FOOD ADDITIVES; HYDROCARBONS; MILITARY EQUIPMENT;

2 KETOGLUTARATE; ACTIVE SITE RESIDUES; ACTIVE SITES; CATALYTIC RESIDUES; COENZYME A (COA); HOMOCITRATE SYNTHASE; IMIDAZOLE (IMD); KETOGLUTARATE; METHYL GROUPS; MUTANT ENZYMES; S. CEREVISIAE; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS; SYNTHASE; WILD-TYPE (WT);

ENZYMES;

ACETYL COENZYME A; CITRATE SYNTHASE; MUTANT PROTEIN;

ARTICLE; CATALYSIS; ENZYME STRUCTURE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; CONSERVED SEQUENCE; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXO-ACID-LYASES; PROBABILITY; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT;

SACCHAROMYCES CEREVISIAE;

EID: 46049084185     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800087k     Document Type: Article

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