Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming

Journal of the American Chemical Society

Volumn 136, Issue 20, 2014, Pages 7348-7362

  Newman, Adam G ^a   Vagstad, Anna L ^a,b   Storm, Philip A ^a   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS;

CHEMICAL FEATURES; ENZYMATIC ACTIVITIES; ENZYMATIC MECHANISMS; MULTI-DOMAIN ENZYMES; MULTIDOMAIN FRAGMENT; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; PRODUCT RELEASE;

ENZYMES;

AROMATIC COMPOUND; POLYKETIDE SYNTHASE; THIOL ESTER HYDROLASE; POLYKETIDE;

ARTICLE; CATALYSIS; CYCLIZATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME RELEASE; IN VITRO STUDY; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM;

BIOCATALYSIS; MOLECULAR STRUCTURE; POLYKETIDE SYNTHASES; POLYKETIDES;

EID: 84901036306     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5007299     Document Type: Article

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