Red cell transfusion-associated hemolysis in cardiac surgery: An observational cohort study

Anesthesia and Analgesia

Volumn 124, Issue 6, 2017, Pages 1986-1991

  Karkouti, Keyvan ^a   Callum, Jeannie L ^b   Acker, Jason P ^c,d   Yip, Paul ^b   Rao, Vivek ^b  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d CANADIAN BLOOD SERVICES   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; TRANSFERRIN; BIOLOGICAL MARKER;

ADULT; ARTICLE; CARDIOPULMONARY BYPASS; COHORT ANALYSIS; CONTROLLED STUDY; ERYTHROCYTE TRANSFUSION; FEMALE; HEART SURGERY; HEMOLYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ADVERSE EFFECTS; AGED; BLOOD; BLOOD LOSS, SURGICAL; METABOLISM; MULTIVARIATE ANALYSIS; ODDS RATIO; RISK FACTOR; STATISTICAL MODEL; TIME FACTOR; TREATMENT OUTCOME;

AGED; BIOMARKERS; BLOOD LOSS, SURGICAL; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBINS; HEMOLYSIS; HUMANS; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TRANSFERRIN; TREATMENT OUTCOME;

EID: 85013460494     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000001807     Document Type: Article

References (53)

1. Vamvakas EC, Blajchman MA. Blood still kills: six strategies to further reduce allogeneic blood transfusion-related mortality. Transfus Med Rev. 2010; 24: 77-124.
2. Rohde JM, Dimcheff DE, Blumberg N, et al. Health care-Associated infection after red blood cell transfusion: a systematic review and meta-Analysis. JAMA. 2014; 311: 1317-1326.
3. Karkouti K, Wijeysundera DN, Yau TM, et al. Influence of erythrocyte transfusion on the risk of acute kidney injury after cardiac surgery differs in anemic and nonanemic patients. Anesthesiology. 2011; 115: 523-530.
4. Karkouti K, Grocott HP, Hall R, et al. Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study. Can J Anaesth. 2015; 62: 377-384.
5. Karkouti K. Transfusion and risk of acute kidney injury in cardiac surgery. Br J Anaesth. 2012; 109(suppl 1): i29-i38.
6. Orlov D, Karkouti K. The pathophysiology and consequences of red blood cell storage. Anaesthesia. 2015; 70(suppl 1): 29-37, e9-e12.
7. Acker JP, Hansen AL, Kurach JD, et al A quality monitoring program for red blood cell components: in vitro quality indicators before and after implementation of semiautomated processing. Transfusion. 2014; 54: 2534-2543.
8. Hansen AL, Kurach JD, Turner TR, et al. The effect of processing method on the in vitro characteristics of red blood cell products. Vox Sang. 2015; 108: 350-358.
9. Greer JP, Arber DA, Glader B, et al. Wintrobe?s Clinical Hematology. 13th ed. Philadelphia: Lippincott Williams & Wilkins; 2014.
10. Ozment CP, Turi JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochim Biophys Acta. 2009; 1790: 694-701.
11. Hod EA, Zhang N, Sokol SA, et al. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood. 2010; 115: 4284-4292.
12. Vermeulen Windsant IC, de Wit NC, Sertorio JT, et al. Hemolysis during cardiac surgery is associated with increased intravascular nitric oxide consumption and perioperative kidney and intestinal tissue damage. Front Physiol. 2014; 5: 340.
13. Karkouti K, McCluskey SA, Callum J, et al. Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis. Anesthesiology. 2015; 122: 560-570.
14. Karkouti K, Callum J, Crowther MA, et al. The relationship between fibrinogen levels after cardiopulmonary bypass and large volume red cell transfusion in cardiac surgery: an observational study. Anesth Analg. 2013; 117: 14-22.
15. Hunter FT, Grove-Rasmussen M, Soutter L A spectrophotometric method for quantitating hemoglobin in plasma or serum. Am J Clin Pathol. 1950; 20: 429-433.
16. Piga A, Longo F, Duca L, et al. High nontransferrin bound iron levels and heart disease in thalassemia major. Am J Hematol. 2009; 84: 29-33.
17. Dresow B, Petersen D, Fischer R, et al. Non-Transferrin-bound iron in plasma following administration of oral iron drugs. Biometals. 2008; 21: 273-276.
18. Sahlstedt L, Ebeling F, von Bonsdorff L, et al. Non-Transferrinbound iron during allogeneic stem cell transplantation. Br J Haematol. 2001; 113: 836-838.
19. de Swart L, Hendriks JC, van der Vorm LN, et al. Second international round robin for the quantification of serum nontransferrin-bound iron and labile plasma iron in patients with iron-overload disorders. Haematologica. 2016; 101: 38-45.
20. Allison PD. Logit analysis of longitudinal and other clustered data. In: Allison PD, ed. Logistic Regression Using SAS System: Theory and Application. Cary, NC: SAS Institute, 2012: 217-264.
21. Eyduran E, Ozdemir T, Alarslan E. Importance of diagnostics in multiple regression analysis. J Applied Sci. 2005; 5: 1792-1795.
22. Vittinghoff E, McCulloch CE. Relaxing the rule of ten events per variable in logistic and Cox regression. Am J Epidemiol. 2007; 165: 710-718.
23. Green SB. How many subjects does it take to do a regression analysis. Multivariate Behav Res. 1991; 26: 499-510.
24. Rother RP, Bell L, Hillmen P, et al. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005; 293: 1653-1662.
25. Schaer DJ, Buehler PW, Alayash AI, et al. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013; 121: 1276-1284.
26. Gladwin MT, Kim-Shapiro DB. Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol. 2009; 16: 515-523.
27. Minneci PC, Deans KJ, Zhi H, et al. Hemolysis-Associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest. 2005; 115: 3409-3417.
28. Donadee C, Raat NJ, Kanias T, et al. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011; 124: 465-476.
29. Sassa S. Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide?. Antioxid Redox Signal. 2004; 6: 819-824.
30. Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006; 26: 323-342.
31. Fleming RE, Ponka P. Iron overload in human disease. N Engl J Med. 2012; 366: 348-359.
32. Hod EA, Spitalnik SL. Harmful effects of transfusion of older stored red blood cells: iron and inflammation. Transfusion. 2011; 51: 881-885.
33. Yoshida T, Shevkoplyas SS. Anaerobic storage of red blood cells. Blood Transfus. 2010; 8: 220-236.
34. Martines AM, Masereeuw R, Tjalsma H, et al. Iron metabolism in the pathogenesis of iron-induced kidney injury. Nat Rev Nephrol. 2013; 9: 385-398.
35. Powell LW, Seckington RC, Deugnier Y. Haemochromatosis. Lancet. 2016; 388: 706-716.
36. Haase M, Bellomo R, Haase-Fielitz A. Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-Associated acute kidney injury. J Am Coll Cardiol. 2010; 55: 2024-2033.
37. Leaf DE, Swinkels DW. Catalytic iron and acute kidney injury. Am J Physiol Renal Physiol. 2016; 311: F871-F876.
38. Baek JH, D'Agnillo F, Vallelian F, et al. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest. 2012; 122: 1444-1458.
39. Vermeulen Windsant IC, de Wit NC, Sertorio JT, et al. Blood transfusions increase circulating plasma free hemoglobin levels and plasma nitric oxide consumption: a prospective observational pilot study. Crit Care. 2012; 16: R95.
40. Nagababu E, Scott AV, Johnson DJ, et al. The impact of surgery and stored red blood cell transfusions on nitric oxide homeostasis. Anesth Analg. 2016; 123: 274-282.
41. Vermeulen Windsant IC, Hanssen SJ, Buurman WA, et al. Cardiovascular surgery and organ damage: time to reconsider the role of hemolysis. J Thorac Cardiovasc Surg. 2011; 142: 1-11.
42. Vercaemst L. Hemolysis in cardiac surgery patients undergoing cardiopulmonary bypass: a review in search of a treatment algorithm. J Extra Corpor Technol. 2008; 40: 257-267.
43. Wang D, Cortés-Puch I, Sun J, et al. Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 2014; 54: 1712-1724.
44. Solomon SB, Wang D, Sun J, et al. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013; 121: 1663-1672.
45. Cortés-Puch I, Wang D, Sun J, et al. Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia. Blood. 2014; 123: 1403-1411.
46. Hod EA, Brittenham GM, Billote GB, et al. Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-Transferrin-bound iron. Blood. 2011; 118: 6675-6682.
47. Leaf DE, Rajapurkar M, Lele SS, et al. Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery. Kidney Int. 2015; 87: 1046-1054.
48. Karkouti K, Wijeysundera DN, Yau TM, et al. Advance targeted transfusion in anemic cardiac surgical patients for kidney protection: an unblinded randomized pilot clinical trial. Anesthesiology. 2012; 116: 613-621.
49. Salaria ON, Barodka VM, Hogue CW, et al. Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients. Anesth Analg. 2014; 118: 1179-1187.
50. Luten M, Roerdinkholder-Stoelwinder B, Schaap NP, et al. Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods. Transfusion. 2008; 48: 1478-1485.
51. Steiner ME, Ness PM, Assmann SF, et al. Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med. 2015; 372: 1419-1429.
52. Ferraris VA, Brown JR, Despotis GJ, et al. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011; 91: 944-982.
53. Karkouti K, Callum J, Wijeysundera DN, et al. Point-of-care hemostatic testing in cardiac surgery: a stepped-wedge clustered randomized controlled trial. Circulation. 2016; 154: 1152-1162.