Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion

Circulation

Volumn 124, Issue 4, 2011, Pages 465-476

  Donadee, Chenell ^a,b   Raat, Nicolaas J H ^a,b,c   Kanias, Tamir ^a   Tejero, Jesús ^a   Lee, Janet S ^a   Kelley, Eric E ^a,b   Zhao, Xuejun ^a,b   Liu, Chen ^d   Reynolds, Hannah ^d   Azarov, Ivan ^d   Frizzell, Sheila ^a   Meyer, E Michael ^e   Donnenberg, Albert D ^b,e   Qu, Lirong ^b,f   Triulzi, Darrel ^b,f   Kim Shapiro, Daniel B ^d   Gladwin, Mark T ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d WAKE FOREST UNIVERSITY   (United States)

^e UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^f INSTITUTE FOR TRANSFUSION MEDICINE   (United States)

Author keywords

blood; blood transfusion; hemoglobin; microparticles, cell derived; nitric oxide; reactive oxygen species; storage lesion

Indexed keywords

HEMOGLOBIN; METHEMOGLOBIN; NITRIC OXIDE; OXYHEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BANK; CELL FREE SYSTEM; CONTROLLED STUDY; ENDOTHELIUM INJURY; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE PRESERVATION; HEMOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MEMBRANE MICROPARTICLE; NONHUMAN; OXIDATION REDUCTION STATE; PLASMA TRANSFUSION; PRIORITY JOURNAL; RAT; SCAVENGING SYSTEM; STOICHIOMETRY; VASCULAR DISEASE; VASOCONSTRICTION;

ANIMALS; BLOOD BANKS; BLOOD PRESERVATION; CELL-DERIVED MICROPARTICLES; ERYTHROCYTES; FREE RADICAL SCAVENGERS; HEMOGLOBINS; HUMANS; MALE; METHEMOGLOBIN; NITRIC OXIDE; RATS; RATS, WISTAR; VASOCONSTRICTOR AGENTS;

EID: 79961025290     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.008698     Document Type: Article

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