Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

Blood

Volumn 115, Issue 21, 2010, Pages 4284-4292

  Hod, Eldad A ^a,b   Zhang, Ning ^c   Sokol, Set A ^a   Wojczyk, Boguslaw S ^a   Francis, Richard O ^a   Ansaldi, Daniel ^c   Francis, Kevin P ^c   Della Latta, Phyllis ^a   Whittier, Susan ^a   Sheth, Sujit ^a   Hendrickson, Jeanne E ^d   Zimring, James C ^d   Brittenham, Gary M ^a   Spitalnik, Steven L ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b NEW YORK BLOOD CENTER   (United States)

^c Caliper Life Sciences   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; LUCIFERASE; NONTRANSFERRIN BOUND IRON; UNCLASSIFIED DRUG; AUTACOID; DEFEROXAMINE; ENDOTOXIN; HEMOGLOBIN; IRON CHELATING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CELL LYSATE; CELL SUBPOPULATION; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; ERYTHROCYTE GHOST; ERYTHROCYTE LIFESPAN; ERYTHROCYTE PRESERVATION; ERYTHROCYTE TRANSFUSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; IRON BLOOD LEVEL; IRON STORAGE; KIDNEY; LIVER; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; SPLEEN; SUPERNATANT; ACUTE PHASE RESPONSE; ANIMAL; BIOLOGICAL MODEL; BLOOD; BLOOD STORAGE; C57BL MOUSE; DISEASE MODEL; ESCHERICHIA COLI INFECTION; HUMAN; MALE; METABOLISM; TIME; TRANSGENIC MOUSE;

ACUTE-PHASE REACTION; ANIMALS; BLOOD PRESERVATION; DEFEROXAMINE; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ENDOTOXINS; ERYTHROCYTE AGING; ERYTHROCYTE TRANSFUSION; ESCHERICHIA COLI INFECTIONS; HEMOGLOBINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; IRON; IRON CHELATING AGENTS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; SPLEEN; TIME FACTORS;

EID: 77953638866     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-10-245001     Document Type: Article

References (41)

1. Dumont LJ, AuBuchon JP. Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials. Transfusion. 2008;48(6):1053-1060.
2. Whitaker B, Sullivan M. The 2005 Nationwide Blood Collection and Utilization Survey Report. Bethesda, MD: AABB; 2006.
3. Luten M, Roerdinkholder-Stoelwinder B, Schaap NP, de Grip WJ, Bos HJ, Bosman GJ. Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods. Transfusion. 2008;48(7):1478-1485.
4. Zeiler T, Muller JT, Kretschmer V. Flow-cytometric determination of survival time and 24-hour recovery of transfused red blood cells. Transfus Med Hemother. 2003;30:14-19. (Pubitemid 37499839)
5. Ozment CP, Turi JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochim Biophys Acta. 2009;1790(7):694-701.
6. Leal-Noval SR, Rincon-Ferrari MD, Garcia-Curiel A, et al. Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. Chest. 2001;119(5):1461-1468.
7. Purdy FR, Tweeddale MG, Merrick PM. Association of mortality with age of blood transfused in septic ICU patients. Can J Anaesth. 1997;44(12):1256-1261.
8. Koch CG, Li L, Sessler DI, et al. Duration of redcell storage and complications after cardiac surgery. N Engl J Med. 2008;358(12):1229-1239.
9. Weinberg JA, McGwin G Jr, Marques MB, et al. Transfusions in the less severely injured: does age of transfused blood affect outcomes? J Trauma. 2008;65(4):794-798.
10. Offner PJ, Moore EE, Biffl WL, Johnson JL, Silliman CC. Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg. 2002;137(6):711-716.
11. Vandromme MJ, McGwin G Jr, Marques MB, Kerby JD, Rue LW 3rd, Weinberg JA. Transfusion and pneumonia in the trauma intensive care unit: an examination of the temporal relationship. J Trauma. 2009;67(1):97-101.
12. Zallen G, Offner PJ, Moore EE, et al. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg. 1999;178(6):570-572. (Pubitemid 30058313)
13. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008;181(4):2723-2731.
14. Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am J Physiol. 1999;277(6 Pt 1):G1240-G1250.
15. Gordeuk VR, Ballou S, Lozanski G, Brittenham GM. Decreased concentrations of tumor necrosis factor-alpha in supernatants of monocytes from homozygotes for hereditary hemochromatosis. Blood. 1992;79(7):1855-1860.
16. von Bonsdorff L, Sahlstedt L, Ebeling F, Ruutu T, Parkkinen J. Apotransferrin administration prevents growth of Staphylococcus epidermidis in serum of stem cell transplant patients by binding of free iron. FEMS Immunol Med Microbiol. 2003;37(1):45-51.
17. Barton Pai A, Pai MP, Depczynski J, McQuade CR, Mercier RC. Non-transferrin-bound iron is associated with enhanced Staphylococcus aureus growth in hemodialysis patients receiving intravenous iron sucrose. Am J Nephrol. 2006;26(3):304-309. (Pubitemid 44114402)
18. Hirano K, Morinobu T, Kim H, et al. Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2001;84(3):F188-F193.
19. Grosse R, Lund U, Caruso V, et al. Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major. Ann N YAcad Sci. 2005;1054:429-432.
20. Gilson CR, Kraus TS, Hod EA, et al. A novel mouse model of red blood cell storage and post-transfusion in vivo survival. Transfusion. 2009;49(8):1546-1553.
21. Moore GL, Ledford ME, Merydith A. A micromodification of the Drabkin hemoglobin assay for measuring plasma hemoglobin in the range of 5 to 2000 mg/dl. Biochem Med. 1981;26(2):167-173.
22. Schelonka RL, Chai MK, Yoder BA, Hensley D, Brockett RM, Ascher DP. Volume of blood required to detect common neonatal pathogens. J Pediatr. 1996;129(2):275-278.
23. Hod EA, Cadwell CM, Liepkalns JS, et al. Cytokine storm in a mouse model of IgG-mediated hemolytic transfusion reactions. Blood. 2008;112(3):891-894.
24. Zhang D, Okada S, Kawabata T, Yasuda T. An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum. Biochem Mol Biol Int. 1995;35(3):635-641. (Pubitemid 26177837)
25. Evans RW, Rafique R, Zarea A, et al. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. J Biol Inorg Chem. 2008;13(1):57-74.
26. Overmoyer BA, McLaren CE, Brittenham GM. Uniformity of liver density and nonheme (storage) iron distribution. Arch Pathol Lab Med. 1987;111(6):549-554.
27. Zhang N, Ahsan MH, Purchio AF, West DB. Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. J Immunol. 2005;174(12):8125-8134.
28. Neupane GP, Kim DM. Comparison of the effects of deferasirox, deferiprone, and deferoxamine on the growth and virulence of Vibrio vulnificus. Transfusion. 2009;49(8):1762-1769.
29. Rao GH, Cox AC, Gerrard JM, White JG. Effects of 2,2′-dipyridyl and related compounds on platelet prostaglandin synthesis and platelet function. Biochim Biophys Acta. 1980;628(4):468-479.
30. Vulcano M, Meiss RP, Isturiz MA. Deferoxamine reduces tissue injury and lethality in LPS-treated mice. Int J Immunopharmacol. 2000;22(8):635-644. (Pubitemid 30320803)
31. Kaye D, Hook EW. The influence of hemolysis or blood loss on susceptibility to infection. J Immunol. 1963;91:65-75.
32. Kaye D, Gill FA, Hook EW. Factors influencing host resistance to Salmonella infections: the effects of hemolysis and erythrophagocytosis. Am J Med Sci. 1967;254(2):205-215.
33. Bullen J, Rogers H, Spalding P, Ward C. Iron and infection: the heart of the matter. FEMS Immunol Med Microbiol. 2005;43(3):325-330.
34. Mangalmurti NS, Xiong Z, Hulver M, et al. Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood. 2009;113(5):1158-1166.
35. Hider RC. Nature of nontransferrin-bound iron. Eur J Clin Invest. 2002;32(suppl 1):50-54.
36. Hershko C. Mechanism of iron toxicity. Food Nutr Bull. 2007;28(4 suppl):S500-S509.
37. Remick DG, Villarete L. Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates. J Leukoc Biol. 1996;59(4):471-475.
38. Schreck R, Albermann K, Baeuerle PA. Nuclear factor kappaB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun. 1992;17(4):221-237.
39. Swanson JA, Hoppe AD. The coordination of signaling during Fc receptor-mediated phagocytosis. J Leukoc Biol. 2004;76(6):1093-1103.
40. Yamamoto K, Johnston RB Jr. Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages. J Exp Med. 1984;159(2):405-416. (Pubitemid 14193985)
41. Debets JM, Van der Linden CJ, Dieteren IE, Leeuwenberg JF, Buurman WA. Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes. J Immunol. 1988;141(4):1197- 1201.