Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

Blood

Volumn 115, Issue 21, 2010, Pages 4284-4292

  Hod, Eldad A ^a,b   Zhang, Ning ^c   Sokol, Set A ^a   Wojczyk, Boguslaw S ^a   Francis, Richard O ^a   Ansaldi, Daniel ^c   Francis, Kevin P ^c   Della Latta, Phyllis ^a   Whittier, Susan ^a   Sheth, Sujit ^a   Hendrickson, Jeanne E ^d   Zimring, James C ^d   Brittenham, Gary M ^a   Spitalnik, Steven L ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b NEW YORK BLOOD CENTER   (United States)

^c Caliper Life Sciences   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; LUCIFERASE; NONTRANSFERRIN BOUND IRON; UNCLASSIFIED DRUG; AUTACOID; DEFEROXAMINE; ENDOTOXIN; HEMOGLOBIN; IRON CHELATING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; CELL LYSATE; CELL SUBPOPULATION; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVITY; ERYTHROCYTE GHOST; ERYTHROCYTE LIFESPAN; ERYTHROCYTE PRESERVATION; ERYTHROCYTE TRANSFUSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; IRON BLOOD LEVEL; IRON STORAGE; KIDNEY; LIVER; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; SPLEEN; SUPERNATANT; ACUTE PHASE RESPONSE; ANIMAL; BIOLOGICAL MODEL; BLOOD; BLOOD STORAGE; C57BL MOUSE; DISEASE MODEL; ESCHERICHIA COLI INFECTION; HUMAN; MALE; METABOLISM; TIME; TRANSGENIC MOUSE;

ACUTE-PHASE REACTION; ANIMALS; BLOOD PRESERVATION; DEFEROXAMINE; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ENDOTOXINS; ERYTHROCYTE AGING; ERYTHROCYTE TRANSFUSION; ESCHERICHIA COLI INFECTIONS; HEMOGLOBINS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; IRON; IRON CHELATING AGENTS; KIDNEY; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; SPLEEN; TIME FACTORS;

EID: 77953638866     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-10-245001     Document Type: Article

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