Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron

Blood

Volumn 118, Issue 25, 2011, Pages 6675-6682

  Hod, Eldad A ^a   Brittenham, Gary M ^a   Billote, Genia B ^a   Francis, Richard O ^a,b   Ginzburg, Yelena Z ^b   Hendrickson, Jeanne E ^c,d   Jhang, Jeffrey ^a   Schwartz, Joseph ^a   Sharma, Shruti ^a   Sheth, Sujit ^a   Sireci, Anthony N ^a   Stephens, Hannah L ^a   Stotler, Brie A ^a   Wojczyk, Boguslaw S ^a   Zimring, James C ^c,d   Spitalnik, Steven L ^a  

^a New York Presbyterian Hospital ^*  (United States)

^b NEW YORK BLOOD CENTER   (United States)

^c CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; LACTATE DEHYDROGENASE; TRANSFERRIN;

ADULT; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BLOOD AUTOTRANSFUSION; BLOOD STORAGE; CELL PROLIFERATION; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CORRELATION COEFFICIENT; ERYTHROCYTE TRANSFUSION; ESCHERICHIA COLI; FEMALE; HEMOLYSIS; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; INFLAMMATION; IRON BINDING CAPACITY; LABORATORY DIAGNOSIS; MALE; METABOLIC PARAMETERS; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 84055177595     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-08-371849     Document Type: Article

References (42)

1. Ness PM. Does transfusion of stored red blood cells cause clinically important adverse effects? A critical question in search of an answer and a plan. Transfusion. 2011;51(4):666-667.
2. Koch CG, Li L, Sessler DI, et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med. 2008;358(12):1229-1239. (Pubitemid 351439224)
3. Pettila V, Westbrook AJ, Nichol AD, et al. Age of red blood cells and mortality in the critically ill. Crit Care. 2011;15(2):R116.
4. Sanders J, Patel S, Cooper J, et al. Red blood cell storage is associated with length of stay and renal complications after cardiac surgery. Transfusion. 2011;51(11):2286-2294.
5. D'Alessandro A, Liumbruno G, Grazzini G, Zolla L. Red blood cell storage: the story so far. Blood Transfus. 2010;8(2):82-88.
6. Kekre N, Chou A, Tokessey M, et al. Storage time of transfused red blood cells and impact on clinical outcomes in hematopoietic stem cell transplantation. Transfusion. 2011;51(11):2488-2494.
7. Lelubre C, Piagnerelli M, Vincent JL. Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality? Transfusion. 2009;49(7):1384-1394.
8. Weinberg JA, McGwin G Jr, Marques MB, et al. Transfusions in the less severely injured: does age of transfused blood affect outcomes? J Trauma. 2008;65(4):794-798.
9. Offner PJ, Moore EE, Biffl WL, Johnson JL, Silliman CC. Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg. 2002;137(6):711-716.
10. Hassan M, Pham TN, Cuschieri J, et al. The association between the transfusion of older blood and outcomes after trauma. Shock. 2011;35(1):3-8.
11. Vandromme MJ, McGwin G Jr, Marques MB, Kerby JD, Rue LW 3rd, Weinberg JA. Transfusion and pneumonia in the trauma intensive care unit: an examination of the temporal relationship. J Trauma. 2009;67(1):97-101.
12. Whitaker B. Report of the United States Department of Health and Human Services: the 2009 National Blood Collection and Utilization Survey Report. Washington, DC: United States Department of Health and Human Services, Office of the Assistant Secretary for Health; 2011.
13. Tinmouth A, Fergusson D, Yee IC, Hebert PC. Clinical consequences of red cell storage in the critically ill. Transfusion. 2006;46(11):2014-2027. (Pubitemid 44631611)
14. Bennett-Guerrero E, Veldman TH, Doctor A, et al. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci U S A. 2007;104(43):17063-17068. (Pubitemid 350210992)
15. Hod EA, Zhang N, Sokol SA, et al. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood. 2010;115(21):4284-4292.
16. Hod EA, Hendrickson JE, Sharma S, et al. Transfusion of mouse RBCs stored in AS-1 induces inflammation and exacerbates bacterial sepsis. Transfusion. 2010;50(suppl):S23-S30.
17. Bratosin D, Mazurier J, Tissier JP, et al. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages: a review. Biochimie. 1998;80(2):173-195. (Pubitemid 28185056)
18. Luten M, Roerdinkholder-Stoelwinder B, Schaap NP, de Grip WJ, Bos HJ, Bosman GJ. Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods. Transfusion. 2008;48(7):1478-1485.
19. Hutchinson C, Al-Ashgar W, Liu DY, Hider RC, Powell JJ, Geissler CA. Oral ferrous sulphate leads to a marked increase in pro-oxidant non-transferrin- bound iron. Eur J Clin Invest. 2004;34(11):782-784. (Pubitemid 39524304)
20. Hider RC. Nature of nontransferrin-bound iron. Eur J Clin Invest. 2002;32(suppl 1):50-54. (Pubitemid 41704988)
21. Breuer W, Hershko C, Cabantchik ZI. The importance of non-transferrin bound iron in disorders of iron metabolism. Transfus Sci. 2000;23(3):185-192.
22. Ratledge C. Iron metabolism and infection. Food Nutr Bull. 2007;28(4 suppl):S515-S523. (Pubitemid 351149502)
23. Nairz M, Schroll A, Sonnweber T, Weiss G. The struggle for iron: a metal at the host-pathogen interface. Cell Microbiol. 2010;12(12):1691-1702.
24. Krewulak KD, Vogel HJ. Structural biology of bacterial iron uptake. Biochim Biophys Acta. 2008;1778(9):1781-1804.
25. Walter PB, Fung EB, Killilea DW, et al. Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol. 2006;135(2):254-263. (Pubitemid 44401624)
26. de Valk B, Addicks MA, Gosriwatana I, Lu S, Hider RC, Marx JJ. Non-transferrin-bound iron is present in serum of hereditary haemochromatosis heterozygotes. Eur J Clin Invest. 2000;30(3):248-251. (Pubitemid 30153666)
27. Riddington C, Owusu-Ofori S. Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. Cochrane Database Syst Rev. 2002(3):CD003427.
28. Ricerca BM, Di Girolamo A, Rund D. Infections in thalassemia and hemoglobinopathies: focus on therapy-related complications. Mediterr J Hematol Infect Dis. 2009;1(1):e2009028.
29. Khan FA, Fisher MA, Khakoo RA. Association of hemochromatosis with infectious diseases: expanding spectrum. Int J Infect Dis. 2007;11(6): 482-487. (Pubitemid 47626050)
30. Dresow B, Petersen D, Fischer R, Nielsen P. Non-transferrin-bound iron in plasma following administration of oral iron drugs. Biometals. 2008;21(3):273-276. (Pubitemid 351579742)
31. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet. 2006;367(9505):133-143. (Pubitemid 43077129)
32. World Health Organization. Conclusions and recommendations of the WHO Consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas. Food Nutr Bull. 2007;28(4 suppl):S621-S627.
33. Mollison PL. The transfusion of red cells. In: Mollison's Blood Transfusion in Clinical Medicine (11th ed). Oxford, United Kingdom: Blackwell; 2005:382.
34. Wiesen AR, Hospenthal DR, Byrd JC, Glass KL, Howard RS, Diehl LF. Equilibration of hemoglobin concentration after transfusion in medical inpatients not actively bleeding. Ann Intern Med. 1994;121(4):278-330.
35. Sekhsaria S, Fomufod A. Readjustment of hematocrit values after packed red cell transfusion in the neonate. J Perinatol. 1991;11(2):161-163.
36. Hod EA, Spitalnik SL. Harmful effects of transfusion of older stored red blood cells: iron and inflammation. Transfusion. 2011;51(4):881-885.
37. Hershko C. Mechanism of iron toxicity. Food Nutr Bull. 2007;28(4 suppl):S500-S509. (Pubitemid 351149500)
38. Matinaho S, von Bonsdorff L, Rouhiainen A, Lonnroth M, Parkkinen J. Dependence of Staphylococcus epidermidis on non-transferrin-bound iron for growth. FEMS Microbiol Lett. 2001;196(2):177-182. (Pubitemid 32232257)
39. Reynolds JD, Ahearn GS, Angelo M, Zhang J, Cobb F, Stamler JS. S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci U S A. 2007;104(43):17058-17062. (Pubitemid 350210991)
40. Gladwin MT, Kim-Shapiro DB. Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol. 2009;16(6):515-523.
41. Lee JS, Gladwin MT. Bad blood: the risks of red cell storage. Nat Med. 2010;16(4):381-382.
42. Donadee C, Raat NJ, Kanias T, et al. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011;124(4):465-476.